[H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1\N=N\C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1O[H])S(=O)(=O)O[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(I)C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(\N=N\C2=C(O[H])N(N=C2C([H])([H])[H])C2=C([H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H])C(O[H])=C1[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])[H] [H]OC(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(\N=N\C2=C(O[H])N(N=C2C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(O[H])=C1[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(=C2C([H])=C([H])C([H])=C([H])C2=C1\N=N\C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1O[H])S(=O)(=O)O[H] [H]OC1=C([H])C(=C2C([H])=C([H])C([H])=C([H])C2=C1\N=N\C1=C2C([H])=C([H])C([H])=C([H])C2=C(O[H])C([H])=C1OC([H])([H])[H])S(=O)(=O)O[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(OC([H])([H])C([H])([H])[H])=NN1C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C([H])=NN1C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1\N=N\C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1O[H])S(=O)(=O)O[H])C([H])([H])[H] [H]OC1=C([H])C(=C2C([H])=C([H])C([H])=C([H])C2=C1\N=N\C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C(O[H])=C1O[H])S(=O)(=O)O[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H] [H]OC1=C([H])C(O[H])=C2C([H])=C([H])C([H])=C([H])C2=C1\N=N\C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1O[H])S(=O)(=O)O[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C2=C(\N=N\C3=C4C([H])=C([H])C([H])=C([H])C4=C(C([H])=C3O[H])S(=O)(=O)O[H])C(O[H])=C([H])C([H])=C2C([H])=C1[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])[H] [H]OC(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(\N=N\C2=C(O[H])N(N=C2C([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C(O[H])=C1[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])N([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C([H])=C([H])C(OC([H])([H])[H])=C([H])C2=C1\N=N\C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1O[H])S(=O)(=O)O[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C(C([H])=C([H])C([H])=C1C1=NC2=C(N1[H])C([H])=C([H])C(\C([H])=C1/SC(=S)N([H])C1=O)=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=S)S\C(=C(\[H])C2=C([H])C3=C(N([H])C(=N3)C3=C([H])C(=C([H])S3)C3=C([H])C([H])=C(C(=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C1=O [H]OC(=O)C(=C(/[H])C1=C([H])C2=C(N([H])C(=N2)C2=NC(=C([H])C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])\C([H])([H])[H] [H]N1C(=S)S\C(=C(\[H])C2=C([H])C3=C(N([H])C(=N3)C3=C([H])C([H])=C(S3)C3=C([H])C([H])=C(C(=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C1=O [H]N1C(=S)S\C(=C(\[H])C2=C([H])C3=C(N([H])C(=N3)C3=C([H])C([H])=C(O3)C3=C([H])C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C1=O [H]N1C(=S)S\C(=C(\[H])C2=C([H])C3=C(N([H])C(=N3)C3=C([H])C([H])=C([H])C(=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C1=O [H]N1C(=S)S\C(=C(\[H])C2=C([H])C3=C(N([H])C(=N3)C3=NC(=C([H])C([H])=C3[H])C3=C([H])C(=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C1=O [H]N1C(=S)S\C(=C(\[H])C2=C([H])C3=C(N([H])C(=N3)C3=C([H])C([H])=C([H])C(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C1=O [H]N1C(=S)S\C(=C(\[H])C2=C([H])C3=C(N([H])C(=N3)C3=NC(=C([H])C([H])=C3[H])C3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])=C2[H])C1=O [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C(=C(F)C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=C2[H])C([H])=C1[H])C1=NC(=NS1)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=C2[H])C([H])=C1[H])C1=NC(=NS1)C1=C([H])C(F)=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC2=C(S1)C([H])([H])C([H])([H])OC1=C(C([H])=C([H])C([H])=C21)C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C(OC([H])([H])[H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C(=NC([H])=N2)N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=NC(=C(Cl)S1)C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C(S1)C([H])([H])[H])C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C(=NC([H])=N2)N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(F)=C(C([H])=C1[H])C(F)(F)F [H]OC([H])([H])C([H])([H])N(C1=NC([H])=NC(N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C(F)=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=C2[H])C([H])=C1[H])C1=NC(=NS1)C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C(=NC([H])=N2)N([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(\C([H])=C2/SC(=O)N([H])C2=O)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(F)C(F)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=C2[H])C([H])=C1[H])C1=NC(=NS1)C1=C(F)C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=C2[H])C([H])=C1[H])C1=NC([H])=C(S1)C1=C([H])C(=C(F)C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC2=C(S1)C([H])([H])OC1=C(C([H])=C([H])C([H])=C21)C(F)(F)F [H]OC([H])([H])C([H])([H])C([H])([H])N(C1=C([H])C(=NC([H])=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=NC(=NS1)C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])O[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C(S1)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]OC1([H])C([H])([H])N(C2=C([H])C(=NC([H])=N2)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N([H])C2=NC(=NS2)C2=C([H])C([H])=C(F)C(=C2[H])C(F)(F)F)C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])N=NC([H])=C2[H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=C2[H])C([H])=C1[H])C1=NC(=NS1)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])N=NC([H])=C2[H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C(=C(F)C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C([H])=C([H])C(=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(=C(F)C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])N=NC([H])=C2[H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C(F)=C(C([H])=C1[H])C(F)(F)F [H]OC([H])([H])C([H])([H])N([H])C1=NC([H])=NC(N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=C2[H])C([H])=C1[H])C1=NC(=NS1)C1=C([H])C(=C(F)C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C(=NC([H])=N2)N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=C([H])C([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C(=NC([H])=N2)N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=NC(=C(S1)C([H])([H])[H])C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])N=C([H])C([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC(=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=NC(=NS1)C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])N=C([H])N=C2[H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC(=C2[H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C1[H])C1=NC(=NS1)C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=C2[H])C([H])=C1[H])C1=C([H])OC(=N1)C1=C([H])C(=C(F)C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(=N1)C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])N=NC([H])=C2[H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(Cl)C(Cl)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C(=NC([H])=N2)C([H])([H])[H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(F)=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])N=C([H])C([H])=C2[H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=C2[H])C([H])=C1[H])C1=C([H])OC(=N1)C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=C2[H])C([H])=C1[H])C1=NN(C([H])=C1[H])C1=C([H])C(=C(F)C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(Cl)=C([H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])N(C1=C([H])C(=NC([H])=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=NC(=NS1)C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F)C([H])([H])[H] [H]OC1([H])C([H])([H])N(C2=NC([H])=NC(N([H])C3=C([H])C([H])=C(C([H])=C3[H])C(=O)N([H])C3=NC(=C([H])S3)C3=C([H])C([H])=C([H])C(=C3F)C(F)(F)F)=C2[H])C1([H])[H] [H]ON([H])[C@]([H])(N(C1=C([H])C(=NC([H])=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=NC(=NS1)C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F)C([H])([H])[H])C([H])([H])O[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(F)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(Br)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=C2[H])C([H])=C1[H])C1=NN(C([H])=C1[H])C1=C(F)C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=C2[H])C([H])=C1[H])C1=NC(=NS1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1([H])C([H])([H])N(C2=NC([H])=NC(N([H])C3=C([H])C([H])=C(C([H])=C3[H])C(=O)N([H])C3=NC(=C([H])S3)C3=C([H])C([H])=C([H])C(OC(F)(F)F)=C3F)=C2[H])C1([H])[H] [H]OC([H])([H])C([H])([H])N([H])C1=C([H])C(=NC([H])=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=NC(=NS1)C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C(OC(F)(F)F)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C(=NC([H])=N2)N2C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC(=C2[H])N2C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=NC(=NS1)C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C(F)C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)C1=C([H])C2=C(C([H])=C1[H])C1=C(N2[H])C2=C([H])C(O[H])=C(C([H])=C2C([H])([H])C1([H])[H])C(=O)O[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C([H])C(=C4[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])\N=C2/C(=O)N(N=C2C([H])([H])[H])C2=C([H])C(=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])=C1O[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(Cl)=C(N=C1[H])N1C([H])([H])C([H])([H])C([H])(C2=NN([H])N=N2)C([H])([H])C1([H])[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]OC(=O)[C@]([H])(N([H])C1=C(Cl)C([H])=C(C([H])=N1)C(=O)N([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F)C([H])([H])[H] [H]OC(=O)[C@@]1([H])N([H])C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C1([H])[H] [H]OC(=O)[C@@]1([H])C([H])([H])N(C2=C(Cl)C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C(C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C([H])C(=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C([H])C(=C(F)C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C([H])C([H])=C(C([H])=C3[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C3[H])C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C([H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C([H])C([H])=C2C3=C(C4=C(N3[H])C(F)=C(C([H])=C4[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H] [H]N1N=NN=C1C1=C([H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C2C3=C(C4=C([H])C([H])=C(C([H])=C4N3[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C([H])C([H])=C2C3=C(C4=C([H])C([H])=C(C(F)=C4N3[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C([H])C([H])=C2C3=C(C4=C([H])C([H])=C(C(F)=C4N3[H])C3=C([H])C([H])=C(F)C(=C3[H])C([H])([H])[H])C([H])([H])C2=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C2C3=C(C4=C([H])C([H])=C(C(F)=C4N3[H])C3=C([H])C([H])=C(F)C(=C3[H])C([H])([H])[H])C([H])([H])C2=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H] [H]N1C2=C(C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C2=C1C1=C([H])C([H])=C(C([H])=C1C([H])([H])C2([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C([H])=C([H])C2=C1[H])C1=C(N3[H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C([H])=C2C([H])=C([H])C3=C(N([H])C4=C3C([H])=C([H])C([H])=C4[H])C2=C1[H])C(=O)OC([H])([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C([H])=C([H])C2=C1[H])C1=C(N3[H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(O[H])C([H])=C2C3=C(C([H])=C([H])C2=C1[H])C1=C(N3[H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C([H])=C([H])C2=C1[H])C1=C(N3[H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C(F)(F)F)C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C(F)=C([H])C([H])=C4C(F)(F)F)C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C([H])C(=C4[H])C(F)(F)F)C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C([H])C([H])=C2C3=C(C4=C([H])C([H])=C(C(F)=C4N3[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(C2=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C2C3=C(C4=C([H])C([H])=C(C([H])=C4N3[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])S(=O)(=O)C2=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C2C3=C(C4=C([H])C([H])=C(C(F)=C4N3[H])C3=C([H])C([H])=C(F)C(=C3[H])C([H])([H])[H])C([H])([H])OC2=C1[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C([H])=C(C(F)=C2N1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C([H])=C(C(F)=C2N1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C([H])=C(C(F)=C2N1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C(C([H])=C1[H])C1=C(C2=C([H])C([H])=C(C(F)=C2N1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C(C([H])=C1[H])C1=C(C2=C([H])C([H])=C(C(F)=C2N1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C(C([H])=C2N1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C(C([H])=C2N1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C2C3=C(C4=C([H])C([H])=C(C(F)=C4N3[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C1[H] [H]OC(=O)C(=O)N([H])C1=C([H])C([H])=C2C3=C(C4=C([H])C([H])=C(C(F)=C4N3[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C([H])C([H])=C2C3=C(C4=C([H])C([H])=C(C([H])=C4N3[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C1[H] [H]OC(=O)C1=C(N([H])C(=O)C([H])([H])[H])C([H])=C2C3=C(C4=C([H])C([H])=C(C(F)=C4N3[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C1[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(Br)C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C(C([H])=C2[H])C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(C#N)C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(F)C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)[C@]1([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H] [H]N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)[C@@]1([H])C([H])([H])N(C2=C(Cl)C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])[C@]1([H])C([H])([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(F)S2)C2=C([H])C([H])=C(F)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(F)S2)C2=C([H])C([H])=C(F)C(Br)=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(F)S2)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(F)S2)C2=C([H])C([H])=C(F)C(OC(F)(F)F)=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(F)S2)C2=C([H])C([H])=C(F)C(OC([H])([H])C(F)(F)F)=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(F)S2)C2=C([H])C([H])=C(F)C(=C2[H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(F)S2)C2=C([H])C([H])=C(F)C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(F)S2)C2=C([H])C([H])=C(F)C(=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(F)S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C(F)C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(F)S2)C2=C([H])C([H])=C(F)C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(S2)C([H])([H])[H])C2=C([H])C([H])=C(F)C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(Cl)S2)C2=C([H])C([H])=C(F)C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(S2)C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C(F)C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(S2)C([H])([H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C(F)C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(S2)C#N)C2=C([H])C([H])=C(F)C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=NS2)C2=C([H])C([H])=C(F)C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NN(C([H])=C2[H])C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=S)N([H])N([H])C(=C1/C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])\C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=S)N([H])N([H])C(=C1/C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H])\C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=S)N([H])N([H])C(=C1/C(=O)N(C2=C([H])C([H])=C(F)C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])\C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=S)N([H])N([H])C(=C1/C(=O)N(C2=C([H])C([H])=C(F)C([H])=C12)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])\C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=S)N([H])N([H])C(=C1/C(=O)N(C2=C([H])C([H])=C(F)C([H])=C12)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H])\C([H])([H])[H] C\C(NNC(=S)N1CCC2=C1C=CC(=C2)C(O)=O)=C1/C(C)=NN(C1=O)C1=CC=C(C)C(C)=C1 C\C(NNC(=S)N1CCC2=C1C=CC(=C2)C(O)=O)=C1/C(C)=NN(C1=O)C1=CC=C2CCCC2=C1 C\C(NNC(=S)N1CCCC2=C1C=CC(=C2)C(O)=O)=C1/C(C)=NN(C1=O)C1=CC=C(C)C(C)=C1 C\C(NNC(=S)N1CCCC2=C1C=CC(=C2)C(O)=O)=C1/C(C)=NN(C1=O)C1=CC=C2CCCC2=C1 CNC(=O)C1=CC2=C(C=C1)N(CC2)C(=S)NN\C(C)=C1\C(C)=NN(C1=O)C1=CC=C(C)C(C)=C1 C\C(NNC(=S)N1CCC2=C1C=CC(=C2)C(=O)N1CCOCC1)=C1/C(C)=NN(C1=O)C1=CC=C(C)C(C)=C1 CCNC(=O)C1=CC2=C(C=C1)N(CC2)C(=S)NN\C(C)=C1\C(C)=NN(C1=O)C1=CC=C(C)C(C)=C1 C\C(NNC(=O)N1CCC2=C1C=CC(=C2)C(O)=O)=C1/C(C)=NN(C1=O)C1=CC=C(C)C(C)=C1 C\C(NNC(=O)N1CCC2=C1C=CC(=C2)C(O)=O)=C1/C(C)=NN(C1=O)C1=CC=C2CCCC2=C1 [H]N([H])C1=NC(=C(S1)C([H])([H])[H])C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F [H]N([H])C1=NC(=C(F)S1)C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F [H]N([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F [H]N([H])C1=NC(=C(S1)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]N([H])C1=NC(=C(F)S1)C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]N([H])C1=NC(=C([H])S1)C1=C([H])C(=C([H])C([H])=C1F)C(F)(F)F [H]N([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1F)C(F)(F)F [H]N([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]N([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1F [H]N([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=C1F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=C2[H])C([H])=C1[H])C1=NC2=C(S1)C([H])([H])OC1=C2C([H])=C([H])C([H])=C1Cl [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=C2[H])C([H])=C1[H])C1=NC2=C(S1)C([H])([H])OC1=C2C([H])=C([H])C([H])=C1F [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=NC([H])=C2[H])C([H])=C1[H])C1=NC2=C(S1)C([H])([H])OC1=C2C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C(=C([H])C([H])=C4[H])C(F)(F)F)C([H])([H])C([H])([H])C2=C1[H]