[H]N(C(=O)C([H])([H])[H])C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1 [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1 [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])N=C([H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])N=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(N([H])C2=NC3=C(C([H])=N2)C([H])=C(C(=O)N3C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C1[H] [H]OC1=C([H])C([H])=C(N([H])C2=NC3=C(C([H])=N2)C([H])=C(C(=O)N3C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]OC([H])([H])C1=C([H])C([H])=C([H])C(N([H])C2=NC3=C(C([H])=N2)C([H])=C(C(=O)N3C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(=C([H])C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(N([H])C2=NC3=C(C([H])=N2)C([H])=C(C(=O)N3C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[N+]([O-])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(N([H])C2=NC3=C(C([H])=N2)C([H])=C(C(=O)N3C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(N([H])C2=NC3=C(C([H])=N2)C([H])=C(C(=O)N3C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C2=NC3=C(C([H])=N2)C([H])=C(C(=O)N3C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=N1)N([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=N1)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Br)C([H])=C([H])C([H])=C1Br)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Br)C([H])=C([H])C([H])=C1Br)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=N1)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(C(=C([H])C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=N1)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=N1)N([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=N1)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=N1)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Br)C([H])=C([H])C([H])=C1Br [H]C1=C([H])C([H])=C(S1)N1C([H])=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12 [H]C1=C([H])C(=C([H])S1)N1C([H])=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12 [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N=C(N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(\C(=N\C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C(=S)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C(=S)N([H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C([H])=C([H])C([H])([H])N([H])C(=O)N([H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N(C(=O)N([H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C(=O)N([H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C(=O)N([H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C(=O)N([H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)N([H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N([H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=NC2=C([H])C([H])=C([H])C([H])=C12 [H]OC1=C([H])C([H])=C2N(C([H])=NC2=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC2=C([H])C(=C([H])C([H])=C2N1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H] [H]N(C(=S)N([H])C([H])([H])C([H])([H])[H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)N([H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C([H])C([H])=C2N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2N(C([H])=NC2=C1O[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C3=C([H])SC([H])=C3[H])C(=O)N(C2=N1)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])N1C(=O)C(=C([H])C2=C([H])N=C(N=C12)N([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl [H]N([H])C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N=C(N([H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])[H] [H]N(C(=S)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])C(=O)OC([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]OC(=O)C([H])([H])N1C(=O)C(=C([H])C2=C([H])N=C(N=C12)N([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Br)C([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N([H])C2=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N([H])C2=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N([H])C2=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C(=O)C(F)(F)F [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C(Cl)=C1Cl [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Br [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(C(=C(C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C1[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C(OC([H])([H])C([H])([H])[H])=C1[H] [H]OC1=C(C([H])=C(F)C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)\C(=C(\[H])C2=C(C(=C(N2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C23)=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(Cl)C([H])=C23)=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(Br)C([H])=C23)=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C23)=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C23)=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C23)=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C23)=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C23)=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1F [H]OC1=C([H])C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C([H])C([H])=C1[H] [H]OC1=C(Cl)C([H])=C(F)C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Br)C([H])=C1[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1F [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Br)C([H])=C1[H] [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])N(C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1F [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Cl)C([H])=C1[H] [H]OC1=C([H])C(N([H])C2=NC([H])=NC3=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C3[H])=C(F)C([H])=C1Cl [H]OC1=C([H])C(N([H])C2=NC([H])=NC3=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C3[H])=C(F)C([H])=C1C([H])([H])[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Cl)C([H])=C1F [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Br)C([H])=C1F [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Br)C([H])=C1[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Cl)C([H])=C1F [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Br)C([H])=C1F [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Br)C([H])=C1[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Br)C([H])=C1[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Br)C([H])=C1[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)=C1C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C([H])=C1C([H])([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C([H])=C1C([H])([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C([H])C(=C12)C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C([H])=C1C([H])([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C(Br)C([H])=C12 [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C([H])=C1C([H])([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C([H])=C1C([H])([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1C([H])([H])[H] [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1F [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1F [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])N3C([H])=NC([H])=C3[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1F [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])N3N=NC([H])=C3[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1F [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])N3N=NC([H])=C3[H])=C(OC([H])([H])[H])C([H])=C12)C1=C(F)C([H])=C(Br)C([H])=C1F [H]OC(=O)C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C(C(=C([H])N3[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])[H])C2=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(C([H])=C23)S(=O)(=O)N([H])[H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C(=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C(=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C(=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C(=C([H])C([H])=C23)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1C([H])([H])[H] [H]N1C(=O)\C(=C(\[H])C2=C(C([H])=C(N2[H])C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])S(=O)(=O)C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C([H])C4=C(N3[H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C2=C1[H] [H]OC(=O)C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C([H])C4=C(N3[H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C2=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)N([H])[H] [H]OC(=O)C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C(C4=C(N3[H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C2=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(Cl)C([H])=C(F)C(N([H])C2=C([H])C([H])=NC3=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H] [H]N(C1=C([H])C([H])=C(Cl)C([H])=C1F)C1=C([H])C([H])=NC2=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12 [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(Br)C([H])=C23)=C1C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C(C(=C(N3[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])[H])C2=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(C([H])=C23)S(=O)(=O)N([H])[H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C(Br)C([H])=C12 [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C(=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C(=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C(=C([H])C([H])=C23)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C([H])C(=O)N(C2=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C2C([H])=C([H])C(=O)N(C2=N1)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(N([H])C3=NC([H])=C4C([H])=C([H])C(=O)N(C4=N3)[C@]3([H])C([H])([H])[C@@]4([H])C([H])([H])C([H])([H])[C@]3([H])C4([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N([H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(SC([H])([H])[H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C([H])C(=O)N2C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N([H])C1=NC([H])=C2C([H])=C(C(=NC2=N1)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1[C@]1([H])N(C2=O)C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]N(C1=C(F)C(C(=O)C2=C([H])N([H])C3=C2C([H])=C(Cl)C([H])=N3)=C(F)C([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N1C(=O)\C(=C(\[H])C2=C(C3=C(N2[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)C([H])([H])C([H])([H])[H] [H]N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C(C4=C(N3[H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])C2=C1[H] [H]N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C(C4=C(N3[H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C2=C1[H] [H]N([H])C(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)C([H])([H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C(N([H])C3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(\[H])=C2/C(=O)N([H])C3=C([H])C([H])=C(C([H])=C23)S(=O)(=O)N([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C2=C1C1=C(C3=C(C([H])=C([H])C([H])=C3[H])C1([H])[H])C1=C2C([H])([H])N([H])C1=O)C([H])([H])OC([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)N([H])C([H])([H])[H] [H]N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C(C4=C(N3[H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C2=C1[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C(N([H])C3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(\[H])=C2/C(=O)N([H])C3=C([H])C([H])=C(C([H])=C23)S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=O)\C(=C(\[H])C2=C(C3=C(N2[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)C([H])([H])C([H])([H])[H] [H]N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C(C4=C(N3[H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C2=C1[H] [H]N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C(C4=C(N3[H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=C1[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C(N([H])C3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(\[H])=C2/C(=O)N([H])C3=C([H])C([H])=C(C([H])=C23)S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C(N([H])C3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(\[H])=C2/C(=O)N([H])C3=C([H])C([H])=C(C([H])=C23)S(=O)(=O)N([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C(N([H])C3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(\[H])=C2/C(=O)N([H])C3=C([H])C([H])=C(C([H])=C23)S(=O)(=O)N([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C(N([H])C3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(\[H])=C2/C(=O)N([H])C3=C([H])C([H])=C(C([H])=C23)S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=NC(=N2)C([H])([H])[H])N([H])C2=NC([H])=C(S2)C(=O)N([H])C2=C(Cl)C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC(=C2[H])C(=O)N([H])C([H])([H])[H])C([H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NN=C(O4)C([H])([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(N([H])C(=O)OC([H])([H])[C@@]4([H])OC([H])([H])C([H])([H])C4([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(N([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NC(=NO4)C([H])([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NN=C(O4)C([H])([H])C([H])([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NN=C([H])O4)C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NOC(=N4)C([H])([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NN=C(O4)C(F)(F)F)C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C4=NN([H])C(=N4)C([H])([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C(F)C([H])=C1F [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NN=C(O4)N(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NC([H])=C(O4)C([H])([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NN=C(O4)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NN=C(O4)C([H])([H])C4([H])C([H])([H])C4([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NN=C(O4)C([H])([H])C(F)(F)F)C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NN=C(O4)C([H])([H])S(=O)(=O)C([H])([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NN=C(O4)C(F)(F)S(=O)(=O)C([H])([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NN=C(O4)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NN=C(O4)C([H])(F)F)C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]OC1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(N([H])[H])=C2N=C([H])C([H])=C([H])C2=N1 [H]OC1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(N([H])[H])=C2C([H])=NC([H])=C([H])C2=N1 [H]OC1=C(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC1=C(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C(N([H])[H])=C2N=C([H])N=C2N1[H] [H]OC1=C(C2=NC3=NC(=C([H])C([H])=C3N2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(N([H])[H])=C2C([H])=C([H])C([H])=C([H])C2=N1 [H]OC1=C(C2=NC3=C([H])C([H])=C(N([H])C3=N2)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(N([H])[H])=C2C([H])=C([H])C([H])=C([H])C2=N1 [H]OC1=NC2=C([H])N=C([H])C([H])=C2C(O[H])=C1C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H] [H]OC1=NC2=C(C([H])=NN2C([H])([H])[H])C(N([H])[H])=C1C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H] [H]OC1=NC2=C([H])N=C([H])C([H])=C2C(N([H])[H])=C1C1=NC2=C([H])C([H])=C([H])N([H])C2=N1 [H]OC1=C(C2=NC3=C([H])C([H])=C([H])N([H])C3=N2)C(N([H])[H])=C2C([H])=C([H])C([H])=C([H])C2=N1 [H]OC1=C(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C(O[H])=C2C([H])=C([H])C([H])=NC2=N1 [H]OC1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(N([H])[H])=C2C([H])=C([H])N=C([H])C2=N1 [H]OC1=C(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C(N([H])[H])=C2C([H])=NN=C2N1[H] [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC1=NC2=C([H])N=C([H])C([H])=C2C(N([H])[H])=C1C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H] [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC1=NC2=C(C([H])=C([H])S2)C(N([H])[H])=C1C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H] [H]OC1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(N([H])[H])=C2C([H])=C([H])N=C([H])C2=N1 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N1N=C2C([H])=C([H])C([H])=C([H])C2=C1C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C2C([H])=C([H])C([H])=C([H])C2=C1C1=NC2=C(N1[H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=C2[H] [H]N1N=C2C(C([H])=C([H])C([H])=C2OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C1=NC2=C([H])C(=C([H])C([H])=C2N1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C2C([H])=C([H])C([H])=C([H])C2=C1C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C2C([H])=C(C([H])=C([H])C2=C1C1=NC2=C([H])C(=C([H])C([H])=C2N1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C(F)(F)F [H]N1N=C2C([H])=C([H])C([H])=C([H])C2=C1C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])N1C([H])=NC([H])=C1[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(N([H])N=C2C2=NC3=C([H])C(=C([H])C([H])=C3N2[H])N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C2=C1C(=NN2[H])C1=NC2=C([H])C(=C([H])C([H])=C2N1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C2C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C2=C1C1=NC2=C([H])C(=C([H])C([H])=C2N1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C2C([H])=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C2=C1C1=NC2=C([H])C(=C([H])C([H])=C2N1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C2C([H])=C([H])C([H])=C([H])C2=C1C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1N=C(C2=NC3=C([H])C(=C([H])C([H])=C3N2[H])N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C(=C2[H])C(=O)OC([H])([H])[H] [H]N1N=C2C([H])=C(F)C([H])=C([H])C2=C1C1=NC2=C([H])C(=C([H])C([H])=C2N1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C(C2=NC3=C([H])C(=C([H])C([H])=C3N2[H])N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C2=C(N([H])N=C12)C1=NC2=C([H])C(=C([H])C([H])=C2N1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(N([H])N=C2C2=NC3=C([H])C(=C([H])C([H])=C3N2[H])N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C3OC4=C(C3=C(C(=O)OC([H])([H])[H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C4=O [H]OC1=C2C([H])=C([H])C([H])=C3C2=NN1C([H])([H])C([H])([H])[N@@]1C([H])([H])[C@@]([H])(OC2=C4N=C3C(O[H])=NC4=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N1N=C(C2=NC3=C([H])C(=C([H])C([H])=C3N2[H])N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])=C2[H] [H]N1N=C2C([H])=C([H])C([H])=C([H])C2=C1C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H] [H]OC1=C([H])C(\C([H])=C(/C#N)C(N([H])[H])=C(C#N)C#N)=C([H])C(O[H])=C1O[H] [H]C1=C([H])C2=C3OC4=C(C3=C(C(=O)OC([H])([H])[H])C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C2C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C4=O [H]N1N=C2C([H])=C([H])C([H])=C([H])C2=C1C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C2C(C([H])=C([H])C([H])=C2F)=C1C1=NC2=C([H])C(=C([H])C([H])=C2N1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])[H])C([H])([H])OC1=C([H])N2N=C([H])N=C(OC3=C(F)C4=C(N([H])C(=C4[H])C([H])([H])[H])C([H])=C3[H])C2=C1C([H])([H])[H] [H]N1N=C2C([H])=C([H])C([H])=C([H])C2=C1C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1N=C2C([H])=C([H])C([H])=C([H])C2=C1C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C(S1)C([H])([H])N([H])C1=C([H])C(C(=O)N([H])C2([H])C([H])([H])C2([H])[H])=C(F)C([H])=C1F)C1=NC([H])=C([H])C([H])=C1[H] [H]N(C1=NC(N([H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=C(C([H])=C2N=N1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C(=C([H])C([H])=C23)C2=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C2[H])=C1C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(N(C(=N1)C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])[S@](=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H] [H]N(C1=C(Cl)C([H])=C2N([H])C(=O)N([H])C3=NC(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C1[H])=C(N=C3[H])C#N)C([H])([H])C1=C([H])N=C([H])S1 [H]N([H])C1=NC2=C(C([H])=N1)C([H])([H])N(C(=O)N2C([H])([H])[H])C1=C(C([H])=C([H])C(N([H])C(=O)C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)=C1[H])C([H])([H])[H] [H]N1C(=O)\C(=C(\[H])C2=C(C(C(=O)N3C([H])([H])C([H])([H])C([H])([H])[C@]3([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C(N2[H])C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C(=O)N([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(=NC([H])=N1)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(OC([H])([H])[C@@](O[H])(C2=O)C([H])([H])C2=C([H])C(O[H])=C(O[H])C([H])=C2[H])=C1O[H] [H]OC1=C([H])C([H])=C2C([H])=C(C([H])([H])C3=C([H])C(O[H])=C(O[H])C([H])=C3[H])C([H])([H])OC2=C1O[H] [H]OC1=C([H])C([H])=C2C(OC([H])([H])[C@]3(O[H])C([H])([H])C4=C(C([H])=C(O[H])C(O[H])=C4[H])[C@]23[H])=C1O[H] [H]OC1=C([H])C([H])=C2C(OC([H])([H])[C@](O[H])(C([H])([H])C3=C([H])C(O[H])=C(O[H])C([H])=C3[H])[C@]2([H])O[H])=C1O[H] [H]OC(=O)C1=C(N([H])C2=C([H])C([H])=C(I)C([H])=C2F)C(F)=C(F)C(\C([H])=N\N([H])C(=O)C2=C([H])C([H])=C(O2)C([H])([H])O[H])=C1[H] [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C(F)=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C3[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C(Cl)C([H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C(F)=C([H])C(F)=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C(F)C([H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C(C(=C3[H])C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C12)N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C(F)=C(F)C([H])=C12 [H]N(C1=C(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H] [H]OC1=C(C2=NC3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N(C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C(=C12)C([H])([H])[H] [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C(F)=C([H])C([H])=C12 [H]N([H])C1=C([H])C([H])=C2N([H])C(=O)C(C3=NC4=C(N3[H])C([H])=C([H])C(=C4[H])N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C(N([H])[H])C2=C1[H] [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C(N([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C12 [H]N(C1=C(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12)[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H] [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C(F)C([H])=C([H])C([H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C(N([H])C([H])([H])[H])=C([H])C([H])=C12 [H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C2=C(N([H])C1=O)C([H])=C([H])C([H])=C2[H] [H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C1=C(N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2N([H])C1=O [H]N(C1=C(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C(F)C([H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(C([H])=C23)C(=O)N([H])N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C(=O)N([H])C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C(=O)N([H])C2=C([H])C([H])=C([H])C(O[C@@]3([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C(Cl)=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C(N([H])C([H])([H])[H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C1=NN([H])C(=C1[H])C([H])([H])[H])C1=NC(=NC(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C1=C([H])C([H])=C(C(=C1[H])N(C1=NC(=NC([H])=C1[H])N([H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C1=C([H])N=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C1=NC(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C1=NC([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]O[C@@]([H])(C1=C([H])C(N(C2=NC(=NC([H])=C2[H])N([H])C2=C([H])C(=C([H])C(=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C1=C(Cl)C([H])=C([H])C(=C1[H])N(C1=NC(=NC([H])=C1[H])N([H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])C(N(C2=NC(=NC([H])=C2[H])N([H])C2=C([H])C(=C([H])C(=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])N(C1=NC(=NC([H])=C1[H])N([H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])N(C1=NC(=NC([H])=C1[H])N([H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C1=C(C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C([H])=C1C1=C2C([H])=C(N([H])C2=NC([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C(N=C([H])C([H])=C1[H])N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N2[H] [H]N(C(=O)N([H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=NC([H])=NC(N([H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=C([H])C(OC3=C([H])C(=NC([H])=C3[H])C3=NC([H])=C(N3[H])C(F)(F)F)=C2[H])N1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N([H])S(=O)(=O)C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)N(C2=C([H])C3=NN(C(=C3C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1C([H])([H])[H] [H]N([H])C1=NC(=NN1C(=O)C1=C(F)C([H])=C([H])C([H])=C1F)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]OC(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=C3C(=N2)C2=C(C([H])=C(Cl)C([H])=C2[H])C(=NC3([H])[H])C2=C(F)C([H])=C([H])C([H])=C2F)C([H])=C1[H] [H]N(C([H])([H])[H])[C@]1([H])C([H])([H])[C@@]2([H])O[C@@](N3C4=C(C([H])=C([H])C([H])=C4[H])C4=C3C3=C(C5=C(C([H])=C([H])C([H])=C5[H])N23)C2=C4C([H])([H])N([H])C2=O)(C([H])([H])[H])[C@]1([H])OC([H])([H])[H] [H]O[C@@]([H])(C([H])([H])N([H])C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C2C([H])=C(F)C([H])=C3[H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(SC2=NC(=C([H])C(=N2)N([H])C2=C([H])C(=NN2[H])C([H])([H])[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1C([H])=N\C(=N/C2=C([H])C([H])=C(Br)C([H])=C2F)C2=C1C([H])=C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(OC([H])([H])[H])=C2[H] [H]OC1=C([H])C([H])=C([H])C2=C1C(=O)\C(O2)=C(/[H])C1=C([H])N(C2=C1C(=C([H])C([H])=N2)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])O[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C1=NC(=O)C2=C(SC3=C([H])C(=C([H])C([H])=C23)C([H])([H])[H])N1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C1=NC(=O)C2=C(SC3=C([H])C(=C([H])C([H])=C23)C([H])([H])C([H])([H])[H])N1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C1=NC(=O)C2=C(SC3=C([H])C([H])=C(C([H])=C23)C([H])([H])[H])N1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(OC2=C3N([H])C(=O)N([H])C3=C([H])C([H])=C2[H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] CN1C=CC2=C1C(OC1=CC=C(NC(=O)NC3=CN(N=C3)C(C)(C)C)C(Cl)=C1)=NC=N2 CN1C=CC2=C1C(OC1=CC=C(NC(=O)NC3=NOC(=C3)C(C)(C)C)C(Cl)=C1)=NC=N2 CN1C=CC2=C1C(OC1=CC=C(NC(=O)NC3=CC(=NN3C)C(C)(C)C)C(Cl)=C1)=NC=N2 CN1C=CC2=C1C(OC1=CC=C(NC(=O)NC3=CC(=C(C=C3)N3CCOCC3)C(F)(F)F)C(Cl)=C1)=NC=N2 CN1C=CC2=C1C(OC1=CC=C(NC(=O)NC3=CC(=C(CN4CCOCC4)C=C3)C(F)(F)F)C(Cl)=C1)=NC=N2 CN1C=CC2=C1C(OC1=CC=C(NC(=O)NC3=CC(=C(CN4CCN(C)CC4)C=C3)C(F)(F)F)C(Cl)=C1)=NC=N2 CN1C=CC2=C1C(OC1=CC=C(NC(=O)NC3=CC(=C(OC4CCN(C)CC4)C=C3)C(F)(F)F)C(Cl)=C1)=NC=N2 CN1C=CC2=C1C(OC1=CC=C(NC(=O)NC3=CC(=CC(CN4CCN(C)CC4)=C3)C(F)(F)F)C(Cl)=C1)=NC=N2 OCCOCCN1C=CC2=C1C(OC1=CC=C(NC(=O)NC3=CC(=CC=C3)C(F)(F)F)C(Cl)=C1)=NC=N2 O=C(N[C@H](CN1CCCC1)C1=CC=CC=C1)C1=CC2=C(S1)C(NC(=O)C1=CC=C(C=C1)N1CCOCC1)=NN2 [H]C([H])=C([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)N(C2=C(Cl)C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C2Cl)C([H])([H])C2=C([H])N=C(N=C12)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)N(C2=C(Cl)C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C2Cl)C([H])([H])C2=C([H])N=C(N=C12)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=NC(C#N)=C([H])N1[H])C1=C(C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C(\C(=C(/[H])C2=C([H])OC([H])=C2[H])C2=C1C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1SC1=C([H])C([H])=C2C(=NN([H])C2=C1[H])C(\[H])=C(/[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(\C(=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)N(C1=NC([H])=NC(N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H])C1=C(Cl)C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1Cl [H]C1=C([H])C2=C3C(=C([H])C([H])=C([H])C3=C1[H])C1=C(C(=O)OC([H])([H])C([H])([H])[H])C(=O)N=C21 [H]C1=C([H])C2=C([H])C([H])=C([H])C3=C2C(=C1[H])C1=C(C#N)C(=O)N=C31 [H]C1=C([H])C2=C3C(=C([H])C([H])=C(S[C@@]([H])(C([H])([H])[H])[C@@]4(OC([H])([H])SC4([H])[H])C([H])([H])[H])C3=C1[H])C1=C(C#N)C(=O)N=C21 [H]C([H])=C([H])C([H])([H])SC1=C([H])C([H])=C2C3=C(C(=O)OC([H])([H])C([H])([H])[H])C(=O)N=C3C3=C2C1=C([H])C([H])=C3[H] [H]C1=NC([H])=C(N=C1[H])C([H])([H])C([H])([H])SC1=C([H])C([H])=C2C3=C(C(=O)OC([H])([H])C([H])([H])[H])C(=O)N=C3C3=C2C1=C([H])C([H])=C3[H] [H]OC([H])([H])C([H])([H])SC1=C([H])C([H])=C2C3=C(C(=O)OC([H])([H])C([H])([H])[H])C(=O)N=C3C3=C2C1=C([H])C([H])=C3[H] [H]C([H])=C([H])C([H])([H])OC(=O)C1=C2C(=NC1=O)C1=C3C2=C([H])C([H])=C([H])C3=C([H])C([H])=C1[H] [H]C1=C([H])C2=C3C(=C([H])C([H])=C([H])C3=C1[H])C1=C(C(=O)OC([H])([H])C(=O)SC([H])([H])C([H])([H])C([H])([H])[H])C(=O)N=C21 [H]C1=C([H])C2=C3C(=C([H])C([H])=C([H])C3=C1[H])C1=NC(=O)C(C(=O)OC([H])([H])C(=O)OC([H])([H])C(F)(F)C(F)(F)F)=C21 [H]C([H])=C([H])C([H])([H])OC(=O)C1=C2C(=NC1=O)C1=C3C2=C([H])C([H])=C(SC([H])([H])C([H])=C([H])[H])C3=C([H])C([H])=C1[H] [H]C([H])=C([H])C([H])([H])SC1=C([H])C([H])=C2C3=C(C(=O)OC([H])([H])C(=O)SC([H])([H])C([H])([H])C([H])([H])[H])C(=O)N=C3C3=C2C1=C([H])C([H])=C3[H] [H]C([H])=C([H])C([H])([H])SC1=C([H])C([H])=C2C3=C(C(=O)OC([H])([H])C(=O)OC([H])([H])C(F)(F)C(F)(F)F)C(=O)N=C3C3=C2C1=C([H])C([H])=C3[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C(N([H])C(=O)C3=C([H])C([H])=C(C(C#CC4=C([H])N=C(N4C([H])([H])[H])C(=O)N([H])C([H])([H])[H])=C3[H])C([H])([H])[H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])OC1([H])[H] [H]N(C1=NC([H])=C(C(=N1)N([H])C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1C(=O)C(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C(C1=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])([H])C(=S)N([H])C1=C([H])C(Cl)=C([H])C([H])=C21)C1=C(N=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])([H])C(=S)N([H])C1=C([H])C(Cl)=C([H])C([H])=C21)C1=C([H])N=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])([H])C(=S)N([H])C1=C([H])C(Cl)=C([H])C([H])=C21)C1=C(C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(F)(F)F [H]N(C1=NC2=C(C([H])=N1)C([H])([H])C(=S)N([H])C1=C([H])C(Cl)=C([H])C([H])=C21)C1=C(OC(F)(F)F)C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])([H])C(=S)N([H])C1=C([H])C(Cl)=C([H])C([H])=C21)C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])([H])C(=S)N([H])C1=C([H])C(Cl)=C([H])C([H])=C21)C1=C(Cl)C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])([H])C(=S)N([H])C1=C([H])C(Cl)=C([H])C([H])=C21)C1=C(C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])([H])C(=S)N([H])C1=C([H])C(Cl)=C([H])C([H])=C21)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1N=C(\C([H])=C(/[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C1=C([H])C([H])=C2OC(C(=O)N([H])C2=N1)(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=NC(=N1)N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N1C2=C(C([H])=C1C([H])([H])[H])C(F)=C(OC1=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H] [H]OC1=C([H])C2=C(N([H])C(=C2[H])C2=NN(C3=C2C(=NC([H])=N3)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1(C(=O)N([H])C2=C([H])C([H])([H])[C@]([H])(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(C1=NC([H])=NN2C([H])=C(C3=NN=C(O3)C([H])([H])[H])C(=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(N=C1[H])N([H])C([H])=C2[H] [H]N(C1=NC([H])=NN2C([H])=C(C3=NN=C(O3)C([H])([H])[H])C(=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(N=C1[H])N([H])C(=C2[H])C([H])([H])[H] [H]N1C(=O)\C(=C(\[H])C2=C(C(C(=O)OC([H])([H])C([H])([H])[H])=C(N2[H])C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C([H])([H])N1C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(N([H])C(=C2/C(=O)N([H])C3=C([H])C(=C([H])C([H])=C23)C(=O)OC([H])([H])[H])\C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=NC([H])=C(C([H])=C1C(=O)N([H])[C@]([H])(C1=C(Cl)C([H])=C([H])C(F)=C1Cl)C([H])([H])[H])C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1(C([H])([H])OC2=C(OC([H])([H])[H])C([H])=C3C(OC4=C([H])C5=C([H])C([H])=C([H])C(C(=O)N([H])C([H])([H])[H])=C5C([H])=C4[H])=C([H])C([H])=NC3=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(N=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C(F)=C1F [H]N([H])C1=NC([H])=C(N=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C(F)=C1C([H])([H])[H] [H]N([H])C1=NC([H])=NC(N([H])C2=C([H])C([H])=C(OC([H])([H])C3=NC([H])=C([H])C([H])=C3[H])C(Cl)=C2[H])=C1C1=NC(=C([H])O1)C([H])([H])N([H])C(=O)C([H])=C([H])[H] [H]N(C1=NC2=C(N=C([H])N2C2=NN([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=N1)C([H])([H])[H] [H]N(C1=NC([H])=C([H])C([H])=N1)C1=C([H])C2=C(C([H])=C1[H])N(C1=C2C2=C(C(=O)N([H])C2([H])[H])C2=C1C([H])([H])C([H])([H])C1=NN(C([H])=C21)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1N=C([H])C(=C1[H])C1=C([H])N=C(N([H])[H])C2=C1SC([H])=C2C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] CC1=CC(NC2=NC(NCCC3=CN=CC=C3)=NC=C2Br)=NN1 CC1=CC(NC2=NC(NCC=C)=NC=C2Br)=NN1 CC1=CC(NC2=NC(NCC3=CC(C)=NO3)=NC=C2Br)=NN1 COCCCC1=CC(NC2=NC(NCC3=CC(C)=NO3)=NC=C2Br)=NN1 CCCC1=CC(NC2=NC(NCC3=CC(C)=NO3)=NC=C2Br)=NN1 CC1=NOC(CNC2=NC=C(Br)C(NC3=NNC(CCC4=CC=CC=C4)=C3)=N2)=C1 CC1=CC(NC2=NC(NCC3=CC(=NO3)C(C)(C)C)=NC=C2Br)=NN1 COC1=CC(OC)=CC(CCC2=CC(NC3=NC(NCC4=CC(C)=NO4)=NC=C3)=NN2)=C1 CC1=CC(NC2=NC(NCC3=CC(C)=NO3)=NC=C2)=NN1 COCCCC1=CC(NC2=NC(NCC3=CC(C)=NO3)=NC=C2)=NN1 CC1=NOC(CNC2=NC=CC(NC3=NNC(CCC4=CC=CC=C4)=C3)=N2)=C1 CC1=CC(NC2=NC(NCCCC3=CNN=C3C)=NC=C2Br)=NN1 CC1=CC(NC2=NC(NCC3=CN=C(C)C=N3)=NC=C2Br)=NN1 CC1=CC(NC2=NC(NCCC3=CC(C)=NO3)=NC=C2Br)=NN1 CC1=CC(NC2=NC(NCC3=C(C)C=CC=N3)=NC=C2Br)=NN1 CC1=CC(NC2=NC(NCC3=CC(=NO3)C(=O)N3CCCC3)=NC=C2Br)=NN1 CC1=CC(NC2=NC(NCC3=CC(=NO3)C(N)=O)=NC=C2)=NN1 CC1=NOC(CNC2=NC=CC(NC3=NNC(CO)=C3)=N2)=C1 CCC1=CC(NC2=NC(NCC3=CC=CC=N3)=NC=C2Br)=NN1 CCC1=CC(NC2=NC(NCC3=CC(=NO3)C3=CC=CC=N3)=NC=C2Br)=NN1 CCCC1=CC(NC2=NC(NCC3=CC=CN=C3)=NC=C2Br)=NN1 COCCCC1=CC(NC2=NC(NCC3=CC(=NO3)C3CC3)=NC=C2)=NN1 COCCCC1=CC(NC2=NC(NCC3=CC(=NO3)C(N)=O)=NC=C2)=NN1 COC1=CC(OC)=CC(CCC2=CC(NC3=NC(NCC4=CC=CC=N4)=NC=C3)=NN2)=C1 COC1=CC(OC)=CC(CCC2=CC(NC3=NC(NCC4=NOC(C)=C4)=NC=C3)=NN2)=C1 CC1=CC(NC2=NC(NCC3=CC=CC=N3)=NC=C2Br)=NN1 CC1=CC(NC2=NC(NCC3=CC(C)=NO3)=NC=C2Cl)=NN1 CC1=CC(NC2=NC(NCCC3=CC=CO3)=NC=C2Br)=NN1 CC1=CC(NC2=NC(NCC3=CC(=NO3)C3CC3)=NC=C2)=NN1 CC(C)C1=CC(NC2=NC(NCC3=CC=CN=C3)=NC=C2Br)=NN1 COC1=CC=C2NC(=NC2=C1)C(=C1C(=O)NC2=C1C=C(N)C=C2)C1=CC=CC=C1 CC1=CC=C(C=C1)C(C1=NC2=CC=CC=C2N1)=C1C(=O)NC2=C1C=CC=C2 CCN1CCC(CC1)NC1=CC2=C(NC(=O)C2=C(C2=NC3=CC=CC=C3N2)C2=CC=C(C)C=C2)C=C1 CCN1CCC(CC1)NC1=CC2=C(NC(=O)C2=C(C2=NC3=CC=CC=C3N2)C2=CC=C(OC)C=C2)C=C1 CCN1CCC(CC1)NC1=CC2=C(NC(=O)C2=C(C2=NC3=CC=CC=C3N2)C2=CC(F)=CC=C2)C=C1 CCN1CCC(CC1)NC1=CC2=C(NC(=O)C2=C(C2=NC3=CC=CC=C3N2)C2=CC(F)=CC(F)=C2)C=C1 CCN1CCC(CC1)NC1=CC2=C(NC(=O)C2=C(C2=NC=CN2)C2=CC=CC=C2)C=C1 CCN1CCC(CC1)NC1=CC2=C(NC(=O)C2=C(C2=NC=CN2)C2=CC(F)=CC=C2)C=C1 CCN1CCC(CC1)NC1=CC2=C(NC(=O)C2=C(C2=NC=CN2)C2=CC=C(Cl)C=C2)C=C1 CCN1CCC(CC1)NC1=CC2=C(NC(=O)C2=C(C2=NC(C)=CN2)C2=CC(F)=CC=C2)C=C1 CCN1CCC(CC1)NC1=CC2=C(NC(=O)C2=C(C2=NC(C)=CN2)C2=CC(F)=CC(F)=C2)C=C1 CCN1CCC(CC1)NC1=CC2=C(NC(=O)C2=C(C2=NC(C)=CN2)C2=C(F)C=CC=C2)C=C1 CC1=CC=CC=C1C(C1=NC2=CC=CC=C2N1)=C1C(=O)NC2=C1C=CC=C2 CC1=CC(=CC=C1)C(C1=NC2=CC=CC=C2N1)=C1C(=O)NC2=C1C=CC=C2 FC1=CC=C(C=C1)C(C1=NC2=CC=CC=C2N1)=C1C(=O)NC2=C1C=CC=C2 FC1=CC(=CC=C1)C(C1=NC2=CC=CC=C2N1)=C1C(=O)NC2=C1C=CC=C2 FC1=CC(=CC(F)=C1)C(C1=NC2=CC=CC=C2N1)=C1C(=O)NC2=C1C=CC=C2 FC1=CC=C(C(C2=NC3=CC=CC=C3N2)=C2C(=O)NC3=C2C=CC=C3)C(F)=C1 FC(F)(F)C1=CC=C(C=C1)C(C1=NC2=CC=CC=C2N1)=C1C(=O)NC2=C1C=CC=C2 ClC1=CC=C(C(C2=NC3=CC=CC=C3N2)=C2C(=O)NC3=C2C=CC=C3)C(Cl)=C1 COC1=CC=C(C=C1)C(C1=NC2=CC=CC=C2N1)=C1C(=O)NC2=C1C=CC=C2 CCOC1=CC=C(C=C1)C(C1=NC2=CC=CC=C2N1)=C1C(=O)NC2=C1C=CC=C2 NC1=CC=C(C=C1)C(C1=NC2=CC=CC=C2N1)=C1C(=O)NC2=C1C=CC=C2 BrC1=CC2=C(NC(=O)C2=C(C2=NC3=CC=CC=C3N2)C2=CC=CC=C2)C=C1 BrC1=CC2=C(C=C1)C(=C(C1=NC3=CC=CC=C3N1)C1=CC=CC=C1)C(=O)N2 BrC1=CC=CC2=C1NC(=O)C2=C(C1=NC2=CC=CC=C2N1)C1=CC=CC=C1 OC(=O)C1=CC2=C(NC(=O)C2=C(C2=NC3=CC=CC=C3N2)C2=CC=CC=C2)C=C1 OC(=O)C1=CC2=C(C=C1)C(=C(C1=NC3=CC=CC=C3N1)C1=CC=CC=C1)C(=O)N2 NC1=CC2=C(NC(=O)C2=C(C2=NC3=CC=CC=C3N2)C2=CC=CC=C2)C=C1 CC1=CC=C(C=C1)C(C1=NC2=CC=CC=C2N1)=C1C(=O)NC2=C1C=C(C=C2)C(O)=O CC1=CC=C(C=C1)C(C1=NC2=CC=CC=C2N1)=C1C(=O)NC2=C1C=C(N)C=C2 COC1=CC=C2NC(=NC2=C1)C(=C1C(=O)NC2=C1C=C(C=C2)C(O)=O)C1=CC=CC=C1 COCCNC(=O)C1=CC2=C(NC(=O)C2=C(C2=NC3=CC=CC=C3N2)C2=CC=CC=C2)C=C1 CN1CCN(CC1)C(=O)C1=CC2=C(NC(=O)C2=C(C2=NC3=CC=CC=C3N2)C2=CC=CC=C2)C=C1 CCCCNS(=O)(=O)C1=CC2=C(NC(=O)C2=C(C2=NC3=CC=CC=C3N2)C2=CC=CC=C2)C=C1 CCN1CCC(CC1)OC1=CC2=C(NC(=O)C2=C(C2=NC3=CC(OC)=CC=C3N2)C2=CC=CC=C2)C=C1 CCN1CCCC(C1)NC1=CC2=C(NC(=O)C2=C(C2=NC3=CC(OC)=CC=C3N2)C2=CC=CC=C2)C=C1 CCN1CCC(CC1)NC1=CC2=C(NC(=O)C2=C(C2=NC3=CC(OC)=CC=C3N2)C2=CC=CC=C2)C=C1 COCCN1CCC(CC1)NC1=CC2=C(NC(=O)C2=C(C2=NC3=CC=CC=C3N2)C2=CC=CC=C2)C=C1 CCN1CCC(CC1)NC1=CC2=C(NC(=O)C2=C(C2=NC3=CC=CC=C3N2)C2=CC=CC=C2)C=C1 O=C1NC2=C(C=CC=C2)\C1=C\C1=NC2=CC=CC=C2N1 [O-][N+](=O)C1=C(C=CC=C1)C1=NNC=C1\C=C1/C(=O)NC2=CC=CC=C12 COC1=CC2=C(C=C1F)C(=NC1=C(C)NN=C1N2)C1=CC=CC=C1Cl CC1=C2N=C(C3=CC=CC=C3Cl)C3=CC(N)=CC=C3NC2=NN1 CN(C)C1CCC(CC1)NC1=C(C=NC(NC2=CC(Cl)=CC(Cl)=C2)=N1)C1=CC(C)=NO1