[H]N(C(=O)C([H])([H])[H])C([H])([H])C#CC1=C([H])N=C(OC2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])S1 [H]N([H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])S1)C([H])([H])[H] [H]C1=C([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C(C(=O)N3C([H])([H])C([H])([H])C([H])(N4C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N5C([H])([H])C([H])([H])OC([H])([H])C5([H])[H])C4([H])[H])C([H])([H])C3([H])[H])=C2C([H])=C1[H] [H]N(C(=O)OC([H])([H])[H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])S1)C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])S1)C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])S1)C1([H])C([H])([H])C1([H])[H] [H]ON(C(=O)N([H])[H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])S1)C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])S1)C([H])([H])[H] [H]N([H])C(=O)N([H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])S1)C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])S1)C([H])([H])[H] [H]N(C(=O)N([H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])S1)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])[C@]([H])(C#CC1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]O[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])S1)C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])N=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])S1)C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(SC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])S1)C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])[C@]([H])(C#CC1=C([H])N=C(SC2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])S1)C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=NC(=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=NC2=C1C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=NC2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=NC2=C1C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=NC2=C1C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C2=C(N1[H])C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=NC2=C1C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C1C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C1C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C(=NC2=C1C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N1N=C(C([H])=C1[H])C1=C([H])C2=C(OC3(C([H])([H])C2=O)C([H])([H])C([H])([H])N(C(=O)C2=C([H])C4=C(N([H])N=C4[H])C(=C2[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C1[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(C([H])=C3[H])C3=NN(C([H])=C3[H])C([H])([H])[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])(C([H])([H])[H])C([H])([H])[H])=NC([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=NC(=C3[H])C([H])([H])[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=NC([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C(C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])(C([H])([H])[H])C([H])([H])[H])=NC([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(C([H])=C3[H])C3=NN([H])C(=C3[H])C([H])([H])[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(C(=C3[H])C([H])([H])[H])C([H])([H])[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(C([H])=C3[H])C([H])([H])[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(Cl)C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(C([H])=C3C([H])([H])[H])C([H])([H])[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C(C2=C1C([H])=C(C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N1N=C(C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(N=C3[H])C3=C([H])N(N=C3[H])C([H])([H])[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(OC([H])([H])[H])N=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C(C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(C(=C3[H])C([H])([H])[H])C([H])([H])[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(C([H])=C3[H])C3=C([H])OC(=N3)C([H])([H])[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(C([H])=C3[H])C3=C([H])N=C(O3)C([H])([H])[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(C([H])=C3[H])C3=C(ON=C3C([H])([H])[H])C([H])([H])[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=NC2=C1C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(N=C3[H])C3=C([H])N(N=C3[H])C([H])([H])[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C1=NN(C([H])=C1[H])C([H])([H])[H] [H]N1N=C(C2=C1C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC2=C([H])N=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC2=C([H])N=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])N=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])N=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)OC([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])N=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C([H])=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])N=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=NC([H])([H])[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])N=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=NN=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])N=C(OC([H])(C([H])([H])[H])C([H])([H])[H])N=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])N=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=NC([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])N=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=NC([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=NC([H])=C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=NC([H])=C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC([H])([H])[C@]([H])(OC2=NC([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])O1 [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC([H])([H])[C@]([H])(OC2=C([H])C([H])=C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])O1 [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC([H])([H])[C@]([H])(OC2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])O1 [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C3([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])O1 [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C([H])([H])O1 [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])O1 [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C3=C([H])C(OC4([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C([H])C([H])=C23)C([H])([H])O1 [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C(F)(F)F)C([H])([H])C2([H])[H])C2=C([H])C([H])=C(C([H])=C2S1)C([H])([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C4=C(OC([H])([H])O4)C([H])=C3[H])C([H])([H])C2([H])[H])=C2C([H])=C([H])C([H])=C([H])C2=N1 [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C([H])C([H])=NC(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C([H])C(=NC(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C3C([H])=C([H])N([H])C3=NC(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=NC(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])C2=C(ON=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])C2=C([H])N([H])N=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])C(=C1[H])C(=O)N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(C(=O)N([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C2C([H])=C([H])C([H])=C([H])C2=N1 [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])C2=C([H])N(N=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C(C(=O)N([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C(C(=O)N([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C(C(=O)N([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C1([H])[H] [H]OC1([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N(C3=C([H])C(C(=O)N([H])C([H])([H])[C@@]4([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C4([H])[H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)N2C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)N2C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)N2C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])OC(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C(C(=O)N([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C2C([H])=C([H])C([H])=C([H])C2=N1 [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])N2C([H])([H])C([H])(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C([H])N(N=C3C(=O)C2([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N(N=C3C(=O)C2([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C([H])N(N=C3C(=O)C2([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N(N=C3C(=O)C2([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C([H])N(N=C3C(=O)C2([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C([H])N(N=C3C(=O)C2([H])[H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C([H])N(N=C3C(=O)C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C([H])N(N=C3C(=O)C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C(C2=C1C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N(N=C3C(=O)C2([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C(C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N(N=C3C(=O)C2([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N(N=C3C(=O)C2([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N1N=C(C2=C1C(OC([H])([H])C([H])([H])[H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N(N=C3C(=O)C2([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C(C2=C1C(OC([H])([H])C([H])([H])[H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N(N=C3C(=O)C2([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N1N=C([H])C2=C1C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N(N=C3C(=O)C2([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N(N=C3C(=O)C2([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=NC2=C1C([H])=C(C([H])=C2C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N(N=C3C(=O)C2([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=NC2=C1C([H])=C(C([H])=C2C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N(N=C3C(=O)C2([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C(C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C([H])N(N=C3C(=O)C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1N=C(C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N(N=C3C(=O)C2([H])[H])[C@]2([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=NC2=C1C([H])=C(C([H])=C2C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C([H])N(N=C3C(=O)C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=NC2=C1C([H])=C(C([H])=C2C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C([H])N(N=C3C(=O)C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=NN(C2=C1C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C([H])N(N=C3C(=O)C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])=NC2=C1C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C([H])N(N=C3C(=O)C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C(C(=O)N3C([H])([H])C([H])([H])C([H])(N4C([H])([H])C([H])([H])C([H])([H])[C@]5(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C5([H])[H])C4([H])[H])C([H])([H])C3([H])[H])=C2C([H])=C1[H] [H]C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(C(=O)N1C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])C3([H])[H])C([H])([H])C1([H])[H])=C(S2)C([H])([H])[H] [H]N([H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N([H])C(=O)N([H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C(C(=O)N3C([H])([H])C([H])([H])C([H])(N4C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C4([H])[H])C([H])([H])C3([H])[H])=C2C([H])=C1[H] [H]C1=C([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C(C(=O)N3C([H])([H])C([H])([H])N(C4=C([H])C(=C([H])C([H])=C4[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])=C2C([H])=C1[H] [H]C1=C([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C(C(=O)N3C([H])([H])C([H])([H])N(C4=C([H])C5=C(C([H])=C4[H])C([H])([H])N(C5=O)C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])=C2C([H])=C1[H] [H]C1=C([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C(C(=O)N3C([H])([H])C([H])([H])C([H])(N4C([H])([H])C([H])([H])C([H])([H])[C@]5(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C5([H])[H])C4([H])[H])C([H])([H])C3([H])[H])=C2C([H])=C1[H] [H]C1=C([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C(C(=O)N3C([H])([H])C([H])([H])C([H])(N4C([H])([H])C([H])([H])C([H])([H])[C@]5(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C5([H])[H])C4([H])[H])C([H])([H])C3([H])[H])=C2C([H])=C1[H] [H]C1=C([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C(C(=O)N3C([H])([H])C([H])([H])C([H])(N4C([H])([H])C([H])([H])C([H])([H])[C@]5(C(=O)O[C@@]([H])(C([H])([H])[H])C5([H])[H])C4([H])[H])C([H])([H])C3([H])[H])=C2C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C4(C(=O)N5N(C4=O)C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C(OC([H])([H])[H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C4(C(=O)N5N(C4=O)C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C(OC([H])([H])[H])=C([H])C([H])=C2[H] [H]N([H])C(=O)N([H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C4(C(=O)N5N(C4=O)C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C(OC([H])([H])[H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C4(C(=O)N5N(C4=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C4(C(=O)N5N(C4=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C4(C(=O)N5N(C4=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C4(C(=O)N5N(C4=O)C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C4(C(=O)N5N(C4=O)C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C4(C(=O)N(N(C4=O)C([H])([H])[H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C([H])=C2OC(SC([H])([H])[C@@]3([H])N=C(OC3([H])[H])C3=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C3[H])=NC2=N1 [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(N=C(N(C4=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)N=C(C([H])=C2[H])C([H])([H])[H] [H]N([H])C(=O)N([H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@@]4(C(=O)N(C(=O)C4([H])[H])C([H])([H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(C(=O)N(C(=O)C4([H])[H])C([H])([H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N([H])C(=O)N([H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(OC(=O)N(C4=O)C([H])([H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(OC(=O)N(C4=O)C([H])([H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@@]4(N([H])C(=O)N(C4=O)C([H])([H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@@]4(N(C(=O)N(C4=O)C([H])([H])C([H])([H])[H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N([H])C(=O)N([H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(N=C(N(C4=O)C([H])([H])C([H])([H])[H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N([H])C(=O)N([H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(N=C(N(C4=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@@]4(C(=O)N([H])C([H])([H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(C(=O)N(C([H])([H])[H])C([H])([H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@@]4(C(=O)N(C([H])([H])C4([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@@]4(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)N=C([H])C([H])=C2[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@@]4(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)N=C(C([H])=C2[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@@]4(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=N2 [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@@]4(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)N=C([H])C([H])=N2 [H]N(C(=O)N([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@@]4(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)N=C(C([H])=C2[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@@]4(C(=O)N(C([H])([H])C4([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)N=C(C([H])=C2[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@@]4(C(=O)N(C(=O)C4([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)N=C(C([H])=C2[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(OC(=O)N(C4=O)C([H])(C([H])([H])[H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)N=C(C([H])=C2[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(N([H])C(=O)N(C4=O)C([H])(C([H])([H])[H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)N=C(C([H])=C2[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=NC([H])=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])N=C(O[C@@]2([H])C([H])([H])O[C@@]([H])(OC2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=NC([H])=C(O[C@]3([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C2[H])C([H])=C1[H] [H]C1=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(O[C@@]2([H])C([H])([H])O[C@@]([H])(OC2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])[H])=N1 [H]C1=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C(Cl)C(O[C@@]2([H])C([H])([H])O[C@@]([H])(OC2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])[H])=N1 [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=N2)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=NC([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2Cl)C([H])=C1[H] [H]C1=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C(=O)C([H])([H])[H])C([H])=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=N1 [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=NC([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C(=O)C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(OC2=NC([H])=C(C([H])=N2)C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C(=O)C([H])([H])[H])C([H])=N1 [H]C1=NC(OC([H])(C([H])([H])[H])C([H])([H])[H])=NC([H])=C1OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C(=O)C([H])([H])[H] [H]C(=O)C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])N=C2[H])C([H])=C1[H] [H]C1=NC(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C(=O)OC([H])([H])[H] [H]N([H])C(=O)C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])N=C2[H])C([H])=C1[H] [H]OC([H])([H])C(=O)C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])N=C2[H])C([H])=C1[H] [H]C1=NC(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])N=C1OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C(=O)C([H])([H])[H] [H]C1=NC(OC([H])([H])C2([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C(=O)C([H])([H])[H] [H]C1=NC(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C(=O)C([H])([H])[H])=C([H])C([H])=C1OC1=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] CNC1=CC=C2C=CC(=CC2=N1)C(=O)N1CCC2(CC1)CC1=CN(N=C1C(=O)C2)C(C)(C)C CC(C)N1N=CC2=C1C(=O)CC1(CCN(CC1)C(=O)C1=CC3=NC(N)=CC=C3C=C1)C2 COC1=CC=C2N=CC(=CC2=C1)C(=O)N1CCC2(CC1)CC1=C(N(N=C1)C(C)C)C(=O)C2 CC(C)N1N=CC2=C1C(=O)CC1(CCN(CC1)C(=O)C1=CC3=C(NC(=C3)C(N)=O)C=C1)C2