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[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC(=O)C1=C([H])C(O[H])=C(C(=O)C2=C(O[H])C([H])=C([H])C([H])=C2O[H])C(O[H])=C1[H]
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[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])OC(=O)C1=C([H])C(O[H])=C(C(=O)C2=C(O[H])C([H])=C([H])C3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(O[H])=C1[H]
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[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC(=O)C1=C([H])C(O[H])=C(C(=O)C2=C(C#N)C([H])=C([H])C([H])=C2O[H])C(O[H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC(=O)C1=C([H])C(O[H])=C(C(=O)C2=C(OC([H])([H])C([H])([H])N([H])[H])C([H])=C([H])C([H])=C2O[H])C(O[H])=C1[H]
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[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC(=O)C1=C([H])C(O[H])=C(C(=O)C2=C(N([H])S(=O)(=O)C(F)(F)F)C([H])=C([H])C([H])=C2O[H])C(O[H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC(=O)C1=C([H])C(O[H])=C(C(=O)C2=C(C([H])=C([H])C([H])=C2O[H])C2=NN=NN2[H])C(O[H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC(=O)C1=C([H])C(O[H])=C(C(=O)C2=C(C([H])=C([H])C([H])=C2O[H])C2=NN(N=N2)C([H])([H])[H])C(O[H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC(=O)C1=C([H])C(O[H])=C(C(=O)C2=C(C([H])=C([H])C([H])=C2O[H])C2=NN=NN2C([H])([H])[H])C(O[H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])OC(=O)C1=C([H])C(O[H])=C2C(=O)C3=C(C([H])=C([H])C([H])=C3O[H])C(=O)C2=C1[H]
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[H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C(C(=O)N([H])C1=O)C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
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[H]OC([H])([H])C([H])([H])C([H])([H])N1C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C2=C1C1=C(C3=C(C([H])=C([H])N3C([H])([H])[H])C([H])=C1[H])C1=C2C(=O)N([H])C1=O
[H]N1C(=O)C2=C(C1=O)C1=C(C3=C2C2=C(C([H])=C([H])C([H])=C2[H])N3C([H])([H])[H])C(=C([H])C2=C1N(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])N1C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C2=C1C1=C(C3=C(C([H])=C([H])N3C([H])([H])[H])C([H])=C1[H])C1=C2C(=O)N([H])C1=O
[H]N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(OC([H])([H])[H])=C3[H])C3=C2C2=C(C4=C(C([H])=C([H])N4C([H])([H])[H])C([H])=C2[H])C2=C3C(=O)N([H])C2=O)C([H])([H])C1([H])[H]
[H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(OC([H])([H])[H])=C3[H])C3=C2C2=C(C4=C(C([H])=C([H])N4C([H])([H])[H])C([H])=C2[H])C2=C3C(=O)N([H])C2=O)C([H])([H])C1([H])[H]
[H]N1C(=O)C2=C(C1=O)C1=C(C([H])=C([H])C3=C1N(C([H])=C3[H])C([H])([H])[H])C1=C2C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C3=C2N([H])C2=C3C3=C(C(=O)N([H])C3=O)C3=C2C([H])=C([H])C2=C3N(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C3=C2N([H])C2=C3C3=C(C(=O)N([H])C3=O)C3=C2C([H])=C([H])C2=C3N(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]N1C(=O)C2=C(C1=O)C1=C(C([H])=C([H])C3=C1N(C([H])=C3[H])C([H])([H])[H])C1=C2C2=C(N1[H])C(=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1N([H])C1=C2C2=C(C(=O)N([H])C2=O)C2=C1C([H])=C([H])C1=C2N(C([H])=C1[H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C3=C2N([H])C2=C3C3=C(C(=O)N([H])C3=O)C3=C2C([H])=C([H])C2=C3N(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1N([H])C1=C2C2=C(C(=O)N([H])C2=O)C2=C1C([H])=C([H])C1=C2N(C([H])=C1[H])C([H])([H])[H]
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[H]OC([H])([H])[C@]1([H])C([H])([H])N2C3=C(C4=C2C(=C([H])C([H])=C4[H])C1([H])[H])C1=C(C(=O)N([H])C1=O)C1=C3N([H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H]
[H]N1C(=O)C2=C(C1=O)C1=C(N3C4=C1C([H])=C([H])C([H])=C4C([H])([H])N([H])C([H])([H])C3([H])[H])C1=C2C2=C(N1[H])C([H])=C(F)C(F)=C2[H]
[H]N1C(=O)C2=C(C1=O)C1=C(N3C4=C1C([H])=C([H])C([H])=C4C([H])([H])N(C([H])([H])C3([H])[H])S(=O)(=O)C([H])([H])[H])C1=C2C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]N([H])C([H])([H])C(=O)N1C([H])([H])C2=C([H])C([H])=C([H])C3=C2N(C2=C3C3=C(C(=O)N([H])C3=O)C3=C2N([H])C2=C3C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@]1([H])C([H])([H])N2C3=C(C4=C2C(=C([H])C([H])=C4[H])C1([H])[H])C1=C(C(=O)N([H])C1=O)C1=C3N([H])C2=C1C([H])=C([H])C(Br)=C2[H]
[H]OC([H])([H])[C@]1([H])C([H])([H])N2C3=C(C4=C2C(=C([H])C([H])=C4[H])C1([H])[H])C1=C(C(=O)N([H])C1=O)C1=C3N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])N2C3=C(C4=C2C(=C([H])C([H])=C4[H])C1([H])[H])C1=C(C(=O)N([H])C1=O)C1=C3N([H])C2=C1C([H])=C([H])C(F)=C2[H]
[H]OC([H])([H])[C@@]1([H])N2C3=C(C4=C2C(=C([H])C([H])=C4[H])C([H])([H])C1([H])[H])C1=C(C(=O)N([H])C1=O)C1=C3N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N1C(=O)C2=C(C1=O)C1=C(N3C4=C1C([H])=C([H])C([H])=C4C([H])([H])N([H])C([H])([H])C3([H])[H])C1=C2C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]N1C(=O)C2=C(C1=O)C1=C(N3C4=C1C([H])=C([H])C([H])=C4C([H])([H])N([H])C([H])([H])C3([H])[H])C1=C2C2=C(N1[H])C([H])=C([H])C(F)=C2[H]
[H]OC([H])([H])[C@]1([H])C([H])([H])N2C3=C(C4=C2C(=C([H])C([H])=C4[H])C1([H])[H])C1=C(C(=O)N([H])C1=O)C1=C3N([H])C2=C1C([H])=C([H])C(F)=C2[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C1=C(C3=C(C([H])=C([H])N3C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C2C(=O)N([H])C1=O
[H]OC([H])([H])[C@]1([H])C([H])([H])N2C3=C(C4=C2C(=C([H])C([H])=C4[H])C1([H])[H])C1=C(C(=O)N([H])C1=O)C1=C3C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N1C(=O)C2=C(C1=O)C1=C(N3C4=C1C([H])=C([H])C([H])=C4C([H])([H])N([H])C([H])([H])C3([H])[H])C1=C2C2=C(N1[H])C([H])=C(C([H])=C2[H])C(F)(F)F
[H]N1C(=O)C2=C(C1=O)C1=C(N3C4=C1C([H])=C([H])C([H])=C4C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C1=C2C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]OC([H])([H])[C@@]1([H])N2C3=C(C4=C2C(=C([H])C([H])=C4[H])C([H])([H])C1([H])[H])C1=C(C(=O)N([H])C1=O)C1=C3N([H])C2=C1C([H])=C([H])C(F)=C2[H]
[H]N1C(=O)C2=C(C1=O)C1=C(N3C4=C1C([H])=C([H])C([H])=C4C([H])([H])N([H])C([H])([H])C3([H])[H])C1=C2C2=C(N1[H])C([H])=C(F)C([H])=C2[H]
[H]N1C([H])=C([H])C2=C1C1=C(C([H])=C2[H])C2=C(C3=C(N2[H])C([H])=C([H])C([H])=C3[H])C2=C1C(=O)N([H])C2=O
[H]N1C(=O)C2=C(C1=O)C1=C(C([H])=C([H])C3=C1N(C([H])=C3[H])C([H])([H])C([H])([H])[H])C1=C2C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]N1C(=O)C2=C(C1=O)C1=C(C([H])=C([H])C3=C1N(C([H])=C3[H])C([H])([H])[H])C1=C2C2=C(N1[H])C([H])=C([H])C(=C2[H])C([H])([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C1=C(N2[H])C2=C(C3=C(C([H])=C([H])N3[H])C([H])=C2[H])C2=C1C(=O)N([H])C2=O
[H]OC1=C([H])C2=C(C([H])=C1[H])C1=C(N2[H])C2=C(C3=C(C([H])=C([H])N3C([H])([H])[H])C([H])=C2[H])C2=C1C(=O)N([H])C2=O
[H]N1C(=O)C2=C(C1=O)C1=C(N([H])C3=C1C(Br)=C([H])C([H])=C3[H])C1=C2C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]N1C(=O)C2=C(C1=O)C1=C(N([H])C3=C1C([H])=C([H])C(F)=C3[H])C1=C2C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]N1C(=O)C2=C(C1=O)C1=C(N([H])C3=C1C([H])=C([H])C(Cl)=C3[H])C1=C2C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]N1C(=O)C2=C(C1=O)C1=C(N([H])C3=C1C([H])=C([H])C(=C3[H])C([H])([H])[H])C1=C2C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]N1C(=O)C2=C(C1=O)C1=C(N([H])C3=C1C([H])=C([H])C(=C3[H])C(F)(F)F)C1=C2C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]N1C(=O)C2=C(C1=O)C1=C(C([H])=C([H])C3=C1N(C([H])=C3[H])C([H])([H])[H])C1=C2C2=C(N1[H])C([H])=C(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=C2[H]
[H]OC([H])([H])[C@@]1([H])C2=C([H])C([H])=C([H])C3=C2N(C2=C3C3=C(C(=O)N([H])C3=O)C3=C2N([H])C2=C3C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C2=C1C1=C(C3=C(C([H])=C([H])N3C([H])([H])[H])C([H])=C1[H])C1=C2C(=O)N([H])C1=O
[H]N1C(=O)C2=C(C1=O)C1=C(N([H])C3=C1C([H])=C([H])C(OC([H])([H])[H])=C3[H])C1=C2C2=C(N1[H])C([H])=C(Br)C([H])=C2[H]
[H]OC([H])([H])[C@]1([H])C([H])([H])N2C3=C(C4=C2C(=C([H])C([H])=C4[H])C1([H])[H])C1=C(C(=O)N([H])C1=O)C1=C3N([H])C2=C1C([H])=C([H])C(=C2[H])C(F)(F)F
[H]OC([H])([H])[C@]1([H])N2C3=C(C4=C2C(=C([H])C([H])=C4[H])C([H])([H])C1([H])[H])C1=C(C(=O)N([H])C1=O)C1=C3C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N1C(=O)C2=C(C1=O)C1=C(N3C4=C1C([H])=C([H])C([H])=C4C([H])([H])N(C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C2C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]OC1=C([H])C([H])=C(OC([H])([H])[H])C(F)=C1C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=NC([H])=C1[H]
[H]OC1=C([H])C([H])=C(OC([H])([H])[H])C(F)=C1C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=NC([H])=C1[H]
[H]OC1=C([H])C([H])=C(OC([H])([H])[H])C(F)=C1C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=NC([H])=C1[H]
[H]OC1=C([H])C([H])=C(OC([H])([H])[H])C(F)=C1C(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]2([H])N([H])C(=O)C2=C([H])C([H])=NC([H])=C2[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=NC([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=NC([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C(F)=C1C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(OC([H])([H])[H])C(F)=C1C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)O[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=NC([H])=C1[H]
[H]OC1=C2C(N([H])C([H])=C2C2=NC(=NC([H])=C2[H])N([H])[H])=C([H])C(Br)=C1[H]
[H]N([H])C1=NC([H])=C([H])C(=N1)C1=C([H])N([H])C2=C([H])C([H])=C(Br)C([H])=C12
[H]N([H])C1=NC([H])=C([H])C(=N1)C1=C([H])N([H])C2=C([H])C(Br)=C([H])C([H])=C12
[H]OC1=C2C(N([H])C([H])=C2C2=NC(=NC([H])=C2[H])N([H])[H])=C(Br)C([H])=C1[H]
[H]N([H])C1=NC([H])=C([H])C(=N1)C1=C([H])N([H])C2=C([H])C(Br)=C(Br)C([H])=C12
[H]OC1=C([H])C([H])=C(C([H])=C1C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=NC([H])=C1[H])N1C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(\C([H])=C(/[H])C2=C([H])C([H])=NC([H])=C2[H])=C([H])N=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
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