[H]N([H])C1=NC([H])=C(C([H])=C1O[C@@]([H])(C1=C(Cl)C([H])=C([H])C(F)=C1Cl)C([H])([H])[H])C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C(C#CC1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C(=O)C1=C([H])C([H])=C(N([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]([H])(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])N([H])C1=C(C2=NC3=C(N2[H])C([H])=C(C([H])=C3C([H])([H])[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(=O)N([H])C([H])=C1[H] [H]N([H])C(C#CC1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=C2C([H])=NC(=NC2=NN1[H])N([H])C1=C(F)C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(S1)C1=NC(=NC([H])=C1[H])N([H])C([H])([H])[H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C2=C(N=NS2)C([H])([H])[H])\C(=C(/[H])C2=C([H])N(C3=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C23)C([H])([H])[H])C1=O [H]N(C1=NC(N([H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=NN2C([H])=C([H])C(=C12)C([H])([H])OC([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])N([H])C1([H])[H])C1=C([H])C2=C(C([H])=C1[H])N(N=C2[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C3N(N=C([H])N=C3N([H])C3=C([H])C4=C(C([H])=C3[H])N(N=C4[H])C([H])([H])C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C3C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C3=NC([H])=C2[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C(=O)C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C(SC3=C([H])N=C(S3)N([H])C3=NC(Br)=C([H])C([H])=C3[H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=O)\C(=C(\[H])C2=C(C(C(=O)N3C([H])([H])C([H])([H])C([H])([H])[C@]3([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C(N2[H])C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C([H])C(=C23)C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C([H])C(=C23)C([H])([H])[H])C(F)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C([H])([H])[H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C([H])C(=C23)C([H])([H])N([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C3N(N=C([H])N=C3OC3=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])=C3F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1([H])C([H])([H])C([H])([H])C(=C([H])C2=C3N(N=C([H])N=C3OC3=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])=C3F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@]1([H])C([H])([H])N(C([H])([H])C2=C3N(N=C([H])N=C3OC3=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])=C3F)C([H])=C2[H])C([H])([H])C([H])([H])[C@@]1([H])N([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])[H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H] [H]N([H])C([H])([H])C1([H])C([H])([H])N(C([H])([H])C2=C3N(N=C([H])N=C3OC3=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])=C3F)C([H])=C2[H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C3N(N=C([H])N=C3OC3=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])=C3F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C2N(N=C([H])N=C2OC2=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C([H])C(Cl)=C([H])C([H])=C1F)C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C3N(N=C([H])N=C3OC3=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])=C3F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C([H])C(=C23)C([H])([H])N2C([H])([H])C([H])([H])C([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C([H])C(=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C([H])C(=C23)C([H])([H])[H])C(F)=C1[H] [H]N([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C3N(N=C([H])N=C3OC3=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])=C3F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C([H])C(=C23)C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C([H])C(=C23)C([H])([H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC([H])=C(SC2=C([H])C(C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C([H])([H])[H])=C(C([H])=C2[H])C([H])([H])[H])S1)C1=NC(Br)=C([H])C([H])=C1[H] [H]N(C1=NC([H])=C(SC2=C([H])C(C(=O)N3C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C3([H])[H])=C(C([H])=C2[H])C([H])([H])[H])S1)C1=NC(Br)=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C(SC3=C([H])N=C(S3)N([H])C3=NC(Br)=C([H])C([H])=C3[H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(C#CC([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(OC2=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2F)=C([H])C([H])=N1 [H]OC([H])([H])C#CC1=C(N=C([H])C([H])=C1OC1=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1F)N([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2C([H])=C(N3[H])C2=C([H])N=C([H])C([H])=C2[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2C(=C([H])N3[H])C2=C([H])N=C([H])C([H])=C2[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC(=C([H])S1)C1=C([H])N([H])C2=C1C(OC1=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C1F)=C([H])C([H])=N2 [H]OC([H])([H])C1=C([H])N([H])C2=C1C(OC1=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C1F)=C([H])C([H])=N2 [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2C(=C([H])N3[H])C(=O)OC([H])([H])[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2C(=C([H])N3[H])C(=O)N([H])C([H])([H])C2=C([H])N=C([H])C([H])=C2[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2C(=C([H])N3[H])C(=O)C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])N([H])C3=C2C(OC2=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])=C2F)=C([H])C([H])=N3)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2C(=C([H])N3[H])C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C([H])C(OC2=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2F)=C([H])C([H])=N1 [H]N([H])C1=C([H])C(OC2=C([H])C([H])=C(N([H])C(=O)C([H])([H])C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2F)=C([H])C([H])=N1 [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2C([H])=C([H])N3[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2C([H])=C([H])N3[H])C(F)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C#CC1=C(N=C([H])C([H])=C1OC1=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1F)N([H])[H] [H]N([H])C1=C(C#CC2=C([H])C([H])=C([H])C([H])=N2)C(OC2=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2F)=C([H])C([H])=N1 [H]N(C(=O)C([H])([H])[H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])N=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])[H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C([H])=C1F)C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C([H])C(Cl)=C23)C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NN3C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C(=C23)C([H])([H])[H])C(F)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])([H])N(C(=O)N2C([H])([H])[H])C1=C(C([H])=C([H])C(N([H])C(=O)C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)=C1[H])C([H])([H])[H] [H]N([H])C1=C(C#CC([H])([H])N([H])[H])C(OC2=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2F)=C([H])C([H])=N1 [H]OC1=C([H])C([H])=C2C(OC([H])([H])[C@]3(O[H])C([H])([H])C4=C(C([H])=C(O[H])C(O[H])=C4[H])[C@]23[H])=C1O[H] [H]OC1=C([H])C([H])=C2C(OC([H])([H])[C@](O[H])(C([H])([H])C3=C([H])C(O[H])=C(O[H])C([H])=C3[H])[C@]2([H])O[H])=C1O[H] [H]OC1=C([H])C([H])=C2C(OC([H])([H])[C@@](O[H])(C2=O)C([H])([H])C2=C([H])C(O[H])=C(O[H])C([H])=C2[H])=C1O[H] [H]OC1=C([H])C([H])=C2C([H])=C(C([H])([H])C3=C([H])C(O[H])=C(O[H])C([H])=C3[H])C([H])([H])OC2=C1O[H] [H]N=C(SC([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C(N3C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])[C@]3([H])C3=C([H])C([H])=C([H])C4=C3N2C([H])=C4[H])C1=O)N([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=NN(C2=C1C([H])=C([H])C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)=C2[H])C([H])([H])[H] [H]N=C(SC([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C(N3C(=C([H])C4=C([H])C([H])=C([H])C([H])=C34)C3=C([H])C([H])=C([H])C4=C3N2C([H])=C4[H])C1=O)N([H])C([H])([H])[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])N(C(=O)N([H])C([H])([H])[H])C([H])([H])C2([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C(=C([H])C([H])=C2[H])C(=O)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C(=O)N2C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C(F)=C1[H] [H]N(C(=S)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=S)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C23)=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1(C(=O)N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C34)C(F)=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NN3C(=NN=C3C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NN2C(=NN=C2C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=NC([H])=C([H])N2C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=NC([H])=C([H])N2C([H])([H])C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C(F)=C1[H] [H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1=O)C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C2N(C(=O)C([H])([H])C2=C([H])C(=C1[H])C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]C1=C([H])C(=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])OC1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C2=NON=C12 [H]N(C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C2=NON=C2C([H])=C1[H] [H]C1=NC2=C([H])C(F)=C([H])C(=C2N=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC2=C([H])C(Cl)=C([H])C(=C2N=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC2=C([H])C(=C([H])C(C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3[H])=C2N=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F [H]C1=C([H])C(Cl)=C(Cl)C(=C1[H])C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1(C(=O)N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=NC4=C3SC(=C4[H])C3=C([H])N(C([H])=N3)C([H])([H])[H])C(F)=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1(C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)[C@@]1([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)[C@@]1([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])(C([H])([H])[H])C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)[C@@]1([H])C([H])([H])N(C(=O)C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])(C([H])([H])[H])C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)[C@]1(C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H] [H]N=C(SC([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C(N3C(=C([H])C4=C([H])C([H])=C([H])C([H])=C34)C3=C([H])C([H])=C([H])C4=C3N2C([H])=C4[H])C1=O)N([H])[H] [H]C1=NC2=C([H])C(=C([H])C(=C2N=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F [H]C1=NC2=C([H])C(=C([H])C(C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F [H]C1=NC2=C([H])C(=C([H])C(=C2N=C1N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(N=C2C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(Cl)=C(F)C([H])=C1[H])C#N [H]N([H])C1=NC([H])=C([H])C(=C1[H])C1=C(C2=NC(C#N)=C([H])C([H])=C2N1[H])C1=C([H])C(Cl)=C(F)C([H])=C1[H] [H]N1C2=C([H])C([H])=C(N=C2C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C#N [H]N1C2=C([H])C([H])=C(N=C2C(=C1C1=C([H])N=C([H])N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C#N [H]N1C2=C([H])C([H])=C(N=C2C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(Cl)=C([H])C(F)=C1[H])C#N [H]N1C2=C([H])C([H])=C(N=C2C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(F)=C(F)C([H])=C1[H])C#N [H]N1C2=C([H])C([H])=C(N=C2C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C#N [H]N1C2=C([H])C([H])=C(N=C2C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C#N [H]N1C2=C([H])C([H])=C(N=C2C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C#N [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(C2=NC(C#N)=C([H])C([H])=C2N1[H])C1=C([H])C(Cl)=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC(N([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3N=C2[H])=C([H])C([H])=N1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)N([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C([H])([H])[H])[C@]1([H])C([H])([H])[C@@]2([H])O[C@@](N3C4=C(C([H])=C([H])C([H])=C4[H])C4=C3C3=C(C5=C(C([H])=C([H])C([H])=C5[H])N23)C2=C4C([H])([H])N([H])C2=O)(C([H])([H])[H])[C@]1([H])OC([H])([H])[H] [H]N1C2=C([H])C(=C([H])C([H])=C2C2=C1C1=C(C([H])=C(N=C1OC([H])([H])[H])C([H])([H])[H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(Br)C([H])=C2C2=C1C1=C(N=C([H])C([H])=C1I)N(C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C2=C(C3=C(C4=C([H])C(Br)=C([H])C([H])=C4N3[H])C([H])([H])C1([H])[H])C(I)=C([H])C([H])=N2 [H]OC1=C([H])C(O[H])=C2C(O[C@@]([H])(C3=C([H])C(O[H])=C(O[H])C(O[H])=C3[H])[C@]([H])(OC(=O)C3=C([H])C(O[H])=C(O[H])C(O[H])=C3[H])C2([H])[H])=C1[H] [H]N([H])C1=NC([H])=C(N=C1OC1=C([H])C2=C(C([H])=C([H])N2[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])[C@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(N=C1OC1=C([H])C2=C(C([H])=C([H])N2[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(N=C1OC1=C([H])C2=C(C([H])=C([H])N2[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(N=C1OC1=C([H])C2=C(C([H])=C([H])N2[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(N=C1OC1=C([H])C2=C(C([H])=C([H])N2[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(N=C1O[C@@]([H])(C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(N(C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C(=O)C2=NC([H])=C([H])N2C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C(=O)C2=C([H])N(C([H])=N2)C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C(=O)C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C(=O)C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N1C([H])=NC(=C1[H])C(=O)C1=C([H])C2=NC([H])=C([H])C(OC3=C(F)C([H])=C(N([H])C(=O)C([H])([H])C(=O)N([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])=C2S1 [H]N(C(=O)C([H])([H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C([H])([H])C(=O)N([H])C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C(F)=C(OC2=C3SC([H])=C([H])C3=NC([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1(C(=O)N([H])C2=C([H])C(F)=C(OC3=C4SC(=C([H])C4=NC([H])=C3[H])C3=C([H])N(C([H])=N3)C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1(C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H])C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C(OC([H])([H])C2=NN=C3C([H])=C([H])C(=NN23)C2=C([H])C(F)=C([H])C(F)=C2[H])=C1[H] [H]C1=C(SN=C1C([H])([H])[H])C1=NN2C(=NN=C2C([H])([H])OC2=C([H])C([H])=NC3=C2C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])=C1[H] [H]C1=NC2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C(O[C@]([H])(C2=NN=C3C([H])=C([H])C(=NN23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H] [H]N(C1=C([H])C([H])=NC2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C(SC([H])([H])C2=NN=C3C([H])=C([H])C(=NN23)C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H] [H]N(C1=C([H])C([H])=NC2=C1N=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=NC2=C1N=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C(F)C(F)=C1[H] [H]N(C1=C([H])C([H])=NC2=C1N=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C(F)=C(F)C(F)=C1[H] [H]N(C1=C([H])C([H])=NC2=C1N=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C(F)=C([H])C(F)=C1[H] [H]N(C1=C([H])C([H])=NC2=C1N=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C(=NS1)C([H])([H])[H] [H]C1=NC2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C(OC([H])([H])C2=NN=C3C([H])=C([H])C(=NN23)C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H] [H]C1=NC2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C(OC([H])([H])C2=NN=C3C([H])=C([H])C(=NN23)C2=C([H])C([H])=C(F)C(F)=C2[H])=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1F [H]N(\N=C1/C(=O)N([H])N=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])N=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])N=C1C1=C([H])N=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C([H])N(C3=C2[H])S(=O)(=O)C2=C(Cl)N=C3SC([H])=C([H])N23)C([H])([H])C1([H])[H] [H]C1=C([H])C2=NC([H])=C(C([H])=C2N1C([H])([H])C1=C([H])C([H])=C([H])C2=NON=C12)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]1([H])C([H])([H])N(C2=NC3=C(C(N([H])[H])=C(S3)C(=O)N([H])[H])C(=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1([H])C([H])([H])C([H])([H])N(C2=NC3=C(C(N([H])[H])=C(S3)C(=O)N([H])[H])C(=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C(N([H])[H])C2=C(S1)N=C(C([H])=C2C([H])([H])C([H])([H])C([H])([H])[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C(N([H])[H])C2=C(S1)N=C(C([H])=C2C([H])([H])C([H])([H])C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])(N([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H] [H]OC([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2N=C([H])C(=C2[H])C2=C([H])C(C3=NC4=C(O3)C([H])=C([H])C([H])=C4[H])=C(N=C2[H])N([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=C([H])C(OC3=C([H])C(=NC([H])=C3[H])C3=NC([H])=C(N3[H])C(F)(F)F)=C2[H])N1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]C([H])=C([H])C(=O)N([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Cl)=C(F)C([H])=C3[H])C2=C1[H] [H]C#CC1=C([H])C([H])=C([H])C(N([H])C2=NC([H])=NC3=C2C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C3[H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)N(C2=C([H])C3=NN(C(=C3C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(SC2=NC(=C([H])C(=N2)N([H])C2=C([H])C(=NN2[H])C([H])([H])[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1C([H])=N\C(=N/C2=C([H])C([H])=C(Br)C([H])=C2F)C2=C1C([H])=C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(OC([H])([H])[H])=C2[H] [H]N(C(=O)C1=C(N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C([H])([H])[C@]([H])(N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[C@@]([H])(N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])C([H])=NC([H])=C1[H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H] [H]OC([H])([H])C([H])([H])N1N=C([H])C(=C1[H])C1=C([H])C(C2=NC3=C(O2)C([H])=C([H])C([H])=C3[H])=C(N=C1[H])N([H])[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H] [H]N([H])C1=NC([H])=C([H])C(OC2=C(F)C([H])=C(N([H])C3=C(C([H])=C([H])C([H])=N3)C(=O)N([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C2[H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(OC2=C(F)C([H])=C(N([H])C3=C(C([H])=C([H])C([H])=N3)C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])=C2[H])=C1[H] [H]N(C(=O)C1=C(N=C([H])C([H])=C1[H])N([H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F [H]N(C(=O)C1=C(N=C([H])C([H])=C1[H])N([H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)C1=C(N=C([H])C([H])=C1[H])N([H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C1=C(C([H])=C([H])C([H])=N1)C(=O)N(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C(N=C([H])C([H])=C1[H])N([H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=N1 [H]N(C(=O)C1=C(N=C([H])C([H])=C1[H])N([H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C(N=C([H])C([H])=C1[H])N([H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C(N=C(C([H])=C1[H])C([H])([H])[H])N([H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F [H]N([H])C1=NC([H])=C([H])C(OC2=C(F)C([H])=C(N([H])C3=C(C([H])=C(Br)C([H])=N3)C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])=C2[H])=C1[H] [H]N(C(=O)C1=C(N=C([H])C(Br)=C1[H])N([H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F [H]N([H])C1=NC([H])=C([H])C(OC2=C(F)C([H])=C(N([H])C3=C(C([H])=NC([H])=C3[H])C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])=C2[H])=C1[H] [H]N(C(=O)C1=C(N([H])C2=C([H])C(F)=C(OC3=C4C([H])=C([H])N([H])C4=NC([H])=C3[H])C([H])=C2[H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F [H]N([H])C1=NC([H])=C([H])C(OC2=C(F)C([H])=C(N([H])C3=C(N=C([H])C([H])=N3)C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])=C2[H])=C1[H] [H]N(C(=O)C1=C(N=C([H])C([H])=N1)N([H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F [H]N([H])C1=NC([H])=C([H])C(OC2=C(F)C([H])=C(N([H])C3=C(C([H])=NC([H])=N3)C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])=C2[H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(OC2=C(F)C([H])=C(N([H])C3=C(C([H])=NC(SC([H])([H])[H])=N3)C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])=C2[H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(OC2=C(F)C([H])=C(N([H])C3=C(C([H])=NC(=N3)N(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])=C2[H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N([H])C(=O)[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C2=C([H])C(O[C@@]([H])(C3=C(Cl)C([H])=C([H])C(F)=C3Cl)C([H])([H])[H])=C([H])C([H])=C2N=C1[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C2=C([H])C(O[C@@]([H])(C3=C(Cl)C([H])=C([H])C(F)=C3Cl)C([H])([H])[H])=C([H])C([H])=C2N=C1[H] [H]N([H])C([H])([H])C(\[H])=C(/[H])C1=C([H])C2=C([H])C(O[C@@]([H])(C3=C(Cl)C([H])=C([H])C(F)=C3Cl)C([H])([H])[H])=C([H])C([H])=C2N=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=N1 [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(SC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])C4([H])C([H])([H])C([H])([H])N([H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])C4([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N1C(=O)N(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)N=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]C1=C([H])C2=NC([H])=C(C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C2=NON=C12)C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C([H])N(C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=NON=C23)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2N=C([H])C(=C2[H])C2=C([H])N=C3C([H])=C([H])N(C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=NON=C23)C([H])([H])C1([H])[H] [H]N([H])C1=C([H])N=C2C([H])=C([H])N(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=NON=C12 [H]C1=C([H])C2=NC([H])=C(C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C2=NON=C12)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2N=C([H])C(=C2[H])C2=C([H])N=C3C([H])=C([H])N(C3=C2[H])S(=O)(=O)C2=C(Cl)N=C3SC([H])=C([H])N23)C([H])([H])C1([H])[H] [H]N([H])C1=C([H])N=C2C([H])=C([H])N(C2=C1[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]OC1=C([H])N=C2C([H])=C([H])N(C2=C1[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]C1=C([H])N2C(S1)=NC(Cl)=C2S(=O)(=O)N1C([H])=C([H])C2=NC([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])N2C(S1)=NC(Cl)=C2S(=O)(=O)N1C([H])=C([H])C2=NC([H])=C(C([H])=C12)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=NC([H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=NC([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])[N+]([O-])=O [H]N1C([H])([H])C([H])([H])C([H])(N2N=C([H])C(=C2[H])C2=C([H])N=C3C([H])=C([H])N(C3=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C3=NON=C23)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C([H])N(C3=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C3=NON=C23)C([H])([H])C1([H])[H] [H]C1=C([H])C2=NC([H])=C(C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C2=NON=C12)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C([H])N(C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=NON=C23)C([H])([H])C1([H])[H] [H]N(C(=O)N1C(=O)N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]C([H])=C([H])C([H])([H])N1C(=O)N(C(=O)N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C34)C(F)=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(N(C2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])[H])C(F)=C1[H] [H]C1=C([H])C2=NC([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]C1=C([H])C2=NC([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=NC([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl [H]C1=C([H])C2=NC([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1Cl [H]C1=C([H])C2=NC([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1Cl [H]C1=C([H])C2=NC([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=C([H])C2=NC([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O [H]C1=C([H])C2=NC([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O [H]C1=C([H])C2=NC([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([H])C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)N1C([H])=C([H])C2=NC([H])=C([H])C([H])=C12 [H]C1=C([H])C2=NC([H])=C([H])N=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O [H]OC(=O)C1=C([H])N=C2C([H])=C([H])N(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O [H]N([H])C(=O)C1=C([H])N=C2C([H])=C([H])N(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O [H]C1=C([H])C2=NC([H])=C(C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O)C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=NC([H])=C(C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O)N1C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C([H])N(C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[N+]([O-])=O)C([H])([H])C1([H])[H] [H]C1=C([H])C2=NC([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C2=NON=C12 [H]C1=C([H])N2C(S1)=NC(Cl)=C2S(=O)(=O)N1C([H])=C([H])C2=NC([H])=C([H])C([H])=C12 [H]N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C2=C([H])C(O[C@@]([H])(C3=C(Cl)C([H])=C([H])C(F)=C3Cl)C([H])([H])[H])=C([H])C([H])=C2N=C1[H] [H]\C(=C(\[H])C1=C([H])C2=C([H])C(O[C@@]([H])(C3=C(Cl)C([H])=C([H])C(F)=C3Cl)C([H])([H])[H])=C([H])C([H])=C2N=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C2=C([H])C(O[C@@]([H])(C3=C(Cl)C([H])=C([H])C(F)=C3Cl)C([H])([H])[H])=C([H])C([H])=C2N=C1[H])C([H])([H])[H] [H]N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C([H])C(O[C@@]([H])(C3=C(Cl)C([H])=C([H])C(F)=C3Cl)C([H])([H])[H])=C([H])C([H])=C2N=C1[H] [H]C1=NC2=C([H])C([H])=C(O[C@]([H])(C3=C(Cl)C([H])=C([H])C(F)=C3Cl)C([H])([H])[H])C([H])=C2C([H])=C1[H] [H]N(C(=O)C([H])([H])[C@@]([H])(N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)C([H])([H])[C@]([H])(N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H])C(F)(F)F)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[C@]([H])(N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[C@@]([H])(N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)C([H])([H])[C@]([H])(N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(OC2=C([H])C([H])=C(N([H])C(=O)C([H])([H])[C@@]([H])(N([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C(F)(F)F)C([H])=C2F)=NC([H])=N1 [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(OC2=C([H])C([H])=C(N([H])[C@@]([H])(C([H])([H])C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C(F)(F)F)C([H])=C2F)=NC([H])=N1 [H]N(C(=O)C([H])([H])[C@]([H])(N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]N(C(=O)C1=C(N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N([H])C1=NN([H])C2=C([H])C([H])=C([H])C(=C12)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C(F)C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=NC([H])=NC(N([H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C(N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C([H])N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(N(N=C1[H])C([H])([H])[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(N(N=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=NC([H])=C([H])N2C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N(C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])=C(C([H])=N2)C(=O)N(C([H])([H])[H])C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])=C(C([H])=N2)C(=O)N([H])C([H])([H])C([H])([H])OC([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C(F)=C1[H] [H][C@]12C[C@H]([C@@H](OC)[C@](C)(O1)N1C3=C(C=CC=C3)C3=C1C1=C(C4=C(C=CC=C4)N21)C1=C3[C@H](O)NC1=O)N(C)C(=O)C1=CC=CC=C1 CNC1=NC(=CC=N1)C1=CC=CN=C1OC1=CC=C(NC(=O)C2=C(NC3=CC=CC=C3)C=CC=C2)C=C1 [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=C(Cl)C([H])=NC(=N1)N([H])C1=C([H])C([H])=C2C(=C1[H])N(C(=O)C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C#CC([H])([H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C(Cl)C([H])=NC(=N1)N([H])C1=C([H])C([H])=C2N(C(=O)C([H])([H])C([H])([H])C([H])([H])C2=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(N([H])C2=C(Cl)C([H])=C([H])C([H])=C2C(=O)N([H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C([H])=C2N([H])C(=O)C([H])([H])C([H])([H])C(C2=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=NS1)C([H])([H])N1C([H])([H])C([H])([H])C(F)(F)C1([H])[H])C1=NC(=C([H])N2C1=NC([H])=C2C1=C([H])N([H])N=C1[H])C([H])([H])[H] [H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])=C([H])C2=NC([H])=NC(N([H])C3=C([H])C(Cl)=C(OC4=C([H])C([H])=C([H])C(Cl)=C4[H])C([H])=C3[H])=C12 [H]OC([H])([H])C(N(C([H])([H])C1=NSC(N([H])C2=NC(=C([H])N3C2=NC([H])=C3C2=C([H])N([H])N=C2[H])C([H])([H])[H])=C1[H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] C[C@@H](N1C[C@H](C)O[C@H](C)C1)C1=NSC(NC2=NC(C)=CN3C(=CN=C23)C2=CNN=C2)=C1 [H]N1C([H])([H])C([H])([H])C([H])(N2N=C([H])C(=C2[H])C2=C([H])N=C3N=C(N=C(O[C@@]([H])(C4=C(Cl)C(F)=C([H])C([H])=C4Cl)C([H])([H])[H])C3=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C1=NC(=NC2=NC([H])=C(C([H])=C12)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=C(Cl)C(F)=C([H])C([H])=C1Cl [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C([H])O1 [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC(=NC2=NC([H])=C(C([H])=C12)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]C1=NN(C([H])=C1C1=C([H])N=C2N=C(N=C(O[C@@]([H])(C3=C(Cl)C(F)=C([H])C([H])=C3Cl)C([H])([H])[H])C2=C1[H])C(F)(F)F)C([H])([H])[H] [H]N(C1=NC(=NC2=NC([H])=C(C([H])=C12)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])N(N=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C([H])=NN12 [H]OC([H])([H])C([H])([H])N1N=C([H])C(=C1[H])C1=C([H])N=C2N=C(N=C(O[C@@]([H])(C3=C(Cl)C(F)=C([H])C([H])=C3Cl)C([H])([H])[H])C2=C1[H])C(F)(F)F [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1N([H])C1=NC(=NC([H])=C1Cl)N([H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=NC(=NC([H])=C1Cl)N([H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C(Cl)C(=N1)N([H])C1=C(F)C([H])=C([H])C([H])=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C2N(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC2=C1[H] [H]N(C1=NC([H])=C(Cl)C(=N1)N([H])C1=C(F)C([H])=C([H])C([H])=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C2N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC2=C1[H] [H]N(C1=NC([H])=C(Cl)C(=N1)N([H])C1=C(F)C([H])=C([H])C([H])=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C2N(C(=O)OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC2=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=NC(=NC([H])=C1Cl)N([H])C1=C([H])C([H])=C2N(C(=O)OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=NC(=NC([H])=C1Cl)N([H])C1=C([H])C([H])=C2N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H] [H]N(C1=NC([H])=C(Cl)C(=N1)N([H])C1=C(F)C([H])=C([H])C([H])=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C2N(C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])OC2=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=NC(=NC([H])=C1Cl)N([H])C1=C([H])C([H])=C2N([H])C([H])([H])C([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=NC(=NC([H])=C1Cl)N([H])C1=C([H])C([H])=C2N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H] [H]N(C1=NC([H])=C(Cl)C(=N1)N([H])C1=C(F)C([H])=C([H])C([H])=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C2N(C(=O)C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])OC2=C1[H] [H]N(C1=NC([H])=C(Cl)C(=N1)N([H])C1=C(F)C([H])=C([H])C([H])=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C2N(C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC2=C1[H] [H]N(C1=NC([H])=C(Cl)C(=N1)N([H])C1=C(F)C([H])=C([H])C([H])=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C2=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=NC(=NC([H])=C1Cl)N([H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])N(C2=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=NC(=NC([H])=C1Cl)N([H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C2=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=NC(=NC([H])=C1Cl)N([H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1N([H])C1=NC(=NC([H])=C1Cl)N([H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C([H])S1 [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C([H])=NN12 [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C(OC([H])([H])[H])=NN12 [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])SC([H])=C1[H] [H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])C([H])(OC([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC(N([H])C2=C([H])C([H])=C([H])C([H])=C2C(=O)N([H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C([H])=C2N(C(=O)C([H])([H])C([H])([H])C([H])([H])C2=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C(Cl)C([H])=NC(=N1)N([H])C1=C([H])C([H])=C2N(C(=O)C([H])([H])C([H])([H])C([H])([H])C2=C1[H])C([H])([H])[H] [H]N(C1=NC(N([H])C2=C(F)C([H])=C([H])C([H])=C2C(=O)N([H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C([H])=C2C(=C1[H])N(C(=O)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=C(Cl)C([H])=NC(=N1)N([H])C1=C([H])C([H])=C2C(N([H])C(=O)C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]C#CC([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C(Cl)C([H])=NC(=N1)N([H])C1=C([H])C([H])=C2N(C(=O)C([H])([H])C([H])([H])C([H])([H])C2=C1[H])C([H])([H])[H] [H]N(C1=NC(N([H])C2=C(F)C([H])=C([H])C([H])=C2C(=O)N([H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C([H])=C2C(=C1[H])N(C(=O)C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=C(Cl)C([H])=NC(=N1)N([H])C1=C([H])C([H])=C2C(N([H])C(=O)C([H])([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=C(Cl)C([H])=NC(=N1)N([H])C1=C([H])C([H])=C2N([H])C(=O)C([H])([H])C([H])([H])C(C2=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(N([H])C2=C([H])C([H])=C([H])C([H])=C2C(=O)N([H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C([H])=C2N([H])C(=O)C([H])([H])C([H])([H])C(C2=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=C(Cl)C([H])=NC(=N1)N([H])C1=C([H])C([H])=C2N(C(=O)C([H])([H])C([H])([H])C(C2=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(N([H])C2=C([H])C([H])=C([H])C([H])=C2C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C([H])=C2N(C(=O)C([H])([H])C([H])([H])C([H])([H])C2=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=C(Cl)C([H])=NC(=N1)N([H])C1=C([H])C([H])=C2C(=C1[H])N(C(=O)C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(N([H])C2=C([H])C([H])=C([H])C([H])=C2C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C([H])=C2N(C(=O)C([H])([H])C([H])([H])C([H])([H])C2=C1[H])C([H])([H])[H] [H]N(C1=NC(N([H])C2=C(C([H])=C([H])C([H])=C2C(=O)N([H])C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C([H])=C2N([H])C(=O)C([H])([H])C([H])([H])C(C2=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(N([H])C(=O)C2=C([H])C(N([H])C(=O)N([H])C3=C([H])C([H])=C(Cl)C(=C3[H])C(F)(F)F)=C([H])C([H])=C2C([H])([H])[H])C([H])=NN1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C3=C(N([H])C([H])([H])C4=C([H])C(=C([H])C([H])=C4[H])[N+]([O-])=O)C([H])=C(C([H])=C3N=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C(=O)C1=C([H])C([H])=C([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C1=O)C1=C2C([H])=C(C([H])=NC2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1[H])C1=C2C([H])=C(C([H])=NC2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(C2=C([H])C(=C([H])C([H])=C2[H])[N+]([O-])=O)=C2C([H])=C(C([H])=NC2=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N1C(=O)\C(=C(\[H])C2=C(C(C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C(N2[H])C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C([H])C(=C2[H])S(=O)(=O)N(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])[N+]([O-])=O)=C2C([H])=C(C([H])=NC2=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OS(=O)(=O)C2=C([H])C(=C([H])C([H])=C2[H])[N+]([O-])=O)=C2C([H])=C(C([H])=NC2=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]C1=C([H])C(=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])OC1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C1=NC([H])=C(C(=N1)N([H])C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=NN(C([H])=C1C1=NN2C(SC3=C([H])C([H])=C4N=C([H])C([H])=C([H])C4=C3[H])=NN=C2C([H])=C1[H])C([H])([H])[H] [H]N1C2=C(C([H])=C1C([H])([H])[H])C(F)=C(OC1=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H] [H]N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(N=C([H])N=C2C([H])=C1O[C@]1([H])C([H])([H])OC([H])([H])C1([H])[H])N([H])C1=C([H])C([H])=C(F)C(Cl)=C1[H] [H]N(C(=O)C1(C(=O)N([H])C2=C([H])C([H])([H])[C@]([H])(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]C1=C2C(=O)N(C(=O)C2=C([H])C(=C1[H])C(=O)OC([H])([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H] [H]N(\N=C(/[H])C1=C([H])C([H])=C(O1)C1=C([H])C(=C(Cl)C([H])=C1[H])[N+]([O-])=O)C1=NN=C([H])N1\N=C(\[H])C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C(Cl)C(=C1[H])[N+]([O-])=O [H]N(\N=C(/[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[N+]([O-])=O)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])\N=C(/[H])C1=C(C([H])=C2OC([H])([H])OC2=C1[H])[N+]([O-])=O [H]OC1=C([H])C([H])=C(Br)C([H])=C1C(=O)N([H])\N=C1/C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N(C2=C([H])C([H])=C(Br)C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(\N=C1/C(=O)N(C2=C([H])C([H])=C(Br)C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1C(=O)N([H])\N=C1/C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])OC1([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N(C1=NC([H])=NC(N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H])C1=C(Cl)C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1Cl [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C(N([H])C(=O)C3=C([H])C([H])=C(C(C#CC4=C([H])N=C(N4C([H])([H])[H])C(=O)N([H])C([H])([H])[H])=C3[H])C([H])([H])[H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)[C@@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C(Cl)C([H])=C2Br [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C(Cl)C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2Cl [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl [H]OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1O[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1F)C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])C1=C([H])N=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=N1)C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C(Cl)=C2[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C(Cl)C([H])=C2[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=NC([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C(C([H])=C2[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl)C(=O)C([H])([H])C1=C([H])N(C(=O)C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2OC([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C(Cl)C([H])=C2Cl [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl)C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl)C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl)C(=O)[C@@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)C([H])([H])OC1=C(OC([H])([H])C([H])([H])[H])C([H])=C(\C([H])=C2\S\C(=N/C3=C4C([H])=C([H])C([H])=C([H])C4=C([H])C([H])=C3[H])N([H])C2=O)C([H])=C1I [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2N=C([H])C(=C([H])N12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=C([H])N12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C(C(=O)N([H])C([H])([H])[H])C(F)=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C([H])S1 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])SC([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C1([H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N(C([H])=C(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N(C([H])=C(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(F)=C1[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])=[N+]1[O-])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]OC([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C2=C([H])C(Br)=C3C(N([H])C(=O)\C3=N\N([H])C(=O)C([H])([H])C3=C([H])C([H])=C4OC([H])([H])C([H])([H])C4=C3[H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(C(OC2=C(F)C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])N(C3=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])=C([H])C([H])=N1)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C1=C(N=C([H])C([H])=C1OC1=C(F)C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])N(C2=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H])N([H])[H] [H]C#CC1=C(N=C([H])C([H])=C1OC1=C(F)C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])N(C2=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H])N([H])[H] [H]N([H])C1=C(Cl)C(OC2=C(F)C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])N(C3=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])=C([H])C([H])=N1 [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C3C([H])=C([H])C(OC([H])([H])[H])=C([H])C3=NC([H])=C2[H])C(F)=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C3C([H])=C([H])C(OC([H])([H])[H])=C([H])C3=NC([H])=C2[H])C(F)=C1[H] [H]O[C@]([H])(C([H])([H])[H])C([H])([H])N1N(C(=O)C(C(=O)N([H])C2=C([H])C([H])=C(OC3=C4C([H])=C([H])C(OC([H])([H])[H])=C([H])C4=NC([H])=C3[H])C(F)=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2C(OC2=C(F)C([H])=C(C([H])=C2[H])C2=C([H])N=C(N(C2=O)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H] [H]C1=NN(C([H])=N1)C([H])([H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C2C(OC3=C(F)C([H])=C(C([H])=C3[H])C3=C([H])N=C(N(C3=O)C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=NC2=C1[H] [H]C1=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2C(OC2=C(F)C([H])=C(C([H])=C2[H])C2=C([H])N=C(N(C2=O)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H] [H]N([H])[C@@]([H])(C1=NC([H])=C(C(=O)N1C([H])([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])[C@@]([H])(C1=NC([H])=C(C(=O)N1C([H])([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2C(OC2=C(F)C([H])=C(C([H])=C2[H])C2=C([H])N=C(N(C2=O)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C1[H] [H]N([H])C1=NC([H])=C(C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C#N)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1OC([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1OC([H])([H])C1=C(F)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1OC([H])([H])C1=C(F)C([H])=C([H])C(F)=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1O[C@]([H])(C1=C(F)C([H])=C([H])C(F)=C1Cl)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1O[C@]([H])(C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1O[C@]([H])(C1=C(Cl)C([H])=C([H])C(F)=C1Cl)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C([H])C([H])=N1 [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(Br)C([H])=N1 [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C#N)C([H])=N1 [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=N1 [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])[C@@]([H])(N([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)N1N=C([H])C([H])=C1[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])N(C([H])=N1)C([H])([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=NC([H])=C([H])S1 [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])ON=C1[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])C([H])=NN1[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])N([H])N=C1[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C(N([H])N=C1C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C(C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1(C([H])([H])N2N=C([H])C(=C2[H])C2=C([H])C(O[C@]([H])(C3=C(Cl)C([H])=C([H])C(F)=C3Cl)C([H])([H])[H])=C(N=C2[H])N([H])[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])C1([H])C([H])([H])N([H])C1([H])[H] [H]N([H])C(=O)C([H])([H])N1C([H])([H])C([H])(C([H])([H])N2N=C([H])C(=C2[H])C2=C([H])C(O[C@]([H])(C3=C(Cl)C([H])=C([H])C(F)=C3Cl)C([H])([H])[H])=C(N=C2[H])N([H])[H])C1([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])N([H])C1([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1OC([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C(C(=O)N1C([H])([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=C(C(=O)N1C([H])([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=C(C(=O)N1C([H])([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]C1=NC2=NN=C(N2N=C1C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2N=C([H])C([H])=NN12 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2N=C(N([H])[H])C(=NN12)C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=N1)C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C(C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=C([H])C3=C2SC(=C3[H])C2=NC([H])=C([H])C([H])=N2)C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C(C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])N(C(=O)C([H])=C1[H])C([H])([H])[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N=C([H])C([H])=C2[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])N1C([H])=C(C(=O)N([H])C2=C([H])C(F)=C(OC3=C4C([H])=C([H])N([H])C4=NC([H])=C3[H])C([H])=C2[H])C(=O)C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC([H])=C(C(=O)N1C([H])([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N1C(=O)C(C2=C([H])C(F)=C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C34)C([H])=C2[H])=C(N=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C(N([H])[H])C(OC([H])([H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C1[H] [H]N([H])C1=NC([H])=C(C([H])=C1OC([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])OC1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C(=O)C(=O)C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])OC1=C(C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)C(=O)C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H])C(=O)C(=O)C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C(=O)C(=O)C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N1C([H])=NC(OC2=C([H])C(=C([H])C([H])=C2[H])C(=O)OC([H])([H])[H])=C(\C([H])=C(/[H])C(=O)C([H])([H])[H])C1=O [H]OC1=C([H])C2=C(C(=O)C3=C(C(O[H])=C(O[H])C([H])=C3O2)C([H])([H])[H])C(O[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(OC2=NC([H])=NC3=C2C(=C([H])S3)C2=C([H])C([H])=C([H])C([H])=C2[H])C(F)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(OC2=NC([H])=NC3=C2C(=C([H])S3)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(F)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(OC2=NC([H])=NC3=C2C(=C([H])S3)C2=C([H])C([H])=C(S2)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(OC2=NC([H])=NC3=C2C(=C([H])S3)C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C(F)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(OC2=NC([H])=NC3=C2C(=C([H])S3)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C(F)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(OC2=NC([H])=NC3=C2C(=C([H])S3)C2=C([H])C([H])=C(F)C([H])=C2[H])C(F)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(OC2=NC([H])=NC3=C2C(=C([H])S3)C2=C([H])C([H])=C(F)C(F)=C2[H])C(F)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(OC2=NC([H])=NC3=C2C(=C([H])O3)C2=C([H])C([H])=C([H])C([H])=C2[H])C(F)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(OC2=NC([H])=NC3=C2C(=C([H])O3)C2=C([H])C([H])=C(F)C([H])=C2[H])C(F)=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C2=O)C([H])([H])C1=NC([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])OC1([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])OC1([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)N1C([H])([H])C([H])(F)C1([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)N1C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])C([H])=N1 [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)N([H])C([H])([H])[H] [H]N([H])S(=O)(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)C(F)(F)F [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)C1=C([H])N(C([H])=N1)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C2=O)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C([H])=C([H])S(=O)(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C2=O [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C2=O)S(=O)(=O)C([H])([H])C([H])([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)C([H])([H])[H] [H]N([H])C1=C(Cl)C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O [H]N([H])C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N([H])N=C1[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])SN=C1[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])SC([H])=C1[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])OC([H])=C1[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N=C([H])N=C1[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N=C([H])C([H])=C1[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])C([H])=NC([H])=C1[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C(OC([H])([H])[H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C(C(=O)N([H])C([H])([H])[H])C(Cl)=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C([H])O1 [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C(C(=O)N([H])C2=C([H])C(F)=C(OC3=C4C([H])=C([H])N([H])C4=NC([H])=C3[H])C([H])=C2[H])C1=O [H]N(C(=O)C1=C([H])N([H])C([H])=C(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])OC([H])=C(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N([H])C1=C([H])C(OC2=C(F)C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])N(C3=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])=C([H])C([H])=N1 [H]N([H])C1=C(C#CC([H])([H])N([H])[H])C(OC2=C(F)C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])N(C3=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])=C([H])C([H])=N1 [H]N([H])C1=C(Cl)C(OC2=C(F)C([H])=C(N([H])C(=O)C3=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])N(C3=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])=C([H])C([H])=N1 [H]OC([H])([H])C([H])([H])OC1=C(C(=O)N([H])C2=C([H])C(F)=C(OC3=C([H])C([H])=NC(N([H])[H])=C3Cl)C([H])=C2[H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C3C([H])=C([H])C(OC([H])([H])[H])=C([H])C3=NC([H])=C2[H])C(F)=C1[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1N(C(=O)C(C(=O)N([H])C2=C([H])C([H])=C(OC3=C4C([H])=C([H])C(OC([H])([H])[H])=C([H])C4=NC([H])=C3[H])C(F)=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C(OC([H])([H])[H])C([H])=C3C(OC4=C(F)C([H])=C(C([H])=C4[H])C4=C([H])N=C(N(C4=O)C([H])([H])[H])C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])=C([H])C([H])=NC3=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])SC([H])([H])[H])[C@@]([H])(C1=NC([H])=C(C(=O)N1C([H])([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C(C(=O)N1C([H])([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2N=C([H])C(=NN12)C1=C([H])C([H])=C([H])S1 [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN2C(=NN=C2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])N=C1[H] [H]O[C@@]([H])(C1=C([H])C2=NC([H])=C([H])C(OC3=C([H])C([H])=C(N([H])C(=S)N([H])C(=O)C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3F)=C2S1)C([H])([H])[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C(=O)[C@@]2([H])OC([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C(=O)N([H])C([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C(F)C([H])=C2[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(=C(Br)C([H])=C2[H])C([H])([H])[H] [H]OC1=C(Cl)C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1Cl)C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl)C(=O)C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C(OC([H])([H])[H])C([H])=C2Cl [H]OC1=C(Br)C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1C#N)C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C(=O)N1N=C(C2=C([H])C(Cl)=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=[N+]1[O-])C1=C([H])C([H])=C([H])C([H])=C1[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C1[H])C([H])=C2[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C([H])C([H])=N1)C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(Cl)C([H])=N1)C2=O)S(=O)(=O)C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(N=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=C1[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C2=O [H]N([H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=C2[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[C@]([H])(F)C([H])([H])OC([H])([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(F)C([H])([H])N1N=C([H])C(=C1[H])C1=C([H])C2=C(N=C1[H])C([H])=C([H])C1=C(C([H])=C(N([H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C2=O [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])C([H])([H])F)C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N1N=C([H])C(=C1[H])C1=C([H])C2=C(N=C1[H])C([H])=C([H])C1=C(C([H])=C(N([H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C2=O [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]2([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=NC([H])=NC3=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C([H])=N1)C(=O)C1=C(F)C([H])=C([H])C([H])=C1F [H]N(C(=S)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC([H])=C3[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Br)=C([H])C(=C2[H])C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl)C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C(=NN1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C([H])([H])C1=C([H])C(=O)N([H])C([H])=N1 [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl)C(=O)C([H])([H])C1=C([H])N([H])C(=O)N=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(O[H])=C(OC([H])([H])[H])C(Cl)=C2Cl [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1Br)C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl [H]OC1=C(Br)C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1Br)[C@]([H])(C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl)C([H])([H])[H] [H]OC1=C(Cl)C2=C(N([H])C(=O)\C2=N/N([H])C(=O)[C@@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=C(Cl)C2=C(N([H])C(=O)\C2=N/N([H])C(=O)C([H])([H])C2=C([H])C([H])=C(O[H])C(C#N)=C2[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1C#N)C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C(OC([H])([H])[H])C([H])=C2Cl)C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2C([H])([H])[H])C(=O)[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2N=C3N([H])C4=C([H])C([H])=C(OC([H])([H])[H])C(Cl)=C4C3=NN12 [H]OC([H])([H])C([H])([H])OC1=C([H])C(Cl)=C(C2=NC(=C(N2[H])C2=NC(=NC([H])=C2[H])N([H])C([H])([H])C([H])([H])C([H])([H])O[H])C2=C([H])C(OC([H])([H])C3=NC([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2[H])C(Cl)=C1[H] [H]OC([H])([H])C1=C([H])C(Cl)=C(C2=NC(=C(N2[H])C2=NC(=NC([H])=C2[H])N([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])C(Cl)=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C3=[N+](C([H])=C([H])[C@]3([H])N=C2[H])S(=O)(=O)C2=C(Cl)N=C3SC([H])=C([H])N23)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=N1 [H]N(C(=O)N([H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=N1 [H]N(C(=O)N([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC([H])=C3[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC([H])=C3[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=NC([H])=C([H])N2C([H])([H])[H])C([H])=C1[H])C(=O)C1=C(F)C([H])=C([H])C([H])=C1F [H]N(C(=O)N([H])C1=C(F)C([H])=C(OC2=C([H])C([H])=NC3=C2SC([H])=C3[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2N=C([H])C(=NN12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C(OC([H])([H])C2=NN=C3C([H])=C([H])C(=NN23)C2=C([H])C([H])=C([H])C([H])=C2F)=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N(C([H])=C(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C(F)=C1[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(C2=C([H])C([H])=C(F)C([H])=C2[H])=[N+]1[O-])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Br)=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C1=C(C(OC2=C(F)C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])N(C3=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])=C([H])C([H])=N1)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=C(S1)C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H] [H]N1C(=O)C(=C([H])N=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N1C(=O)\C(=C(\[H])C2=C(C(C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C(N2[H])C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C([H])C(=C2[H])S(=O)(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(\C(=N\N([H])C(=O)C([H])([H])C3=C([H])C4=C(OC([H])([H])C4([H])[H])C([H])=C3[H])C(=O)N2[H])C(Br)=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=C([H])C3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=NC([H])=NN2C([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=NC([H])=C([H])S2)C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])=C([H])S2)C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])OC([H])=C2[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])OC1([H])[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])OC1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])OC1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]C#CC1=C([H])C2=C(C([H])=C1N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])OC1([H])[H])C(C1=C(C3=C(N1[H])C([H])=C(C#N)C([H])=C3[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)N1C([H])([H])C([H])([H])N(C3=C([H])N=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)N1C([H])([H])C([H])([H])C3(OC([H])([H])C([H])([H])O3)C([H])([H])C1([H])[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(N=C1[H])C([H])=C([H])C1=C(C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C2=O)C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=NC([H])=C(C(=O)N1C([H])([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]C1=NC2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C(OC([H])([H])C2=NN=C3C([H])=C([H])C(=NN23)C2=C([H])C([H])=C(F)C([H])=C2[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN2C(=NN=C2C([H])([H])OC2=C([H])C([H])=NC3=C2C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C2=NC([H])=C([H])C([H])=C2[H])C1=O)C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N(C([H])=C(C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H] [H]OC([H])([H])C#CC1=C(N=C([H])C([H])=C1OC1=C(F)C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])N(C2=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H])N([H])[H] [H]N([H])C1=C(Cl)C(OC2=C(F)C([H])=C(N([H])C(=O)C3=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])N(C3=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])=C([H])C([H])=N1 [H]C1=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C(OC2=C(F)C([H])=C(C([H])=C2[H])C2=C([H])N=C(N(C2=O)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H] [H]N(C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C(C(=O)N1C([H])([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]C1=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2C(OC2=C(F)C([H])=C(C([H])=C2[H])C2=C([H])N=C(N(C2=O)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C1[H] [H]N(C1=NC([H])=C(C(=O)N1C([H])([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C(S1)C1=NN2C(=NN=C2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])N=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC([H])=C3[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=NC([H])=C([H])N2C([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C([H])=N1)C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Br)=C([H])C(=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H] [H]OC1=C(Cl)C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C(C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C(Br)C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Br)=C(C([H])=C2[H])C([H])([H])[H] [H]N([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C3=C(S2)C(OC2=C(F)C([H])=C(N([H])C(=O)N4C(=O)N(C5=C([H])C([H])=C([H])C([H])=C5[H])C([H])([H])C4([H])[H])C([H])=C2[H])=C([H])C([H])=N3)C([H])([H])C1([H])[H] [H]N1C(=O)\C(=C(\[H])C2=C(C(=C(N2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])[H])C2=C1C([H])=C([H])C(=C2[H])S(=O)(=O)N(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(SC([H])([H])[H])=C3[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C(=O)OC([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C2=C(S1)C(OC1=C(F)C([H])=C(N([H])C(=S)N([H])C(=O)C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C1[H])=C([H])C([H])=N2 [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=C([H])C3=C2SC(=C3[H])C2=NC([H])=C([H])N2C([H])([H])C([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(N=C2[H])C([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=NC([H])=C([H])C([H])=C2[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=NN=C([H])S2)C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])=C([H])N2C([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N=C([H])N=C2[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])OC1([H])[H])C([H])([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])OC1([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C(C([H])=N2)C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O [H]C1=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2C(OC2=C(F)C([H])=C(C([H])=C2[H])C2=C([H])N=C(N(C2=O)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H] [H]O[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C2=C([H])C3=C(\C(=N\N([H])C(=O)C([H])([H])C4=C([H])C5=C(OC([H])([H])C5([H])[H])C([H])=C4[H])C(=O)N3[H])C(Br)=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC2=C1N=C(C([H])=N2)C1=C([H])C([H])=C([H])S1 [H]C1=NC2=C(N=C1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C1[H])N(N=N2)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(=C([H])C([H])=C2[H])C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl)C(=O)C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]OC(=O)C1=C(Cl)C2=C(N([H])C(=O)\C2=N/N([H])C(=O)[C@@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl)C(=O)[C@@]([H])(C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N([H])\N=C1/C(=O)N(C2=C1C(=C(C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C(=C2[H])C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C(=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Br)=C([H])C(=C2[H])C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Br)=C([H])C(=C2[H])C(=O)N([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Br)=C([H])C(=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C2=C([H])C3=C(\C(=N\N([H])C(=O)C([H])([H])C4=C([H])C5=C(OC([H])([H])C5([H])[H])C([H])=C4[H])C(=O)N3[H])C(Br)=C2[H])C([H])([H])C1([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Br)=C([H])C(=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])=C2[H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Br)=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])=C2[H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Br)=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])=N2)C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Br)=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])C2=C(SC([H])=C2[H])C([H])=C1[H] [H]N([H])C1=NOC2=C1C([H])=C(C([H])=C2[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Br)=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC2=NC([H])=C(N=C2N1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC2=NC([H])=C(N=C12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C(S1)C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H])C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C2=C(C([H])=C1C1=C([H])N=C3N=NN(C3=N1)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])=C([H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC2=NC([H])=C(Br)C([H])=C12 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]OC(=O)C1=C([H])C2=C(N([H])C(=O)\C2=N/N([H])C(=O)C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C(C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(=C(Br)C([H])=C2[H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(=C([H])C([H])=C2[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C(OC(F)(F)F)C([H])=C2[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C(C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C(Br)C([H])=C2[H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C(C([H])=C2[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N([H])\N=C1/C(=O)N([H])C2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C(C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C(C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C(=O)[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C(C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(Cl)C2=C(N([H])C(=O)\C2=N/N([H])C(=O)C([H])([H])C2=C([H])N(C(=O)C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C(C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])N(C(=O)C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1=C(Cl)C2=C(N([H])C(=O)\C2=N/N([H])C(=O)C([H])([H])C2=C([H])C([H])=C(O[H])C(Cl)=C2[H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C(C([H])=C2[H])C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C(C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=N1)C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C(C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N([H])C1([H])C([H])([H])C1([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(Cl)=C2[H])C(=O)C([H])([H])C1=C([H])N(C(=O)C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=N2 [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C(C#CC([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C(=O)[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C(Br)C([H])=C2[H])C(=O)[C@@]([H])(C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C(N([H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])=C2[H])C(=O)[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C(N([H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])=C2[H])C(=O)[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(=C([H])C([H])=C2[H])C(=O)OC([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(=C(C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C(=O)[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(=C(C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C(=O)[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])OC1([H])[H] [H]N(C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12 [H]N(C(=O)N([H])[C@@]([H])(C1=NC([H])=C([H])S1)C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N1C(=O)C2(C3=C([H])C(=C([H])C([H])=C13)C1=NC3=C(N=NN3C([H])([H])C3=C([H])C4=C([H])C([H])=C([H])N=C4C([H])=C3[H])N=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H] [H]N1C2=C([H])C([H])=C(C([H])=C2C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=N[N+]2=C(N=N[C@@]2([H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])N=C3C([H])=C2[H])C([H])=C1[H] [H]N1C(=O)C2(C3=C1C([H])=C(C([H])=C3[H])C1=NC3=C(N=NN3C([H])([H])C3=C([H])C4=C([H])C([H])=C([H])N=C4C([H])=C3[H])N=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H] [H]N1C2=C(C([H])=C([H])C(=C2[H])C2=N[N+]3=C(N=N[C@]3([H])C([H])([H])C3=C([H])C4=C([H])C([H])=C([H])N=C4C([H])=C3[H])C([H])=C2[H])C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H] [H]OC1=C([H])C2=C3C(OC(=O)C4=C3C(OC2=O)=C(O[H])C(O[H])=C4[H])=C1O[H] [H]N([H])C1=NC(=NN1C1=NC([H])=C([H])C([H])=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C(=C1[H])N1C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C(=C1[H])N1C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C(=C1[H])N1C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])OC1([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])OC1([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)C(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C(C1=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]N(C(=O)C1=NC(C#N)=C([H])N1[H])C1=C(C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2OC(C(=O)N([H])C2=N1)(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=NC(=N1)N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1SC1=C([H])C([H])=C2C(=NN([H])C2=C1[H])C(\[H])=C(/[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Cl)=C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=N4)C([H])=C3[H])C2=C1[H] [H]N(\C(=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(SC([H])([H])[H])=C([H])C([H])=C1[H] [H]N1N=C(\C([H])=C(/[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C1=NC(N([H])C2=C(F)C([H])=C([H])C([H])=C2C(=O)N([H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@]([H])(N([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N2[H] [H]N(C1=NC(N([H])C2=C(F)C([H])=C([H])C([H])=C2C(=O)N([H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])[H])C(=O)N2[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=C(Cl)C([H])=NC(=N1)N([H])C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@@]([H])(N([H])C(=O)C(F)(F)F)C(=O)N2[H])C([H])([H])[H] [H]N(C1=NC(N([H])C2=C(F)C([H])=C([H])C([H])=C2C(=O)N([H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])OC([H])([H])[H])C(=O)N2[H] [H]N([H])[C@]1([H])C(=O)N([H])C2=C(C([H])=C([H])C(N([H])C3=NC(N([H])C4=C(F)C([H])=C([H])C([H])=C4C(=O)N([H])C([H])([H])[H])=C(Cl)C([H])=N3)=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H] [H]N(C1=NC(N([H])C2=C(F)C([H])=C([H])C([H])=C2C(=O)N([H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)N2[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=C(Cl)C([H])=NC(=N1)N([H])C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N2[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])N(N=C1[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=C([H])C(=C1[H])C1=NN2C(=NN=C2C([H])([H])C2=C3C([H])=C([H])N([H])C(=O)C3=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])N1N=C([H])C(=C1[H])C1=NN2C(=NN=C2C([H])([H])C2=C3C([H])=C([H])N([H])C(=O)C3=C([H])C([H])=C2[H])C([H])=C1[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])SC([H])=C1[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])N=C([H])C([H])=C1[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])SC2=C1C([H])=C([H])C([H])=C2[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=NN2C(=NN=C2C([H])([H])C2=C3C([H])=C([H])N([H])C(=O)C3=C([H])C([H])=C2[H])C([H])=C1[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C(F)=C1[H])C1=NN2C(=NN=C2C([H])([H])C2=C3C([H])=C([H])N(C(=O)C3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C(F)=C1[H])C1=NN2C(=NN=C2C([H])([H])C2=C3C([H])=C([H])N(C(=O)C3=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N1C([H])=C([H])C2=NC([H])=NC(N([H])C3=C([H])C(Cl)=C(OC4=C([H])C(=C([H])C([H])=C4[H])C(F)(F)F)C([H])=C3[H])=C12 [H]N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N2C(SC3=C2C([H])=C([H])C([H])=C3[H])=N1 [H]N(C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N2C(SC3=C2C([H])=C([H])C([H])=C3[H])=N1 [H]N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N2C(SC3=C2C([H])=C([H])C([H])=C3[H])=N1 [H]N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N2C(SC3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=N1 [H]N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N2C(SC3=C2C([H])=C([H])C(Br)=C3[H])=N1 [H]N(C(=O)C1=C([H])C([H])=C([H])C2=C([H])C(OC3=C4C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C4=NC([H])=C3[H])=C([H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C2=C(OC3=C([H])C([H])=C4C(C([H])=C([H])C([H])=C4C(=O)N([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C3[H])C([H])=C([H])N=C2C([H])=C1OC([H])([H])[H] [H]N([H])C(=O)C1=C2C([H])=C([H])C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C34)=C([H])C2=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C2=C([H])C(OC3=C4C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C4=NC([H])=C3[H])=C([H])C([H])=C12)C1(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C2=C([H])C(OC3=C4C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C4=NC([H])=C3[H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C2=C(OC3=C([H])C([H])=C4C(C([H])=C([H])C([H])=C4C(=O)N([H])[H])=C3[H])C([H])=C([H])N=C2C([H])=C1OC([H])([H])[H] [H]N(C(=O)C1=C2C([H])=C([H])C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C34)=C([H])C2=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC(=C1[H])C(=O)N([H])C([H])([H])[H])C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=NC([H])=NC3=C1C([H])=C([H])N3[H])C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=NC([H])=NC3=C1C([H])=C([H])N3[H])C([H])=C2[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C(=O)C1=C(OC([H])([H])[H])C([H])=C2N=C([H])C([H])=C(OC3=C([H])C4=C(C([H])=C3[H])N(C(=O)N([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])O4)C2=C1[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H])C([H])([H])[H] [H]N([H])C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N1C2=C([H])C([H])=C(OC3=C4C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C4=NC([H])=C3[H])C([H])=C2OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC(=C1[H])C(=O)N([H])C([H])([H])[H])C([H])=C2[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C(=O)C1=C(OC([H])([H])[H])C([H])=C2N=C([H])C([H])=C(OC3=C([H])C4=C(C([H])=C3[H])N(C(=O)N([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])O4)C2=C1[H] [H]N(C1=NC2=C([H])N=C(N=C2N1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])[C@]([H])(C1=C(Cl)C([H])=C([H])C(F)=C1Cl)C([H])([H])[H])C1=C([H])C2=C(N([H])C(=O)C2([H])[H])C([H])=C1[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])[C@]([H])(C1=C(Cl)C([H])=C([H])C(F)=C1Cl)C([H])([H])[H])C1=C([H])N=C([H])N=C1[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])[C@]([H])(C1=C(Cl)C([H])=C([H])C(F)=C1Cl)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])[C@]([H])(C1=C(Cl)C([H])=C([H])C(F)=C1Cl)C([H])([H])[H])C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1F)C1=C([H])N(N=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1F)C1=C([H])N(N=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1F)C1=C([H])N(N=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H])C1=C([H])N(N=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C1=C([H])N(N=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1Cl)C1=C([H])N(N=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])C([H])([H])C1=C(F)C([H])=C([H])C(Cl)=C1F)C1=C([H])N(N=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])C([H])([H])C1=C(F)C([H])=C([H])C(F)=C1Cl)C1=C([H])N(N=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])C([H])([H])C1=C(F)C([H])=C([H])C(Cl)=C1Cl)C1=C([H])N(N=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])[C@]([H])(C1=C(Cl)C([H])=C([H])C(F)=C1Cl)C([H])([H])[H])C1=C([H])N(N=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])[C@]([H])(C1=C(Cl)C([H])=C([H])C(F)=C1Cl)C([H])([H])[H])C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])[C@]([H])(C1=C(Cl)C([H])=C([H])C(F)=C1Cl)C([H])([H])[H])C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1(C(=O)N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N5C([H])([H])C([H])([H])OC([H])([H])C5([H])[H])=C(OC([H])([H])[H])C([H])=C34)C(F)=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])C([H])=N1)C(=O)C1=NC(=C([H])C([H])=C1C(F)(F)F)N1C([H])([H])C([H])([H])N([H])[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N([H])C1=NC([H])=C(N=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C(F)=C1F [H]N([H])C1=NC([H])=C(N=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C(F)=C1C([H])([H])[H] [H]N([H])C1=NC([H])=NC(N([H])C2=C([H])C([H])=C(OC([H])([H])C3=NC([H])=C([H])C([H])=C3[H])C(Cl)=C2[H])=C1C1=NC(=C([H])O1)C([H])([H])N([H])C(=O)C([H])=C([H])[H] [H]OC1=C([H])C2=C(OC(=N2)C2=C(N=C([H])C(=C2[H])C2=C([H])N(N=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N([H])[H])C([H])=C1C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1N=C([H])C(=C1[H])C1=C([H])C(C2=NC3=C(O2)C(=C([H])C([H])=C3[H])C2=NC([H])=C([H])C([H])=C2[H])=C(N=C1[H])N([H])[H] [H]N([H])C(=O)C1=C(O[C@@]([H])(C(\[H])=C(\[H])C(F)(F)F)C([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])N=C1N([H])[H])C1=C([H])C(=C([H])S1)C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(C2=C(OC(=N2)C2=C(N=C([H])C(=C2[H])C2=C([H])N(N=C2[H])C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])N([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C2=C(OC(=N2)C2=C(N=C([H])C(=C2[H])C2=C([H])N(N=C2[H])C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])N([H])[H])C([H])=C1C([H])([H])[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C(Cl)C([H])=C2[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2N=C([H])C(=C2[H])C2=C([H])C(C3=NC4=C(O3)C([H])=C(F)C([H])=C4[H])=C(N=C2[H])N([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C(F)C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C1=NC2=C(O1)C([H])=C(Cl)C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C(N([H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C(N([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C(N([H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C(N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C(N([H])[H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C(N([H])[H])=C2[H] [H]OC1=C(C2=C(N=C(O2)C2=C(N=C([H])C(=C2[H])C2=C([H])N(N=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C2=C(N=C(O2)C2=C(N=C([H])C(=C2[H])C2=C([H])N(N=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N([H])[H])C([H])=C1[H])C1=NC([H])=C([H])N=C1[H] [H]OC1=C(C2=C(N=C(O2)C2=C(N=C([H])C(=C2[H])C2=C([H])N(N=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N([H])[H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]OC1=C(C2=C(N=C(O2)C2=C(N=C([H])C(=C2[H])C2=C([H])N(N=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C2=C(N=C(O2)C2=C(N=C([H])C(=C2[H])C2=C([H])N(N=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N([H])[H])C([H])=C1C([H])([H])[H] [H]OC1=C([H])C2=C(OC(=N2)C2=C(N=C([H])C(=C2[H])C2=C([H])N(N=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N([H])[H])C([H])=C1C([H])([H])C([H])([H])[H] [H]OC1=C(C2=C(OC(=N2)C2=C(N=C([H])C(=C2[H])C2=C([H])N(N=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C2=C1OC(=N2)C1=C(N=C([H])C(=C1[H])C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N([H])[H] [H]OC1=C([H])C2=C(N=C(O2)C2=C(N=C([H])C(=C2[H])C2=C([H])N(N=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N([H])[H])C([H])=C1[H] [H]OC1=C([H])C2=C(OC(=N2)C2=C(N=C([H])C(=C2[H])C2=C([H])N(N=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N([H])[H])C([H])=C1[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C(OC1=NC([H])=C([H])C([H])=N1)C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C(OC1=NC([H])=NC([H])=C1[H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C(N([H])C1=NC([H])=C([H])C([H])=N1)C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C(N([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C(N([H])C(=O)C([H])([H])[H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C(N([H])C([H])([H])[H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C(=C([H])C([H])=C2[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C(=C([H])C([H])=C2[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C(C([H])=C2[H])C1=NN([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C(C([H])=C2[H])C1=C([H])N=C([H])C([H])=C1[H] [H]O[C@]([H])(C1=C([H])C2=C(N=C(O2)C2=C(N=C([H])C(=C2[H])C2=C([H])N(N=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C(C([H])=C2[H])C(=O)C([H])([H])[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C(F)=C([H])C(Cl)=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C(Cl)=C2[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C1=NC2=C(O1)C(=C([H])C([H])=C2[H])C1=NC([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(S1)N1C([H])=C([H])C2=C(N(N=N2)[C@]([H])(C2=C([H])C([H])=C3N=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C3=C2[H])C([H])([H])[H])C1=O [H]C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])N1N=NC2=C1C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]C1=C(SN=C1C([H])([H])[H])N1C([H])=C([H])C2=C(N(N=N2)C([H])([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C2[H])C1=O [H]C1=C(SN=C1C([H])([H])[H])N1C([H])=C([H])C2=C(N(N=N2)C([H])([H])C2=C([H])C([H])=C3N=C([H])C(OC([H])([H])[H])=C([H])C3=C2[H])C1=O [H]C1=C(SN=C1C([H])([H])[H])N1C([H])=C([H])C2=C(N(N=N2)C([H])([H])C2=C([H])C([H])=C3N=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C3=C2[H])C1=O [H]C1=C(SN=C1C([H])([H])[H])N1C([H])=C([H])C2=C(N(N=N2)[C@]([H])(C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C2[H])C([H])([H])[H])C1=O [H]C1=C(SN=C1C([H])([H])[H])N1C([H])=C([H])C2=C(N(N=N2)[C@]([H])(C2=C([H])C([H])=C3N=C([H])C(OC([H])([H])[H])=C([H])C3=C2[H])C([H])([H])[H])C1=O [H]C1=C(SN=C1C([H])([H])[H])N1C([H])=C([H])C2=C(N(N=N2)[C@]([H])(C2=C([H])C([H])=C3N=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C3=C2[H])C([H])([H])[H])C1=O [H]C1=C([H])C([H])=C(S1)N1C([H])=C([H])C2=C(N(N=N2)C([H])([H])C2=C([H])C([H])=C3N=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C3=C2[H])C1=O [H]C1=C(C([H])=C(S1)N1C([H])=C([H])C2=C(N(N=N2)[C@]([H])(C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C2[H])C([H])([H])[H])C1=O)C([H])([H])[H] [H]C1=C(SC(=C1[H])C([H])([H])[H])N1C([H])=C([H])C2=C(N(N=N2)[C@]([H])(C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C2[H])C([H])([H])[H])C1=O [H]C1=NN(C([H])=C1N1C([H])=C([H])C2=C(N(N=N2)[C@]([H])(C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C2[H])C([H])([H])[H])C1=O)C([H])([H])[H] [H]C1=C([H])C2=C(N(N=N2)C([H])([H])C2=C([H])C([H])=C3N=C([H])C(OC([H])([H])[H])=C([H])C3=C2[H])C(=O)N1C1=C([H])C(F)=C([H])C(F)=C1[H] [H]C1=C([H])C2=C(N(N=N2)C([H])([H])C2=C([H])C([H])=C3N=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C3=C2[H])C(=O)N1C1=C([H])C(F)=C([H])C(F)=C1[H] [H]C1=C([H])C2=C(N(N=N2)[C@]([H])(C2=C([H])C([H])=C3N=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C3=C2[H])C([H])([H])[H])C(=O)N1C1=C([H])C(F)=C([H])C(F)=C1[H] [H]C1=C([H])C2=C(N(N=N2)[C@]([H])(C2=C([H])C([H])=C3N=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C3=C2[H])C([H])([H])[H])C(=O)N1C1=C([H])C([H])=C(F)C(F)=C1[H] [H]N([H])C(C(=O)N([H])C([H])([H])C([H])([H])N1C([H])=C([H])C2=C1C(=NC([H])=N2)N([H])C1=C([H])C(Cl)=C(OC2=C([H])C([H])=C([H])C3=C2C([H])=NS3)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]N([H])C(=O)C1=C([H])C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2C([H])=NN([H])C2=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C#N)C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C3=C(F)C([H])=C([H])C([H])=C3F)C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C(C#N)=C3[H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C3=C([H])C([H])=C([H])N=C3[H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=N3)C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C([H])([H])[H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1C([H])([H])[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])[N+]([O-])=O)C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C(C#N)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C#N)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C(F)=C3[H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C3=C([H])SC([H])=N3)C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2C(N([H])C([H])([H])C2([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(OC2=C3C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C3=NC([H])=N2)=C1[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])C([H])(N2N=C([H])C(=C2[H])C2=C([H])N=C3N=NN(C3=N2)C([H])([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N2N=C([H])C(=C2[H])C2=C([H])N=C3N=NN(C3=N2)C([H])([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C2[H])C1([H])[H] [H]C1=NN(C([H])=C1C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H] [H]C1=NN(C([H])=C1C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NN(C([H])=C1C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1N=C([H])C(=C1[H])C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H] [H]OC(=O)C([H])([H])N1N=C([H])C(=C1[H])C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H] [H]OC([H])([H])C([H])([H])N1N=C([H])C(=C1[H])C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H] [H]N1N=C([H])C(=C1[H])C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])N=C2C([H])=C1[H] [H]C1=NN(C([H])=C1C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H])C([H])([H])[H] [H]C1=NN(C([H])=C1C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H] [H]C1=NN(C([H])=C1C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])C2=C1[H])C([H])([H])[H] [H]C1=NN(C([H])=C1C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])N1N=NC2=NC([H])=C(N=C12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C(N=C2N(N=NC2=N1)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C(N=C2N(N=NC2=N1)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=NC2=NC([H])=C(N=C12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NN(C([H])=C1C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C2=C([H])N=C([H])N=C2C([H])=C1[H])C([H])([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)C([H])([H])C1=NN=C2N=C([H])C(=NN12)C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])C1=NN=C2N=C([H])C(=NN12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C(=O)C1=C(SN=C1SC([H])([H])C1=NN=C2N=C([H])C(=NN12)C1=C([H])C([H])=C(F)C([H])=C1[H])N([H])C([H])([H])[H] [H]N1N=C([H])C2=C(SC([H])([H])C3=NN=C4N=C([H])C(=NN34)C3=C([H])C([H])=C(F)C([H])=C3[H])N=C([H])N=C12 [H]C1=C([H])C2=NC([H])=C([H])C(OC([H])([H])C3=NN=C4N=C([H])C(=NN34)C3=C([H])C([H])=C(F)C([H])=C3[H])=C2S1 [H]C1=C([H])C(=O)C([H])=C([H])N1C([H])([H])C1=NN=C2N=C([H])C(=NN12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1Cl)C([H])([H])C1=NN=C2N=C([H])C(=NN12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC2=NN=C(N2N=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2N=C([H])C(=NN12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C(OC([H])([H])C2=NN=C3N=C([H])C(=NN23)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=N1 [H]C1=NC2=NN=C(N2N=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])N1N=NC2=NC([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])N=C12 [H]C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])N1N=NC2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])N(C2=C([H])N=C3N=NN(C3=N2)C([H])([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])N(C2=C([H])N=C3N=NN(C3=N2)C([H])([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N([H])C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H] [H]N(C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C([H])N=C2N=NN(C2=N1)C([H])([H])C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H] [H]C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])N1N=NC2=NC([H])=C(N=C12)C([H])([H])[H] [H]C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])N1N=NC2=NC([H])=C([H])N=C12 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2N=C3N([H])C4=C(C([H])=C([H])C(Cl)=C4C3=NN12)C([H])([H])[H] [H]N1\C(=N/C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])N(C2=C([H])C(=C([H])C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2\C(=N\C(=O)C3=C([H])C([H])=C([H])C(=C3[H])S(=O)(=O)N([H])C([H])([H])C([H])=C([H])[H])N([H])C3=C2C([H])=C([H])C(=C3[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=N1 [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=N1 [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=N1 [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]1([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=N1 [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=N1 [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C(F)=C1[H] [H]N([H])C([H])([H])C1=C(C(=O)N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C([H])C([H])=C34)C(F)=C2[H])C(=O)N(N1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=N1 [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=N1 [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=N1 [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=C1OC([H])([H])[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1Cl [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])N=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(C([H])=C23)C([H])([H])C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(C([H])=C23)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C23)C(F)=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N([H])C(C1=C(C(=O)N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C([H])C([H])=C34)C(F)=C2[H])C(=O)N(N1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1N(C(=O)C(C(=O)N([H])C2=C([H])C([H])=C(OC3=C4C([H])=C([H])C(OC([H])([H])[H])=C([H])C4=NC([H])=C3[H])C([H])=N2)=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])N1N(C(=O)C(C(=O)N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C([H])C([H])=C34)C(F)=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=NOC(=C1[H])C([H])([H])[H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=C1[H] [H]O[C@]([H])(C([H])([H])N([H])[H])C([H])([H])N1N(C(=O)C(C(=O)N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C([H])C([H])=C34)C(F)=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])N1N(C(=O)C(C(=O)N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C([H])C([H])=C34)C(F)=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])[H])C([H])([H])N1N(C(=O)C(C(=O)N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C([H])C([H])=C34)C([H])=N2)=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=N1 [H]OC([H])([H])C([H])([H])N1N(C(=O)C(C(=O)N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C([H])C([H])=C34)C([H])=N2)=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])N1N(C(=O)C(C(=O)N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C([H])C([H])=C34)C(F)=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C([H])=C(C([H])([H])[H])C([H])([H])N1N(C(=O)C(C(=O)N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C([H])C([H])=C34)C(F)=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=N1 [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=N1 [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])SC(=N1)C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=N1 [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=NC([H])=C([H])N=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=N1 [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=N1 [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])OC(=O)N([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)[C@]1([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)[C@@]1(C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)[C@]1(F)C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)[C@]1([H])C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N1C(=O)[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]C1=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C(OC([H])([H])C2=NN=C3C([H])=C([H])C(=C([H])N23)C2=C([H])C(F)=C(F)C(F)=C2[H])=C1[H] OCCNC(=O)C1=CC2=C(NCC1)N=CN=C2NC1=CC(Cl)=C(OC2=CC=CC3=C2C=CS3)C=C1 FC1=CC(NC(=O)C2=CC=CN(C3=CC=C(C=C3)C(F)(F)F)C2=O)=CC=C1OC1=NC=NC2=C1N=CN2 FC1=CC=C(C=C1)N1C=CC=C(C(=O)NC2=CC=C(OC3=NC=NC4=C3N=CN4)C(F)=C2)C1=O FC1=CC(=CC=C1)N1C=CC=C(C(=O)NC2=CC=C(OC3=NC=NC4=C3N=CN4)C(F)=C2)C1=O [O-][N+](=O)C1=C(C=CC=C1)C1=NNC=C1\C=C1/C(=O)NC2=CC=CC=C12 CC1=C(F)C(=CC=C1C(=O)N1CCOC2=CC=C(C=C2C1)C1=CC=C(N)N=C1)S(C)(=O)=O C\C=C(\C=O)[C@@H](CC=O)CC(=O)OCCC1=CC=C(O)C=C1 [Na+].[Na+].CC1=CC(=CC=C1NC1=CC(=C(N)C2=C1C(=O)C1=CC=CC=C1C2=O)S([O-])(=O)=O)C1=CC=C(NC2=CC(=C(N)C3=C2C(=O)C2=CC=CC=C2C3=O)S([O-])(=O)=O)C(C)=C1 [Na+].[Na+].COC1=C(C=CC(NC2=CC(=C(N)C3=C2C(=O)C2=CC=CC=C2C3=O)S([O-])(=O)=O)=C1)C1=C(OC)C=C(NC2=CC(=C(N)C3=C2C(=O)C2=CC=CC=C2C3=O)S([O-])(=O)=O)C=C1 [Na+].[Na+].CC1=C(C=CC(NC2=CC(=C(N)C3=C2C(=O)C2=CC=CC=C2C3=O)S([O-])(=O)=O)=C1)C1=C(C)C=C(NC2=CC(=C(N)C3=C2C(=O)C2=CC=CC=C2C3=O)S([O-])(=O)=O)C=C1 [Na+].[Na+].NC1=C(C=C(NC2=CC=C(C=C2)C2=CC=C(NC3=CC(=C(N)C4=C3C(=O)C3=CC=CC=C3C4=O)S([O-])(=O)=O)C=C2)C2=C1C(=O)C1=CC=CC=C1C2=O)S([O-])(=O)=O [Na+].NC1=C(C=C(NC2=CC=C(C=C2)C2=CC=C(NC3=NC=CC=N3)C=C2)C2=C1C(=O)C1=CC=CC=C1C2=O)S([O-])(=O)=O [H][C@]12C[C@H]([C@H](OC)[C@@](C)(O1)N1C3=CC=CC=C3C3=C1C1=C(C4=C(C=CC=C4)N21)C1=C3CNC1=O)N(C)C(=O)C1=CC=CC=C1 O\N=C(/CC1=CC(OC2=C(Br)C=C(CCNC(=O)C(\CC3=CC(Br)=C(O)C(=C3)C3=C(O)C(Br)=CC(C\C(=N/O)C(=O)NCCC4=CC(Br)=C(O)C=C4)=C3)=N\O)C=C2)=C(O)C(Br)=C1)C(=O)NCCC1=CC(Br)=C(O)C=C1 [H]O\N=C(/C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(O[H])C(Br)=C1[H])C([H])([H])C1=C([H])C(=C(O[H])C(Br)=C1[H])C1=C([H])C(=C([H])C(Br)=C1O[H])C([H])([H])C(=N\O[H])\C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(O[H])C(Br)=C1[H] [H]O\N=C1\C(=O)N([H])\C([H])=C([H])\C2=C([H])C(Br)=C(OC3=C(O[H])C(Br)=C([H])C(=C3[H])C([H])([H])C([H])([H])N([H])C(=O)\C(=N\O[H])C([H])([H])C3=C([H])C([H])=C(OC4=C(O[H])C(Br)=C([H])C(=C4[H])C1([H])[H])C(Br)=C3[H])C([H])=C2[H] [H][C@@]12C[C@@](O)(CO)[C@](C)(O1)N1C3=C(C=CC=C3)C3=C1C1=C(C4=C(C=CC=C4)N21)C1=C3CNC1=O ClC1=CC(CNC2=NC=C(C(=O)NCCCN3CCOC3=O)C(NC3CCCC3)=N2)=C(Cl)C=C1 ClC1=CC(CNC2=NC=C(C(=O)NCCCN3CCCC3=O)C(NC3CCCC3)=N2)=C(Cl)C=C1 COC1=C(CNC2=NC=C(C(=O)NCCCN3CCCC3=O)C(NC3CCCC3)=N2)C=CC=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)NCC4=NC=CC=C4)C=C3)C2=O)N=C1 O=C1C2=C(C=CC(CS(=O)(=O)NCC3=NC=CC=C3)=C2)C=CC2=C1C=C(C=N2)C1=CN(N=C1)C1CCNCC1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)NC4CCCCC4)C=C3)C2=O)N=C1 CN(C1=CC2=C(C=C1)C=CC1=C(C=C(C=N1)C1=CN(C)N=C1)C2=O)S(=O)(=O)NCC1=NC=CC=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)CCC4=NC=CC=C4)C=C3)C2=O)N=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CC(=O)NC4=CC=CC=C4)C=C3)C2=O)N=C1 CN(C)C(=O)CC1=CC2=C(C=C1)C=CC1=C(C=C(C=N1)C1=CN(C)N=C1)C2=O CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CC(N)=O)C=C3)C2=O)N=C1 CCN(CC1=NC=CC=C1)S(=O)(=O)CC1=CC2=C(C=C1)C=CC1=C(C=C(C=N1)C1=CN(C)N=C1)C2=O CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)NCC4=CC=NC=C4)C=C3)C2=O)N=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)NCC4=CN=CC=C4)C=C3)C2=O)N=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)NCC4=CSN=C4)C=C3)C2=O)N=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)NCC4=NC(C)=NC=C4)C=C3)C2=O)N=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)NCC4=NN=CC=C4)C=C3)C2=O)N=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)NCC4=C(Cl)C=CC=C4)C=C3)C2=O)N=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)NCC4=C(F)C=C(F)C=C4)C=C3)C2=O)N=C1 CC(NS(=O)(=O)CC1=CC2=C(C=C1)C=CC1=C(C=C(C=N1)C1=CN(C)N=C1)C2=O)C1=CC=CC=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)NC4=CC=CC=C4)C=C3)C2=O)N=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)N[C@@H]4CCCC[C@H]4N)C=C3)C2=O)N=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)NCC4COCCO4)C=C3)C2=O)N=C1 CCCNS(=O)(=O)CC1=CC2=C(C=C1)C=CC1=C(C=C(C=N1)C1=CN(C)N=C1)C2=O CN(C)S(=O)(=O)CC1=CC2=C(C=C1)C=CC1=C(C=C(C=N1)C1=CN(C)N=C1)C2=O CNS(=O)(=O)CC1=CC2=C(C=C1)C=CC1=C(C=C(C=N1)C1=CN(C)N=C1)C2=O CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(N)(=O)=O)C=C3)C2=O)N=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(C=C3)C(O)C(N)=O)C2=O)N=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CC(=O)NCC4=NC=CC=C4)C=C3)C2=O)N=C1 CN(CC1COCCO1)C(=O)CC1=CC2=C(C=C1)C=CC1=C(C=C(C=N1)C1=CN(C)N=C1)C2=O CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CC(=O)NCC4=CC=CC=C4)C=C3)C2=O)N=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)NCCC4=NC=CC=C4)C=C3)C2=O)N=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)NCC4CCCCN4)C=C3)C2=O)N=C1 CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CS(=O)(=O)NCC4=[N+]([O-])C=CC=C4)C=C3)C2=O)N=C1