[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])S[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OP(=O)(O[H])[C@@]([H])(N([H])[C@]([H])(C1=NN=NN1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])S[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])S[H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])S[H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])S[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])S[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])S[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])P([O-])(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[P@@](=O)(O[H])O[C@]1([H])O[C@@]([H])(C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@@]1([H])O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])P([O-])(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]ON([H])C(=O)[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C(=O)O[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@]([H])(C(=O)N([H])C([H])([H])C(=O)O[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([O-])=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C([H])([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C(=O)O[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])O[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C(=O)O[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(N=N1)C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(N=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C#CC1=C([H])C([H])=C(F)C([H])=C1F [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC2=C([H])C([H])=C(F)C([H])=C2F)C1=O [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#CC1=C([H])C([H])=C(F)C([H])=C1F [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C1=NN([H])N=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C1=NN([H])N=N1)C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1F [H]OP(=O)(O[H])[C@]([H])(N([H])[C@]([H])(C1=NN([H])N=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C1=C(C2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C#CC1=C([H])C([H])=C(F)C([H])=C1F [H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(S1)C#CC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1F)C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C#CC1=C(F)C([H])=C([H])C([H])=C1[H] [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#CC1=C([H])C([H])=C(F)C([H])=C1F [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1F [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C#CC1=C([H])C([H])=C(F)C([H])=C1F [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1F [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1F [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C#CC1=C([H])C([H])=C(F)C([H])=C1F [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C(F)C([H])=C1F [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#CC1=C([H])C([H])=C(F)C([H])=C1F [H]OC(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1F [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C#CC1=C([H])C([H])=C(F)C([H])=C1F [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1F [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C([H])([H])SC([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#CC1=C([H])C([H])=C(F)C([H])=C1F [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C1=C(C2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1F [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C1=NN([H])N=N1)C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1[H] [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1F [H]OC(=O)C1=NC(C2=C([H])SC(=N2)N([H])C([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]OC(=O)C1=NC(C2=C([H])SC(=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(O[H])C([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]OC(=O)C1=NC(C2=C([H])SC(=N2)C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=NC(C2=C([H])SC(=N2)C([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]OC(=O)C1=NC(C2=C([H])SC(=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]OC(=O)C1=NC(C2=C([H])SC(=N2)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=NC(C2=C([H])N([H])C([H])=N2)=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=NC(C2=C([H])SC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=NC(C2=C([H])SC([H])=N2)=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]OC(=O)C1=NC(C2=C([H])SC(=N2)C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=NC(C2=C([H])SC(=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@@]1([H])[C@@]([H])(O[P@](=O)(N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([O-])=O)C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])[C@]([H])(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])[C@]([H])(C([H])([H])[H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])[C@]([H])(C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1OC([H])([H])[H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@]([H])(S[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@]([H])(S[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)C(S[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])[C@@]([H])(OC([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C(Cl)=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])O1 [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C([H])N=C1[H] [H]S[C@@]1([H])C([H])([H])N([C@]([H])(C2=NN=C(SC([H])([H])[H])N2C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]S[C@@]1([H])C([H])([H])N([C@]([H])(C2=NN=C(SC([H])([H])[H])N2C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])S[H])[C@@]1([H])C2=C(C([H])=C(O[H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])S[H])[C@@]1([H])C2=C(C([H])=C(SC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])S[H])[C@]1([H])C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])S[H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])S[H])[C@@]1([H])C2=C(C([H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])S[H])[C@]1([H])C2=C(C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])S[H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])S[H])[C@@]1([H])C2=C(C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]S[C@@]1([H])C([H])([H])N([C@]([H])(C2=NN=C(SC([H])([H])C3([H])C([H])([H])C3([H])[H])N2C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]S[C@@]1([H])C([H])([H])N([C@]([H])(C2=NN=C(SC([H])([H])[H])N2C2=C(F)C(F)=C([H])C(F)=C2F)C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]S[C@@]1([H])C([H])([H])N([C@]([H])(C2=NN=C(SC([H])([H])[H])N2C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]S[C@@]1([H])C([H])([H])N([C@]([H])(C2=NN=C(SC([H])([H])[H])N2C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]S[C@@]1([H])C([H])([H])N([C@]([H])(C2=NN=C(SC([H])([H])[H])N2C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]S[C@@]1([H])C([H])([H])N([C@]([H])(C2=NN=C(SC([H])([H])[H])N2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]S[C@@]1([H])C([H])([H])N([C@]([H])(C2=NN=C(SC([H])([H])[H])N2C2=C([H])C([H])=C(F)C(Cl)=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])S[H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]S[C@@]1([H])C([H])([H])N([C@]([H])(C2=NN=C(SC([H])([H])[H])N2C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]S[C@@]1([H])C([H])([H])N([C@]([H])(C2=NN=C(SC([H])([H])[H])N2C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]S[C@@]1([H])C([H])([H])N([C@]([H])(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])[H])N2C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]S[C@@]1([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C2=NN=C(SC([H])([H])[H])N2C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])S[H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])[H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@]([H])(S[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1 [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])C([H])=C([H])O1 [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])[H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1 [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])OC([H])=C1[H] [H]S[C@@]1([H])C([H])([H])N([C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2C(=O)OC([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)S[C@@]1([H])C([H])([H])N(C(=O)OC2=C([H])C([H])=C([H])C3=C2OC([H])([H])C([H])([H])O3)[C@]([H])(C([H])([H])OC([H])([H])C2=C(F)C([H])=C(F)C(F)=C2[H])C1([H])[H] [H]S[C@@]1([H])C([H])([H])N([C@@]([H])(C(=O)N([H])N(C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]S[C@@]1([H])C([H])([H])N(C2=NC([H])=C(C([H])=N2)C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])N([H])C([H])([H])C2=C(F)C([H])=C([H])C(F)=C2[H])C1([H])[H] [H]C1=C([H])C([H])=C2C(=O)C([H])=C(OC2=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C(OC(=O)N2C([H])([H])[C@]([H])(SC(=O)C([H])([H])[H])C([H])([H])[C@@]2([H])C([H])([H])OC([H])([H])C2=C(F)C([H])=C(F)C(F)=C2[H])=C1[H] [H]OP(=O)(O[H])[C@]([H])(N([H])[C@]([H])(C1=NN([H])N=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]S[C@@]1([H])C([H])([H])N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])N([H])C([H])([H])C2=C(F)C([H])=C([H])C(F)=C2[H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])[S@](=O)C([H])([H])[H] [H]N([H])C1=NC([H])=C(N([H])C(=O)C2=C([H])C3=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C3N2C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]S\C(=N/C1=C([H])C2=C(C([H])=C1[H])N(C(=C2[H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C3=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C3N2C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=NN=C([H])S1 [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])C(N([H])C(=O)C3=C([H])C4=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C4N3C([H])([H])C3=C(F)C([H])=C([H])C([H])=C3[H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=NC([H])=C(N([H])C(=O)C2=C([H])C3=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C3N2C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C3=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C3N2C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C3(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])SC(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])S(=O)(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])N=C(N([H])C(=O)C2=C([H])C3=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C3N2C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1(C(=O)N([H])C2(C([H])([H])O[H])C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1(C(=O)N([H])C2=NN=C(S2)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1(C(=O)N([H])C2=NN=C(S2)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])[C@@]([H])(C([H])([H])S[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]SC([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]SC([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]SC([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]SC([H])([H])[C@]([H])(N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]SC([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])N=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]SC([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]SC([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])S1)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])C1=C([H])C(=NO1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[P@@](=O)(O[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])C1=C([H])C(=NO1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[P@@](=O)(O[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])C1=C([H])C(=NO1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[P@@](=O)(O[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C([H])=C2C(OC3=C2C([H])=C([H])C([H])=C3[H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[P@](=O)(O[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])[C@@]1([H])ON=C(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])[H])C([H])([H])[P@@](=O)(O[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])[C@@]1([H])ON=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[P@@](=O)(O[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])[C@@]1([H])ON=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[P@@](=O)(O[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[P@@](=O)(O[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OP(=O)(O[H])[C@]([H])(N([H])[C@@]([H])(C1=NN([H])N=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C2N=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]OP(=O)(O[H])[C@]([H])(N([H])[C@@]([H])(C1=NN([H])N=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C2OC([H])([H])OC2=C([H])C([H])=C1[H] [H]OP(=O)(O[H])[C@]([H])(N([H])[C@]([H])(C1=NN([H])N=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OP(=O)(O[H])[C@]([H])(N([H])[C@]([H])(C1=NN([H])N=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]OP(=O)(O[H])[C@]([H])(N([H])[C@@]([H])(C1=NN([H])N=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C(=O)N([H])[C@@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])P([O-])(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([O-])=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])P([O-])(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([O-])=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C(=O)N([H])[C@@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])P([O-])(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([O-])=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(C([H])([H])P([O-])(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([O-])=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C(=O)N([H])[C@@]([H])(C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])P([O-])(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([O-])=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])P([O-])(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([O-])=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C(=O)N([H])[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])P([O-])(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([O-])=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C(=O)N([H])[C@@]([H])(C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])P([O-])(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([O-])=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(C([H])([H])P([O-])(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([O-])=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])P([O-])(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([O-])=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[P@@](=O)(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[P@](=O)(O[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[P@](=O)(O[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[P@](=O)(O[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[P@](=O)(O[H])[C@@]([H])(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[P@](=O)(O[H])[C@@]([H])(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[C@]([H])(C(=O)O[H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[P@](=O)(O[H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])P(=O)(O[H])O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[P@](=O)(O[H])[C@@]([H])(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[P@](=O)(O[H])[C@@]([H])(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[P@](=O)(O[H])[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[P@](=O)(O[H])[C@]([H])(N([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[P@](=O)(O[H])[C@@]([H])(N([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[P@](=O)(O[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[P@](=O)(O[H])C([H])([H])N([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C1=NN([H])N=N1)C([H])([H])C1=C([H])C([H])=C2C(OC3=C2C([H])=C([H])C([H])=C3[H])=C1[H] [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C1=NN([H])N=N1)C([H])([H])C1=C([H])C([H])=C2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2=C1[H] [H]OP(=O)(O[H])[C@]([H])(N([H])[C@]([H])(C1=NN([H])N=N1)C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C1=NN([H])N=N1)C([H])([H])C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])[C@]([H])(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])N=C12)P(=O)(O[H])O[H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])[C@]([H])(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)P(=O)(O[H])O[H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])[C@]([H])(C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C([H])=C2C(OC3=C2C([H])=C([H])C([H])=C3[H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H] [H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C1=NN([H])N=N1)C([H])([H])C1=C([H])C([H])=C2C(=C1[H])C(=O)C1=C2C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C([H])=C2C(OC3=C2C([H])=C([H])C([H])=C3[H])=C1[H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])[C@]([H])(C([H])([H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])[C@]([H])(C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])[C@@]([H])(S[H])C(F)(F)C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]SC([H])([H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]