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[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])[C@]1([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N(C(=O)[C@]([H])(N1C([H])([H])C([H])([H])N2C(=NC(OC([H])([H])[H])=C2[C@]1([H])C([H])([H])C([H])([H])C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C2=C(C(=NN2C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C1=C([H])C(F)=C(C(F)=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@]([H])(N1C([H])([H])C([H])([H])N2C(=NC(OC([H])([H])[H])=C2[C@]1([H])C([H])([H])C([H])([H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C(N=C2SC([H])=C([H])N12)C([H])([H])[H])[C@@]1([H])C([H])([H])N(C(=O)C2=C(SC(=N2)C([H])([H])[H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC(C(=O)N2C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])N([H])C(=O)C2=C(Cl)N=C3SC([H])=C([H])N23)=C(S1)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C1=NC(C(=O)N2C([H])([H])[C@@]3([H])C([H])([H])[C@@]3([H])[C@@]2([H])C([H])([H])N([H])C(=O)C2=C(N=C3SC([H])=C([H])N23)C([H])([H])[H])=C(S1)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C(N=C2SC([H])=C([H])N12)C([H])([H])[H])C([H])([H])[C@@]1([H])N(C(=O)C2=C(SC(=N2)C([H])([H])[H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])[C@@]2([H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]C1=C(N(N=C1C([H])([H])N(C(=O)C([H])([H])N(C1=C(Cl)C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=NN1C([H])([H])[H])C([H])([H])N(C(=O)C([H])([H])N(C1=C(Cl)C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=NC(=C1[H])C([H])([H])[H])C([H])([H])N(C(=O)C([H])([H])N(C1=C(Cl)C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])=C1Cl)N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C([H])([H])SC2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])[C@@]1([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(C(=O)N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1C(=O)N1C([H])([H])[C@@]2([H])N(C3=NC([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])[C@]([H])(C2([H])[H])C1([H])[H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1C(=O)N1C([H])([H])C([H])([H])[C@@]2([H])N(C3=NC([H])=C4C([H])=C(F)C([H])=C([H])C4=N3)C([H])([H])[C@]1([H])C2([H])[H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1C(=O)N1C([H])([H])[C@@]2([H])N(C3=NC([H])=C4C([H])=C(F)C([H])=C([H])C4=N3)C([H])([H])[C@]([H])(C2([H])[H])C1([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C3C([H])=C(F)C([H])=C([H])C3=N2)C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])[C@]1([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N([H])[C@]([H])(C(=O)N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1C(=O)N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])N(C1=NC([H])=C3C([H])=C([H])C(F)=C([H])C3=N1)C2([H])[H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1C(=O)N1C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N(C1=NC([H])=C3C([H])=C([H])C(F)=C([H])C3=N1)C2([H])[H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1C(=O)N1C([H])([H])C([H])([H])[C@@]2([H])N(C3=NC([H])=C4C([H])=C([H])C(F)=C([H])C4=N3)C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C3C([H])=C(F)C([H])=C([H])C3=N2)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C(F)C(F)=C([H])C3=N2)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C3C(=N2)C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C2=NC3=C(O2)C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C2=NC3=C(O2)C([H])=C([H])C(Cl)=C3[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C2=C(C(=NN2C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C2=C(C(=NN2C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C2=C(C(=NN2C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C2=C(C(=NN2C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C2=C(C(=NN2C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C2=C(C(=NN2C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C2=C(C(=NN2C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C2=C(C(=NN2C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C2=C(C(=NN2C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C2=C(C(=NN2C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C2=C(C(=NN2C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])S(=O)(=O)N(C1=C([H])C2=C(SN=C2C([H])([H])[H])C([H])=C1Cl)C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=NC(=C1[H])N(C(=O)C([H])([H])N(C1=C([H])C(=C([H])C([H])=C1Cl)N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])N=C1C([H])([H])[H])N(C(=O)C([H])([H])N(C1=C([H])C(=C([H])C([H])=C1Cl)N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=NN1C([H])([H])[H])N(C(=O)C([H])([H])N(C1=C([H])C(=C([H])C([H])=C1Cl)N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C(N(N=C1N(C(=O)C([H])([H])N(C1=C([H])C(=C([H])C([H])=C1Cl)N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])N(C(=O)C([H])([H])N(C1=C([H])C2=C(SN=C2C([H])([H])[H])C([H])=C1Cl)S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=NC(=C1[H])N(C(=O)C([H])([H])N(C1=C([H])C2=C(SN=C2C([H])([H])[H])C([H])=C1Cl)S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Br)S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C#N)S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1Cl)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1Cl)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1Cl)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])N(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C(=C1[H])N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC(F)(F)F)S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C(C([H])=C1[H])S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(Cl)=C(C([H])=C1[H])S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(F)=C(C([H])=C1[H])S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1[H])S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(F)=C1[H])S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1C#N)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])S(=O)(=O)N(C1=C([H])C(C#N)=C([H])C([H])=C1Cl)C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1Cl)C(F)(F)F)C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C(C#N)C(=C1[H])N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])S(=O)(=O)N(C1=C([H])C([H])=C(Cl)C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1C#N)C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])S(=O)(=O)N(C1=C([H])C(Cl)=C([H])C([H])=C1N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N1[C@]([H])(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2OC([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(OC([H])([H])[C@]([H])(N(C(=O)C3=C([H])C([H])=C(Cl)C([H])=C3[H])[C@@]2([H])C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N1[C@]([H])(C2=C([H])C(=C([H])C([H])=C2OC([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N1[C@]([H])(C2=C([H])C(=C([H])C([H])=C2OC([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N1[C@]([H])(C2=C([H])C(SC([H])([H])[H])=C([H])C([H])=C2OC([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N1[C@]([H])(C2=C([H])C(C#N)=C([H])C([H])=C2OC([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N1[C@]([H])(C2=C([H])C(=C([H])C([H])=C2OC([H])([H])[C@@]1([H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N1[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2OC([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N1[C@]([H])(C2=C([H])C(Cl)=C([H])C([H])=C2OC([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N1[C@]([H])(C2=C([H])C(Br)=C([H])C([H])=C2OC([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N1[C@]([H])(C2=C([H])C(=C([H])C([H])=C2OC([H])([H])[C@@]1([H])C([H])([H])[H])C(F)(F)F)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N1[C@]([H])(C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C2OC([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N1[C@]([H])(C2=C([H])C(OC([H])(F)F)=C([H])C([H])=C2OC([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC11C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3N=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C2(OC([H])([H])C([H])([H])N2S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])[C@]2(OC([H])([H])C([H])([H])N2S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C(F)(F)C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])[C@]2(OC([H])([H])C([H])([H])N2S(=O)(=O)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])[C@]([H])(F)C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])[C@]2(OC([H])([H])C([H])([H])N2S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@]([H])(F)C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])[C@]2(OC([H])([H])C([H])([H])N2S(=O)(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])[C@]([H])(F)C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])C2=NC3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C([H])([H])SC2=NC3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C([H])([H])SC2=NC3=C(C([H])=C(C([H])=C3[H])C([H])([H])[H])N2C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C([H])([H])SC2=NC3=C(C([H])=C([H])C(=C3[H])C([H])([H])[H])N2C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C([H])([H])SC2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C([H])([H])SC2=NC3=C(O2)C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C([H])([H])SC2=NC3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])C2=NC3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C([H])([H])SC2=NC3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])=C([H])C([H])=C1[H]
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[H]N(C(=O)C([H])([H])SC1=NN=C(N1C([H])([H])C1=C([H])C([H])=C([H])O1)C1=C(OC([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C2C([H])=C([H])OC2=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])N(C(=O)C2=C(SC(=N2)C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])SC1=NN=C(N1C([H])([H])C1=C([H])C([H])=C([H])O1)C1=C(OC([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])[C@@]1([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])[C@@]1([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@]1([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])OC1=C(F)C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(C#N)=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C(=O)C([H])([H])[C@@]1([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C([H])C([H])=C([H])C(C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(F)C([H])=C3[H])=C2C([H])=C1[H]
[H]N(C(=O)N([H])[C@@]1([H])C([H])([H])OC(O[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Br)C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])[C@@]1([H])C([H])([H])OC(O[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C1=C(I)C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])[C@@]1([H])C([H])([H])OC(O[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C(Cl)=C1[H]
[H]N(C(=O)N([H])[C@@]1([H])C([H])([H])OC(O[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N(C(=O)N([H])[C@@]1([H])C([H])([H])OC(O[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C(Br)C([H])=C1[H]
[H]N(C(=O)N([H])[C@@]1([H])C([H])([H])OC(O[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)N([H])[C@@]1([H])C([H])([H])OC(O[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Br)C([H])=C(Br)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])[C@]2(OC([H])([H])C([H])([H])N2S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(F)C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NN(N=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NC(O[C@@]2([H])C([H])([H])N(C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C3=NOC(=N3)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C(C#N)=C1[H]
[H]C1=NC(=NC([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])[C@]([H])(OC2=C([H])C(C#N)=C([H])C([H])=N2)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C([H])C(=C1C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C(F)C([H])=C([H])C([H])=C1C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C(C([H])=C([H])C(Cl)=C1[H])C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C(C([H])=C([H])C(F)=C1[H])C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C(C(=O)N2C([H])([H])[C@]([H])(OC3=NC([H])=C([H])C(C#N)=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])=C(S1)N1N=C([H])C([H])=N1
[H]C1=NN(N=C1[H])C1=C([H])SN=C1C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=NN(C([H])=C1C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C(C(=O)N2C([H])([H])[C@]([H])(OC3=NC([H])=C([H])C(C#N)=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C(=NS1)C([H])([H])[H]
[H]C1=C([H])C(N2N=C([H])C([H])=N2)=C(S1)C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C(C([H])=C([H])C(OC([H])([H])[H])=N1)C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C(C(=O)N2C([H])([H])[C@]([H])(OC3=NC([H])=C([H])C(C#N)=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])=C(C([H])=C1[H])N1N=C([H])C([H])=N1
[H]C1=NN(N=C1[H])C1=C(C([H])=C([H])C(C#N)=C1[H])C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C(C#N)=C([H])C(O[C@@]2([H])C([H])([H])N(C(=O)C3=C(N=C(OC([H])([H])[H])C([H])=C3[H])C3([H])C([H])([H])C3([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C2([H])[H])=N1
[H]C1=NN(N=C1[H])C1=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C1C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C(C(=O)N2C([H])([H])[C@]([H])(OC3=NC([H])=C([H])C(C#N)=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C(F)=C([H])C([H])=C1[H]
[H]C1=NN(N=C1[H])C1=C(C([H])=C([H])C(OC([H])([H])F)=C1[H])C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C(C([H])=C([H])C(=N1)C([H])([H])[H])C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=NC(=C([H])C([H])=C1C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C(F)(F)F
[H]C1=C([H])C(C#N)=C([H])C(O[C@@]2([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C(OC([H])([H])[H])N=C3Cl)[C@]([H])(C([H])([H])[H])C([H])([H])C2([H])[H])=N1
[H]C1=C([H])C(=C(S1)C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C1=NC([H])=C([H])C([H])=N1
[H]C1=C([H])C(C(=O)N2C([H])([H])[C@]([H])(OC3=NC([H])=C([H])C(C#N)=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])=C(S1)C1=NC([H])=C([H])C([H])=N1
[H]C1=NC(=NC([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1F)C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NC(=NC([H])=C1[H])C1=C(C([H])=C([H])C(F)=C1[H])C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NC(=NC([H])=C1[H])C1=C(C([H])=C(F)C([H])=C1[H])C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NC(=NC([H])=C1[H])C1=C(C(=O)N2C([H])([H])[C@]([H])(OC3=NC([H])=C([H])C(C#N)=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C(F)=C([H])C([H])=C1[H]
CNC(=O)[C@H](N1CCN2C(CC3CC3)=NC(Cl)=C2[C@@H]1CCC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1
CNC(=O)[C@H](N1CCN2C(=NC(Cl)=C2[C@@H]1CCC1=CC=C(C=C1)C(F)(F)F)C(C)C)C1=CC=CC=C1
CNC(=O)[C@H](N1CCN2C(COC)=NC(Cl)=C2[C@@H]1CCC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1
CNC(=O)[C@H](N1CCN2C(C)=NC(Cl)=C2[C@@H]1CCC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1
CCC1=NC(C(=O)N(C)C)=C2C(CCC3=CC=C(C=C3)C(F)(F)F)N(CCN12)[C@@H](C(=O)NC)C1=CC=CC=C1
CCC1=NC(C(N)=O)=C2C(CCC3=CC=C(C=C3)C(F)(F)F)N(CCN12)[C@@H](C(=O)NC)C1=CC=CC=C1
CCC1=NC(C#N)=C2C(CCC3=CC=C(C=C3)C(F)(F)F)N(CCN12)[C@@H](C(=O)NC)C1=CC=CC=C1
CCC1=NC(=C2[C@H](CCC3=CC=C(C=C3)C(F)(F)F)N(CCN12)[C@@H](C(=O)NC)C1=CC=CC=C1)S(C)(=O)=O
CCC1=NC(SC)=C2[C@H](CCC3=CC=C(C=C3)C(F)(F)F)N(CCN12)[C@@H](C(=O)NC)C1=CC=CC=C1
CCOC1=C2C(CCC3=CC=C(C=C3)C(F)(F)F)N(CCN2C(CC)=N1)[C@@H](C(=O)NC)C1=CC=CC=C1
CCC1=NC(OC)=C2C(CCC3=CC=C(C=C3)C(F)(F)F)N(CCN12)[C@@H](C(=O)NC)C1=CC=CC=C1
CCC1=NC(=C2[C@H](CCC3=CC=C(C=C3)C(F)(F)F)N(CCN12)[C@@H](C(=O)NC)C1=CC=CC=C1)C(F)(F)F
CCC1=NC(I)=C2C(CCC3=CC=C(C=C3)C(F)(F)F)N(CCN12)[C@@H](C(=O)NC)C1=CC=CC=C1
CCC1=NC(C=C)=C2C(CCC3=CC=C(C=C3)C(F)(F)F)N(CCN12)[C@@H](C(=O)NC)C1=CC=CC=C1
CCC1=NC(C2CC2)=C2[C@H](CCC3=CC=C(C=C3)C(F)(F)F)N(CCN12)[C@@H](C(=O)NC)C1=CC=CC=C1
CCC1=NC(C(C)C)=C2C(CCC3=CC=C(C=C3)C(F)(F)F)N(CCN12)[C@@H](C(=O)NC)C1=CC=CC=C1
CCC1=NC(C)=C2C(CCC3=CC=C(C=C3)C(F)(F)F)N(CCN12)[C@@H](C(=O)NC)C1=CC=CC=C1
CCC1=NC=C2C(CCC3=CC=C(C=C3)C(F)(F)F)N(CCN12)[C@@H](C(=O)NC)C1=CC=CC=C1
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C4C([H])=C([H])C([H])=C([H])C4=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])([H])C2=C([H])C([H])=C([H])C(=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2N=C(C([H])=NC2=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C4OC([H])([H])C([H])([H])OC4=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C([H])=C4OC([H])([H])OC4=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2N=C(C([H])=NC2=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C4OC([H])([H])OC4=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C4C([H])=C([H])C([H])=C([H])C4=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C([H])C(=C2C([H])=C1C([H])([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C(=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C(C(=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2N=C(C([H])=NC2=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C(=C([H])C([H])=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC2=C(C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C(F)(F)F)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C([H])C([H])=C2N1C([H])([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2N=C(C([H])=NC2=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=NC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2N=C(C([H])=NC2=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=NN=C(O3)C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=NO1)C([H])([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C4C([H])=C([H])C([H])=C([H])C4=NC(=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NOC(=C1C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])N(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=NO2)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C11C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C1([H])[H]
[H]C1=C([H])C(C2=NC(=NO2)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(O3)C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC2=C(N=C1N1C([H])([H])C([H])([H])C3(N(C(=O)C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C3=C(C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])=C([H])C([H])=C2[H]
[H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C11C([H])([H])C([H])([H])N(C2=NC3=C(O2)C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C11C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C([H])C([H])=C2N1C([H])([H])[H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C11C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C1([H])[H]
[H]C1=C([H])N(N=N1)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])C4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NN(N=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(S3)C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C([H])C(=N1)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C([H])C([H])=C2C([H])=N1)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C1N=C([H])C([H])=C2[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NN(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC(=NC([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NN(C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C([H])=N1)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])N(N=N2)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(=N1)C([H])([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(N=C(C([H])=N2)N2C([H])([H])C([H])([H])C3(C(=O)N(C([H])([H])C4=C(SC(=N4)C([H])([H])[H])C4=C([H])C([H])=C([H])C(=C4[H])C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C(N2C([H])=C([H])C([H])=C([H])C2=N1)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])N2C(=NC(=C2C([H])([H])N2C(=O)C3(C([H])([H])C([H])([H])N(C4=NC5=C(N=C4[H])C([H])=C([H])C([H])=C5[H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(Br)=N1)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C(SC(=N3)C([H])([H])[H])C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])[C@@]([H])(N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N=C1C([H])=C([H])C([H])=C([H])\C1=C(\N([H])C([H])([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(N=C(C([H])=N2)N2C([H])([H])C([H])([H])C3(C(=O)N(C([H])([H])C4=C([H])C([H])=C([H])C5=NON=C45)C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N=C([H])C(=C1/N([H])C([H])=C([H])C([H])=C1[H])\C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2N=C(C([H])=NC2=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NN(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(O1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C([H])=C([H])C4=C3OC([H])([H])C([H])([H])O4)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NN(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NN(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])N(C(=N1)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C(Cl)=C([H])C4=C3OC([H])([H])OC4([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C(C#N)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C(=N1)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C([H])=C(F)C(C#N)=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=O)C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C3=NOC(=N3)C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C(C#N)=C([H])C([H])=C3F)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C(F)C(OC([H])([H])[H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C([H])=C([H])C(=N3)N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C3=NC(=NO3)C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(ON=C1C([H])([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(N=C2C([H])=C([H])C([H])=C([H])C2=N1)N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C(=C([H])C(=N3)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N=C([H])C1=C([H])C([H])=C([H])C(=C1N([H])C([H])([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NN(C2=C([H])C([H])=C([H])C(=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N=C(OC(=N[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C(N1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C(N1C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])N(C(=N1)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C([H])=C([H])C4=NSN=C34)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])S1)C1=NC(=C(O1)C([H])([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(N(N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2N=C(C([H])=NC2=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])N=C(C4=C3C([H])([H])OC(O4)(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C(O1)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2N=C(C([H])=NC2=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C4OC([H])([H])OC([H])([H])C4=C([H])C(F)=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C2=C(C([H])=C1C([H])([H])N1C(=O)C3(C([H])([H])C([H])([H])N(C4=NC5=C([H])C([H])=C([H])C([H])=C5N=C4[H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])=C([H])C([H])=C2[H]
[H]N([H])\N=C(/N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(C#N)=C(C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C([H])C(=C2C([H])([H])C1([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NN(C([H])=C1[H])C1=C([H])C([H])=NC(=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C(=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N=C(C1=C(N([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(O3)C([H])=C([H])C(Cl)=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C([H])C(=C2OC([H])([H])C1([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C2=C(C([H])=C([H])C([H])=C2[H])C(=C1C([H])([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1N1C([H])([H])C([H])([H])C2(N(C(=O)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=NO2)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C11C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C11C([H])([H])C([H])([H])N(C2=NC3=C(O2)C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C11C([H])([H])C([H])([H])N(C2=NN=C(O2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C11C([H])([H])C([H])([H])N(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C11C([H])([H])C([H])([H])N(C2=NC3=C(O2)C([H])=C(Cl)C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C11C([H])([H])C([H])([H])N(C2=NC3=C(O2)C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C11C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C1([H])[H]
[H]N=C(C1=C(N([H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])[H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C11C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(N=C(C([H])=N2)N2C([H])([H])C([H])([H])C3(C(=O)N(C([H])([H])C4=C5OC([H])([H])C([H])([H])N(C5=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C2=C(N=C(C([H])=N2)N2C([H])([H])C([H])([H])C3(C(=O)N(C([H])([H])C4=C5C(=C([H])C([H])=C4[H])N(C([H])([H])[H])C([H])([H])C5([H])[H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])C4=C(N=C([H])C([H])=N4)N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(OC(=N1)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])N=C(O1)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(O1)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC(=NC([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC([H])=NC4=C3C([H])=C([H])C4([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])=C([H])O4)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NN=C(C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])C(=NC([H])=N3)N3C([H])=NC([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C(OC([H])([H])[H])=C([H])C([H])=C4N3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=N3)C3=NC([H])=C([H])S3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]2(C1([H])[H])C([H])([H])C(=O)N(C1=NC([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C2([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C(=C([H])C([H])=C4N3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4C(=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])C(=NC([H])=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C(=N3)C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])C4=NC([H])=C([H])N=C4C([H])=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N=C(\C([H])=C(\[H])C1=NC([H])=C([H])N1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])N([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NN=C(S3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])[C@]2(C1=O)C([H])([H])C([H])([H])N(C1=NC(=C([H])C(=N1)C([H])([H])[H])N1N=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])[C@]2(C1=O)C([H])([H])C([H])([H])N(C1=NC(=C([H])C([H])=N1)N1N=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C4C([H])=C([H])C([H])=C([H])C4=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C([H])=C4OC([H])([H])C([H])([H])OC4=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=NC([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])N=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=N1
[H]N(C(=O)C1=C([H])C(=NC([H])=C1C1=C([H])C(F)=C([H])C([H])=C1[H])C1=C([H])N=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N=C(OC([H])([H])[H])C(OC([H])([H])[H])=N1
[H]N(C(=O)C1=C([H])C(=NC([H])=C1C1=C([H])C(F)=C([H])C([H])=C1[H])C1=C([H])N=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=N1
[H]N(C(=O)C1=C([H])C(=NC([H])=C1C1=NC([H])=C([H])S1)C1=C([H])N=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=N1
[H]N(C(=O)C1=C([H])C(=NC([H])=C1C1=NC([H])=C([H])S1)C1=C([H])N=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C(OC([H])([H])[H])=N1)C1([H])C([H])([H])C1([H])[H]