[H]N([H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C([H])([H])[H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1C2([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1C(=C([H])N2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C3=C(SC2=C1[H])C([H])=C([H])C(Cl)=C3[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[C@]1([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1C(=C([H])N2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1C(=C([H])N2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1C(=C([H])N2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1C(=C([H])N2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1C(=C([H])N2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C(S2)C([H])([H])[H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12 [H]N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N(C([H])([H])C1=C([H])C([H])=C(I)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H] [H]N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H] [H]N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H] [H]N(C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H] [H]N(C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N(C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N(C([H])([H])C1=C([H])C([H])=C(I)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(OC([H])([H])[H])C(=C([H])C(OC([H])([H])[H])=C1Br)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(OC([H])([H])[H])C(=C([H])C(OC([H])([H])[H])=C1Br)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=NC2=C1C([H])=C([H])C(Cl)=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)[C@]4(S[C@@]3([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C(F)C([H])=C2[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)C(S[C@]3([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C(F)C([H])=C2[H] [H]OC1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N([H])[H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H] [H]N(C([H])([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C2OC([H])([H])C([H])([H])C2=C(Br)C2=C1C([H])([H])C([H])([H])O2 [H]N(C(=O)N1C2=C(C([H])=C3N(C([H])=C([H])C3=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(=C2[H])N1C([H])=NN=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C2C(OC([H])([H])C2([H])[H])=C(OC([H])([H])[H])C2=C1C([H])([H])C([H])([H])O2 [H]N([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C#N)C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C2=C1C([H])([H])C([H])([H])O2 [H]N([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N([H])[C@@]1([H])C([H])([H])C2=C3C(OC([H])([H])[C@@]3([H])C1([H])[H])=C(Br)C([H])=C2OC([H])([H])[H] [H]N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])O[C@@]2([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]([H])(OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@]([H])(C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H] [H]N([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(I)C([H])=C1OC([H])([H])[H] [H]N([H])[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])N([H])C2=C1C([H])=C(F)C([H])=C2[H] [H]N([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])N([H])C2=C1C(OC([H])([H])[H])=C([H])C([H])=C2[H] [H]N([H])C([H])([H])[C@]([H])(C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]C1=NC(=NC([H])=C1F)N1C([H])([H])C([H])([H])N2C([H])([H])[C@]([H])(C([H])([H])OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])OC2=C(Br)C2=C1OC([H])=C2[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)C([H])([H])[C@]2([H])N([H])C(=O)OC2([H])[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)C([H])([H])S(=O)(=O)N([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C(C2=C1SC([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])S2)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@]([H])(N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C(C([H])=C3[H])N2C([H])=NN=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C([H])C(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])N=C23)C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C(N2C3=C1C([H])=C(F)C([H])=C3C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])N2C3=C1C([H])=C(F)C([H])=C3C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N2C3=C1C([H])=C(Cl)C([H])=C3SC([H])([H])C2([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C(N2C3=C1C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N2C3=C1C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C2([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N2C3=C1C([H])=C(F)C([H])=C3C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H] [H]N1C(=O)C([H])([H])C2=C1C([H])=C(Cl)C(=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3SC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C(=O)O[C@@]([H])(C([H])([H])[H])[C@]1([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(F)=C([H])C2=C1C(=NO2)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C(N=C3N(C2=O)C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C([H])([H])[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1F [H]O[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C(F)=C([H])C([H])=C2C(=C1C1=C([H])OC([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F [H]N(C(=O)C1=C(C2=C([H])C([H])=C(F)C([H])=C2N1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C([H])C(Cl)=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N2C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])OC([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)N3C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C2=O)C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])[H] [H]N1C2=C([H])C(F)=C([H])C([H])=C2C(=C1C(=O)OC([H])([H])[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])OC([H])([H])C([H])([H])N([H])C1([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(C1=C([H])C([H])=C([H])C([H])=C1C([H])=C2[H])=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F [H]N1C2=C([H])C(F)=C([H])C([H])=C2C(=C1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F [H]N1C2=C([H])C(F)=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=C(C2=C([H])C([H])=C([H])C(Cl)=C12)[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C(F)C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F [H]N1C([H])=C(C2=C([H])C([H])=C(F)C([H])=C12)[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F [H]N1C2=C([H])C(F)=C([H])C([H])=C2C(=C1C1=C([H])SC([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F [H]O[C@]1([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=O)N([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F [H]N1C2=C([H])C(F)=C([H])C([H])=C2C(=C1C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F [H]N1C2=C([H])C(F)=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])N=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F [H]N1C(=C(C2=C([H])C([H])=C([H])C(F)=C12)[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C([H])C(F)=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=O)N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]C([H])=C([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N([H])C3=NC([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C([H])C3=C(N2C([H])([H])C1([H])[H])C(Cl)=C([H])C([H])=C3[H] [H]N([H])C([H])([H])[C@]([H])(N1C([H])=C([H])C2=C1C1=C(C([H])=C([H])C([H])=C1[H])C([H])=C2[H])C([H])([H])[H] [H]N1C([H])([H])C2=C([H])C3=C(C([H])=C([H])C(Cl)=C3[H])N2C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C(F)C(F)=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C3(OC4=C(C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]C1=C([H])C2=C(C([H])=C1C#N)C(=O)C([H])([H])C1(O2)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C#N)S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(C#N)=C1[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C1(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C1C([H])=C(F)C(F)=C2[H] [H]N1C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C1=C(C([H])=C([H])C([H])=C1[H])C([H])=C2[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C2=C([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3N2C([H])([H])C1([H])[H] [H]N1C([H])=C(\C([H])=C2\N(\C(=N\C([H])([H])C([H])([H])[H])N(C2=O)C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N=C1N(C(=O)\C(=C(\[H])C2=C([H])N([H])C3=C([H])C(Br)=C([H])C([H])=C23)N1C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(O[C@@]([H])(OC([H])([H])[H])C([H])([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]O[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]11C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C([H])C3(O2)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C3([H])[H])C([H])=C1F [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1(O2)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(OC3(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4F)C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])=C1F [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(C(=O)C3=C([H])C([H])=C(Cl)C([H])=C3C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C([H])C3=C(N2C([H])([H])C1([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C3[H] [H]N1C([H])([H])C2=C(C3=C(C([H])=C([H])C(Cl)=C3[H])N2C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])([H])C2=C([H])C3=C(C([H])=C(Cl)C([H])=C3[H])N2C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C([H])C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C3N2C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(OC([H])([H])[H])C3=C(C([H])=C([H])C(Cl)=C3[H])N2C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C1C1=C(C([H])=C([H])C([H])=C1[H])C([H])=C2[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C2C(N([H])C(=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(O[C@]([H])(OC([H])([H])[H])C([H])([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3(OC4=C(C([H])=C(OC([H])([H])[H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C(C#N)=C1[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C(F)=C1[H])C([H])([H])C([H])([H])C1(O2)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C1(O2)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(OC3(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4F)C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C(F)=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])S(=O)(=O)C1(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C([H])([H])OC(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(I)=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=S)N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(I)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(I)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(I)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(I)=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(I)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(I)=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C(I)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C(I)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]12C3=C([H])C([H])=C([H])C([H])=C3[C@@]([H])(C3=C1C([H])=C([H])C([H])=C3[H])C2([H])[H] [H]N([H])C([H])([H])C1(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]N([H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])=C([H])C([H])=C2[H] [H]N1C([H])([H])C2=C([H])C([H])=C([H])C3=C2[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2C3([H])[H])C1([H])[H] [H]N([H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C([H])([H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C(C2=C1C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])C([H])([H])[C@@]12C3=C([H])C([H])=C([H])C([H])=C3[C@@]([H])(C3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C([H])C([H])=C3[C@]1([H])C1=C2C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C([H])C([H])=C([H])C(Cl)=C2[C@@]([H])(N1[H])C([H])([H])[H])C([H])([H])C([H])(F)F [H]N([H])C1=NC2=C([H])C([H])=C([H])C(Cl)=C2[C@@]([H])(N1[H])C([H])([H])[H] [H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=NC(N([H])[H])=C1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])C2([H])[H])=NC(N([H])[H])=C1C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])=NC(N([H])[H])=C1C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])C2([H])[H])=NC(N([H])[H])=C1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])C2([H])[H])=NC(N([H])[H])=C1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])=NC(N([H])[H])=C1C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])=NC(N([H])[H])=C1C([H])([H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C(F)(F)F)C([H])([H])C2([H])[H])=NC(N([H])[H])=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C(F)(F)F)C([H])([H])C2([H])[H])=NC(N([H])[H])=C1C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])C2([H])[H])=NC(N([H])[H])=C1C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C1=C(N=C(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])C2([H])[H])N=C1N([H])[H])N([H])[H] [H]OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(N=C(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])N=C1N([H])[H])N([H])[H] [H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])C2([H])[H])=NC(N([H])[H])=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])=NC(N([H])[H])=C1C([H])([H])C1=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C(F)=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(SC([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H] [H]C1=C([H])C2=C3N(C([H])([H])C([H])([H])C([H])([H])S2)[C@@]2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])[C@@]2([H])C3=C1[H] [H]N([H])C1=C([H])C([H])=C(F)C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(SC([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H])C([H])([H])C([H])([H])C3([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(F)=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(SC([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H] [H]N([H])C1=C([H])C(F)=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]2([H])N3C4=C(SC([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@@]2([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]2([H])N3C4=C(OC([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@@]2([H])C1([H])[H] [H]N([H])C1=C([H])C(F)=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(SC([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H] [H]N([H])C1=C([H])C(Cl)=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(SC([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C(F)=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(SC([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]2([H])N3C4=C(C([H])=C([H])C([H])=C4[C@@]2([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(SC([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C([H])C(=C([H])C([H])=C3C([H])([H])[C@]2([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C([H])=C3C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[C@]2([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C([H])=C3C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C(Cl)C([H])=C3C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3C(C(=O)C(F)(F)F)=C2C([H])([H])C1([H])[H] [H]C1=C2N(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C(Cl)C([H])=C3C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C(Cl)C([H])=C3C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]C1=C2N(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C(Cl)C([H])=C3C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3C(C#N)=C2C([H])([H])C1([H])[H] [H]N([H])C(=O)C(=O)C1=C2N(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C4N2C([H])([H])C([H])([H])OC4=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C(Cl)C([H])=C3C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C(Cl)C([H])=C3C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C(Cl)=C1[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C([H])=C3C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C([H])=C3C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C(Cl)C([H])=C3C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C2N(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C(Cl)C([H])=C3C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C([H])C(Cl)=C1[H] [H]N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])N(C4=C([H])C([H])=C(Cl)C([H])=C34)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3C(C([H])=O)=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3C(Cl)=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C(Cl)C([H])=C3C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N2C(=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3C(=C2C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N2C(=C([H])C3=C([H])C(Cl)=C([H])C(=C23)C2=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C(Cl)C([H])=C3C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(F)=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(SC([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N([H])C1=C(F)C([H])=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(SC([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H] [H]N([H])C1=C([H])C(F)=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H] [H]N([H])C1=C([H])C(Br)=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(SC([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(SC([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H] [H]N1C2=C(C(OC([H])([H])C3([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C(=O)C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3([H])N4C5=C(SC([H])([H])C([H])([H])C4([H])[H])C([H])=C([H])C([H])=C5[C@]3([H])C2([H])[H])C(N([H])[H])=C1[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]2([H])N3C4=C(SC([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@@]2([H])C1([H])[H] [H]N([H])C1=C([H])C(F)=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]2([H])N3C4=C(OC([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@@]2([H])C1([H])[H] [H]N([H])C1=C([H])C(F)=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]2([H])N3C4=C(C([H])=C([H])C([H])=C4[C@@]2([H])C1([H])[H])C([H])([H])C([H])([H])C3([H])[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(SC([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H])C([H])([H])[H] [H]N(C([H])=O)C1=C([H])C(F)=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(SC([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H] [H]N1C2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C4C([H])=C([H])C([H])=C([H])C4=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1=O [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C1=NC2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1\C([H])=C(/[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]C1=C([H])C(SC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=NC(Br)=C1[H] [H]C1=C(N=C(SC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])O[C@@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1OC2([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@]1([H])O[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1C2([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])O[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])O2 [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])O[C@]([H])(C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1S2 [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]C1=C(N=C(SC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S1)C1=C([H])C([H])=NC([H])=C1[H] [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(N=C(SC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(N=C(SC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S2)C([H])=C1[H] [H]C1=C([H])C(SC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=NC(=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1(C2=C([H])C([H])=C([H])C(SC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(SC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=N1 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C2=C([H])C(SC([H])([H])[H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C2=C([H])C(Cl)=C(F)C([H])=C2C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C2=C([H])C(SC([H])([H])[H])=C(F)C([H])=C2C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C(F)=C(Cl)C([H])=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C2=C([H])C(Br)=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C2=C3C(OC([H])([H])C3([H])[H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C2=C([H])C(=C(F)C([H])=C2C([H])([H])C1([H])[H])C(F)(F)F [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C2=C3C(OC([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C2=C([H])C(SC([H])([H])C([H])([H])[H])=C(F)C([H])=C2C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C2=C([H])C(I)=C(F)C([H])=C2C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C2=C([H])C(Cl)=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C2=C([H])C(SC([H])([H])C([H])([H])[H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C3=C2C([H])=C([H])C([H])=C3[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C2(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C3=C2C([H])=C([H])C([H])=C3[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C3=C2C([H])=C([H])C([H])=C3[H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])O[C@@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1N2C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])O[C@@]([H])(C([H])([H])N3C([H])([H])C([H])([H])C([H])(C(=O)C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])O[C@]3([H])C4=C(SC5=C([H])C([H])=C([H])C([H])=C5[C@@]3([H])C2([H])[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])O[C@@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1O2 [H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])O[C@]3([H])C4=C(C([H])=C([H])C([H])=C4[H])C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[C@@]3([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C([H])C([H])=C([H])C3=C2N(C2=C3C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N1C([H])([H])C2=C([H])C(=C([H])C3=C2N(C2=C3C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])([H])C2=C([H])C(=C([H])C3=C2N(C2=C3C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])([H])C2=C([H])C([H])=C([H])C3=C2N(C2=C3C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C([H])C([H])=C([H])C3=C2N(C2=C3C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])O[C@@]([H])(C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C(Cl)=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1C2([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[C@]1([H])N2O[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])O[C@@]([H])(C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1C2([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])O[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1S2 [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])O[C@@]([H])(C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1C2([H])[H] [H]N(C([H])([H])[H])C([H])([H])[C@]1([H])O[C@]2([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[C@@]2([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])O[C@]3([H])C4=C(C([H])=C([H])C([H])=C4[H])C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[C@@]3([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C2=C(C([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])=C(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[C@@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C(Br)C([H])=C2[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C2[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N1C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C(Br)C([H])=C2[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C2[C@@]([H])(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[C@@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(I)C([H])=C2[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C2[C@@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C(F)=C2[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C(Br)=C(OC([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C(F)=C(Cl)C([H])=C2[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(C([H])=C2[C@]([H])(C([H])([H])[H])C1([H])[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[C@]([H])(C([H])([H])[H])C1([H])[H] [H]OC1=C(Br)C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]2([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(Cl)C([H])=C(Cl)C([H])=C2[C@@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[C@]([H])(C([H])([H])[H])C1([H])[H])C(F)(F)F [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]O[C@]1([H])C([H])([H])C([H])([H])C2=C(N=C(C([H])=C2C2=C([H])C([H])=C(F)C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C1=C([H])C(=NC2=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]1([H])C([H])([H])C([H])([H])C2=C(C(=C([H])C(=N2)N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=NC([H])([H])[C@@]1([H])C([H])([H])[C@@]1([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2C1([H])[H] [H]C1=C([H])N2C(=C1[H])C(=C([H])C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]([H])(O[C@]1([H])C1=C(S2)C([H])=C([H])C(F)=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@]([H])(O[C@]1([H])C1=C(O2)C([H])=C([H])C(Cl)=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2O1)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]([H])(O[C@]1([H])C1=C(O2)C([H])=C([H])C(Br)=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]([H])(O[C@]1([H])C1=C(O2)C([H])=C([H])C(F)=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(OC3=C(C([H])=C(Br)C([H])=C3[H])[C@@]3([H])O[C@]([H])(C([H])([H])N4OC5=C4C([H])=C(C#N)C([H])=C5[H])C([H])([H])[C@@]23[H])=C1[H] [H]C1=C([H])C([H])=C2C(OC3=C(C([H])=C(Br)C([H])=C3[H])[C@@]3([H])O[C@]([H])(C([H])([H])N4OC5=C4C([H])=C(C([H])=C5[H])N4C(=O)C([H])([H])C4([H])[H])C([H])([H])[C@@]23[H])=C1[H] [H]C1=C([H])C([H])=C2C(OC3=C(C([H])=C(Br)C([H])=C3[H])[C@@]3([H])O[C@]([H])(C([H])([H])N4OC5=C4C([H])=C(C([H])=C5[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]23[H])=C1[H] [H]OC1=C2C(N([H])C([H])=C2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]N1C([H])=C(C2=C(F)C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C2C(N([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC1=C2C(=C([H])C([H])=C1[H])N(C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C2C(N([H])C([H])=C2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]OC1=C2C(N([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC1=C2C(=C([H])C([H])=C1[H])N(C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C(F)=C([H])C(=C1[H])S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(F)=C1[H])S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]N1C(=O)C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C(=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(SN=C2N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C4N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C4=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]N1C(=O)C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C(=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C#N)S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(SN=C2N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C4N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C4=C([H])C(F)=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]N1C(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C(=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(SN=C2N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C4N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C4=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]N1C(=O)C([H])([H])[C@]([H])(C2=C([H])C(Cl)=C([H])C(=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=O)C([H])([H])[C@@]([H])(C2=C([H])C(F)=C([H])C(=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NOC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[C@@]([H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N1C(=O)C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C(=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=N[S@@](=O)C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=O)C([H])([H])[C@]([H])(C2=C([H])C(=C([H])C(=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NOC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(ON=C2N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C4N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(C4=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(=C1C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C2C(N([H])C(=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]N1C([H])([H])[C@@]2([H])N(C3=C(C(=C([H])C([H])=C3C2([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])[C@]2([H])N(C3=C([H])C(=C([H])C([H])=C3C2([H])[H])C(F)(F)F)[C@]([H])(C([H])([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C2C(SN=C2N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C4N(C(=O)C([H])([H])C5=C(OC([H])([H])[H])C([H])=C([H])C([H])=C5OC([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C4=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]N1C(=O)C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C(=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NOC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C2=C([H])C([H])=C([H])C(=C2N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(SN=C2N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C4N(C(=O)C5([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C4=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]C1=C([H])C([H])=C2C(SN=C2N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C4N(C(=O)C([H])([H])[C@@]([H])(C4=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]N1C2=C(C([H])=C(F)C([H])=C2C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(ON=C2N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C4N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C4=C([H])C(F)=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]N1C(=O)C([H])([H])[C@]([H])(C2=C(C([H])=C([H])C(=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(SN=C2N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C4N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C4=C([H])C(Cl)=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]N1C(=O)C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C(=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C([H])=C2C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(SN=C2N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C4N(C(=O)C([H])([H])C5=C([H])C(OC([H])([H])[H])=C([H])C([H])=C5[H])C([H])([H])C([H])([H])[C@@]([H])(C4=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(=C1C([H])([H])[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC1=C2C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC1=C2C(=C([H])C([H])=C1[H])N(C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OP(=O)(O[H])OC1=C2C(=C([H])C([H])=C1[H])N(C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C2C(N([H])C([H])=C2C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OP(=O)(O[H])OC1=C2C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C(=C1C([H])([H])[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(OC3=C(C([H])=C(Br)C([H])=C3[H])[C@@]3([H])O[C@]([H])(C([H])([H])N4OC5=C4C([H])=C(C([H])=C5[H])C([H])([H])[H])C([H])([H])[C@@]23[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])S1)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])S1)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])S1)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])S1)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C(F)=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])S1)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])N(N=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=NN(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C3C([H])=C([H])N=C([H])C3=C12 [H]N(C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C12 [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C12 [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C12 [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C(C([H])=C1[H])C1=NOC(=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C([H])=C2N=C(C([H])=C(C2=C1[H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C(Cl)=C3N=C([H])C([H])=C([H])C3=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=NC3=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C3C([H])=NC([H])=C([H])C3=C12 [H]N(C(=O)N1C2=C(C([H])=C(C(=C2[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)N=C1[H] [H]C1=C([H])C([H])=C(N2C(=O)N(C3=C([H])C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C(Cl)=C1[H] [H]\C(=C(\[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C(=O)N1C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1N1C(=O)N(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C2=C([H])C(=C(C([H])=C2C([H])([H])C1([H])[H])C([H])([H])[H])C(F)(F)F)C1=C([H])N=C(OC2=C(N=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])N(C(=O)N1C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]C1=C([H])C(F)=C([H])C(=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1N1C(=O)N(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(Cl)=C(Cl)C(=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1N1C(=O)N(C2=C([H])C([H])=C(C(=C2[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1N1C(=O)N(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(F)=C([H])C(=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C2=C(C([H])=C(C(Cl)=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])N=C2C([H])([H])[H])N=C1[H] [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1N1C(=O)N(C2=C([H])C([H])=C(C(=C2[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1N1C(=O)N(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(F)=C([H])C(=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C([H])C(Cl)=C([H])C([H])=C3C([H])([H])[C@]2([H])C1([H])[H] [H]N1C([H])([H])[C@]2([H])N(C3=C(C([H])=C([H])C([H])=C3C2([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C(Cl)=C([H])C([H])=C3C([H])([H])[C@]2([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])([H])[C@]2([H])N(C3=C(C(Cl)=C([H])C([H])=C3C2([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C2C(OC3=C(C([H])=C(Br)C([H])=C3[H])[C@@]3([H])O[C@]([H])(C([H])([H])N4OC5=C4C([H])=C(C([H])=C5[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[C@@]23[H])=C1[H] [H]C1=C([H])C([H])=C2C(OC3=C(C([H])=C(OC([H])([H])[H])C([H])=C3[H])[C@@]3([H])O[C@@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]23[H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(ON2C([H])([H])[C@@]2([H])O[C@]3([H])C4=C(OC5=C([H])C([H])=C([H])C([H])=C5[C@]3([H])C2([H])[H])C([H])=C([H])C(Br)=C4[H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(OC3=C(C([H])=C(Br)C([H])=C3[H])[C@@]3([H])O[C@]([H])(C([H])([H])N4OC5=C4C([H])=C(C([H])=C5[H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])[C@@]23[H])=C1[H] [H]C1=C([H])C([H])=C2C(OC3=C(C([H])=C(Br)C([H])=C3[H])[C@@]3([H])O[C@]([H])(C([H])([H])N4OC5=C4C([H])=C(C([H])=C5[H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])[C@@]23[H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C2C(=C1[H])N1[C@]([H])(C2([H])[H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N1C([H])([H])[C@]2([H])N(C3=C([H])C(C#N)=C([H])C([H])=C3C2([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]OC([H])([H])C1=C([H])C([H])=C2C(=C1[H])N1[C@]([H])(C2([H])[H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(SC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C3=C(S2)C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C(=O)N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])N=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])OC1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C2N=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C(C2=C1[H])C([H])([H])[H] [H]N1C([H])([H])[C@]2([H])N(C3=C([H])C(=C([H])C([H])=C3C2([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N([H])C1=C([H])C2=C(ON2C([H])([H])[C@@]2([H])O[C@]3([H])C4=C(OC5=C([H])C([H])=C([H])C([H])=C5[C@]3([H])C2([H])[H])C([H])=C([H])C(Br)=C4[H])C([H])=C1[H] [H]OC([H])([H])C1=C([H])C([H])=C2C(=N1)N1[C@]([H])(C2([H])[H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N1C([H])([H])[C@]2([H])N(C3=NC(C#N)=C([H])C([H])=C3C2([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12 [H]OC1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C([H])=NN(C2=C1C([H])([H])[H])C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]C1=C([H])C2=C(C([H])=C(O[11C]([H])([H])[H])C([H])=C2[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2N=C([H])C(=O)N(C2=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2C([H])=NN(C2=C1I)C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C([H])=NN(C2=C1[H])C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C([H])=NN(C2=C1F)C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=NC(Cl)=C([H])C([H])=C3C([H])([H])[C@]2([H])C1([H])[H] [H]N1C([H])([H])[C@@]2([H])N(C3=C(C([H])=C([H])C(Br)=N3)C2([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])[C@]2([H])N(C3=C(C([H])=C([H])C(Cl)=N3)C2([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]C([H])=C([H])C([H])([H])N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C12 [H]N(C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C12 [H]N1C([H])([H])[C@]2([H])N(C3=NC(=C([H])C([H])=C3C2([H])[H])C(F)(F)F)[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])[C@]2([H])N(C3=NC(=C([H])C([H])=C3C2([H])[H])[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])[C@]2([H])N(C3=NC(=C([H])C([H])=C3C2([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])[C@]2([H])N(C3=NC(=C([H])C([H])=C3C2([H])[H])C([H])([H])OC([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])[C@]2([H])N(C3=NC(OC([H])([H])[H])=C([H])C([H])=C3C2([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])[C@]2([H])N(C3=NC(=C([H])C([H])=C3C2([H])[H])C([H])([H])OC([H])([H])C2([H])C([H])([H])C2([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C2C(=N1)N1[C@]([H])(C2([H])[H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H] [H]C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C([H])=NC3=C(C4=C(S3)C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C2=O)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(C#N)=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C(C3=C([H])C([H])=C([H])C([H])=C3S(=O)(=O)N3C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C4=C(F)C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])=C2C([H])=C1[H] [H]C1=C([H])C([H])=C2C([H])=C([H])C([H])=C(C(=O)N3C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C4=C(F)C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])C2=N1 [H]N1C([H])=C(C#N)C2=C([H])C([H])=C([H])C(C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4F)C([H])([H])C3([H])[H])=C12 [H]C1=C([H])C(=C([H])C([H])=C1F)S(=O)(=O)N1C([H])([H])C([H])([H])C(F)(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])[C@@]2([H])N(C3=NC(=C([H])C([H])=N3)C(F)(F)F)[C@]([H])(C([H])([H])[H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N1C([H])([H])[C@]2([H])N(C3=NC(=C([H])C([H])=N3)C(F)(F)F)C([H])([H])C([H])([H])[C@]2([H])C1([H])[H] [H]N1C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@]([H])(C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)[C@]2([H])C1([H])[H] [H]N1C([H])([H])[C@@]2([H])N(C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N1C([H])([H])[C@@]2([H])N(C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N1C([H])([H])[C@@]2([H])N(C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]OC1=C([H])C([H])=C2C([H])=NN(C2=C1[H])C([H])([H])C([H])([H])N([H])[H] [H]OC1=C([H])C([H])=C2C([H])=NN(C2=C1Cl)C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2N=C([H])C(=O)N(C2=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(N1C2=C([H])C([H])=C(Cl)C([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(C(=O)N([H])N2C3=C([H])C([H])=C(Cl)C([H])=C3N=C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C3=C2C([H])=C([H])C([H])=C3[H])C(Cl)=C([H])C([H])=C1[H] [H]N(N1C2=C([H])C([H])=C(Cl)C([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(N1C2=C([H])C([H])=C(Cl)C([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]N([H])C1=C(C(=O)N([H])N2C3=C([H])C([H])=C(Cl)C([H])=C3N=C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C3=C2C([H])=C([H])C([H])=C3[H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(F)=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C3=C(C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])O1)C1=C(OC([H])([H])[H])N=C(N=C1OC([H])([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(N1C2=C([H])C([H])=C(Cl)C([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C(C([H])=C([H])C([H])=C1F)C(F)(F)F [H]O[C@]1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(N1C2=C([H])C([H])=C(Cl)C([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]O[C@]1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C(F)C([H])=C1F)C([H])([H])C([H])([H])C1=C([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(F)=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C([H])C([H])=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(F)=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=C([H])C(=NC([H])([H])C1([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1F)C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=C([H])C(=NC([H])([H])C1([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F)C1(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)\C(N([H])C1=O)=C(/[H])C1=C([H])N([H])C2=C([H])C(Br)=C([H])C([H])=C12 [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C1(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C(C([H])([H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C(=C([H])C(=NC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC([H])([H])C([H])([H])N([H])C(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])C(=O)[C@]1([H])C([H])=C2C3=C([H])C([H])=C([H])C4=C3C(=C([H])N4C([H])([H])[H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N1C([H])=C2C3=C1C([H])=C([H])C([H])=C3C1=C([H])[C@@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])N(C([3H])([3H])[3H])[C@]1([H])C2([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C(OC([H])([H])[H])C([H])=C(Br)C(OC([H])([H])[H])=C2C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@]1([H])C2=C(OC([H])([H])[H])C([H])=C(Br)C(OC([H])([H])[H])=C2C1([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F)C(C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C([H])([H])[C@]1([H])C2=C3C(OC([H])([H])[C@@]3([H])C([H])([H])C([H])([H])C1([H])[H])=C(Br)C([H])=C2OC([H])([H])[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(Cl)C([H])=C([H])C(=C3[C@]2([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(OC([H])([H])[H])C(Cl)=C([H])C([H])=C3[C@]2([H])C1([H])[H] [H]\C(=C(\[H])C1=C(C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=N1)S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(N=C1[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)[S@@](=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])[C@]1([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(C([H])=C3[C@]2([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(Cl)C([H])=C([H])C([H])=C3[C@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C([H])C([H])=C3[C@]2([H])[C@]1([H])C([H])([H])C([H])([H])[H])C(F)(F)F [H]OC([H])([H])C1=C([H])C(=C2C(=O)N3C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]3([H])C2=C1[H])C(F)(F)F [H]\C(=C(\[H])C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(OC([H])([H])[H])C(=C([H])C([H])=C3[C@]2([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]\C(=C(\[H])C1=C(C#N)C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C1=C(Cl)C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(C([H])=C3[C@]2([H])C1([H])[H])C([H])([H])C([H])([H])[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C([H])C([H])=C3[C@@]2([H])C1([H])[H])C(F)(F)F [H]N1C([H])([H])[C@]2([H])N(C(=O)C3=C(C([H])=C([H])C([H])=C23)C(F)(F)F)[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(Cl)C([H])=C(C([H])=C3[C@]2([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC1=C2C(=O)N3C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]3([H])C2=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C3[C@@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(C([H])=C3[C@]2([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C([H])C([H])=C3[C@]2([H])[C@]1([H])C([H])([H])[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C([H])C(OC([H])([H])[H])=C(C([H])=C3[C@]2([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(SC([H])([H])[H])C([H])=C([H])C([H])=C3[C@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(C([H])=C3[C@]2([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(OC(F)(F)F)C([H])=C([H])C([H])=C3[C@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(C([H])=C3[C@]2([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[C@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(Cl)C(Cl)=C([H])C([H])=C3[C@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C([H])C([H])=C([H])C([H])=C3[C@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(OC([H])([H])[H])C([H])=C3[C@]2([H])C1([H])[H])C(F)(F)F [H]N1C(=O)N(C(=O)\C1=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C(=C2C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]3([H])C2=C1[H])C(F)(F)F [H]\C(=C(\[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(\C([H])=C(/[H])C2=C([H])C([H])=C(C([H])=N2)S(=O)(=O)C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1[H] [H]OC1=C(\C([H])=C(/[H])C2=C([H])C([H])=C(C([H])=N2)S(=O)(=O)C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])=C([H])C(F)=C1[H] [H]\C(=C(\[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)[S@@](=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)[S@@](=O)C1=C([H])C([H])=C([H])C([H])=C1F [H]C1=NC(=C([H])C([H])=C1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C([H])C(Cl)=C3[C@]2([H])C1([H])[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(Cl)C([H])=C([H])C(=C3[C@]2([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]C1=NC(=C([H])C([H])=C1C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(F)C([H])=C1F)C1=NC([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C1=C([H])C(F)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)[S@@](=O)C1=C([H])C([H])=C([H])C([H])=C1F [H]\C(=C(\[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]C#CC1=C([H])C(=C2C(=O)N3C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]3([H])C2=C1[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C3[C@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(C([H])=C3[C@]2([H])C1([H])[H])C([H])([H])[H])C(F)(F)F [H]C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])N2C(=O)N(C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])C([H])([H])C2=O)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(Cl)C([H])=C(OC([H])([H])[H])C([H])=C3[C@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C3[C@]2([H])C1([H])[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(Cl)C([H])=C3[C@]2([H])C1([H])[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(Cl)C([H])=C([H])C(OC([H])([H])[H])=C3[C@]2([H])C1([H])[H] [H]C([H])=C([H])C1=C([H])C(=C2C(=O)N3C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]3([H])C2=C1[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(C([H])=C3[C@]2([H])C1([H])[H])C(=O)C([H])([H])[H])C(F)(F)F [H]O[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])[N+]1([O-])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(OC(=O)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NSC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NSC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C1=C(C#N)C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N=C([H])C([H])=C1[H])[C@@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=NO1)[C@@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])O1)[C@@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NSC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])[C@@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=O)N1[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=[N+]([O-])C([H])=C([H])C([H])=C1[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C(F)(F)F)[C@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NSC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])ON2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(C([H])([H])[H])C([H])([H])C(=O)[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])ON3C(=O)[C@]4([H])[C@]([H])(C3=O)[C@]3(C([H])([H])[H])C([H])([H])C(=O)[C@@]4([H])[C@]([H])(C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C(F)=C1[H] [H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])ON2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(C([H])([H])[H])C([H])([H])C(=O)[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])ON3C(=O)[C@]4([H])[C@]([H])(C3=O)[C@]3(OC([H])([H])[H])C([H])=C([H])[C@@]4([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)[C@@]4([H])[C@@]([H])(C3=O)[C@@]3(OC(=O)C([H])([H])[H])C([H])([H])C(=O)[C@]4([H])C(C([H])([H])[H])(C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)[C@@]4([H])[C@@]([H])(C3=O)[C@]3(OC([H])([H])C([H])([H])[H])C([H])([H])C(=O)[C@@]4([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C3(C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2=O)C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NSC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C(Cl)=C([H])C(Cl)=C2C(=O)[C@](C1=O)(C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N=C([H])C([H])=C1[H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NSC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]N([H])C1=NC2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])N1[H] [H]N([H])C1=NC2=C([H])C([H])=C(Cl)C(Cl)=C2C([H])([H])N1[H] [H]N([H])C(=N/S(=O)(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])\N1N=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)[C@]4([H])[C@]([H])(C3=O)[C@]3(OC(=O)C([H])([H])[H])C([H])=C(C([H])([H])[H])[C@@]4([H])[C@]([H])(C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(OC(=O)C([H])([H])[H])C([H])=C(C([H])([H])[H])[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(OC(=O)C([H])([H])[H])C([H])=C(C([H])([H])[H])[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(OC(=O)C([H])([H])[H])C([H])=C(C([H])([H])[H])[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(OC(=O)C([H])([H])[H])C([H])=C(C([H])([H])[H])[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(OC(=O)C([H])([H])[H])C([H])=C(C([H])([H])[H])[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)[C@]4([H])[C@]([H])(C3=O)[C@]3(C([H])([H])[H])C([H])([H])C(=O)[C@@]4([H])[C@]([H])(C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(C([H])([H])[H])C([H])([H])C(=O)[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(C([H])([H])[H])C([H])([H])C(=O)[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(C([H])([H])[H])C([H])([H])C(=O)[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(C([H])([H])[H])C([H])([H])C(=O)[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(C([H])([H])[H])C([H])([H])C(=O)[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C(=NC2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C(=O)N([H])C2=O)C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC(=C(S1)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H] [H]N([H])C([H])([H])[C@]1([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])[C@@]2([H])C([H])([H])N([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])C([H])([H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C([H])([H])[C@]1([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(Br)C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N3C(=O)[C@]4([H])[C@]([H])(C3=O)[C@]3(OC(=O)C([H])([H])[H])C([H])=C(C([H])([H])[H])[C@@]4([H])[C@]([H])(C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(OC(=O)C([H])([H])[H])C([H])=C(C([H])([H])[H])[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N3C(=O)[C@]4([H])[C@]([H])(C3=O)[C@]3(C([H])([H])[H])C([H])([H])C(=O)[C@@]4([H])[C@]([H])(C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(C([H])([H])[H])C([H])([H])C(=O)[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])ON3C(=O)[C@]4([H])[C@]([H])(C3=O)[C@]3(OC(=O)C([H])([H])[H])C([H])=C(C([H])([H])[H])[C@@]4([H])[C@]([H])(C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])ON2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(OC(=O)C([H])([H])[H])C([H])=C(C([H])([H])[H])[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])ON2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(OC(=O)C([H])([H])[H])C([H])=C(C([H])([H])[H])[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])ON3C(=O)[C@]4([H])[C@]([H])(C3=O)[C@]3(OC(=O)C([H])([H])[H])C([H])=C(C([H])([H])[H])[C@@]4([H])[C@]([H])(C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C(F)=C1[H] [H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])ON2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(OC(=O)C([H])([H])[H])C([H])=C(C([H])([H])[H])[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])ON3C(=O)[C@]4([H])[C@]([H])(C3=O)[C@]3(C([H])([H])[H])C([H])([H])C(=O)[C@@]4([H])[C@]([H])(C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@]1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])SC4=C([H])C([H])=C([H])C([H])=C34)[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(Br)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C(F)(F)F [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]C1=C(OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])S(=O)(=O)N([H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C(C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]C1=C(OC2=C([H])C([H])=C(C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C(Cl)C(Cl)=C1[H] [H]O[C@]1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])N([H])C4=C([H])C([H])=C([H])C([H])=C34)[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C(=C1[H])C([H])([H])N([H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C(F)(F)F [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(Cl)C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(F)=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(F)C(Cl)=C1[H] [H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C(F)(F)F)C([H])([H])[H] [H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C([H])([H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]O[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(Cl)C(Cl)=C2[H])=C1[H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(OC2=C([H])C(=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)C([H])=C(Cl)C(Cl)=C1[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(F)C(F)=C2[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(OC([H])([H])[H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C(F)(F)F [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(F)(F)F [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(=C1[H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(Cl)C(=C1[H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(C(Cl)=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(Cl)C(=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(F)C(=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(F)C(Cl)=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(Cl)C(F)=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]O[C@]1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])OC4=C([H])C([H])=C([H])C([H])=C34)[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])N=C(OC2=C([H])N=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N([H])C2=C([H])C([H])=C(C([H])=C12)C([H])([H])[H])C1=C([H])N=C(OC2=C(N=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC1=C(O[H])C(C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])=C2C(=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])N=C(OC2=C(Cl)N=C([H])C([H])=C2[H])C([H])=C1[H] [H]O[C@]1(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])N([H])C4=C([H])C([H])=C([H])C([H])=C34)[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])N1C1=NN(C(=O)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=C([H])N(C([H])=N1)C1=NN(C(=O)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC1=C(O[H])C(C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])=C2C(=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C2([H])[H] [H]OC1=C(O[H])C(C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])=C2C(=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C(OC([H])([H])[H])=C([H])C([H])=C2[H] [H]N([H])C([H])([H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N([H])C([H])([H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2OC([H])([H])[H] [H]C1=C([H])C2=C3C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]3([H])C([H])([H])C1=C2C(OC(=O)C([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1([H])C1=C(Br)C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(Cl)=C3Cl)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=C([H])C2=C3C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]3([H])C([H])([H])C1=C2C(OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C3C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]3([H])C([H])([H])C1=C2C(OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C3C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]3([H])C([H])([H])C1=C2C(OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C3C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]3([H])C([H])([H])C1=C2C(OC(=O)C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C3C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]3([H])C([H])([H])C1=C2C(OC(=O)C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C2=C1C1=C3C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]3([H])C2([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(Cl)C(Cl)=C2[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(SC([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(Cl)C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(Br)C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(F)C(=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])[C@]1([H])C([H])([H])N([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@@]1([H])C([H])([H])[C@]1([H])C([H])([H])N([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(F)C(F)=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(F)C([H])=C(Cl)C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(Cl)C([H])=C(F)C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C(=C(F)C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1F)C([H])([H])N1C(=O)O[C@]([H])(C([H])([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C(F)C(Cl)=C1[H])C([H])([H])N1C(=O)O[C@]([H])(C([H])([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1O[C@]([H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])N1C(=O)O[C@]([H])(C([H])([H])[H])C1([H])[H] [H]C1=NC(=C([H])C([H])=C1C([H])([H])N1C(=O)O[C@]([H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(F)C(F)=C1[H] [H]C1=NC(=C([H])C([H])=C1C([H])([H])N1C(=O)O[C@]([H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1F [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])N1C(=O)O[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C(=O)N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C2C3=C(C([H])=C4OC([H])([H])OC4=C3[H])C([H])([H])[C@]3([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C(C([H])=C1OC([H])([H])[H])=C23 [H]N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C1=C(OC([H])([H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C3OC([H])([H])C([H])([H])C([H])([H])C3=C12)C([H])([H])[H] [H]N1C([H])=C(C2=C3C(OC([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C3OC([H])([H])C([H])([H])C([H])([H])C3=C12 [H]N(C(=O)C1=C([H])C2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(O1)C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(O1)C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2=C1[H])C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C21)C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])[C@@]([H])(C([H])=C2C3=C([H])C([H])=C([H])C4=C3C(=C([H])N4[H])C([H])([H])[C@@]12[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C2C3=C1C([H])=C([H])C([H])=C3C1=C([H])[C@@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])N([H])[C@]1([H])C2([H])[H] [H]N(C(=O)[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(F)=C(OC2([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])[H] [H]N(C(=O)[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(F)=C(OC2([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1F [H]C1=C2OC([H])([H])OC2=C([H])C2=C1C1=C3C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])[C@@]3([H])C2([H])[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C2[H])C([H])([H])C([H])([H])[C@]3([H])OC([H])([H])C2=C([H])C(F)=C([H])C([H])=C2C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C2[H])C([H])([H])C([H])([H])[C@]3([H])OC([H])([H])C2=C([H])C(F)=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C2[H])C([H])([H])C([H])([H])[C@]3([H])OC([H])([H])C2=C([H])C(F)=C([H])C([H])=C2F)[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[C@]3([H])OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C2[H])C([H])([H])C([H])([H])[C@@]3([H])OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(F)=C(O[C@@]2([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C2([H])[H])C(F)=C1[H] [H]N(C(=O)[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(F)=C(OC([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2=C(C3=C(N2[H])C([H])=C([H])C(F)=C3[H])C([H])([H])C1([H])[H])C([H])([H])[C@]1([H])OC2=C(OC1([H])[H])C1=C(N([H])C(=O)C1([H])[H])C([H])=C2[H] [H]N(C([H])([H])[C@]1([H])OC2=C(OC1([H])[H])C1=C(N([H])C(=O)C1([H])[H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])C2=C(N([H])C3=C2C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H] [H]N1C(=O)OC2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])C([H])([H])C3=C(N([H])C4=C3C([H])=C(F)C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C(=O)OC2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])[C@]2([H])N(C([H])([H])[C@]3([H])C([H])([H])C4=C(N([H])C5=C4C([H])=C(F)C([H])=C5[H])C([H])([H])C3([H])[H])C([H])([H])[C@@]1([H])C2([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C([H])=C([H])C([H])=C2S(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C([H])=C([H])C([H])=C2S(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C([H])=C([H])C([H])=C2S(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C([H])=C([H])C([H])=C2S(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N([C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N([C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N([C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N([C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC2=NC3=C([H])C([H])=C([H])C([H])=C3C3=C([H])N(C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C2C(=C([H])N1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N=C2OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC2=NC3=C([H])C([H])=C([H])C([H])=C3C3=C([H])N(C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC2=NC3=C([H])C([H])=C([H])C([H])=C3C3=C([H])N(C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC2=NC3=C([H])C([H])=C([H])C([H])=C3C3=C([H])N(C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C2C(=C([H])N1C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N=C2OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C2C(=C([H])N1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N=C2OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C2C(=C([H])N1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N=C2OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N([H])C(=O)C2=NN(C3=C([H])C([H])=C([H])C([H])=C23)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N([H])C(=O)C2=NN(C3=C([H])C([H])=C([H])C([H])=C23)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[N@@+](C([H])([H])[H])(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C(F)(F)C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1F)C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C([H])C(C2=C(Cl)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C([H])=C([H])C([H])=C(C2=N1)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(F)C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1F [H]N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1[H] [H]O[C@]([H])(C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C(F)=C1[H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C(=O)N([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C(C2=C(Cl)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C(=O)N([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C([H])C(C2=C(Cl)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C(=O)N(C(=N2)C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C(C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])=C2[H])C2=C([H])C([H])=NN2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])OC1=C(C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=NN1C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])OC1=C(C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=NN1C([H])([H])[H] [H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])SC1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C(F)C([H])=C2[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])N2C3=C4N(C([H])([H])C([H])([H])C([H])([H])C4=C([H])C([H])=C3[H])S2(=O)=O)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])O[C@]([H])(C([H])([H])OC2=C3C(=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C3([H])[H])C1([H])[H] [H]N(C(=O)N1C2=C(C([H])=C(F)C(Cl)=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])N=C2C([H])([H])[H])N=C1[H] [H]N(C(=O)N1C2=C(C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])N=C2C([H])([H])[H])N=C1[H] [H]N(C(=O)N1C2=C(C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])N=C2C([H])([H])[H])N=C1[H] [H]N(C(=O)N1C2=C(C([H])=C(I)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])N=C2C([H])([H])[H])N=C1[H] [H]N(C(=O)N1C2=C(C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])N=C2C([H])([H])[H])N=C1[H] [H]N(C(=O)N1C2=C(Cl)C(Cl)=C([H])C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)N1C2=C([H])C(I)=C(C([H])=C2C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)N1C2=C([H])C(Br)=C(C([H])=C2C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)N1C2=C([H])C(Cl)=C(C([H])=C2C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)N1C2=C([H])C(=C(Cl)C([H])=C2C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)N1C2=C([H])C(Cl)=C(I)C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)N1C2=C([H])C([H])=C(C(I)=C2C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C2=C([H])C([H])=C(Cl)C(Cl)=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)N1C2=C([H])C(Cl)=C(Cl)C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)N1C2=C([H])C(Cl)=C([H])C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)N1C2=C([H])C([H])=C(Cl)C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C(F)C([H])=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C(Br)=C([H])C([H])=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C(Cl)=C([H])C([H])=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C(F)=C([H])C([H])=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])[H] [H]N=C1N(\C(=C(/[H])C2=C([H])N([H])C3=C2C([H])=C([H])C(F)=C3[H])C(=O)N1C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C2=C([H])C([H])=C(C(Br)=C2C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)C1=C(N([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N=C1N(\C(=C(\[H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C(=O)N1C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N=C1N(C(=O)\C(=C(\[H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)N1C([H])([H])[H])C([H])([H])[H] [H]N=C1N(C(=O)\C(=C(\[H])C2=C([H])N([H])C3=C2C([H])=C([H])C(F)=C3[H])N1C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C(Cl)=C3C(=O)N([H])[C@]2([H])C1([H])[H] [H]N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2N2C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]12[H] [H]N1C(=O)C2=C(C([H])=C([H])C([H])=C2N2C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]12[H])C([H])([H])[H] [H]N1C(=O)C2=C([H])C([H])=C(C([H])=C2N2C([H])([H])C([H])([H])N([H])C([H])([H])[C@]12[H])C([H])([H])[H] [H]N1C(=O)C2=C([H])C([H])=C(C([H])=C2N2C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H] [H]N1C(=O)C2=C([H])C(=C([H])C([H])=C2N2C([H])([H])C([H])([H])N([H])C([H])([H])[C@]12[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C([H])C([H])=C(Cl)C([H])=C3C(=O)N([H])[C@@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C(=C3C(=O)N([H])[C@]2([H])C1([H])[H])C(F)(F)F [H]N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2N2C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@]12[H] [H]N1C(=O)C2=C(C([H])=C([H])C([H])=C2N2C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@]12[H])C([H])([H])[H] [H]N1C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2N2C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@]12[H] [H]N([H])C([H])([H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C([H])=C2[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C([H])=C2C(=C1[H])C(=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C(N=C1[H])C([H])([H])C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]C1=C([H])C([H])=C2C(SC(=C2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C(Br)C([H])=NN1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C(Br)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C(Br)C([H])=NN1C([H])([H])[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C([H])=C([H])C([H])=C2S(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C([H])=C([H])C([H])=C2S(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C([H])=C([H])C([H])=C2S(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C([H])=C([H])C([H])=C2S(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C([H])=C([H])C([H])=C2S(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]C1=NN(C(=C1C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(C2=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F [H]N(C(=O)C1=C(N(C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2Br)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])N=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C3=C([H])C([H])=C(N=C23)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Br)=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(F)=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])N=C23)C([H])([H])C1([H])[H] [H]C1=C(N(C(=C1C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(N(C(=C1C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(N(C(=C1C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])SC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C(Br)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=NN(C(=C1C([H])([H])N1C([H])([H])C([H])(OC2=C(F)C([H])=C([H])C([H])=C2OC([H])([H])[H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=NN(C(=O)C([H])=C2[H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NN(C(=O)C([H])=C2[H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2Cl)[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NN(C(=O)C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NN(C(=O)C([H])=C2[H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NN(C(=O)C([H])=C2[H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N1C([H])=C(C#N)C2=C([H])C([H])=C([H])C(C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])=C12 [H]N(C(=O)N([H])C1=C([H])C([H])=C(F)C([H])=C1F)C1=C([H])C(C2=C(Br)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(C2=C(Cl)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C2=NN(C(=C2Br)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C(C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C(Br)=C1C([H])([H])[H] [H]N1N=C(C([H])=C1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(N(N=C1C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C(N(N=C1C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C(Cl)C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C(=NN1C([H])([H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1N=C(C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C(Cl)=C1[H] [H]C1=C(C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C(F)(F)F [H]C1=C(I)C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(N(N=C1C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC(OC([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3Cl)=C([H])N=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C(C([H])=C(N([H])C(=O)N([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C2[H])C2=C([H])C([H])=NN2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C(Cl)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C(Br)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C(Cl)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C(Br)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=NN([H])C([H])=C1Br [H]C1=C(Br)C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(Br)C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(Br)C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(Br)C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(Br)C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(Br)C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(Br)C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(Br)C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(Br)C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(Br)C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(Br)C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=C(Br)C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C2=NN(C([H])=C2Br)C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C(Br)C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=N\OC([H])([H])[H])\C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])(OC([H])([H])[H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C([H])([H])[H] [H]N(C(=O)N([H])C1=C(F)C([H])=C(F)C([H])=C1[H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C(F)C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(F)=C([H])C(F)=C1[H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N([H])C1=C(F)C([H])=C(F)C([H])=C1[H])C1=C([H])C(C2=C(Br)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C(F)C([H])=C(F)C([H])=C1[H])C1=C([H])C(C2=C(Cl)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C(Br)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(C3=C(Br)C([H])=NN3C([H])([H])[H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C(F)C([H])=C(F)C([H])=C1[H])C1=C([H])C(C2=C(Cl)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(F)=C([H])C(F)=C1[H])C1=C([H])C(C2=C(Cl)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C(Cl)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(C#N)=C2[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H] FC1=CC=C2C=CC=C(N3CCN(CCCOC4=CC=C5CNC(=O)C5=C4F)CC3)C2=C1 FC1=C2C(=O)NCC2=CC=C1OCCCCN1CCN(CC1)C1=CC=CC2=CC=CC=C12 FC1=C2C(C=CC=C2N2CCN(CCCCOC3=CC=C4CNC(=O)C4=C3Cl)CC2)=CC=C1 FC1=C(OCCCN2CCN(CC2)C2=CC=CC3=CC=CC(F)=C23)C=C2C(=O)NCC2=C1 CC1=C2C(=O)NCC2=CC=C1OCCCCN1CCN(CC1)C1=CC=CC2=CC=CC=C12 C(COC1=CC=C2CNCC2=C1)CN1CCN(CC1)C1=CC=CC2=CC=CC=C12 FC1=C2C(C=CC=C2N2CCN(CCCCOC3=CC=C4CNC(=O)C4=C3)CC2)=CC=C1 ClC1=C2C(=O)NCC2=CC=C1OCCCN1CCN(CC1)C1=CC=CC2=CC=CC=C12 FC1=CC=C2C=CC=C(N3CCN(CCCCOC4=CC=C5CNC(=O)C5=C4F)CC3)C2=C1 FC1=C2C(=O)NCC2=CC=C1OCCCN1CCN(CC1)C1=CC=CC2=CC=CC=C12 FC1=CC=C2C=CC=C(N3CCN(CCCOC4=C(F)C=C5CNC(=O)C5=C4)CC3)C2=C1 FC1=CC=C2C(C=CC=C2N2CCN(CCCCOC3=CC=C4CNC(=O)C4=C3F)CC2)=C1 O=C1NCC2=CC=C(OCCCN3CCN(CC3)C3=CC=CC4=C3CCC4)C=C12 O=C1NCC2=CC=C(OCCCCN3CCN(CC3)C3=CC=CC4=C3CCCC4)C=C12 FC1=CC=C2C=CC=C(N3CCN(CCCOC4=CC=C5CNC(=O)C5=C4)CC3)C2=C1 FC1=C2C(C=CC=C2N2CCN(CCCOC3=CC=C4CNC(=O)C4=C3F)CC2)=CC=C1 FC1=C(OCCCCN2CCN(CC2)C2=CC=CC3=CC=CC(F)=C23)C=C2C(=O)NCC2=C1 FC1=CC=C2C(C=CC=C2N2CCN(CCCOC3=CC=C4CNC(=O)C4=C3)CC2)=C1 FC1=C2C(C=CC=C2N2CCN(CCCOC3=CC=C4CNC(=O)C4=C3Cl)CC2)=CC=C1 CC1=C2C(=O)NCC2=CC=C1OCCCCN1CCN(CC1)C1=CC=CC2=CC=CC(F)=C12 [H]N1C(=O)C([H])([H])C([H])([H])C2=C1C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(Cl)=C3Cl)C([H])([H])C1([H])[H])C([H])=C2[H] O=C1NCC2=CC=C(OCCCN3CCN(CC3)C3=CC=CC4=C3CCO4)C=C12 O=C1NCC2=CC=C(OCCCN3CCN(CC3)C3=CC=CC4=C3CCCC4)C=C12 O=C1NCC2=CC=C(OCCCCN3CCN(CC3)C3=CC=CC4=CC=CC=C34)C=C12 O=C1NCC2=CC=C(OCCCCN3CCN(CC3)C3=CC=CC4=C3COC4)C=C12 CC1=C2C(=O)NCC2=CC=C1OCCCN1CCN(CC1)C1=CC=CC2=CC=CC=C12 FC1=CC=C2C(C=CC=C2N2CCN(CCCCOC3=CC=C4CNC(=O)C4=C3)CC2)=C1 FC1=CC=C2C=CC=C(N3CCN(CCCCOC4=C(F)C=C5CNC(=O)C5=C4)CC3)C2=C1 O=C1NCC2=CC=C(OCCCCN3CCN(CC3)C3=CC=CC4=C3CCC4)C=C12 O=C1NCC2=CC=C(OCCCN3CCN(CC3)C3=CC=CC4=C3COCC4)C=C12 O=C1NCC2=CC=C(OCCCCN3CCN(CC3)C3=CC=CC4=C3CCOC4)C=C12 FC1=C2C(C=CC=C2N2CCN(CCCOC3=CC=C4CNC(=O)C4=C3)CC2)=CC=C1 FC1=CC=C2C=CC=C(N3CCN(CCCCOC4=CC=C5CNC(=O)C5=C4)CC3)C2=C1 CC1=C2C(=O)NCC2=CC=C1OCCCN1CCN(CC1)C1=CC=CC2=CC(F)=CC=C12 FC1=C(OCCCCN2CCN(CC2)C2=CC=CC3=CC=CC=C23)C=C2C(=O)NCC2=C1 FC1=CC=C2C(C=CC=C2N2CCN(CCCCOC3=C(F)C=C4CNC(=O)C4=C3)CC2)=C1 CC1=C2C(=O)NCC2=CC=C1OCCCCN1CCN(CC1)C1=CC=CC2=CC(F)=CC=C12 O=C1NCC2=CC=C(OCCCN3CCN(CC3)C3=CC=CC4=CC=CC=C34)C=C12 CC1=C2C(=O)NCC2=CC=C1OCCCN1CCN(CC1)C1=CC=CC2=CC=CC(F)=C12 O=C1NCC2=CC=C(OCCCCN3CCN(CC3)C3=CC=CC4=C3OCCC4)C=C12 FC1=C(F)C=C2C(C=CC=C2N2CCN(CCCOC3=CC=C4CNC(=O)C4=C3)CC2)=C1 ClC1=C(OCCCCN2CCN(CC2)C2=CC=CC3=CC=CC=C23)C=C2C(=O)NCC2=C1 O=C1NCC2=CC=C(OCCCN3CCN(CC3)C3=CC=CC4=C3OCCC4)C=C12 FC1=C2C(C=CC=C2N2CCN(CCCCOC3=C(Cl)C=C4CNC(=O)C4=C3)CC2)=CC=C1 CC1=C(OCCCCN2CCN(CC2)C2=CC=CC3=CC(F)=CC=C23)C=C2C(=O)NCC2=C1 FC1=C(OCCCN2CCN(CC2)C2=CC=CC3=CC=CC=C23)C=C2C(=O)NCC2=C1 C(CCN1CCN(CC1)C1=CC=CC2=CC=CC=C12)COC1=CC=C2CNCC2=C1 FC1=CC=C2C(C=CC=C2N2CCN(CCCOC3=CC=C4CNC(=O)C4=C3F)CC2)=C1 O=C1NCC2=CC=C(OCCCCN3CCN(CC3)C3=CC=CC4=C3COCC4)C=C12 FC1=C(F)C=C2C(C=CC=C2N2CCN(CCCCOC3=CC=C4CNC(=O)C4=C3)CC2)=C1 FC1=C2C(C=CC=C2N2CCN(CCCOC3=C(Cl)C=C4CNC(=O)C4=C3)CC2)=CC=C1 ClC1=C(OCCCN2CCN(CC2)C2=CC=CC3=CC=CC=C23)C=C2C(=O)NCC2=C1 CC1=C(OCCCCN2CCN(CC2)C2=CC=CC3=CC=CC=C23)C=C2C(=O)NCC2=C1 FC1=CC=C2C(C=CC=C2N2CCN(CCCOC3=C(F)C=C4CNC(=O)C4=C3)CC2)=C1 CC1=C(OCCCN2CCN(CC2)C2=CC=CC3=CC(F)=CC=C23)C=C2C(=O)NCC2=C1 O=C1NCC2=CC=C(OCCCCN3CCN(CC3)C3=CC=CC4=C3CCO4)C=C12 CC1=C(OCCCCN2CCN(CC2)C2=CC=CC3=CC=CC(F)=C23)C=C2C(=O)NCC2=C1 CC1=C(OCCCN2CCN(CC2)C2=CC=CC3=CC=CC=C23)C=C2C(=O)NCC2=C1 CC1=C(OCCCN2CCN(CC2)C2=CC=CC3=CC=CC(F)=C23)C=C2C(=O)NCC2=C1 CCCCN1CCC(COC(=O)C2=C3OCCOC3=C(NC)C(Cl)=C2)CC1 FC1=CC=C2C=CC=C(N3CCN(CCCCOC4=CC=C5CNCC5=C4)CC3)C2=C1 FC1=C2C(C=CC=C2N2CCN(CCCCOC3=CC=C4CNC(=O)C4=C3F)CC2)=CC=C1 FC1=CC=C2C=CC=C(N3CCN(CCCOC4=CC=C5CNCC5=C4)CC3)C2=C1 [H]N(C(=O)C1=C(OC([H])([H])[H])C(=NC(=N1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(OC([H])([H])[H])C(=NC(=N1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(OC([H])([H])[H])C(=NC(=N1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC(=N1)C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC(SC([H])([H])[H])=N1)C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC(SC([H])([H])[H])=N1)C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC(SC([H])([H])[H])=N1)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC(=N1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC(=N1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC(=N1)C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC(=N1)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC(=N1)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC(=N1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C(=C([H])C([H])=C2C(=O)C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C(=O)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C(=C([H])C([H])=C2C(=O)C([H])([H])[C@]1([H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C(=O)C([H])([H])[C@]1([H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C(=O)C([H])([H])[C@]1([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C(=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C(=O)C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=NN3C(N3C([H])([H])C([H])(OC4=C([H])C([H])=C(OC([H])([H])[H])C([H])=C4[H])C3([H])[H])=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=NN3C(N3C([H])([H])C([H])(OC4=C([H])C([H])=C([H])C([H])=C4OC([H])([H])[H])C3([H])[H])=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=NN3C(N3C([H])([H])C([H])([H])C3([H])[H])=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=NN3C(N3C([H])([H])C([H])(OC4=NC([H])=C([H])C([H])=C4[H])C3([H])[H])=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=NN3C(N3C([H])([H])C([H])(OC4=C([H])C([H])=C([H])C([H])=C4[H])C3([H])[H])=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=NN3C(N3C([H])([H])C([H])(OC4=C([H])C([H])=C(F)C([H])=C4[H])C3([H])[H])=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=NN3C(N3C([H])([H])C([H])(OC4=C([H])C([H])=C([H])C(F)=C4[H])C3([H])[H])=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=NN3C(N3C([H])([H])C([H])(OC4=C([H])C([H])=C([H])C(OC([H])([H])[H])=C4[H])C3([H])[H])=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=NN3C(N3C([H])([H])C([H])(OC4=C([H])C([H])=C([H])N=C4[H])C3([H])[H])=C2C([H])([H])C1([H])[H] [H]N(C1=C2C(=NC3=C([H])C([H])=NN13)C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=NN3C(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=NN3C(N3C([H])([H])C([H])(OC4=C([H])C([H])=C([H])C([H])=C4F)C3([H])[H])=C2C([H])([H])C1([H])[H] [H]N1C(=O)C([H])([H])C2=C1C([H])=C([H])C(OC1([H])C([H])([H])N(C3=C4C(=NC5=C([H])C([H])=NN35)C([H])([H])C([H])([H])N([H])C([H])([H])C4([H])[H])C1([H])[H])=C2[H] [H]N1C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=NN3C(N3C([H])([H])C([H])(OC4=C([H])C([H])=NC([H])=C4[H])C3([H])[H])=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=NN3C(N3C([H])([H])C([H])(OC4=C([H])C([H])=C(C([H])=C4[H])N(C(=O)C([H])([H])[H])C([H])([H])[H])C3([H])[H])=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=NN3C(N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H])[C@]1([H])[C@@]2([H])[C@@]3([H])C([H])([H])[C@]4([H])[C@@]5([H])C([H])([H])[C@]([H])([C@]2([H])[C@@]35[H])[C@]14[H] [H]C1=C(N=NN1C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])OC1=C([H])C([H])=C([H])C2=C1C1=C([H])C([H])=C([H])C3=C1[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])C2([H])[H] [H]C1=C(N=NN1C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C2=C1C1=C([H])C([H])=C([H])C3=C1[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])C2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C(Br)C([H])=C([H])C([H])=C1[H])C1(C#N)C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C(Br)C([H])=C([H])C([H])=C1[H])C1(C#N)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=NC(=NC([H])=C2C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C(C([H])=C([H])C(=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C(Cl)C(Cl)=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1=O [H]N1C(=O)C([H])([H])C([H])([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C(Cl)C(Cl)=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]N1C(=O)C([H])=C([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C(Cl)C(Cl)=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]N1C(=O)C([H])=C([H])C2=C1C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C(Cl)C(Cl)=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])N=C2[H] [H]N1C(=O)C([H])=C([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C(Cl)C(Cl)=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])N=C2[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C(Cl)C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C(Cl)C(F)=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C(Cl)C(=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]N1C2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C(C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])C3([H])[H])=N2)C([H])([H])C([H])([H])C1=O [H]N1C2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C(C(=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])=N2)C([H])([H])C([H])([H])C1=O [H]N1C(=O)C([H])([H])C([H])([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C(C(Cl)=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C(F)C(Cl)=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C(Cl)C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])=C2[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C(C(Cl)=C([H])C([H])=C3[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])=C2[H] [H]N1C2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C5C(=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C5([H])[H])C([H])([H])C3([H])[H])=N2)C([H])([H])C([H])([H])C1=O [H]N1C2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C5C(=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C([H])([H])C3([H])[H])=N2)C([H])([H])C([H])([H])C1=O [H]N1C(=O)C([H])([H])C([H])([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C4C(OC([H])([H])C([H])([H])C4([H])[H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C4OC([H])([H])C([H])([H])C([H])([H])C4=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]N1C2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C5C([H])=C([H])C([H])=C([H])C5=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])=N2)C([H])([H])C([H])([H])C1=O [H]N1C(=O)C([H])([H])C([H])([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C4C([H])=C([H])C([H])=C([H])C4=C([H])C([H])=C3F)C([H])([H])C1([H])[H])C([H])=C2[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C4C([H])=C([H])C([H])=C([H])C4=C([H])C(F)=C3[H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C4C([H])=C([H])C([H])=C([H])C4=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C4C([H])=C([H])C(F)=C([H])C4=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]C1=C2C(ON=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3OC([H])([H])[H])C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C(F)=C1[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2N=C2SC(=C([H])C2=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C(Cl)C([H])=C1[H])N2C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C(C(=O)N([H])C([H])([H])[C@]2([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])[H] [H]N([H])[C@]([H])(C([H])([H])[H])C([H])([H])N1N=C([H])C2=C1C1=C(OC(=C1[H])C([H])([H])C([H])([H])[H])C([H])=C2[H] [H]C1=C([H])N2C(S1)=NC(=C(C2=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C(=C(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C2([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C(N([H])C5=C([H])C([H])=C([H])C([H])=C45)[C@]3([H])C([H])([H])[C@]2([H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])[C@]2([H])C3=C([H])C(C#N)=C([H])C([H])=C3OC([H])([H])[C@@]2([H])C1([H])[H] [H]N([H])C1=C(Cl)C([H])=C(C(=O)OC([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1OC([H])([H])C([H])([H])O2 [H]C1=C([H])C(=C([H])C([H])=C1C(=O)N1C2=C(C([H])=C3OC([H])([H])C4(C3=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C1=NOC(=N1)C([H])([H])[H] [H]N([H])C1=C(Cl)C([H])=C(C2=NN(C(=O)O2)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C2=C1OC([H])([H])C([H])([H])O2 [H]C1=C(C2=NSN=C2OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]1([H])C2=NC(=C(C(=O)N2C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=NOC3=C2C([H])=C([H])C(F)=C3[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C(=N/C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1Cl)\C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C(N=C3C([H])=C([H])C([H])=C([H])C3=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])=C([H])C(Cl)=C2[H] [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C2([H])[H] [H]C1=C([H])C([H])=C2C(OC3=C(C([H])=C(Cl)C([H])=C3[H])[C@]3([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]23[H])=C1[H] [H]N([H])C(=O)C1(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1(C2=C([H])C(=C(Cl)C([H])=C2[H])C(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]O[C@@]12O[C@@](N([H])C(=O)[C@]3([H])C([H])=C4C5=C6C(N([H])C([H])=C6C([H])([H])[C@@]4([H])N(C([H])([H])[H])C3([H])[H])=C([H])C([H])=C5[H])(C(=O)N1[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]21[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])=C2C3=C([H])C([H])=C([H])C4=C3C(=C([H])N4[H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C1([H])[H] [H]N([C@]1([H])C([H])([H])N(C([H])([H])[H])[C@]2([H])C([H])([H])C3=C([H])N(C4=C([H])C([H])=C([H])C(=C34)[C@@]2([H])C1([H])[H])C([H])([H])[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])[C@]2([H])C([H])([H])C3=C([H])N(C4=C([H])C([H])=C([H])C(=C34)[C@@]2([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(SC([H])([H])[H])=C([H])C([H])=C1S2 [H]N([H])C([H])([H])C([H])([H])[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C([H])=C(C(=C1C([H])([H])[H])C([H])([H])C1=NC([H])([H])C([H])([H])N1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3(N([H])C(=O)N([H])C3=O)C([H])([H])C2([H])[H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])[H])C1=C([H])C(=NS1)C([H])([H])[H] [H]C1=C([H])C2=C3N(C([H])([H])C2([H])[H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]2([H])C3=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1Cl)C(=O)N([H])[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]O[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C(C([H])=C1[H])C1=NOC(=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])N(C1=C([H])C(Cl)=C([H])C([H])=C1S2)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C(SC4=C2C([H])=C(C([H])=C4[H])C(F)(F)F)C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N=C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C3=C(OC2=C1[H])C([H])=C([H])C(Cl)=C3[H] [H]N1C(=C(C2=C1C([H])([H])C([H])([H])[C@]([H])(C2=O)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3SC3=C2C([H])=C(Cl)C([H])=C3[H])C([H])([H])C1([H])[H] [H]N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N(C3=C(SC2=C1[H])C([H])=C([H])C(SC([H])([H])[H])=C3[H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]\C(=C1\C2=C([H])C([H])=C([H])C([H])=C2SC2=C1C([H])=C(C([H])=C2[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N(C3=C(SC2=C1[H])C([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])N([H])\N=C(\C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])S[C@@]([H])(Cl)C([H])([H])C1([H])[H] [H]OC1=C(C(=C([H])C([H])=C1C(=O)C([H])([H])[H])C([H])([H])OC1=C([H])C([H])=C(\C([H])=N\N([H])C(=N[H])N([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C(C(=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])[H])C([H])([H])OC1=C([H])C([H])=C(\C([H])=N\N([H])C(=N[H])N([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])\N=C(/[H])C1=C([H])C(OC2=C([H])C([H])=C(C([H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC1=C(C(=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])[H])C([H])([H])OC1=C([H])C([H])=C(\C([H])=N\N([H])C(=N[H])N([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])\N=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N=C(N([H])[H])N([H])\N=C(/[H])C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])C1=C([H])C([H])=C([H])S1)C([H])=C2[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(OC1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])S1 [H]N([H])C1=NC(=C([H])C(=N1)C1=C([H])C([H])=C(F)C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=S)N([H])C3=C(C([H])=C([H])C([H])=C3[H])C2=O)C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])F)=C1OC([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=S)N([H])C3=C(C([H])=C([H])C([H])=C3[H])C2=O)C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])C([H])([H])F)=C(OC([H])([H])[H])C(=C1[H])C(=N\OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])\C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=S)N(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C(N=C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C3=C1C([H])=C([H])C(Cl)=C3[H])C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C(=N2)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C(Cl)C([H])=C(Cl)C(OC([H])([H])[H])=C1C(=O)N([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C(Br)=C1OC([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(C(OC([H])([H])[H])=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(Br)=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=C2S(=O)(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C([H])=C2[H])S(=O)(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12 [H]O[C@]1(C([H])([H])C([H])([H])N2C([H])([H])[C@@]3([H])C4=C(C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C4=C3C(=C([H])C([H])=C4[H])[C@]2([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C(F)=C([H])C([H])=C2[C@](C1=O)(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])O[C@@]21[H] [H]OC1=C([H])C([H])=C2N([H])C(=C(C2=C1[H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2C([H])([H])C([H])([H])N([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C2=C1C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C(Cl)=N2)C(F)(F)F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(C2=C(OC([H])([H])[H])C([H])=C([H])C3=C2C([H])([H])C([H])([H])C3([H])[H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC1=C(Cl)C([H])=C2C(=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C2N(C3=C(SC2=C1[H])C([H])=C([H])C(C#N)=C3[H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C([H])([H])[C@]2([H])OC3=C(O[C@]2([H])C1([H])[H])C(F)=C([H])C([H])=C3[H] [H]N(C(=O)OC1=C([H])C([H])=C([H])C2=C1C1=C3C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]3([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C2=C(N([H])C3=C2C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C1[H] [H]N(C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])[H])[C@@]2([H])C([H])([H])C3=C([H])N(C4=C([H])C([H])=C([H])C(=C34)[C@@]2([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(Cl)C([H])=C(C(=O)N([H])[C@]2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[C@]2([H])OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N1C(Br)=C2C3=C(C([H])=C([H])C([H])=C13)C1=C([H])[C@@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])[C@]1([H])C2([H])[H] [H]N(C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])[H])[C@]2([H])C([H])([H])C3=C([H])N([H])C4=C([H])C([H])=C([H])C(=C34)[C@@]2([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])N2C(=NC(=C(C2=O)C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])=C1[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C(=O)N(N=C2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C([H])N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C([H])N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=NC1=C(O2)C([H])=C([H])C(Cl)=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1N=C([H])N=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(=C1O[H])C1=C3C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]3([H])C2([H])[H] [H]O[C@@]12O[C@@](N([H])C(=O)[C@]3([H])C([H])=C4C5=C([H])C([H])=C([H])C6=C5C(=C(Br)N6[H])C([H])([H])[C@@]4([H])N(C([H])([H])[H])C3([H])[H])(C(=O)N1[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]21[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C([H])=C([H])C([H])([H])N1C([H])([H])[C@@]([H])(C(=O)N(C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]2([H])C3=C4C(N([H])C([H])=C4C([H])([H])[C@]12[H])=C([H])C([H])=C3[H] [H]N1C([H])=C2C3=C(C([H])=C([H])C([H])=C13)[C@@]1([H])C([H])([H])[C@@]([H])(C([H])([H])SC([H])([H])[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C2([H])[H] [H]N1N=C([H])C2=C1C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C2([H])[H] [H]OC1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])N(C([H])([H])[H])[C@]2([H])C([H])([H])C3=C([H])N([H])C4=C3C(=C([H])C([H])=C4[H])[C@@]2([H])C1([H])[H] [H]OC1=C(O[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]([H])(C2([H])[H])[N+]([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C2([H])[H] [H]C1=C([H])N2C(=C1[H])C(=NC1=C2C([H])=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])C(=O)[C@]1([H])C([H])=C2C3=C4C(N([H])C([H])=C4C([H])([H])[C@]2([H])N(C([H])([H])[H])C1([H])[H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC(Cl)=C([H])N=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(OC2=C(OC([H])([H])[H])C([H])=C([H])C3=C2C([H])([H])C([H])([H])C3([H])[H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C2=C(C([H])=C(SC([H])([H])[H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]C1=C([H])N2C(=O)N(N=C2C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(C(=O)C([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(C#N)C(OC([H])([H])[H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(F)C(OC([H])([H])[H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(C(OC([H])([H])[H])=C1[H])[N+]([O-])=O [H]C1=C(OC([H])([H])[H])C(=C([H])C(OC([H])([H])[H])=C1Br)C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])Cl [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1F [H]C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1F [H]C1=C([H])C(=C([H])C([H])=C1F)[S@](=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1F [H]C1=C([H])C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])=C([H])C([H])=C1F [H]C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1F [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C2C(=C([H])C(F)=C1[H])C([H])([H])[C@]([H])(C2=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1F [H]C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1F [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(N=C(S2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C([H])C2=C(N=C(S2)C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C([H])C2=C(N=C(S2)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C([H])C2=C(N=C(S2)C(=O)C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]O[C@@]1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(F)C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]O[C@]1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]C1=NN2C(=C1C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=NN2C([H])=C(Cl)C([H])=C([H])C2=C1C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C2C([H])=C([H])C([H])=C([H])N2N=C1C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C2N=C([H])C([H])=C([H])N2N=C1C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])N2C([H])=C(Br)C([H])=C(C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4F)C([H])([H])C3([H])[H])C2=N1 [H]C1=C(N=C2C([H])=C([H])C([H])=C([H])N12)C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=NN2C([H])=C([H])C([H])=NC2=C1C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])N2C(=N1)C(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])([H])C1([H])[H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])N2C(=NC(=C2C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])([H])C2([H])[H])C([H])([H])[H])C([H])=C1[H] [H]C1=C(N=C2N1C([H])=C([H])C([H])=C2C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H])C#N [H]N([H])C1=C([H])C([H])=C([H])N2C([H])=C(N=C12)C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C2N(N=C1C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=C([H])N2C(=NC(C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4F)C([H])([H])C3([H])[H])=C2Br)C([H])=C1[H] [H]C1=NN2C([H])=C([H])C([H])=C([H])C2=C1C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C(Br)N=C2N1C([H])=C([H])C([H])=C2C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C(N2C([H])=C([H])C([H])=C([H])C2=N1)C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])N2C([H])=C([H])C([H])=C(C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4F)C([H])([H])C3([H])[H])C2=N1 [H]C1=C(Cl)N=C2N1C([H])=C([H])C([H])=C2C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C2=NC(=C([H])N12)C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])N2N=C(C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4F)C([H])([H])C3([H])[H])C(Br)=C2C([H])=C1[H] [H]C1=C([H])N2N=C(C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4F)C([H])([H])C3([H])[H])C(Cl)=C2C([H])=C1[H] [H]C1=NN2C(=C1[H])C([H])=C([H])C([H])=C2C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(Cl)=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=C2S(=O)(=O)N(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1I)S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC(F)(F)F)S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C(F)(F)F)S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(F)=C1[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])N2C([H])=C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C3=C([H])C([H])=C([H])C([H])=C3SC2=C1[H] [H]N([H])[C@]1([H])C2=C([H])C([H])=C3C4=C2C2=C1C([H])=C([H])C([H])=C2C([H])([H])[C@@]4([H])N(C([H])([H])[H])C([H])([H])C3([H])[H] [H]N1C([H])([H])C2=C(N=C(N=C2C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(N=C(N=C2C2=C([H])C([H])=C(F)C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C(=NC(=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C(=NC(=N2)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C(=NC(=N2)C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C(=NC(=N2)C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(N=C(N=C2C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(C(=NC(=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(C(=NC(=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(N=C(N=C2C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(N=C(N=C2C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(N=C(N=C2C2=C([H])C([H])=C(F)C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(N=C(N=C2C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(N=C(N=C2C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C(=NC(=N2)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C(=NC(=N2)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(N=C(N=C2C2=C([H])C([H])=C(F)C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(N=C(N=C2C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C(=NC(=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C(=NC(=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C(=NC(=N2)C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C(=NC(=N2)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])N3C([H])([H])C([H])([H])C([H])([H])S3(=O)=O)C([H])([H])C2([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N1C2=C([H])C([H])=C(F)C([H])=C2[C@@]([H])(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C(OC([H])([H])[H])C2=C([H])C([H])=C3OC(=C([H])C3=C12)C([H])([H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C(C2=C([H])C([H])=C3OC(=C([H])C3=C12)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C(C2=C([H])C([H])=C3OC(=C([H])C3=C12)C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C([H])C2=C([H])C([H])=C3OC(=C([H])C3=C12)C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C(OC([H])([H])[H])C2=C([H])C([H])=C3OC([H])=C([H])C3=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C(C2=C([H])C([H])=C3OC([H])=C([H])C3=C12)C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C(C2=C([H])C([H])=C3OC([H])=C([H])C3=C12)C([H])([H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C(C2=C([H])C([H])=C3OC([H])=C([H])C3=C12)C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C([H])C2=C([H])C([H])=C3OC([H])=NC3=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C([H])C2=C([H])C([H])=C3OC([H])=C([H])C3=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C([H])C2=C([H])C([H])=C3SC([H])=C([H])C3=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C([H])C2=C([H])C(Cl)=C(Cl)C([H])=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(Cl)=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C([H])C2=C([H])C(F)=C([H])C([H])=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C([H])C2=C([H])C([H])=C(Cl)C(Cl)=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C([H])C2=C([H])C([H])=C(F)C([H])=C12 [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C3OC([H])=C([H])C3=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(Br)C(Cl)=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(C#N)C(Cl)=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])OC3=C2C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2C(=C1Cl)C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(Cl)=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C(Cl)=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C(Cl)=C2C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(C(Cl)=C2C([H])([H])C1([H])[H])[N+]([O-])=O [H]C1=C(C(Cl)=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])[N+]([O-])=O [H]N([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C(F)=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C(F)=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C([H])=C(F)C([H])=C2C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C([H])=C(F)C([H])=C2C(=O)N1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C(F)=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [3H]C([3H])(N1CCC(CC1)C(=O)C1=CC=C(F)C=C1)C([3H])([3H])N1C(=O)NC2=C(C=CC=C2)C1=O [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([3H])([3H])[3H])C([H])([H])C([H])([H])C1=C(OC([3H])([3H])[3H])C([H])=C(I)C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(SC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1N=C2OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])=NC1=C(I)C([H])=C([H])C([H])=C21 [H]C1=C([H])C2=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(Cl)=C1N=C2OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(I)=C1N=C2OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C(I)C([H])=C3[H])C([H])([H])C1([H])[H])=NC1=C(F)C([H])=C([H])C([H])=C21 [H]N(C(=O)N([H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC(=C2[H])C(=O)N([H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(C4=C([H])C([H])=C([H])C(Cl)=C4Cl)C([H])([H])C3([H])[H])=C([H])C([H])=C2S1 [H]N1C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C(Cl)C(Cl)=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C12 [H]N1C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N=C(SC2=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N=C(SC2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C1([H])[H] [H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N=C(SC2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N=C(SC2=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C1([H])[H] [H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C1([H])[H] [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C1=NC3=C([H])C([H])=C([H])C([H])=C3S1)C([H])([H])C2([H])[H] [H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N=C(SC2=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C([H])C(=N1)N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C([H])C(=N1)N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])N3C2=NC(=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])N3C([H])=C(N=C23)C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])N3C([H])=C(Cl)N=C23)C([H])([H])C1([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])N3C([H])=C(F)N=C23)C([H])([H])C1([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])N3C(OC([H])([H])[H])=C([H])N=C23)C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N1[C@@]([H])(C([H])([H])[H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])N3C([H])=C([H])N=C23)C([H])([H])[C@]1([H])C([H])([H])[H] [H]OC(=O)[C@]1([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C3=C([H])C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])N4C([H])=C([H])N=C34)C([H])([H])C2([H])[H])C1([H])[H] [H]OC(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C3=C([H])C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])N4C([H])=C([H])N=C34)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])N3C(Cl)=C([H])N=C23)C([H])([H])C1([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])N3C([H])=C([H])N=C23)C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=N1)C(=O)C([H])([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C2([H])[H] [H]C1=NC2=C(C([H])=N1)C(=O)C([H])([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C3=NOC4=C3C([H])=C([H])C(F)=C4[H])C([H])([H])C1([H])[H])C2([H])[H] [H]C1=NC(SC([H])([H])[H])=NC2=C1C(=O)C([H])([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C3=NOC4=C3C([H])=C([H])C(F)=C4[H])C([H])([H])C1([H])[H])C2([H])[H] [H]N(C1=NC2=C(C([H])=N1)C(=O)C([H])([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C2([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C(=O)C([H])([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C3=NOC4=C3C([H])=C([H])C(F)=C4[H])C([H])([H])C1([H])[H])C2([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=N1)C(=O)C([H])([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=N1)C(=O)C([H])([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C3=NOC4=C3C([H])=C([H])C(F)=C4[H])C([H])([H])C1([H])[H])C2([H])[H] [H]C1=NC(SC([H])([H])[H])=NC2=C1C(=O)C([H])([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C2([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H])C2([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])N3C([H])=C([H])N=C23)C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])N3C([H])=C([H])N=C23)C([H])([H])C1([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])N3C([H])=C([H])N=C23)C([H])([H])C1([H])[H] [H]OC(=O)C(=C([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])N3C([H])=C([H])N=C23)C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C(F)=C([H])C([H])=C1OC([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])[H] [H]OC(=O)C1(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3([H])C([H])([H])C4=C(C5=C([H])C(=C([H])C([H])=C5N4[H])C(F)(F)F)[C@]([H])(C([H])([H])[H])[C@@]3([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(OC2=C1C([H])=C(C([H])=C2[H])C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]C1=C(OC2=C1C([H])=C(C([H])=C2[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=C2C([H])([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]2([H])OC([H])([H])C([H])([H])C2([H])[H])=C1[H] [H]N(C1=NC2=C([H])C(Cl)=C([H])C([H])=C2OC2=C1C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C(Cl)=C([H])C([H])=C3OC3=C2C([H])=C([H])C([H])=N3)C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C(=NC1=C([H])C(Cl)=C([H])C([H])=C1O2)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C(=NC1=C([H])C(Cl)=C([H])C([H])=C1O2)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C(=NC1=C([H])C(Cl)=C([H])C([H])=C1O2)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C([H])C(Cl)=C([H])C([H])=C2OC2=C1C([H])=C([H])C([H])=N2)C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C([H])C(Cl)=C([H])C([H])=C2OC2=C1C([H])=C([H])C([H])=N2)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C([H])C(Cl)=C([H])C([H])=C2OC2=C1C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C(=NC1=C([H])C(Cl)=C([H])C([H])=C1O2)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3OC3=C2C([H])=C(Cl)C([H])=C3[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)N1C([H])=C(C2=C([H])C(Cl)=C([H])N=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)N1C([H])=C(C2=C([H])C(Cl)=C([H])C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C(Br)C(F)=C([H])C(Br)=C1[H])S(=O)(=O)C1=C([H])C(N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(=C2[H])C([H])([H])N1N=C([H])N=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(O1)C([H])([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C2=O [H]C1=C2C(ON=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]3([H])C([H])([H])C4=C(C(=C(O4)C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H])C(=O)C3([H])[H])C([H])([H])C2([H])[H])=C([H])C(F)=C1[H] [H]C1=C(OC2=C1C(=O)C([H])([H])[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C3=NOC4=C([H])C(F)=C([H])C([H])=C34)C([H])([H])C1([H])[H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C(=O)OC([H])([H])[H])C2=C(O1)C([H])([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C3=NOC4=C([H])C(F)=C([H])C([H])=C34)C([H])([H])C1([H])[H])C([H])([H])C2=O [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])C([H])([H])C3=C(C(=C(O3)C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C(OC2=C1C(=O)C([H])([H])[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C(=O)OC([H])([H])[H])C2=C(O1)C([H])([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C2=O [H]C1=C([H])C2=C(O1)C([H])([H])[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C3=NOC4=C([H])C(F)=C([H])C([H])=C34)C([H])([H])C1([H])[H])C([H])([H])C2=O [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C(C([H])=C1[H])C1=NOC(=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])C3(C2=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1N=C([H])C(N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])=C(Cl)C1=O [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])N1N=C([H])C(N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])=C(Cl)C1=O [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C(=C([H])C([H])=C1[H])C([H])([H])N1N=C([H])C(N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])=C(Cl)C1=O)C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C(=C([H])C([H])=C1[H])C([H])([H])N1N=C([H])C(N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])=C(Cl)C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C(OC([H])([H])[H])C([H])=C1[H])C1=C(C(=C([H])C([H])=C1[H])C([H])([H])N1N=C([H])C(=C([H])C1=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C(=C([H])C([H])=C1[H])C([H])([H])N1N=C([H])C(=C([H])C1=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=O)C([H])([H])OC2=C([H])C([H])=C(C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C(OC([H])([H])[H])C([H])=C1[H])C1=C(C(=C([H])C([H])=C1[H])C([H])([H])N1N=C([H])C(N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])=C(Cl)C1=O)C([H])([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=O)C([H])([H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C2C(OC([H])([H])[C@]([H])(C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)C([H])([H])C4(C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C3=O)C2([H])[H])=C1[H] [H]C1=C([H])C(OC([H])([H])[H])=C2C(OC([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)C([H])([H])C4(C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C3=O)C2([H])[H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=O)C([H])([H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2C1([H])[H] [H]C1=C([H])C2=C(C([H])=N1)N1O[C@@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]N1C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1([H])[H] Cl[H].[H][C@]12CNC[C@]1([H])C1=CC(CC)=CC(=C1C(=O)N2)C(F)(F)F Cl[H].[H][C@]12CNC[C@]1([H])C1=CC=C(Cl)C(Cl)=C1C(=O)N2 Cl[H].[H][C@]12CNC[C@]1([H])C1=CC=CC(C)=C1C(=O)N2 Cl[H].[H][C@]12CNC[C@]1([H])C1=CC=CC(Cl)=C1C(=O)N2 Cl[H].[H][C@]12CNC[C@]1([H])C1=CC(=CC(C)=C1C(=O)N2)C(C)C Cl[H].[H][C@]12CNC[C@]1([H])C1=CC(CC)=CC(Cl)=C1C(=O)N2C Cl[H].[H][C@]12CNC[C@]1([H])C1=CC=CC=C1C(=O)N2 Cl[H].[H][C@@]12CNC[C@@]1([H])C1=CC=CC(=C1C(=O)N2)C(F)(F)F Cl[H].[H][C@]12CNC[C@]1([H])C1=CC=C(C)C(Cl)=C1C(=O)N2 [H][C@]12CCNC[C@@]1([H])C1=CC(=CC3=C1N2CCC3)C1=C(C=C(OC)C=C1)C(F)(F)F [H][C@]12CCNC[C@@]1([H])C1=CC=CC3=C1N2CCCS3 Cl[H].[H][C@]12CNC[C@]1([H])C1=C(CC)C=CC(Cl)=C1C(=O)N2 Cl[H].[H][C@]12CNC[C@]1([H])C1=CC(C)=CC(Cl)=C1C(=O)N2 Cl[H].[H][C@]12CNC[C@]1([H])C1=CC(C)=CC(C)=C1C(=O)N2 [H][C@@]12CN(C)C[C@@]1([H])C1=C(OC3=C2C=CC=C3)C=CC(Cl)=C1 [H]N1C(=O)[C@@]2([H])N(C3=C([H])C(Cl)=C(Cl)C([H])=C13)C([H])([H])C([H])([H])N([H])C2([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC(OC([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])=C([H])N=C2[H])C([H])([H])C1([H])[H] OC(=O)\C=C\C(O)=O.C[C@H](N)CN1C=CC2=CC(F)=C(Cl)C=C12 C(OC1=NOC2=C1CCNCC2)C1=CC=CC=C1 O=C1N(CC2=CC=CC=C2)OC2=C1CCNCC2 [H]OC1=C(OC([H])([H])[H])C2=C(C([H])=C1[H])C([H])([H])[C@]1([H])N(C2([H])[H])C([H])([H])C([H])([H])C2=C([H])C(O[H])=C(OC([H])([H])[H])C([H])=C12 [H][C@@]12CC3=C(CN1CCC1=CC4=C(OCC4)C=C21)C(OC)=C(O)C=C3 [H][C@@]12CC3=C(CN1CCC1=CC4=C(OCCO4)C=C21)C(OC)=C(O)C=C3 CN1C=NC(=N1)C1=CC2=C(C=C1)N(C=C2C1CCN(C)CC1)C1=CC=C(F)C=C1 ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNS(=O)(=O)C2=CN=CC3=CC=CC=C23)CC1 ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNS(=O)(=O)C2=CC3=CC=CC=C3C=N2)CC1 ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNS(=O)(=O)C2=CC=CC3=CC=CN=C23)CC1 ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNS(=O)(=O)C2=CC3=NC=CC=C3C=C2)CC1 ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNS(=O)(=O)C2=CC3=CC=CN=C3C=C2)CC1 ClC1=CC=C2N=CC(=CC2=C1)S(=O)(=O)NCCCCN1CCN(CC1)C1=CC=CC(Cl)=C1Cl ClC1=C(Cl)C(=CC=C1)N1CCN(CCCNS(=O)(=O)C2=CC3=NC=CC=C3C=C2)CC1 ClC1=C(Cl)C(=CC=C1)N1CCN(CCCNS(=O)(=O)C2=CC3=CC=CN=C3C=C2)CC1 ClC1=CC=C2N=CC(=CC2=C1)S(=O)(=O)NCCCN1CCN(CC1)C1=CC=CC(Cl)=C1Cl Cl[H].COCCCOC1=CC(=CC=C1OC)C(=O)N(C[C@@H]1CNC[C@H]1CC1=CC=CC=C1)C(C)C [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)[C@]([H])(OC([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])S(=O)(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]O[C@@]([H])(C([H])([H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C(O1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(O1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])[C@]3([H])C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)N([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=NC([H])=C([H])C5=C4C([H])=C([H])O5)C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(O1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])=C([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])=C([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(O1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])=C([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(O1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(O1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(O1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(O1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(O1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(O1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])=C([H])S4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])[C@]3([H])C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])=C([H])S4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)N([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=NC([H])=C([H])C5=C4C([H])=C([H])S5)C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(O1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C3=C4C([H])=C([H])C([H])=C([H])C4=NC([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4([H])C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C4([H])C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])[C@@]4([H])OC([H])([H])C([H])([H])OC4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]OC([H])([H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)[C@@]4([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)[C@@]4([H])OC([H])([H])C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C(Cl)C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C(C([H])=C4[H])C(F)(F)F)C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])S(=O)(=O)C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)[C@@]4([H])C([H])([H])OC([H])([H])C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]O[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(C(=O)C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=NC([H])=C([H])C5=C4C([H])([H])C([H])([H])O5)C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C(C([H])=C4[H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C(C([H])=C4[H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]OC1(C(=O)C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=NC([H])=C([H])C5=C4C([H])([H])C([H])([H])O5)C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C#N)C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C(F)(F)F)C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C5C([H])=C([H])C([H])=C([H])C5=NC([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])[C@@]4([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)[C@]4([H])C([H])([H])C4(F)F)C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C4([H])C([H])([H])OC4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C(C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])=C(C([H])([H])[H])C([H])([H])[H] [H]\C(=C(\[H])C([H])([H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C#CC([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C(ON=C1C([H])([H])[H])C([H])([H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C(ON=C1C([H])([H])[H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]O[C@]([H])(C([H])([H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C(F)(F)F [H]O[C@]1([H])C([H])([H])O[C@@]([H])(C([H])([H])C(=O)C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=NC([H])=C([H])C5=C4C([H])([H])C([H])([H])O5)C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C2=C(O1)C([H])=C(N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(O1)C([H])=C(N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(O1)C([H])=C(N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(O1)C([H])=C(N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C(N=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C2=C1OC([H])([H])C2([H])[H])C([H])([H])[H] [H]C1=C(N=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4([H])C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C2=C1OC([H])([H])C2([H])[H])C([H])([H])[H] [H]C1=C(N=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C4([H])C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C2=C1OC([H])([H])C2([H])[H])C([H])([H])[H] [H]C1=C(N=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C2=C1OC([H])([H])C2([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(O1)C(=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(O1)C(=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2)C([H])([H])[H] [H]C1=C([H])C2=C(O1)C(=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(O1)C(=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4([H])C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2)C([H])([H])[H] [H]C1=C(C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C4([H])C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2)C([H])([H])[H] [H]C1=C(C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2)C([H])([H])[H] [H]O[C@]([H])(C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C(F)(F)F [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C([H])(OC([H])([H])[H])OC([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C([H])([H])C([H])(OC([H])([H])[H])OC([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C(SC(=C1[H])S(=O)(=O)C([H])([H])[H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])N=C(C([H])=C4[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C(C#N)C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C(C([H])=C4[H])N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])N=C(C([H])=C4[H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C5OC([H])([H])OC5=C4[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C(C([H])=C4[H])N4C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=NN(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C([H])C(=C4[H])C4=NOC(=N4)C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C4=NOC5=C([H])C([H])=C([H])C([H])=C45)C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=NC([H])=C(N=C4[H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C(C([H])=C4[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C(Cl)C([H])=C4Cl)C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])N(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C(C([H])=C4[H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2