[H]N1N=C2C3=C(C([H])=C(C([H])=C3[H])C3=C([H])N(N=C3C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])[H])C([H])([H])C2=C1[H] [H]N1C(=O)C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]O\N=C1\N([H])C([H])([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]O\N=C1\N([H])C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N1N=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])N=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])N=C([H])O2)C([H])([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC(N([H])[H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N([H])N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])[C@@]2([H])C([H])([H])N([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=C3N(N=C([H])C3=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=NC([H])=NC([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O\N=C(/N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C(F)C(C(=O)C2=C([H])N([H])C3=C2C([H])=C(Cl)C([H])=N3)=C(F)C([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C(O[H])C([H])=NC([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C([H])C2=C1C([H])=C(C([H])=C2[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N1N=C(C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C(N(N=C2[H])C([H])([H])[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])O[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(O[H])C2([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])O[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])O[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])[C@]([H])(O[H])C([H])([H])O[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])(C([H])([H])O[H])C([H])([H])O[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1([H])[H] [H]O\N=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]O\N=C1\C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])C1=C(N([H])C(=N1)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]O\N=C(/[H])C1=C(Cl)C([H])=C(C([H])=C1[H])C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC1=C(Cl)C([H])=C([H])C(=C1[H])C1=C(N([H])C(=N1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N1C(=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC(=N1)N([H])[H] [H]OC1=C(Cl)C([H])=C([H])C(=C1[H])C1=C(N([H])C(=N1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N=C([H])N1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=N1 [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=NC([H])=C1[H] [H]OC([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1C([H])([H])O[H])C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C(Cl)C([H])=C([H])C(=C1[H])C1=C(N([H])C(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NN=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N([H])C(=N1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]O[C@]1([H])C2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N([H])C(=N1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]O\N=C(/N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]O\N=C(/[H])C1=C(O[H])C([H])=C(C([H])=C1[H])C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N1C(=NC(=C1C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O\N=C(\C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(Cl)C([H])=C([H])C(=C1[H])C1=C(N([H])C(=N1)C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC([H])([H])C1=C([H])C([H])=C(C([H])=C1Cl)C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])OC1=C([H])C(N([H])C2=C([H])N=C([H])C(=N2)C2=C([H])C(N([H])C(=O)C([H])([H])[H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC(=C2[H])C(=O)N([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NC(N([H])C2=C([H])C3=C(OC([H])([H])C([H])([H])O3)C([H])=C2[H])=C([H])N=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NC(N([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])=C([H])N=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C(=N1)N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NC(N([H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])=C([H])N=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NC(N([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])=C([H])N=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NC(N([H])C([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])=C([H])N=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NC(N([H])C2=C([H])C3=C(C([H])=C2[H])C([H])([H])OC3=O)=C([H])N=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NC(N([H])C2=C([H])C3=C(OC([H])([H])C([H])([H])C([H])([H])O3)C([H])=C2[H])=C([H])N=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NC(N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])N=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N=C([H])C(=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NC(N([H])C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])=C([H])N=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NC(N([H])C2=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C2[H])=C([H])N=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NC(N([H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])=C([H])N=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NC(N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])N=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NC(N([H])C2=C([H])C(Cl)=NC(Cl)=C2[H])=C([H])N=C1[H] [H]N([H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(=N1)N([H])C([H])([H])[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C(N([H])C([H])([H])C2=C([H])C([H])=NC(=C2[H])C(=O)N([H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])[H])C1=NC([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C(C([H])=NN1C([H])([H])[H])C(=O)N([H])C1=C([H])C2=C(OC(F)(F)C(F)(F)O2)C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=NC([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C(SC([H])=N1)C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]OC([H])([H])C([H])([H])N([H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C(N([H])C([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(OC(F)(F)C(F)(F)O2)C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])[H])C1=NC([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C(SC([H])=N1)C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(N([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C1[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C(N([H])C([H])([H])C2=C([H])C([H])=NC(=C2[H])C(=O)N([H])C([H])([H])[H])N(N=C1[H])C([H])([H])[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(N([H])C([H])([H])[H])=C1[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N([H])C(=S)C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C(N([H])C([H])([H])C2=C([H])C([H])=NC(=C2[H])C(=O)N([H])C([H])([H])[H])C([H])=C([H])S1)C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(=N1)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])N([H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(C#N)=C1[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C(N=C([H])S1)N([H])C([H])([H])C1=C([H])C([H])=NC(=C1[H])C(=O)N([H])C([H])([H])[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])[H])C1=NC([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C(C([H])=NN1C([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=C(SC(F)(F)F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(N([H])C([H])([H])C([H])([H])C2=C([H])N=C([H])N2[H])=C1[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C(SC([H])=N1)N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C2=C(OC(F)(F)C(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N([H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(=C1[H])C1=NC([H])([H])C([H])([H])N1[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(N([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C1[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]OC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C(N=C([H])S1)N([H])C([H])([H])C1=C([H])C([H])=NC(=C1[H])C(=O)N([H])C([H])([H])[H])C1=C([H])C2=C(OC(F)(F)C(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])=NC([H])=C2[H])=C1[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(N([H])S(=O)(=O)C([H])([H])[H])=C1[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C2=C(N=C([H])C([H])=C2C2=C([H])N(N=C2C2=C([H])C(N([H])C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])N1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C(N2[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C(Br)=C([H])N2[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1F)C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C(=O)N([H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(SC2=NC([H])=C([H])N2C([H])([H])[H])C(Cl)=C1[H])C1=C(C#N)C([H])=NC2=C([H])C(\C([H])=C(/[H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])=C([H])C([H])=C12 [H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C1=C([H])N=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C1OC([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C(=C(F)C([H])=C1[H])C(F)(F)F [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)OC([H])([H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)OC([H])([H])[H] [H]OC1=C(C([H])=C([H])C([H])=C1[H])[C@]1([H])N(N=C(C2=C([H])N=C([H])C([H])=C2[H])C1([H])[H])C(=O)C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C([H])C([H])=N1 [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N1N=C([H])C2=C(C([H])=C([H])C(=C12)C([H])([H])[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C(=C12)C([H])([H])[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C(=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H] [H]OC1=C(Cl)C([H])=C([H])C(=C1[H])C1=C2N=C([H])C3=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])N(C([H])([H])[H])[C@@]([H])(C3([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C1([H])[H] [H]OC1=C(Cl)C([H])=C([H])C(=C1[H])C1=C2N=C([H])C3=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])N(C([H])([H])[H])[C@@]([H])(C3([H])[H])[C@]([H])(C([H])([H])O[H])C1([H])[H] [H]OC1=C(Cl)C([H])=C([H])C(=C1[H])C1=C2N=C([H])C3=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])N(C([H])([H])[H])[C@@]([H])(C3([H])[H])[C@@]([H])(C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)OC([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)OC([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)OC([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)OC([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)OC([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1C(=O)N([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]OC(=O)[C@]1([H])N(C(=O)N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=NC4=C(C(=NN24)C2=C([H])C([H])=NC([H])=C2[H])C2=C4C([H])=NN([H])C4=C([H])C([H])=C2[H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N([C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=NN2C(N=C([H])C([H])=C2[C@@]2([H])C([H])([H])[C@@]3([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C1C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=NN2C(N=C([H])C([H])=C2[C@@]2([H])C([H])([H])[C@@]3([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C1C1=C([H])C([H])=C(Cl)C(OC([H])([H])[H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=NC3=C(C(=NN13)C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=NC3=C(C(=NN13)C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C(OC([H])([H])[H])=C1[H])C2([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N([H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N([H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=NN2C(N=C([H])C([H])=C2[C@@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C1C1=C([H])C([H])=C(Cl)C(OC([H])([H])[H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1C#N)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1F)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=NN2C(N=C([H])C([H])=C2[C@@]2([H])C([H])([H])[C@@]3([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C1C1=C([H])C([H])=C(F)C(F)=C1[H] [H]C1=NN=C(O1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=NC3=C(C(=NN13)C1=C([H])C([H])=NC([H])=C1[H])C1=C3C([H])=NN([H])C3=C([H])C([H])=C1[H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]OC([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=NC3=C(C(=NN13)C1=C([H])C([H])=NC([H])=C1[H])C1=C3C([H])=NN([H])C3=C([H])C([H])=C1[H])C2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)N3C([H])([H])C([H])([H])C([H])([H])[C@]3([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C(=O)C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C(Cl)=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C(Cl)=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C(F)=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C(F)=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N([H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C(=C12)C(F)(F)F)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C(=C12)C(F)(F)F)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C([H])C(N([H])C(=O)C2=C([H])C(=C([H])C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=NC([H])=NC(N([H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC([H])=C(SC([H])([H])C2=NC([H])=C(O2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S1 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C(N1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)N(C2=C([H])C3=NN(C(=C3C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=NC(=N2)C([H])([H])[H])N([H])C2=NC([H])=C(S2)C(=O)N([H])C2=C(Cl)C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[S@+]([O-])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=NC(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C2OC3=C(C([H])=C([H])C([H])=N3)C2=N1 [H]N(C(=O)C1=C(N=C([H])C([H])=C1[H])N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N2[H] [H]N([H])C1=NC([H])=C(C(=N1)N([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=C([H])C(OC3=C([H])C(=NC([H])=C3[H])C3=NC([H])=C(N3[H])C(F)(F)F)=C2[H])N1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]OC1=C(Br)C([H])=C(\C([H])=C2/C3=C([H])C(I)=C([H])C([H])=C3N([H])[C@]2([H])O[H])C([H])=C1Br [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C(C#N)C([H])=NC2=C1SC(=C2[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=NC([H])=NC2=C1SC(=C2[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=NC([H])=NC2=C1C([H])=C(S2)C1=C([H])N=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=NC([H])=NC2=C1C([H])=C(S2)C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C([H])=NC([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=NN2C(N=C([H])C([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])[C@@]3([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=NN2C(N=C([H])C([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])[C@@]3([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C1C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(N([H])C([H])([H])[C@@]23C([H])([H])C([H])([H])[N@@](C([H])([H])C2([H])[H])C([H])([H])C3([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C#CC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=NN12 [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C#CC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=NN12 [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C2N=C([H])C([H])=C(N2N=C1[H])C1=C([H])C(N([H])C(=O)C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(F)C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])N([H])N=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(Cl)C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])N([H])N=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])N([H])N=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(F)C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(N([H])[C@]2([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N([H])C([H])([H])[C@]1([H])C2([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]OC1=C(F)C([H])=C([H])C(=C1[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]OC1=C(F)C([H])=C([H])C(=C1[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C(=O)C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N1C([H])([H])[C@@]2([H])N(C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=NC4=C(C(=NN34)C3=C([H])C([H])=NC([H])=C3[H])C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C3[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N1C([H])([H])[C@@]2([H])N(C3=C([H])C([H])=C(C(F)=C3[H])C3=C([H])C([H])=NC4=C(C(=NN34)C3=C([H])C([H])=NC([H])=C3[H])C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C3[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N1C([H])([H])[C@@]2([H])N(C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=NC4=C(C(=NN34)C3=C([H])C([H])=NC([H])=C3[H])C3=C([H])C(OC([H])([H])[H])=C(F)C([H])=C3[H])C([H])([H])[C@]1([H])C2([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=NN2C(N=C([H])C([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])[C@@]3([H])N(C([H])([H])[H])C([H])([H])[C@]2([H])C3([H])[H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=NN2C(N=C([H])C([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])[C@@]3([H])N(C([H])([H])[H])C([H])([H])[C@]2([H])C3([H])[H])=C1C1=C([H])C(OC([H])([H])[H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=NN2C(N=C([H])C([H])=C2C2=C([H])C([H])=C(C([H])=C2C([H])([H])[H])N2C([H])([H])[C@@]3([H])N(C([H])([H])[H])C([H])([H])[C@]2([H])C3([H])[H])=C1C1=C([H])C(OC([H])([H])[H])=C(F)C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=N1)C1=C2N=C([H])C([H])=C(N2N=C1[H])C1=C([H])C(N([H])C(=O)C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C(N=C1[H])N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])N=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])N([H])N=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])N(N=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])OC([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])OC(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])OC(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])N=C([H])N1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])N=C([H])N1C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C(=NC([H])=C1[H])N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C(=NC([H])=C1[H])N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C(=NC([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C(=NC([H])=C1[H])N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C(=NC([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C(=NC([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C(=NC([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C1=NC([H])=C([H])N1[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N([H])C2=NC([H])=C([H])C(=C2[H])C2=NN3C(N=C([H])C([H])=C3C3=C([H])C(N([H])C(=O)C4=C([H])C(=C([H])C([H])=C4[H])C(F)(F)F)=C([H])C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1[H])C1=C(F)C(F)=C(F)C(OC2=C3N([H])C(=O)N([H])C3=C([H])C([H])=C2[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(OC2=C3N([H])C(=O)N([H])C3=C([H])C([H])=C2[H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(OC2=C3N([H])C(=O)N([H])C3=C([H])C([H])=C2[H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C(N([H])C2=NC(=C([H])C([H])=N2)C2=C([H])N=C([H])C([H])=C2[H])=C1[H])C([H])([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F [H]N(C(=O)N([H])C1=C([H])C(N([H])C2=NC(=C([H])C([H])=N2)C2=C([H])N=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC(=C2[H])C(=O)N([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])[C@@]2([H])OC([H])([H])[C@]1([H])C2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(F)=C(N2C([H])([H])[C@@]3([H])N(C([H])([H])[H])C([H])([H])[C@]2([H])C3([H])[H])C(F)=C1[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1N(C([H])([H])[H])C([H])([H])[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])[C@@]2([H])N([H])C([H])([H])[C@]1([H])C2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(N2C([H])([H])[C@@]3([H])N(C([H])([H])[H])C([H])([H])[C@]2([H])C3([H])[H])C(=C1[H])C(F)(F)F [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(N2C([H])([H])[C@@]3([H])N(C([H])([H])[H])C([H])([H])[C@]2([H])C3([H])[H])C(F)=C1[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1C(F)(F)F)N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1F)C([H])([H])N1C([H])([H])[C@@]2([H])OC([H])([H])[C@]1([H])C2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(N2C([H])([H])[C@@]3([H])N(C([H])([H])[H])C([H])([H])[C@]2([H])C3([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1F)C([H])([H])N1[C@@]2([H])C([H])([H])OC([H])([H])[C@]1([H])C([H])([H])OC2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(N2C([H])([H])[C@@]3([H])N(C([H])([H])[H])C([H])([H])[C@]2([H])C3([H])[H])C(F)=C1F [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C(F)=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1F)N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C(F)C(F)=C(N2C([H])([H])[C@@]3([H])N(C([H])([H])[H])C([H])([H])[C@]2([H])C3([H])[H])C(F)=C1F [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1F)N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C(F)C([H])=C(C([H])=C1F)N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C(F)=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C(F)C([H])=C(C([H])=C1F)N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] CN1C=CC2=C1C(OC1=CC=C(NC(=O)NC3=CC(=CC=C3)C(F)(F)F)C(F)=C1)=NC=N2 CC(C)(C)C1=NN(C(NC(=O)NC2=C(Cl)C(Cl)=CC=C2)=C1)C1=CC=CC(CC(N)=O)=C1 [H]N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)[C@@]1([H])C([H])([H])C2=C([H])C(OC3=C([H])C([H])=NC4=C3C([H])([H])C([H])([H])C(=O)N4[H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N([H])C(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(=O)N([H])[C@@]1([H])C([H])([H])C2=C([H])C(OC3=C([H])C([H])=NC4=C3C([H])([H])C([H])([H])C(=O)N4[H])=C([H])C([H])=C2C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(SC([H])([H])[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C2=C(N([H])C(=C2[H])C2=NN(C3=C2C(=NC([H])=N3)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C(N([H])C(=O)C3=C([H])C([H])=C(C(C#CC4=C([H])N=C(N4C([H])([H])[H])C(=O)N([H])C([H])([H])[H])=C3[H])C([H])([H])[H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N1N=C(C(=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N1N=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C21)C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N1N=C2C(=C1[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])C2([H])[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N1N=C2C(=N1)C([H])([H])C1=C([H])C(=C([H])C([H])=C21)C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N1N=C([H])C(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N1C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C([H])=C([H])C([H])=C2C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N1N=C([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C1C([H])=C(C([H])=C2[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N1N=C2C3=C([H])C([H])=C(C([H])=C3C([H])([H])C2=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1N=C2C3=C([H])C([H])=C(C([H])=C3C([H])([H])C2=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C2C3=C([H])C([H])=C(C([H])=C3C([H])([H])C2=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N([H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1N=C2C3=C([H])C([H])=C(C([H])=C3C([H])([H])C2=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1N=C2C3=C([H])C([H])=C(C([H])=C3C([H])([H])C2=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2N=C(C(=C2[H])C2=C([H])C([H])=C3C4=NN([H])C([H])=C4C([H])([H])C3=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])N1N=C(C(=C1[H])C1=C([H])C([H])=C2C3=NN([H])C([H])=C3C([H])([H])C2=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]O[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N2N=C(C(=C2[H])C2=C([H])C([H])=C3C4=NN([H])C([H])=C4C([H])([H])C3=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C1([H])[H] [H]N1N=C2C3=C([H])C([H])=C(C([H])=C3C([H])([H])C2=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])N1N=C(C(=C1[H])C1=C([H])C([H])=C2C3=NN([H])C([H])=C3C([H])([H])C2=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N1N=C2C3=C([H])C([H])=C(C([H])=C3C([H])([H])C2=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N([H])[C@]([H])(C([H])([H])OC2([H])[H])C1([H])[H] [H]N1N=C2C3=C([H])C([H])=C(C([H])=C3C([H])([H])C2=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])F [H]N1N=C2C3=C([H])C([H])=C(C([H])=C3C([H])([H])C2=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@]1([H])F [H]N([H])C1=NC(N([H])C2=C([H])C(=C([H])C([H])=C2[H])C(=O)OC([H])([H])C([H])([H])[H])=C2N=C([H])N([H])C2=N1 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C1=C([H])C([H])=C2OC(C(=O)N([H])C2=N1)(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=NC(=N1)N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])N=C2[H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C2=C3C(OC(=O)C4=C3C(OC2=O)=C(O[H])C(O[H])=C4[H])=C1O[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC(=C2[H])C(=O)N([H])C([H])([H])[H])C([H])=C1F)C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F [H]N(C1=NC2=C([H])C([H])=C(OC3=C([H])C(=NC([H])=C3[H])C3=C([H])N=C(N3[H])C(F)(F)F)C([H])=C2N1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N1C([H])=C([H])C2=C1N=C([H])N=C2C1=C([H])N(N=C1[H])[C@]([H])(C([H])([H])C#N)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=NC2=C(N=C1C1=C([H])C([H])=C([H])C(O[H])=C1[H])C(=NC(=N2)N([H])[H])N([H])[H] [H]N(C1=NC([H])=C(C(=N1)N([H])C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1(C(=O)N([H])C2=C([H])C([H])([H])[C@]([H])(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])C([H])=C([H])N=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H])C(F)(F)F [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N([H])C2=C([H])C3=C(C([H])=C12)C(=O)N([H])C3=O [H]OC1=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2N([H])C2=C([H])C(O[H])=C([H])C([H])=C2[H])C(=O)N([H])C3=O)=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])N([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C(Br)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C(I)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])N([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C(Br)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])N([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C(I)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])N([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])N([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])N([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])N([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])N([H])C3=O)=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C1C([H])=NN=C2N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C1C([H])=NN=C2N([H])C1=C([H])C([H])=C(OC([H])([H])C(=O)N([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C1C([H])=NN=C2N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C1C([H])=NN=C2N([H])C1=C([H])C(O[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C1C([H])=NN=C2N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C1C([H])=NN=C2N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])[H] [H]OC1=C([H])C([H])=C([H])C(N([H])C2=NN=C([H])C3=C2C([H])=C([H])C([H])=C3C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C(N([H])C2=C3N=C([H])N([H])C3=NC([H])=N2)C([H])=C1[H] [H]OC1=C([H])C(N([H])C2=C3N=C([H])N([H])C3=NC(=N2)N([H])[H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(N([H])C2=C([H])C([H])=C([H])C(Br)=C2[H])=C2N=C([H])N([H])C2=N1 [H]N([H])C1=NC(N([H])C2=C([H])C([H])=C([H])C(=C2[H])C(=O)C([H])([H])C([H])([H])[H])=C2N=C([H])N([H])C2=N1 [H]N([H])C1=NC(N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])=C2N=C([H])N([H])C2=N1 [H]N([H])C1=NC(N([H])C2=C([H])C([H])=C([H])C(F)=C2[H])=C2N=C([H])N([H])C2=N1 [H]N([H])C1=NC(N([H])C2=C([H])C([H])=C(F)C(Cl)=C2[H])=C2N=C([H])N([H])C2=N1 [H]N([H])C1=NC(N([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])=C2N=C([H])N([H])C2=N1 [H]N([H])C1=NC(N([H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])=C2N=C([H])N([H])C2=N1 [H]N([H])C1=NC(N([H])C2=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])=C2N=C([H])N([H])C2=N1 [H]N([H])C1=NC(N([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])=C2N=C([H])N([H])C2=N1 [H]N([H])C1=NC(N([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)=C2N=C([H])N([H])C2=N1 [H]N(C1=NC(N([H])C2=C([H])C([H])=C3OC([H])([H])C([H])([H])OC3=C2[H])=C2N=C([H])N([H])C2=N1)C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H] [H]N([H])C1=NC(N([H])C2=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C2[H])=C2N=C([H])N([H])C2=N1 [H]OC1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C2N=C([H])N([H])C2=NC(=N1)N([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(N([H])C2=C3N=C([H])N([H])C3=NC([H])=N2)C([H])=C1[H] [H]OC([H])([H])C(N([H])C1=NC(=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=N1)C1=C([H])N=C([H])C(OC([H])([H])[H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@]([H])(N([H])C1=NC(=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=N1)C1=C([H])N=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C(N([H])[H])C2=C(N=C([H])N=C2S1)C1=C([H])C([H])=C([H])C(N([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C1[H] [H]OC([H])([H])C(N([H])C1=NC(=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=N1)C1=C([H])C([H])=C([H])C(N([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(F)C(=C([H])C([H])=C1[H])C1=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=NC(=N1)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])O[H] [H]OC1=C([H])C(=C([H])C(Cl)=C1[H])C1=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=NC(=N1)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])O[H] [H]N([H])C(=O)C1=C(N([H])[H])C2=C(N=C(N=C2S1)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(N([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C1[H] [H]N([H])C(=O)C1=C(N([H])[H])C2=C(N=C(N=C2S1)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(N([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C1[H] [H]N([H])C(=O)C1=C(N([H])[H])C2=C(N=C(N=C2S1)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])N=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1F)C1=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=NC(=N1)N([H])C1([H])C([H])([H])C1([H])[H] [H]OC1=C(C([H])=C([H])C(=C1[H])C1=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=NC(=N1)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC1=C(Cl)C([H])=C([H])C(=C1[H])C1=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=NC(=N1)N([H])C1([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(Cl)=C([H])C(=C1[H])C1=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=NC(=N1)N([H])C1([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=NC(=N1)N([H])C1([H])C([H])([H])C1([H])[H] [H]OC([H])([H])[C@]([H])(OC1=NC(=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=N1)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C(N([H])C1=NC(=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=N1)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@]([H])(N([H])C1=NC(=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=N1)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C(N([H])[H])C2=C(N=C(N=C2S1)N([H])C([H])([H])C([H])([H])N([H])[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]OC([H])([H])C([H])([H])N([H])C1=NC(=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=N1)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N([H])C(=O)C1=C(N([H])[H])C2=C(N=C(N=C2S1)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C(N([H])C(=N1)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC(=N1)N([H])C([H])([H])C([H])([H])N1C(=O)N([H])C([H])([H])C1([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C(N1[H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C(N([H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C(=O)N([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(N([H])C2=NC(=C([H])C([H])=N2)C2=C(N=C(N2[H])C2([H])C([H])([H])C2([H])[H])C2=C([H])C(N([H])C(=O)N([H])C3=C([H])C(=C(Cl)C([H])=C3[H])C(F)(F)F)=C([H])C([H])=C2[H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C(N([H])C(=N1)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC(=N1)N([H])C([H])([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C(N([H])C(=N1)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC(=N1)N([H])C([H])([H])C([H])([H])N1C(=O)N([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C(N([H])C(=N1)C(F)(F)F)C1=C([H])C([H])=NC(=N1)N([H])C([H])([H])C([H])([H])N1C(=O)N([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C1=NC(=C([H])C([H])=N1)C1=C(N=C(N1[H])C1([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C(N1[H])C1([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])N1C(=O)N([H])C([H])([H])C1([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C(N1[H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C(N([H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C(N([H])C2=NC(=C([H])C([H])=N2)C2=C(N=C(N2[H])C2([H])C([H])([H])C2([H])[H])C2=C([H])C(N([H])S(=O)(=O)C([H])([H])C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C(N([H])C(=N1)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC(=N1)N([H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(N([H])C2=NC(=C([H])C([H])=N2)C2=C(N=C(N2[H])C2([H])C([H])([H])C2([H])[H])C2=C([H])C(N([H])C(=O)C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C([H])C([H])=C2[H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C(N([H])C(=N1)C(F)(F)F)C1=C([H])C([H])=NC(=N1)N([H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C(N([H])C2=NC(=C([H])C([H])=N2)C2=C(N=C(N2[H])C(F)(F)F)C2=C([H])C(N([H])C(=O)C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=C2C(=O)N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])N3C2=N1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=NC([H])=C([H])C2=C1N([H])C1=C2C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)C1=NC([H])=C([H])C2=C1N([H])C1=C2C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=NC([H])=C([H])C2=C1N([H])C1=C2C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=NC([H])=C([H])C2=C1N([H])C1=C2C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C(=O)C1=NC([H])=C([H])C2=C1N([H])C1=C2C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=NC([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=NC([H])=C([H])C2=C1N([H])C1=C2C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C2=C(N([H])C3=C2C([H])=C([H])N=C3[H])C([H])=C1[H] [H]N([H])C(=O)C1=NC([H])=C([H])C2=C1N([H])C1=C2C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=NC([H])=C([H])S1 [H]N([H])C1=NC([H])=NC2=C1SC([H])=C2C(=O)N([H])C1=C(F)C(N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])F)=C([H])C([H])=C1Cl [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(OC2=C3C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C3=NC([H])=N2)=C1[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C(F)(F)F [H]N([H])C1=C(C(=NN1C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C(F)C(C(=O)C2=C([H])N([H])C3=NC([H])=C(C([H])=C23)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C(F)C([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C2=C(N([H])C3=C(C([H])=C([H])C([H])=N3)C3=NC([H])=NC4=C3N=C([H])N4[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] OC1=C2N=CC=CC2=C(Cl)C=C1C(NC1=NC=CC=C1)C1=CC=CO1 OC1=C(C=CC2=CC=CN=C12)C(NC1=CN=CC=C1)C1=CSC=C1 COC1=CC=C(C=C1)C(N1CCOCC1)C1=C(O)C2=NC=CC=C2C=C1 CC1=CC(C)=C2C(SN(C(=O)C3=CC=CS3)C2=O)=N1 FC1=CC=C(C=C1)C(=O)\C=C\S(=O)(=O)C1=CC=C(Cl)C=C1 COC1=C(O)C(Br)=CC(=C1)C(NC1=NC=CC=C1)C1=C(O)C2=NC=CC=C2C(Cl)=C1 OC1=C(SC2=NC=NN2)C=C(NS(=O)(=O)C2=CC=CS2)C2=CC=CC=C12 O=C1C(SC2=NC=NN2)=C\C(=N/S(=O)(=O)C2=CC=CS2)C2=CC=CC=C12 [H]OC1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])S2)C2=C([H])C([H])=C([H])C([H])=C12 OC1=C(Cl)C=C(NS(=O)(=O)C2=CC=CS2)C2=CC=CC=C12 OC1=C(Br)C=C(NS(=O)(=O)C2=CC=CS2)C2=CC=CC=C12 OC1=C(SC2=NC=CN2)C=C(NS(=O)(=O)C2=CC=CS2)C2=CC=CC=C12 OC1=C(SC2=CC=CC=N2)C=C(NS(=O)(=O)C2=CC=CS2)C2=CC=CC=C12 CN1N=NN=C1SC1=C(O)C2=CC=CC=C2C(NS(=O)(=O)C2=CC=CS2)=C1 OC1=C(SC2=CC=CC=C2)C=C(NS(=O)(=O)C2=CC=CS2)C2=CC=CC=C12 OC1=C(SC2=CN=NN2)C=C(NS(=O)(=O)C2=CC=CS2)C2=CC=CC=C12 CC(=O)N1CCC2=CC(=CC=C12)S(=O)(=O)NC1=CC(SC2=NC=NN2)=C(O)C2=CC=CC=C12 OC1=C(SC2=NC=NN2)C=C(NS(=O)(=O)C2=CC=C(C=C2)C(F)(F)F)C2=CC=CC=C12 CCCCCCCCS(=O)(=O)NC1=CC(SC2=NC=NN2)=C(O)C2=CC=CC=C12 OC1=C(SC2=NC=NN2)C=C(NS(=O)(=O)C2=C(F)C=CC(N(CC3=CC=CC=C3)CC3=CC=CC=C3)=C2F)C2=CC=CC=C12 OC1=C(SC2=NC=NN2)C=C(NS(=O)(=O)C2=C(F)C(F)=C(F)C(F)=C2F)C2=CC=CC=C12 OC1=C(SC2=NC=NN2)C=C(NS(=O)(=O)C2=C(F)C=CC(N3C(=O)CCC3=O)=C2F)C2=CC=CC=C12 OC1=C(SC2=NC=NN2)C=C(NS(=O)(=O)C2=CC=C(C=C2)C2=CC=CC=C2)C2=CC=CC=C12 OC1=C(SC2=NC=NN2)C=C(NS(=O)(=O)C2=CC=C3C=CC=CC3=C2)C2=CC=CC=C12 OCCNC(=O)C1=CC2=C(NCC1)N=CN=C2NC1=CC(Cl)=C(OC2=CC=CC3=C2C=CS3)C=C1 FC1=CC=CC(=C1)C(=O)NC1=CC=CC(OC2=NN3C=C(NC(=O)C4CC4)N=C3C=C2)=C1 CN1C=NC2=CC=C(NC3=CC(NC(=O)C4=CC(=CC=C4)C(C)(C)C#N)=CC=C3C)C=C2C1=O NC1=C2C(SC=C2C2=CC(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)=CC=C2)=C(C=N1)C1=CN=CC=C1 NC1=C2C(SC=C2C2=CC(NC(=O)NC3=C(F)C=CC(=C3)C(F)(F)F)=CC=C2)=C(C=N1)C1=CN=CC=C1 NC1=C2C(SC=C2C2=CC(NC(=O)NC3=CC=C(C=C3)C(F)(F)F)=CC=C2)=C(C=N1)C1=CN=CC=C1 NC1=C2C(SC=C2C2=CC(NC(=O)NC3=CC=C(OCC4=CC=CC=C4)C=C3)=CC=C2)=C(C=N1)C1=CN=CC=C1 NC1=C2C(SC=C2C2=CC(NC(=O)NC3=C(F)C=CC=C3F)=CC=C2)=C(C=N1)C1=CN=CC=C1 COC1=CC(NC(=O)NC2=CC=CC(=C2)C2=CSC3=C(C=NC(N)=C23)C2=CN=CC=C2)=CC=C1 NC1=C2C(SC=C2C2=CC(NC(=O)NC3=CC=CC=C3)=CC=C2)=C(C=N1)C1=CN=CC=C1 NC1=C2C(SC=C2C2=CC(NC(=O)NCC3=CC=CC=C3)=CC=C2)=C(C=N1)C1=CN=CC=C1 NC1=C2C(SC=C2C2=CC(NC(=O)NC3CCCCC3)=CC=C2)=C(C=N1)C1=CN=CC=C1 CC1=C(NC(=O)NC2=CC=CC(=C2)C2=CSC3=C(C=NC(N)=C23)C2=CN=CC=C2)C(C)=NO1 NC1=C2C(SC=C2C2=CC(NC(=O)CC3=CC=CS3)=CC=C2)=C(C=N1)C1=CN=CC=C1 NC1=C2C(SC=C2C2=CC(NC(=O)CC3=CC=CC=C3)=CC=C2)=C(C=N1)C1=CN=CC=C1 NC1=C2C(SC=C2C2=CC(NC(=O)C3=CC=CC(=C3)C(F)(F)F)=CC=C2)=C(C=N1)C1=CN=CC=C1 NC1=C2C(SC=C2C2=CC(NC(=O)C3=C(F)C=CC(F)=C3)=CC=C2)=C(C=N1)C1=CN=CC=C1 NC1=C2C(SC=C2C2=CC(NC(=O)C3=CC=CC=C3)=CC=C2)=C(C=N1)C1=CN=CC=C1 NC1=C2C(SC=C2C2=CC(NC(=O)C3CCCCC3)=CC=C2)=C(C=N1)C1=CN=CC=C1 CC(C)(C)NC(=O)NC1=CC=CC(=C1)C1=CSC2=C(C=NC(N)=C12)C1=CN=CC=C1 CN1C=CC=C1C(=O)NC1=CC=CC(=C1)C1=CSC2=C(C=NC(N)=C12)C1=CN=CC=C1