[H]N([H])C1=C(C([H])=C(SC2=NC([H])=C([H])N2C([H])([H])[H])C(F)=C1[H])C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C(C([H])=C(SC2=NC([H])=C([H])N2C([H])([H])[H])C(F)=C1[H])C(=O)N([H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N([H])C1=C([H])C(F)=C(SC2=NC([H])=C([H])N2C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC([H])=C([H])S1 [H]N([H])C1=C(C([H])=C(SC2=NC([H])=C([H])N2C([H])([H])[H])C(F)=C1[H])C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]N([H])C1=C(C([H])=C(SC2=NC([H])=C([H])N2C([H])([H])[H])C(F)=C1[H])C(=O)N([H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])C([H])([H])C3=C([H])N=C([H])C([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(SC([H])([H])[H])=C([H])C([H])=C2OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(\C([H])=C(/[H])C2=C([H])C(SC([H])([H])[H])=C([H])C([H])=C2OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])C([H])([H])C3=C([H])SC([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])C([H])([H])C3=C([H])C([H])=NC([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3F)=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3Cl)=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3F)=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3F)=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])C([H])([H])C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@]([H])(C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(SC2=NN=C([H])N2C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C(=O)OC([H])([H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])SC(=N1)N([H])C(=O)C1=C([H])C(SC2=NN=C([H])N2C([H])([H])[H])=C([H])C([H])=C1N([H])[H] [H]N([H])C1=C([H])C([H])=C(SC2=NN=C([H])N2C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C(F)(F)F [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC([H])=C(F)S1 [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC([H])=C(F)S1 [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC([H])=C(F)S1 [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC([H])=C(F)S1 [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC([H])=C(S1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC([H])=C([H])S1 [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C(=C(/[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])\C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C(=C(/[H])C1=C([H])C([H])=C([H])S1)\C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=NC([H])=C([H])S1 [H]N([H])C1=C([H])C([H])=C(SC([H])([H])C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(SC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(SC2=C([H])C([H])=C([H])C([H])=N2)C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(SC2=NC([H])=C([H])N2[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(SC2=NC([H])=C([H])N2C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(SC2=NN=C([H])N2[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(SC2=NN=C([H])N2C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(SC2=NN=C([H])N2C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC([H])=NS1 [H]N([H])C1=C([H])C([H])=C(SC2=NN=C([H])N2C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC(=NS1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(SC2=NN=C([H])N2C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(SC2=NN=C([H])N2C([H])([H])[H])=C([H])C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(SC2=NN=C([H])N2C([H])([H])[H])=C([H])C([H])=C1N([H])C([H])([H])[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(OC2=C(F)C([H])=C([H])C([H])=C2[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(OC2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(OC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(OC2=C(C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(SC2=NN=C([H])N2C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC([H])=C([H])S1 [H]N([H])C1=C([H])C([H])=C(SC2=NN=C([H])N2C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC([H])=C(S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C(C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C([H])C(=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C(C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C(C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(OC([H])([H])C([H])([H])[H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C(C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C(C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C([H])C(=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C([H])C(=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C(F)C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C([H])C(F)=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(Cl)C([H])=C1C(=O)N([H])C1=NC([H])=C([H])S1 [H]N([H])C1=C([H])C([H])=C(Cl)C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=NC(SC2=NN=C([H])N2C([H])([H])[H])=C([H])C([H])=C1SC1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(SC2=NN=C([H])N2C([H])([H])[H])=C([H])C([H])=C1SC1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=NC(SC2=NN=C([H])N2C([H])([H])[H])=C([H])C([H])=C1SC1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=NC(SC2=NN=C([H])N2[H])=C([H])C([H])=C1SC1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=NC(SC2=NN=C([H])N2[H])=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1F)C1=NC([H])=C([H])S1 [H]N(C(=O)C1=NC(SC2=NN=C([H])N2[H])=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C(F)=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=NC(SC2=NN=C([H])N2[H])=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=NC(SC2=NN=C([H])N2[H])=C([H])C([H])=C1SC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=NC(SC2=NN=C([H])N2[H])=C([H])C([H])=C1SC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=NC([H])=C([H])S1 [H]N(C(=O)C1=NC(SC2=NN=C([H])N2[H])=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=NC(SC2=NN=C([H])N2[H])=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]N([H])C([H])([H])[C@]([H])(OC1=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(=O)N([H])C1=NC([H])=C([H])S1)C([H])([H])[H] [H]O[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])OC1=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(=O)N([H])C1=NC([H])=C([H])S1 [H]OC([H])([H])C([H])([H])OC1=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(=O)N([H])C1=NC([H])=C([H])S1 [H]OC([H])([H])[C@]([H])(OC1=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(=O)N([H])C1=NC([H])=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(O[C@@]2([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C(O[C@]([H])(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C(OC([H])(C([H])([H])OC([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C(OC2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C(O[C@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C(O[C@@]([H])(C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]OC([H])([H])[C@]([H])(OC1=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(=O)N([H])C1=NC([H])=C([H])S1)C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@]([H])(OC1=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(=O)N([H])C1=NC([H])=C([H])S1)C(F)(F)F [H]OC([H])([H])C([H])([H])[C@]([H])(OC1=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(=O)N([H])C1=NC([H])=C([H])S1)C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(=O)N([H])C1=NC([H])=C([H])S1 [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])N1C([H])=NC([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C1=C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])=C2N=C(N([H])C2=C1[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N(C1=NC(=C([H])S1)C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C12 [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C([H])=C([H])C([H])=C3[H])S(=O)(=O)C([H])([H])[H])C([H])=C12 [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C12 [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(F)C([H])=C([H])C([H])=C3F)C([H])=C12 [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C([H])=C([H])C([H])=C3F)S(=O)(=O)C([H])([H])[H])C([H])=C12 [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C([H])=C([H])C([H])=C3Cl)S(=O)(=O)C([H])([H])[H])C([H])=C12 [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C([H])=C([H])C([H])=C3C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])=C12 [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C([H])=C(C([H])=C3[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])=C12 [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C#N)C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])=C12 [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=N3)C([H])=C12 [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C([H])N=C([H])C([H])=N3)C([H])=C12 [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C([H])C([H])=NC([H])=N3)C([H])=C12 [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(F)C([H])=C([H])C([H])=N3)C([H])=C12 [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(Cl)C([H])=C([H])C([H])=N3)C([H])=C12 [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(Br)C([H])=C([H])C([H])=N3)C([H])=C12 [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C([H])=C([H])C([H])=N3)C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C12 [H]OC([H])([H])C1=C(OC2=C([H])C([H])=C3N=C([H])N=C(N([H])C4=NN(C([H])=C4[H])C([H])([H])[H])C3=C2[H])N=C([H])C([H])=C1[H] [H]N(C1=NN(C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C([H])=C([H])C([H])=C3F)S(=O)(=O)C([H])([H])[H])C([H])=C12 [H]N(C1=NN([H])C([H])=C1[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C([H])=C([H])C([H])=C3F)S(=O)(=O)C([H])([H])[H])C([H])=C12 [H]N(C1=NC(=NS1)C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C([H])=C([H])C([H])=C3F)S(=O)(=O)C([H])([H])[H])C([H])=C12 [H]N(C1=NN=C([H])C([H])=C1[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C([H])=C([H])C([H])=C3F)S(=O)(=O)C([H])([H])[H])C([H])=C12 [H]N(C1=NC([H])=C([H])N=C1[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C([H])=C([H])C([H])=C3F)S(=O)(=O)C([H])([H])[H])C([H])=C12 [H]N(C1=NC([H])=C(N=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C([H])=C([H])C([H])=C3F)S(=O)(=O)C([H])([H])[H])C([H])=C12 [H]N(C1=NC([H])=C(Cl)N=C1[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C([H])=C([H])C([H])=C3F)S(=O)(=O)C([H])([H])[H])C([H])=C12 [H]N(C1=NC([H])=C([H])S1)C1=NC([H])=NC2=C([H])C([H])=C(SC3=NN=C([H])N3C([H])([H])[H])C([H])=C12 [H]N(C1=NC(=C([H])S1)C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(SC3=NN=C([H])N3C([H])([H])[H])C([H])=C12 [H]N(C1=NC(=C([H])S1)C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C([H])=C([H])C([H])=C3[H])S(=O)(=O)C([H])([H])[H])C([H])=C12 [H]N(C1=NC(=C([H])S1)C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(F)C([H])=C([H])C([H])=C3[H])C([H])=C12 [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])N1C(=O)N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])N1C(=O)N([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])S1(=O)=O)C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])N1C(=O)C([H])([H])OC([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1=O)C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])N1C(=O)OC([H])([H])C1=O)C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])N1C(=O)N(C([H])([H])[H])C([H])([H])C1=O)C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])N1C(=O)OC([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])C1=NN=NN1C([H])([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])C(=O)OC([H])([H])C([H])([H])[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3F)=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C([H])C(=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(F)C([H])=C3[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(F)C([H])=C3[H])=C(C([H])=C12)[C@]1([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(F)C([H])=C3[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C([H])C(F)=C3[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C(OC2=C(C([H])=C3N([H])C(=NC3=C2[H])C2=NC([H])=C([H])C([H])=C2[H])[C@]2([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C([H])C(C#N)=C3[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C#N)C([H])=C3[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])[N+]([O-])=O)=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC(=C([H])S1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C2[H])C([H])=C1[H] [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC(=C([H])S1)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC(=C([H])S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC2=C(S1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC(=O)C([H])([H])S1 [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC2=C(S1)C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC(=C(Br)S1)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC2=C(S1)C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC(=C(S1)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC(=C([H])S1)C([H])(C([H])([H])[H])C([H])([H])[H] [H]C([H])=C(C1=C([H])SC(=N1)N([H])C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1C([H])([H])[H])C1=C(C#N)C([H])=NC([H])=C1\C([H])=C(/[H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(OC3=C([H])C(F)=C([H])C(F)=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])C3=C([H])C(F)=C([H])C(F)=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C(Cl)O3)=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(OC([H])([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(OC([H])([H])C(F)(F)C3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC3([H])C([H])([H])C4=C(C([H])=C([H])C([H])=C4[H])C3([H])[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(OC3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(OC3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(OC3=C([H])C([H])=C([H])C(Cl)=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(OC3=C([H])C([H])=C(Cl)C([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(OC3=C([H])C([H])=C([H])C(F)=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(OC3=C([H])C([H])=C([H])C(=C3[H])N(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])=C2[H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C(Cl)C1=O)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C(Cl)C(=C([H])C1=O)S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=N1 [H]N(C(=O)[C@@]([H])(N1C([H])=C(C(=C([H])C1=O)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C(Cl)C(=C([H])C1=O)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NN(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C(F)(F)F [H]N(C(=O)[C@@]([H])(N1C([H])=C(C(=C([H])C1=O)S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C(Cl)C(=C([H])C1=O)S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])N=C([H])C([H])=N1 [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]N([H])C1=C([H])C(F)=C(SC2=NC([H])=C([H])N2C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])S1 [H]N(C(=O)[C@@]([H])(N1C([H])=C(Cl)C(=C([H])C1=O)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])N=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NN([H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NN(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])N=C([H])C([H])=N1 [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])S1 [H]N(C(=O)[C@@]([H])(C1=C([H])C(Cl)=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C(=O)C([H])([H])C1([H])[H])C1=C([H])N=C([H])C([H])=N1 [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NN(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])N=C(C([H])=N1)C([H])([H])[H] [H]N([H])C(=O)[C@@]1([H])[C@]2([H])C([H])=C([H])[C@@]([H])(C2([H])[H])[C@@]1([H])N([H])C1=NC(=NC([H])=C1Cl)N([H])C1=C([H])C([H])=C2C(=C1OC([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C(O2)C([H])([H])[H])C(OC2=C([H])N=C(C([H])=N2)C(=O)N(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=NC([H])=C(N=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C(O2)C([H])([H])[H])C(OC2=C([H])N=C(N=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=NC([H])=C(N=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1N=C(N([H])C(=O)[C@@]([H])(N2C([H])=NC(=C2[H])C(F)(F)F)C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)C(=O)N([H])C1=C([H])C([H])=C(N=C1[H])N([H])C(=O)[C@@]([H])(N1C([H])=NC(=C1[H])C(F)(F)F)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=NC(=C1[H])C(F)(F)F)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C1=NN=NN1[H] [H]OS(=O)(=O)C1=C([H])C([H])=C(N=C1[H])N([H])C(=O)[C@@]([H])(N1C([H])=NC(=C1[H])C(F)(F)F)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(N=C1[H])N([H])C(=O)[C@@]([H])(N1C([H])=NC(=C1[H])C(F)(F)F)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(N=C1[H])N([H])C(=O)[C@@]([H])(N1C([H])=NC(=C1[H])C(F)(F)F)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=NC(=C1[H])C(F)(F)F)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(O[C@@]([H])(C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)OC([H])([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C2([H])C([H])([H])C2([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H])C1=NN(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C2([H])C([H])([H])C2([H])[H])=C1[H])C1=NC([H])=C(F)S1 [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H])C1=NC([H])=C(F)S1 [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])=C1[H])C1=NC([H])=C(F)S1 [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C1[H])C1=NC([H])=C(F)S1 [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])[C@]([H])(F)C2([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])[C@]([H])(F)C2([H])[H])=C1[H])C1=NC([H])=C(F)S1 [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])C([H])(OC([H])([H])[H])C([H])([H])C2([H])[H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])C([H])(OC([H])([H])[H])C([H])([H])C2([H])[H])=C1[H])C1=NC([H])=C(F)S1 [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C2([H])C([H])([H])C2([H])[H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C2([H])C([H])([H])C2([H])[H])=C1[H])C1=NC(=C([H])S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C2([H])C([H])([H])C2([H])[H])=C1[H])C1=NC(=O)C([H])([H])S1 [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C2([H])C([H])([H])C2([H])[H])=C1[H])C1=NN(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C2([H])C([H])([H])C2([H])[H])=C1[H])C1=C([H])N=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C2([H])C([H])([H])C2([H])[H])=C1[H])C1=NC([H])=C([H])N2C([H])=C([H])N=C12 [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H])C1=NN(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])=C1[H])C1=NN(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])=C1[H])C1=NN(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C1[H])C1=NN(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C1[H])C1=NN(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])[C@]([H])(F)C2([H])[H])=C1[H])C1=NN(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])[C@]([H])(F)C2([H])[H])=C1[H])C1=NN(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])C([H])(OC([H])([H])[H])C([H])([H])C2([H])[H])=C1[H])C1=NN(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])C([H])(OC([H])([H])[H])C([H])([H])C2([H])[H])=C1[H])C1=NN(C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])N=C2N(C([H])=C([H])C([H])=C2C2=C(F)C([H])=C([H])C([H])=C2F)C1=O [H]N([H])C1=NN2C([H])=C(N=C([H])C2=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] CC1=CC(=CC(=O)N1[C@@H](CC1CCCC1)C(=O)NC1=NC=C(Cl)S1)S(=O)(=O)C1CC1 CC1=CC(=CC(=O)N1[C@@H](CC1CCCCO1)C(=O)NC1=NC=C(Cl)S1)S(=O)(=O)C1CC1 CC1=CC(=CC(=O)N1[C@@H](CC1CCCC1)C(=O)NC1=NC=C(F)S1)S(=O)(=O)C1CC1 CC1=CC(=CC(=O)N1[C@@H](CC1CCCCO1)C(=O)NC1=NC=C(F)S1)S(=O)(=O)C1CCCC1 CC1=CC(=CC(=O)N1[C@@H](CC1CCCCO1)C(=O)NC1=NC=C(Cl)S1)S(=O)(=O)C1CCCC1 CCCCC(N1C(C)=CC(=CC1=O)S(=O)(=O)C1CCCC1)C(=O)NC1=NC=CS1 CC1=CC(=CC(=O)N1C(CC1CCCCO1)C(=O)NC1=NC=CS1)S(=O)(=O)C1CCCC1 CC1=CC(=CC(=O)N1C(CC1CCCC1)C(=O)NC1=NC=CS1)S(=O)(=O)C1CCCC1 CC(C)CC(N1C(C)=CC(=CC1=O)S(=O)(=O)C1CCCC1)C(=O)NC1=NC=CS1 CCS(=O)(=O)C1=CC(=O)N([C@@H](CC2CCCCC2)C(=O)NC2=NC=CS2)C(C)=C1 CC1=CC(=CC(=O)N1[C@@H](CC1CCCCC1)C(=O)NC1=NC=CS1)S(C)(=O)=O CC(C)S(=O)(=O)N1CCN([C@@H](CC2CCCCC2)C(=O)NC2=NC=CS2)C(=O)C1 O=C(NC1=NC=CS1)[C@H](CC1CCCCC1)N1CCN(CC1=O)S(=O)(=O)CC1=CC=CC=C1 O=C(NC1=NC=CS1)[C@H](CC1CCCCC1)N1CCN(CC1=O)S(=O)(=O)C1=CC=CO1 CC1=CC=C(C(F)=C1)S(=O)(=O)N1CCN([C@@H](CC2CCCCC2)C(=O)NC2=NC=CS2)C(=O)C1 CC1=CC=CC(=C1)S(=O)(=O)N1CCN([C@@H](CC2CCCCC2)C(=O)NC2=NC=CS2)C(=O)C1 FC1=CC(=CC(F)=C1)S(=O)(=O)N1CCN([C@@H](CC2CCCCC2)C(=O)NC2=NC=CS2)C(=O)C1 ClC1=CC=CC(=C1)S(=O)(=O)N1CCN([C@@H](CC2CCCCC2)C(=O)NC2=NC=CS2)C(=O)C1 CS(=O)(=O)N1CCN([C@@H](CC2CCCCO2)C(=O)NC2=NC=C(Cl)S2)C(=O)C1 ClC1=CN=C(NC(=O)[C@H](CC2CCCCO2)N2CCN(CC2=O)S(=O)(=O)C2CC2)S1 O=C(NC1=NC=CS1)[C@H](CC1CCCCC1)N1CCN(CC1=O)S(=O)(=O)C1CCCC1 O=C(NC1=NC=CS1)C(CC1CCCCC1)N1CCN(CC1=O)S(=O)(=O)C1CC1 CS(=O)(=O)N1CCN(C(CC2CCCCC2)C(=O)NC2=NC=CS2)C(=O)C1 O=C(NC1=NC=CS1)[C@H](CC1CCCC1)N1C=NC2=C(C=CC(=C2)S(=O)(=O)C2CC2)C1=O CCS(=O)(=O)C1=CC2=C(C=C1)C(=O)N(C=N2)[C@@H](CC1CCCCO1)C(=O)NC1=NC=C(F)S1 CCS(=O)(=O)C1=CC2=C(C=C1)C(=O)N(C=N2)[C@@H](CC1CCCCC1)C(=O)NC1=NC=C(F)S1 ClC1=CN=C(NC(=O)[C@H](CC2CCCCC2)N2C=NC3=C(C=CC(=C3)S(=O)(=O)C3CCCC3)C2=O)S1 FC1=CN=C(NC(=O)[C@H](CC2CCCCC2)N2C=NC3=C(C=CC(=C3)S(=O)(=O)C3CCCC3)C2=O)S1 CNC(=O)C1=CC2=C(C=C1)C(=O)N(C=N2)[C@@H](CC1CCCCC1)C(=O)NC1=NC=C(Cl)S1 CC1=CC2=C(C=C1)N=CN([C@@H](CC1CCCCC1)C(=O)NC1=NC=CS1)C2=O FC1=CC2=C(C=C1)N=CN([C@@H](CC1CCCCC1)C(=O)NC1=NC=CS1)C2=O ClC1=CC2=C(C=C1)N=CN(C(CC1CCCCC1)C(=O)NC1=NC=CS1)C2=O ClC1=CN=C(NC(=O)C(CC2CCCCO2)N2C=NC3=C(C=CC(=C3)C(=O)NC3CC3)C2=O)S1 CS(=O)(=O)C1=CC2=C(C=C1)C(=O)N(C=N2)[C@@H](CC1CCCCC1)C(=O)NC1=NC=CS1 CS(=O)(=O)C1=CC2=C(C=C1)C(=O)N(C(CC1CCCCC1)C(=O)NC1=NC=C(Cl)S1)C(=O)N2 FC1=CC2=C(NC(=O)N([C@@H](CC3CCCCC3)C(=O)NC3=NC=CS3)C2=O)C=C1 ClC1=CC2=C(C=C1)C(=O)N([C@@H](CC1CCCCC1)C(=O)NC1=NC=CS1)C(=O)N2 O=C(NC1=NC=CS1)[C@H](CC1CCCCC1)N1C(=O)NC2=C(C=CC=C2)C1=O CS(=O)(=O)C1=CC2=C(C=C1)C(=O)N([C@@H](CC1CCCCC1)C(=O)NC1=NC=CS1)C(=O)N2 COC[C@H](C)OC1=CC(CCC2=C(F)C=CC=C2F)=CC(=C1)C(=O)NC1=NC=C(C=C1)C(O)=O COC[C@H](C)OC1=CC(\C=C\C2=CC=CC=C2OC)=CC(=C1)C(=O)NC1=NC=C(C=C1)C(O)=O COC[C@H](C)OC1=CC(\C=C\C2=CC(F)=CC(F)=C2F)=CC(=C1)C(=O)NC1=NC=C(C=C1)C(O)=O COC[C@H](C)OC1=CC(\C=C\C2=C(F)C=CC=C2F)=CC(=C1)C(=O)NC1=NC=C(C=C1)C(O)=O COC[C@H](C)OC1=CC(\C=C\C2=CC(F)=CC=C2F)=CC(=C1)C(=O)NC1=NC=C(C=C1)C(O)=O COC[C@H](C)OC1=CC(\C=C\C2=CC=C(F)C=C2F)=CC(=C1)C(=O)NC1=NC=C(C=C1)C(O)=O COC[C@H](C)OC1=CC(\C=C\C2=CC=C(F)C=C2)=CC(=C1)C(=O)NC1=NC=C(C=C1)C(O)=O COC[C@H](C)OC1=CC(\C=C\C2=CC=CC=C2F)=CC(=C1)C(=O)NC1=NC=C(C=C1)C(O)=O COC[C@H](C)OC1=CC(\C=C\C2=CC=C(C=C2)[N+]([O-])=O)=CC(=C1)C(=O)NC1=NC=C(C=C1)C(O)=O COC[C@H](C)OC1=CC(\C=C\C2=CC=CC(=C2)[N+]([O-])=O)=CC(=C1)C(=O)NC1=NC=C(C=C1)C(O)=O COC[C@H](C)OC1=CC(\C=C\C2=CC=CC=C2[N+]([O-])=O)=CC(=C1)C(=O)NC1=NC=C(C=C1)C(O)=O COC[C@H](C)OC1=CC(CCC2=CC=CC=C2OC)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(CCC2=CC(F)=CC(F)=C2F)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(CCC2=C(F)C=CC=C2F)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(CCC2=CC=C(F)C=C2F)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(CCC2=CC=C(F)C=C2)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(CCC2=CC=CC=C2F)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(\C=C\C2=CC=CC(C)=N2)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(\C=C\C2=CC=CC=C2OC)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(\C=C\C2=CC(F)=CC(F)=C2F)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(\C=C\C2=C(F)C=CC=C2F)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(\C=C\C2=CC(F)=CC=C2F)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(\C=C\C2=CC=C(F)C=C2F)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(\C=C\C2=CC=C(F)C=C2)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(\C=C\C2=CC=CC=C2F)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(\C=C\C2=CC=C(C=C2)[N+]([O-])=O)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(\C=C\C2=CC=CC(=C2)[N+]([O-])=O)=CC(=C1)C(=O)NC1=NN(C)C=C1 COC[C@H](C)OC1=CC(\C=C\C2=CC=CC=C2[N+]([O-])=O)=CC(=C1)C(=O)NC1=NN(C)C=C1 [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C2=C([H])N([H])C3=NC([H])=C([H])C(=C23)C2=C(N([H])C1=O)C([H])=C([H])C([H])=C2[H]