[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])O1)C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])O1)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])O1)C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])O1)C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])O1)C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])O1)C(=O)N([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])O1)C(=O)N([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(OC([H])=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])O1)C(=O)N([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1=C(OC([H])=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])O1)C(=O)N([H])C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])O1)C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])O1)C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=C(C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=C([H])C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=C(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C(\N=N\C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C3OC4=C(C([H])=C([H])C(=C4[H])[N+]([O-])=O)C3=C2[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@]([H])(N([H])S(=O)(=O)C2=C(OC([H])([H])[H])C([H])=C3C(OC4=C3C([H])=C([H])C([H])=C4[H])=C2[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])([C@]1([H])N([H])S(=O)(=O)C1=C([H])C([H])=C3OC4=C(C([H])=C([H])C([H])=C4[H])C3=C1[H])C2(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@]([H])(N([H])C(=O)C2=C([H])C([H])=C(\N=N\C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])([C@]1([H])N([H])C(=O)C1=C([H])C([H])=C3OC4=C(C([H])=C([H])C([H])=C4[H])C3=C1[H])C2(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])S[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC([H])([H])C([H])([H])C([H])([H])S[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])C([H])([H])[C@]([H])(O[H])C1(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])C(\[H])=C(/[H])[C@@]1([H])[C@]([H])(O[H])C([H])([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C1(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@@]1([H])C(\[H])=C(/[H])C([H])([H])[C@]([H])(O[H])C1(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@]([H])(C(\[H])=C(/[H])[C@@]1([H])[C@]([H])(O[H])C([H])([H])[C@]2([H])OC3=C(C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C([H])([H])C([O-])=O)[C@]12[H])[C@]([H])(C([H])([H])[H])C([H])([H])C#CC([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(C([H])([H])N1N=C(C([H])=C([H])C1=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])SC([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])SC([H])([H])[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])SC([H])([H])C([H])([H])[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1 [H]OC(=O)[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])SC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C1/C([H])([H])C2([H])C([H])([H])C([H])(O[H])C([H])(C(\[H])=C(/[H])C([H])(O[H])C([H])(C([H])([H])[H])C([H])([H])C#CC([H])([H])[H])C2([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C(O1)C1=C([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([O-])=O)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C(O1)[C@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([O-])=O)=C2C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])OC(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@@](O[H])(C([H])([H])OC(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])[C@@]([H])(O[H])[C@@](O[H])(C([H])([H])OC(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C(=C([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC(=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C(=C([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC(=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C(=C([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC(=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C(=C([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC(=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C2OC([H])=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])SC([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=NC(=C(O2)C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([O-])=O)=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C(O1)[C@]12O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([O-])=O)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C2OC([H])=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])SC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C2OC([H])=C(C2=C([H])C([H])=C1[H])C([H])([H])SC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C2OC([H])=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C2OC([H])=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C2OC(=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])O[H] [H]OC(=O)C([H])([H])OC1=C2OC(=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])O[H] [H]OC(=O)C([H])([H])OC1=C2OC([H])=C(C2=C([H])C([H])=C1[H])C([H])([H])SC([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C2OC(=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[H] [H]OC(=O)C([H])([H])OC1=C2OC([H])=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C2OC([H])=C(C2=C([H])C([H])=C1[H])C([H])([H])SC([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C2OC(=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])O[H] [H]OC(=O)C([H])([H])OC1=C2OC(=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])O[H] [H]OC(=O)C([H])([H])OC1=C2OC([H])=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C2OC(=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])O[H] [H]OC(=O)C([H])([H])OC1=C2OC(=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])O[H] [H]OC(=O)C([H])([H])OC1=C2OC([H])=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])SC([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C2OC(=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])S(=O)(=O)C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])O[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C3=C([H])C(F)=C([H])C(F)=C3N2C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C(O1)[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([O-])=O)=C2[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C(O1)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([O-])=O)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C(O1)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([O-])=O)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C(O1)C1=C(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([O-])=O)=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C(\[H])=C(/[H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2C([H])=C1[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1\C([H])=C(/[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C(\[H])=C(/[H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])S(=O)(=O)C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2C([H])=C1[H])S(=O)(=O)C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1 [H]OC(=O)C([H])([H])[C@]1([H])C2=C(C3=C([H])C(F)=C([H])C(=C3N2C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]1([H])C2=C(C3=C([H])C(F)=C([H])C(Br)=C3N2C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C2C(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])N(C2=C([H])C([H])=C([H])C(OC3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=C3[H])=C12)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C(F)=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])N(C2=C([H])C([H])=C([H])C(OC3=C([H])C(Cl)=C(F)C([H])=C3[H])=C12)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C(F)=C1[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])C(=N\OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])\C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])C([H])([H])C(\[H])=N\OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])ON=C(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])C(=O)N([H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])C([H])([H])ON=C(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])C([H])([H])C(=O)N([H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C(=C([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])N1N=C([H])C(=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])C([H])([H])N1N=C([H])C(=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])N1N=C([H])C(=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=N\OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])C(\[H])=C(/[H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])C([H])([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])C(\[H])=N\OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])C(\[H])=C(/[H])[C@]([H])(O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])C(\[H])=C(/[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])C(=N\OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])\C([H])([H])[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])=C(C([H])([H])N1N=C([H])C(=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C(F)=C([H])C2=C1N(C([H])=C2C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1 [H]N(C(=O)C([H])([H])OC1=C2N(C([H])=NC2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1 [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N([H])C(=O)C1=C([H])SC([H])=C1C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N([H])C(=O)C1=C(Cl)SC(Cl)=C1C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N([H])C(=O)C1=C(SC(=C1C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N([H])C(=O)C1=C(SC(=C1C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N([H])C(=O)C1=C(SC(=C1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N([H])C(=O)C1=C(SC(=C1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1(N([H])C(=O)C2=C(SC(=C2C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(SC(=C1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C([H])([H])[H])C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=NN=NN2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(Cl)SC(Cl)=C1C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(SC2=C(C([H])=C(C([H])=C12)C([H])([H])[H])C([H])([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C([H])([H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C([H])([H])C([H])([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])O[C@]2([H])C([H])([H])[C@]([H])(O[H])[C@@]([H])(C(\[H])=C(/[H])[C@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]2([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C1\C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])(O[H])[C@]([H])(C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]2([H])C1([H])[H] [H]OC(=O)C([H])([H])OC([H])([H])C(\[H])=C1\C([H])([H])[C@@]2([H])C([H])([H])[C@]([H])(O[H])[C@]([H])(C#C[C@]([H])(O[H])[C@]([H])(C([H])([H])[H])C([H])([H])C#CC([H])([H])C([H])([H])[H])[C@@]2([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/[H])C([H])([H])[C@@]1([H])[C@]([H])(Cl)C([H])([H])[C@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C2C([H])=C(N(C(=O)C3=C([H])C([H])=C(OC([H])([H])[C@@]4([H])OC5=C(C([H])=C([H])C([H])=C5[H])N(C([H])([H])[H])C4([H])[H])C([H])=C3[H])C2=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C(C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(OC3([H])[H])C([H])=C([H])C([H])=C4[H])C([H])=C2[H])C([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C(C([H])=C(OC([H])([H])[C@@]3([H])C4=C(OC3([H])[H])C([H])=C([H])C([H])=C4[H])C([H])=C2[H])C([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C(C([H])=C(OC([H])([H])[C@@]3([H])C4=C(OC3([H])[H])C([H])=C([H])C([H])=C4[H])C([H])=C2[H])C([H])([H])[H])C2=C1C([H])=C(F)C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C(C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])C3([H])[H])C([H])=C2[H])C([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C(C([H])=C(OC([H])([H])C3([H])OC4=C(O3)C([H])=C([H])C([H])=C4[H])C([H])=C2[H])C([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C(C([H])=C(OC([H])([H])[C@@]3([H])N(C4=C(C([H])=C([H])C([H])=C4[H])C3([H])[H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2[H])C2=C1C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2[H])C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2[H])C2=C1C([H])=C(F)C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2[H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2C([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2F)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C(=C2[H])C([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C(Cl)=C2[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C(F)=C2[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C(OC([H])([H])[H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C(=C2C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C(=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2C([H])([H])[H])C2=C1C([H])=C(F)C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2Cl)C2=C1C([H])=C(F)C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2F)C2=C1C([H])=C(F)C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C(=C2[H])C([H])([H])[H])C2=C1C([H])=C(F)C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C(OC([H])([H])[H])=C2[H])C2=C1C([H])=C(F)C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C(=C2C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C(F)C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C(=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C(F)C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2Cl)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2[H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2[H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[C@@]2([H])OC3=C(C([H])=C([H])C([H])=C3[H])N(C([H])([H])[H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2C([H])([H])[H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(=C([H])C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2C([H])([H])[H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2Cl)=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C(=C2C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2Cl)=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2Cl)=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2C(=O)C1=C([H])C([H])=C(OC([H])([H])[C@@]2([H])OC3=C(C([H])=C([H])C([H])=C3[H])N(C([H])([H])[H])C2([H])[H])C([H])=C1[H] [H]OC(=O)C(C1=C([H])C([H])=C(Cl)C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2Cl)=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(C1=C([H])C([H])=C(Cl)C(N([H])C(=O)C2=C([H])C(=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1(C2=C([H])C([H])=C(Cl)C(N([H])C(=O)C3=C([H])C(=C(OC([H])([H])[C@@]4([H])OC5=C(C([H])=C([H])C([H])=C5[H])N(C([H])([H])[H])C4([H])[H])C([H])=C3C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C(F)(F)C1=C([H])C([H])=C(Cl)C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2Cl)=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C(N([H])C(=O)C2=C([H])C(=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C(=C2C([H])([H])[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C(=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C(=C(C([H])=C1[H])N1C(=O)C2=C(OC([H])([H])C([H])([H])[H])C3=C([H])C([H])=C([H])N=C3C(OC([H])([H])C([H])([H])[H])=C2C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C(=C(C([H])=C1[H])N1C(=O)C2=C(OC([H])([H])C(F)(F)F)C3=C(N=C([H])C([H])=C3[H])C(OC([H])([H])C(F)(F)F)=C2C1([H])[H])C([H])([H])[H] [H]C1=C([H])C(=NC(=C1[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C1=C(F)C([H])=C(Cl)C([H])=C1[H])C([O-])=O