[H]OC(=O)C1=C2N(C(OC([H])([H])C([H])([H])[H])=NC2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN=NN1[H] [H]OC(=O)C1=C([H])C2=C(N=C(OC([H])([H])C([H])([H])[H])N2C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C2=NN([H])N=N2)C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(SC([H])([H])[H])=N2)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C2N(C(=NC2=C([H])C([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(SC([H])([H])C([H])([H])[H])=NC2=C1C(=C([H])C([H])=C2[H])C(=O)OC([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(SC([H])([H])C([H])([H])[H])=N2)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(OC([H])([H])C(F)(F)F)=N2)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=NC2=C1C(=C([H])C([H])=C2[H])C(=O)OC([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)C([H])([H])OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C1C(=C([H])C([H])=C2[H])C(=O)OC([H])([H])[H])[S@](=O)C([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(OC([H])([H])[H])=NC2=C1C(=C([H])C([H])=C2[H])C(=O)OC([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)C([H])([H])N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(OC([H])([H])C([H])([H])[H])=NC2=C1C(=C([H])C([H])=C2[H])C(=O)OC([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(OC([H])([H])C(F)(F)F)=NC2=C1C(=C([H])C([H])=C2[H])C(=O)OC([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]C([H])=C([H])C([H])([H])OC1=NC2=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C(=C([H])C([H])=C2[H])C(=O)OC([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(OC([H])([H])C([H])([H])C([H])([H])[H])=NC2=C1C(=C([H])C([H])=C2[H])C(=O)OC([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)C([H])([H])SC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)C([H])([H])SC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(OC([H])([H])C([H])([H])C([H])([H])[H])=N2)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(OC([H])([H])[H])=N2)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(SC([H])([H])C([H])([H])C([H])([H])[H])=N2)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C2N(C(=NC2=C([H])C([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(OC([H])([H])C([H])([H])[H])=N2)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H] [H]OC(=O)C1=C2N(C(=NC2=C([H])C([H])=C1[H])N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C2N(C(=NC2=C([H])C([H])=C1[H])N([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])N=C1O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C(=C(N=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C(N(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])=C([H])N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NN=C1C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C(N(C1=O)C([H])([H])C1=C(C([H])=C([H])S1)C(=O)OC([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NN=C1C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C(N(C1=O)C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(SC([H])=C1[H])C([H])([H])N1C(=O)C(=C(N=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C(N(C1=O)C([H])([H])C1=C(C([H])=C([H])O1)C(=O)OC([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC(=C(C1=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=NC(=NC(=C1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C(N(C1=O)C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C(N=C1O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(OC([H])=C1[H])C([H])([H])N1C(=O)C(=C(N=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C(N(C1=O)C([H])([H])C1=C(SC([H])=C1[H])C(=O)OC([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(OC([H])=C1[H])C([H])([H])N1C(=O)C(=C(N=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H] [H]OC(=O)C1=C(SC([H])=C1[H])C([H])([H])N1C(=O)C(=C(N=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])N(C1=O)C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])[C@@](C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])\C1=C(\[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C([H])([H])[C@@]1([H])C2=C([H])C(=C([H])C([H])=C2C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN=NN1[H])C([H])([H])C([H])([H])C([H])([H])[H])C(O[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC(=C1C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])[H])[C@](O[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])O[H] [H]OC(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC(Cl)=C1C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(O[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C(=O)O[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC(=C1C([H])([H])O[H])C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C(=O)OC([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C([H])([H])C([H])([H])[H])C(O[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])[H])C(O[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC(=C1C(=O)OC([H])([H])C([H])([H])[H])C(O[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H])C(=O)O[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(O[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])O[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@]1([H])N(C(=N[C@@]1([H])Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(Cl)N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])O[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])[H])C(O[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])[H])C(O[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])[H] [H]OC(=O)C1=C(Cl)N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NN=C1C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C(C(=O)OC([H])([H])[H])=C12)C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C(C(=O)O[H])=C12)C([H])([H])[H] [H]OC(=O)C1=C2N(C(=NC2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C1C1=NN=NN1[H] [H]N1N=NN=C1C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C(C(=O)OC([H])([H])[H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NN=C1C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C(C(=O)OC([H])([H])C([H])([H])[H])=C12)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C2N(C(=NC2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C1C1=NN=NN1[H] [H]OC(=O)C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C(C(=O)O[H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NN=C1C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C(C(=O)OC([H])([H])C([H])([H])[H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C(C(=O)O[H])=C12)C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C(C(=O)O[H])=C12)C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NN=C1C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C(C(=O)OC([H])([H])[H])=C12)C([H])([H])[H] [H]N1N=NN=C1C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C(C(=O)OC([H])([H])[H])=C12)C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])C2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])\C1=C(\[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])C(C([H])([H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])\C1=C(\[H])C(=O)C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])C(C([H])([H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])\C1=C(\[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])\C1=C(\[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])\C1=C(\[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])[C@](C([H])([H])C([H])([H])[H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])\C1=C(\[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])C(C([H])([H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])\C1=C(\[H])C(=O)OC([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])[C@@](C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])\C1=C(\[H])C(=O)OC([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C(C2=C([H])C([H])=C3N([H])C(=NC3=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=O [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(=C2[H])[C@@]1([H])[N@]2OC([H])([H])[C@]1([H])C([H])([H])C([H])([H])C2([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])OC([H])([H])[C@]2([H])ON3[C@@]([H])(C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])[C@]12[H] [H]OC([H])([H])[C@]1([H])ON(C([H])([H])[H])[C@]([H])(C2=C([H])C([H])=C3N=C(N(C(=O)C3=C2[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C2=NN([H])N=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])N(O[C@@]2([H])C([H])([H])OC(=O)[C@@]12[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])OC([H])([H])[C@@]2([H])[C@]1([H])ON1[C@]2([H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])N(O[C@@]2([H])C([H])([H])OC(=O)[C@@]12[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])O[C@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[C@]2([H])ON=C(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])[C@]2([H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])N(O[C@@]2([H])C([H])([H])C([H])([H])C(=O)[C@@]12[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])N=C2[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(OC([H])([H])C([H])([H])[H])=NC2=C1C([H])=C([H])C([H])=C2[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C([H])C([H])=NN2C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C2N(C(SC([H])([H])C([H])([H])[H])=NC2=C(S1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C1=NC([H])=C(C2=C1N(C(=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(SC([H])([H])C([H])([H])[H])=NC2=C(SC([H])=C12)C([H])([H])[H] [H]OC(=O)C1=C2N(N=C1[H])C([H])=C(N2C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C(=O)C3=C(N=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(=C3[H])[C@@]2(ON3C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C2([H])[H])C([H])([H])[H])C(=C1[H])C1=NN=N[N-]1 [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])N(O[C@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C(=O)C3=C([H])C(=C([H])C([H])=C3N=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(OC([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C1=NN=N[N-]1 [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=NN([H])[C@@]2([H])C(=O)N(C(=O)[C@@]12[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])N(O[C@@]2([H])C([H])([H])C([H])([H])C(=O)[C@@]12[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=NN2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])N(O[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C(=O)[C@@]12[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[C@]2([H])ON3[C@@]([H])(C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])[C@]2([H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])ON2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]1([H])C(=O)OC([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])ON=C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]1(ON2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])ON2[C@]([H])(C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(OC([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1(ON2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]O[C@](C1=C([H])C2=C(N=C(N(C2=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C2=NN([H])N=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[C@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C(=O)C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(C(=O)N(C2=C1C([H])=C(S2)C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C(=O)N(C2=C1C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C(=O)N(C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C(=O)C([H])=C1C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N([H])C(=O)C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C(=O)C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N2N=C([H])N=C2C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C(=O)C([H])=C(N(C1=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(=C2[H])[C@@]1([H])[N@]2O[C@@]([H])(C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]OC1=C(C(=O)N(C2=C1SC([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C(=O)N(C2=C1C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(C2=C([H])C([H])=C([H])C([H])=C2[H])=C(O[H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C12 [H]OC1=C(C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C(=O)N(C2=C1C([H])=C([H])C(SC([H])([H])[H])=C2[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C(=O)N(C2=NC(=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(C2=C([H])C([H])=C([H])C([H])=C2[H])=C(O[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12 [H]OC(=O)C1=C2N(C(=NC2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NOC(O[H])=N1 [H]OC(=O)C1=C2N(C(=NC2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NOC(O[H])=N1 [H]OC(=O)C1=C2N(C(OC([H])([H])C([H])([H])[H])=NC2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NOC(O[H])=N1 [H]OC(=O)C1=C2N(C(=NC2=C([H])C([H])=C1[H])N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NOC(O[H])=N1 [H]OC(=O)C1=C2N(C(SC([H])([H])[H])=NC2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NOC(O[H])=N1 [H]OC(=O)C1=C2N(C(SC([H])([H])C([H])([H])C([H])([H])[H])=NC2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NOC(O[H])=N1 [H]OC(=O)C1=C2N(C(SC([H])([H])C([H])([H])[H])=NC2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NOC(O[H])=N1 [H]OC(=O)C1=C2N(C(=NC2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NOC(O[H])=N1 [H]OC(=O)C1=C2N(C(OC([H])([H])[H])=NC2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NOC(O[H])=N1 [H]OC(=O)C1=C2N(C(OC([H])([H])C([H])([H])C([H])([H])[H])=NC2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NOC(O[H])=N1 [H]OC(=O)C1=C2N(C(=NC2=C([H])C([H])=C1[H])N([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NOC(O[H])=N1 [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=NC(=NN2C(=O)C([H])=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C([H])=C([H])C([H])([H])N1C(=O)C([H])=C(N(C1=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C(=O)C([H])=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C(=O)C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)OC([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C(=O)C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C(=O)C([H])=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)OC([H])([H])[H] [H]N(C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C(=O)C([H])=C(N(C1=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C(=O)C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])N1C(=O)C([H])=C(N(C1=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C(=O)C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C(=O)C(=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(C([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])OC([H])([H])[H] [H]OC(=O)C1=C(N(C(=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H])C([H])([H])O[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H])C([H])([H])C([H])([H])[H])C([H])([H])O[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])O[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])C2(\C1=C(/[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])[C@@](\C1=C(/[H])C(=O)OC([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])[C@]([H])(\C1=C(/[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])C([H])([H])[H])N=C2C([H])=C([H])C([H])=C([H])N2C1=O [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])[H])N=C2N(C([H])=C([H])C([H])=C2C([H])([H])[H])C1=O [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(OC([H])(C([H])([H])[H])C([H])([H])[H])N=C2C([H])=C([H])C(=C([H])N2C1=O)C(=O)OC([H])([H])C([H])([H])[H] [H]O[C@]([H])(C1=C([H])N2C(=O)C(=C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N=C2C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])[H])N=C2C([H])=C([H])C(=C([H])N2C1=O)C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])[H])N=C2C([H])=C(C([H])=C([H])N2C1=O)C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])N=C2C([H])=C([H])C([H])=C([H])N2C1=O [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(OC([H])(C([H])([H])[H])C([H])([H])[H])N=C2C([H])=C([H])C(=C([H])N2C1=O)C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])[H])N=C2C([H])=C([H])C([H])=C([H])N2C1=O [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]1(ON2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H])C(=O)OC([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])ON=C(C(=O)OC([H])([H])C([H])([H])[H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])ON=C(C2=C([H])C(=C([H])S2)C([H])([H])[H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])ON2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]1(ON2[C@]([H])(C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])ON2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])ON=C(C2=C([H])C(=C([H])O2)C([H])([H])[H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1(ON=C(C(=O)OC([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1(ON2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C(I)C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H] [H]OC1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])[N+]([O-])=O [H]OC1=C(Cl)C([H])=C(C([H])=C1Cl)C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H] [H]OC1=C(Br)C([H])=C(C([H])=C1Br)C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H] [H]OC1=C(I)C([H])=C(C([H])=C1I)C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H] [H]OC1=C(C([H])=C(C([H])=C1[N+]([O-])=O)C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])[N+]([O-])=O [H]OC1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H] [H]OC([H])([H])[C@@]1(ON2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H])C1=C([H])C([H])=C2N=C(N(C(=O)C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]1(ON2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H])C1=C([H])C([H])=C2N=C(N(C(=O)C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=NO[C@@]([H])(C2=C([H])C([H])=C3N=C(N(C(=O)C3=C2[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C2=NN([H])N=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]1(ON2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C([H])N=C1C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])C(=C2[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])C(=C2[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])[H])C([H])([H])[H] [H]N1N=C([H])N=C1C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])C(=C2[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])[H])C([H])([H])[H] [H]N1C(Cl)=C([H])N=C1C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])C(=C2[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C1C([H])=C([H])C(=C2[H])C1=NN([H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C1C([H])=C(C([H])=C2[H])C1=NN([H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C1C([H])=C([H])C(=C2[H])C1=NN([H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(Cl)=C2[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC2=C1C([H])=C([H])C([H])=C2[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])[H])C([H])=C([H])C([H])=C2[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(=C2[H])C([H])([H])[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C2[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(Br)=C2[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(F)=C2[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(=C2[H])C(F)(F)F [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(=C2[H])[N+]([O-])=O [H]OC([H])([H])C1=C(Cl)N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])N1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])([H])C([H])([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]