[H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C(Br)C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(I)C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1 [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Br)S1 [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1 [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC(=C(S1)S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N=C(N([H])[H])N([H])\N=C(/[H])C1=C([H])N([H])C2=C([H])C([H])=C(Br)C([H])=C12 [H]N=C(N([H])[H])N([H])\N=C(\C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C(I)C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(O[C@]([H])(C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=NC(OC([H])([H])C3=C([H])C(F)=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=NC(OC([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(C2=C(S1)C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C(F)=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C(C#N)=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C(F)C([H])=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C(F)=C(F)C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C(Cl)=C(Cl)C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=NC(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3F)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OS(=O)(=O)C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OS(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3F)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OS(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C2=C(C([H])=NN2S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N([H])C([H])([H])[H])C1=C([H])C2=C(C([H])=NN2S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(C([H])=NN2S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(C([H])=NN2S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(C([H])=NN2S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=NC(OC([H])([H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=NC(OC([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C2=C(C([H])=NN2S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(C([H])=NN2S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=NC(O[C@@]([H])(C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=NC(O[C@@]([H])(C3=C([H])C(Cl)=C([H])C([H])=C3[H])C(F)(F)F)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])N=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(O[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=NC(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3F)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=NC(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=NC(O[C@@]([H])(C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(C([H])=NN2S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1C([H])=NN2S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])N(N=C2[H])S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OS(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OS(=O)(=O)C3=C([H])C(Cl)=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OS(=O)(=O)C3=C([H])C(F)=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OS(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OS(=O)(=O)C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OS(=O)(=O)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OS(=O)(=O)C3=C([H])C([H])=C([H])C4=C([H])C([H])=C([H])C([H])=C34)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=NC(O[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C(F)=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C(C#N)=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C(F)=C(F)C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C(Cl)=C(Cl)C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])N=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(O[C@]([H])(C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(O[C@@]([H])(C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=NC(OC([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=NC(O[C@@]([H])(C3=C([H])C(F)=C([H])C([H])=C3[H])C(F)(F)F)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1(C2=C([H])C([H])=NC(OC([H])([H])C3=C([H])C(F)=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])OC2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])OC2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1I [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C(Br)C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C(=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])=C2[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(=C1C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C(Cl)=C2C([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C(=C2[H])C([H])([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=C([H])C2=C(C([H])=C1[H])C(C([H])=C2C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=C([H])C2=C(C([H])=C1OC([H])([H])[H])C([H])([H])C(=C2C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C(=C2[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]OC([H])([H])C([H])([H])N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C4=C(N([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C(F)C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])SC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])N(C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])SC4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(C#N)C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]OC1=C2N(C3=C(C2=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(Cl)=C([H])N=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)N3N=C([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1C2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([N+]#[C-])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C(OC(F)(F)F)C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]OC([H])([H])C([H])([H])OC1=C2N(C3=C(C2=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(OC([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(OC([H])([H])C5=C([H])C([H])=C([H])C([H])=N5)C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(OC([H])([H])C5=C([H])C([H])=C([H])N=C5[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C(C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@]1([H])N([H])[C@@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])N(C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C4=C(SC([H])=C4[H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C4=C3N=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])SC4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C4=C(C([H])=C3[H])N(C([H])=C4[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1C2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([N+]#[C-])C([H])=C3[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])N=C([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@]1([H])N(C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([H])C4=C3C([H])=C(F)C([H])=C4[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([H])C4=C3C([H])=C([H])C(F)=C4[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([H])C4=C3C([H])=C(Cl)C([H])=C4[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([H])C4=C3C([H])=C([H])C(Cl)=C4[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([H])C4=C3N=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1C2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([N+]#[C-])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C2([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(=C([H])C([H])=C3[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(Cl)=C([H])C(Cl)=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(F)=C([H])C(F)=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])SC([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(Cl)=C([H])N=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(F)=C([H])N=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=N3)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])N=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C3C([H])=C(C([H])=C4[H])S(=O)(=O)N3C([H])=C([H])C4=C3C([H])=C([H])C([H])=C4F)C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([H])C4=C3C([H])=C([H])C(=C4[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C(Cl)C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1C2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([H])C4=C3C([H])=C([N+]#[C-])C([H])=C4[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C(C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]OC1=C2N(C3=C(C2=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])[C@]1([H])N([H])[C@@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]OC1=C2N(C3=C(C2=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]OC1=C2N(C3=C(C2=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]OC1=C2N(C3=C(C2=C([H])C(=C1[H])S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C(F)C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])N(C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]C1=C([H])C(Cl)=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C2N(C3=C(C2=C1[H])[C@]1([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C(C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])N=C([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(OC([H])([H])C([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])S1)S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C3C([H])=C(C([H])=C4C([H])([H])[H])S(=O)(=O)C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C3C([H])=C(C([H])=C4C([H])([H])[H])S(=O)(=O)C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C2=C(N(C3=C2[C@@]2([H])N([H])[C@]([H])(C([H])([H])C2([H])[H])C3([H])[H])C([H])([H])[H])C(=C1[H])C([H])([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])N=C([H])N=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C(C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C(F)C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C(Cl)C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(OC([H])([H])C5=C([H])C([H])=C([H])C([H])=C5[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]OC([H])([H])C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C2=C1C([H])([H])[C@]1([H])N([H])[C@@]2([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C(=C([H])C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([H])C4=C3C([H])=C(F)C([H])=C4[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1C2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([H])C4=C3C([H])=C([N+]#[C-])C([H])=C4[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(=C([H])C([H])=C3[H])N3N=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C(OC([H])([H])[H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(=C([H])C([H])=C3[H])N3N=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C4=C(C([H])=C([H])C4([H])[H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(F)=C([H])C([H])=N3)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(Cl)=C([H])C([H])=N3)C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1C([H])=C([H])C2=C([H])C([H])=C([H])C(=C12)S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@]1([H])N([H])[C@@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C1N=C([H])C(=C2[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])N(C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])N(C4=C3C([H])=C([H])C([H])=C4[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]OC1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@]1([H])N([H])[C@@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([H])C4=C3C([H])=C([H])C([H])=N4)C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1C([H])([H])C2=C(N3N=C(SC([H])([H])[H])C(=C3N=C2C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C([H])C3=C(N2N=C1SC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C3([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C([H])C3=C(N2N=C1C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C3([H])[H] [H]N1C([H])([H])C2=C(N3N=C(C(=C3N=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(N3N=C(SC([H])([H])[H])C(=C3N=C2C([H])([H])[H])S(=O)(=O)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C3C(=C([H])N2N=C1SC([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)S(=O)(=O)C1=C2N=C3C(=C([H])N2N=C1SC([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([H])C4=C([H])C([H])=NC([H])=C34)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])N(C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C4=C3C([H])=C([H])C([H])=N4)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C4=C3C([H])=C([H])N=C4[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C(F)C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C4=C(OC([H])=C4[H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@]1([H])N([H])[C@@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C4=C(C([H])=C3[H])N(C([H])=C4[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(=C([H])C([H])=C3[H])C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1C([H])=C([H])C2=C1C(=C([H])C(=C2[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H])C(F)(F)F [H]N1C([H])=C([H])C2=C1C(F)=C([H])C(=C2[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@]1([H])N([H])[C@@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1N=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@]1([H])N([H])[C@@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C4=C(C([H])=C3C([H])([H])[H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C4=C(C([H])=C([H])C([H])=C4[H])C4=C3C([H])([H])C([H])([H])C4([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C(F)C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C4=C3C([H])=NC([H])=C4[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(OC([H])([H])C4=C([H])C([H])=NC([H])=C4[H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@]1([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])[C@@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C([H])C3=C(N2N=C1C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C3([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C3=C(N2N=C1C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C3([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C3C(=C(N2N=C1C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C3C(=C([H])N2N=C1C([H])([H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H] [H]C1=NN2C(N=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1SC([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1SC([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1SC([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(F)=C1[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1SC([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1SC([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1SC([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1SC([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1SC([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1SC([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1F)S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1SC([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])OC1=NN2C(N=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C1C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(=C1C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N([H])[H])C([H])=C1[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=NC2=C1C([H])=C([H])C(Cl)=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C([H])C2=C1N1C(=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C(=C1C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2N([H])C(=C(C2=C1[H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12 [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2OC([H])([H])[H])N1S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(N1S(=O)(=O)C1=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C1[H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(N1S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(N1S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(N1S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C(=NC(N([H])C([H])([H])[H])=C1[H])N([H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)[C@]1([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=NC(=NC(N([H])C([H])([H])[H])=C1[H])N([H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]O[C@@]1(C2=C([H])C([H])=C3C([H])=C([H])N(C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1F)N1C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C([H])([H])OC(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(N(C2=C1C(=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])C2=C([H])C([H])=C([H])C3=C2C(=C([H])N3S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=C([H])C2=C1C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2N(C([H])=C(C2=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C(C([H])=C([H])C(C#N)=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C2C(N([H])C(=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(S1)S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@]([H])(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C(=C1C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(=C1C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C(=C1C1=NC(=NO1)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C2C3=C(C([H])=C([H])C([H])=C3[C@]([H])(OC([H])([H])[H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])N1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C(I)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(I)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(Br)C([H])=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(I)=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(I)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C([H])C([H])=C([H])C(Cl)=C2[C@@]([H])(N1[H])C([H])([H])[H])C([H])([H])C([H])(F)F [H]N([H])C1=NC2=C([H])C([H])=C([H])C(Cl)=C2[C@@]([H])(N1[H])C([H])([H])[H] [H]N1C([H])=C2C3=C(C([H])=C([H])C([H])=C13)C1=C([H])[C@@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])[C@]1([H])C2([H])[H] [H]N1C([H])=C2C3=C(C([H])=C([H])C([H])=C13)C1=C([H])[C@@]([H])(C(=O)N3[C@@]([H])(C([H])([H])[H])C([H])([H])[C@]3([H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])[C@@]1([H])C2([H])[H] [H]N([H])C1=NC(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])[H])C([H])=C2[H])=C([H])C(=N1)N([H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C(N([H])C([H])([H])[H])=C([H])C(N([H])C([H])([H])[H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C(Br)=C([H])C2=C1C([H])=C([H])N2[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]\C(=C1/C2=C([H])C([H])=C([H])C([H])=C2SC2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C(Br)=C([H])C(N([H])C([H])([H])[H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(SC([H])([H])[H])=C([H])C([H])=C1S2 [H]N1C([H])=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])N([H])C([H])([H])C2([H])[H] [H]N1C(=O)N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C1C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])N(C1=C([H])C(Cl)=C([H])C([H])=C1S2)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C1=C(Br)C(F)=C([H])C(Br)=C1[H])S(=O)(=O)C1=C([H])C(N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@@]1([H])C2=C([H])C([H])=C([H])C3=C2C(=C([H])N3S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[C@]1([H])N([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C1=NC2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C(=C2[H])S(=O)(=O)N2C([H])=C([H])C3=C2C([H])=C(Br)C([H])=C3[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])[C@]2([H])C([H])([H])C3=C([H])N([H])C4=C3C(=C([H])C([H])=C4[H])[C@@]2([H])C1([H])[H] [H]N(C([H])([H])[H])S(=O)(=O)C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C2([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[C@]1([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])C2=C([H])N(C3=C2C(=C([H])C([H])=C3[H])[C@]1([H])OC([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])[C@@](C([H])([H])[H])(C([H])([H])N([H])C(=O)[C@]1([H])C([H])=C2C3=C4C(N([H])C([H])=C4C([H])([H])[C@@]2([H])N(C([H])([H])[H])C1([H])[H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1\C([H])=C(/[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]C1=C([H])C([H])=C2N=C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C3=C(OC2=C1[H])C([H])=C([H])C(Cl)=C3[H] [H]N1C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(Br)=C2C3=C(C([H])=C([H])C([H])=C13)C1=C([H])[C@@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])[C@]1([H])C2([H])[H] [H]N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C([H])=C(/C#N)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]N=C1N2C([H])=C(C([H])=C(Br)C2=NC(SC([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N=C1N2C([H])=C([H])C([H])=C([H])C2=NC(SC([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C(=NC([H])([H])C2([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C1C(=NC([H])([H])C2([H])[H])C([H])([H])[H] [H]N=C1N2C([H])=C(F)C([H])=C([H])C2=NC(SC([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C1N2C([H])=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C2=NC(SC([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=[N+](C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C2=C1C(=NC([H])=C2[H])C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C(=C1C1=C([H])C(Br)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C1N2C([H])=C([H])C(=C([H])C2=NC(SC([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N=C1N2C([H])=C([H])C([H])=C([H])C2=NC(SC([H])([H])[H])=C1S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(=NC(=N1)N([H])C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])N([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC(=NC(=N1)N([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(F)C([H])=C1[H])N([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C2N(C3=C(C2=C([H])C(OC([H])([H])[H])=C1[H])[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(I)C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C(N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C2N(C3=C(C2=C([H])C(OC([H])([H])[H])=C1[H])[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C1C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C2N(C3=C(C2=C([H])C(OC([H])([H])[H])=C1[H])[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])S(=O)(=O)N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C2=C1C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C2=C1C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C([H])=C([H])C([H])=C(C2=N1)S(=O)(=O)N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C2=C1C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=C2N(C3=C(C2=C([H])C(OC([H])([H])[H])=C1[H])[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C2N(C3=C(C2=C([H])C(OC([H])([H])[H])=C1[H])[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H] [H]N([H])C1=NC(=NC(=N1)N([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC(=NC(=N1)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])S1)N([H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC(=NC(=N1)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])N([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])N=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])N=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])N=C2[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=NC([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C(C([H])=NC([H])=C2[H])C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])[H] [H]N1C2=C(C([H])=NC([H])=C2[H])C(=C1C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=NC([H])=C2[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C(F)=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C(F)C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(OC(F)(F)F)C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C(F)C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C(C2=C([H])C(F)=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C(N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C(Cl)C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]ON([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C3=C2C([H])=C([H])C([H])=C3[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Br)C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])=C(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])=C(C2=C([H])N(C3=C2C([H])=C(F)C([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])=C(C2=C([H])N(C3=C2C([H])=C(OC([H])([H])[H])C([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])=C(C2=C([H])N(C3=C2C([H])=C(F)C([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C(Cl)C([H])=C2[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])C(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])=C2[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])=C(C2=C([H])N(C3=C2C([H])=C(F)C([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])C(F)=C2[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])=C(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=NC([H])=C([H])C3=C2C([H])=NS3)C([H])([H])C1([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])=C(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])=C(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])=C(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])=C(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C(Cl)S2)C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C(C([H])=C2[H])[N+]([O-])=O)C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C(F)=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])=C(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])C(=C2[H])[N+]([O-])=O)C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C(Cl)C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C([H])=C(Cl)C([H])=C12)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Br [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1F [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1F [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1Cl [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(I)C([H])=C1[H] [H]N1C([H])([H])C([H])=C(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C3=C(OC([H])([H])O3)C([H])=C12)C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])C(Br)=C2[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C([H])=C(F)C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(I)C([H])=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C2=C(S1)C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1F [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1Cl [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C(Cl)C([H])=C([H])C([H])=C12 [H]N(C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2S1)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(C([H])=C([H])N2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=N1 [H]N(C1=C([H])C2=C(C([H])=C([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C(=O)C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=C([H])C2=C(C([H])=C([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=C2S(=O)(=O)N2C([H])([H])C([H])([H])C([H])(N3C(=O)OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2S1)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C(=C23)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]C1=NC2=C(C([H])=C1[H])C([H])=C([H])C([H])=C2S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])N(C(=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])N(C(=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C(=C2N(C(=O)OC([H])([H])C2=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C(Cl)C([H])=C([H])C([H])=C12 [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]\C(=C1\C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(S[C@@]2([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(\C([H])=C2/C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C2C([H])=C([H])C([H])=C(C2=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C(=C23)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=C([H])C2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C([H])N2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1N=C([H])C([H])=C2[H] [H]N(C1=C([H])C2=C(C([H])=C([H])N2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C1=C([H])C2=C(N([H])C([H])=C2C(=O)C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1N=C([H])C([H])=C2[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C(=O)OC2([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C(=O)C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C1=C([H])C2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C1=C([H])C2=C(C([H])=C([H])N2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=NC2=C(C([H])=C1[H])C([H])=C([H])C([H])=C2S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C(=C23)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1 [H]N(C1=C([H])C2=C(N([H])C([H])=C2C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=C2S(=O)(=O)N2C([H])([H])C([H])([H])C([H])(N3C(=O)OC([H])([H])C4=C([H])C([H])=C([H])C(=C34)C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]C1=C([H])C(=C2N(C(=O)OC([H])([H])C2=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C([H])C2=C1C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])N([H])C([H])([H])C2([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC(=C(S1)S(=O)(=O)N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(ON=C1C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C(F)=C(F)C([H])=C2[H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(I)C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(Cl)S1 [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C([H])([H])N1N=C(C([H])=C1Cl)C([H])([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(I)C([H])=C1[H] [H]C1=C(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C(C2=C(S1)C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C(Br)C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C(Cl)S2)C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])S2)C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(I)C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C(Cl)SC(=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(=C1C([H])([H])[H])C1=C([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(=C1C([H])([H])[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C(N=C(O1)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C(=C1C([H])([H])[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C(=C1C([H])([H])C([H])([H])[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(=C1C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(=C1C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(=C1C([H])([H])[H])C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(=C1C([H])([H])C([H])([H])[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(=C1C([H])([H])[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(=C1C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C(=C1C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C(C2=C(S1)C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Br)C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(Br)SC(=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(Br)SC(=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(=C1C([H])([H])[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(=C1C([H])([H])[H])C1=C([H])C2([H])N(C([H])([H])[H])C([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(=C1C([H])([H])[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(=C1C([H])([H])C([H])([H])[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C(C([H])=C1[H])C1=NOC(=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C(F)=C(F)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Br [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C(Cl)C(Cl)=C([H])C([H])=C1[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(Cl)S1 [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(Br)S1 [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C(C3=C(S2)C([H])=C([H])C(Cl)=C3[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(N([H])C([H])([H])[H])=C2C([H])=C([H])N(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C([H])C([H])=C(N([H])C([H])([H])[H])C([H])=C12 [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C3=C2C([H])=C([H])N3S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C(N([H])C([H])([H])[H])C([H])=C(N([H])C([H])([H])[H])C([H])=C12 [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C(N([H])C([H])([H])[H])C([H])=C([H])C([H])=C12 [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C(C([H])=C(C([H])=C12)[N+]([O-])=O)[N+]([O-])=O [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])[C@]2([H])N(C3=NC(=C([H])C([H])=C3C2([H])[H])C([H])([H])OC([H])([H])C2([H])C([H])([H])C2([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C(O[11C]([H])([H])[H])C([H])=C2[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2N=C([H])C(=O)N(C2=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C12 [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C12 [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C(C3=C1C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C2[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C(C3=C1C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(N([H])C([H])([H])[H])=C([H])C([H])=C2[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12 [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C(C([H])=C([H])C(N([H])C([H])([H])[H])=C2[H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])S(=O)(=O)N1C3=C([H])C([H])=C([H])C([H])=C3C(=C21)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C(SC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1OC([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])[C@@]3([H])C4=C(C([H])=C([H])C([H])=C4[H])S(=O)(=O)N1[C@@]23[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C(Br)=C(OC3([H])C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(Cl)=C(N2C([H])=C([H])S[C@]12[H])S(=O)(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C(F)C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(Cl)SC(=C1[H])S(=O)(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C2N([H])C(=NS(=O)(=O)C2=C([H])C(=C1[H])[N+]([O-])=O)N([H])C1=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N1C(Cl)=C(N2C([H])=C([H])S[C@]12[H])S(=O)(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C1([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2C1=O)C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2F)C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1Br)[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2C1=O)C([H])([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2C1=O)C([H])([H])[H] [H]N1C(=O)[C@@](C(=O)C2=C(Cl)C([H])=C(Cl)C([H])=C12)(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N1C2=C([H])C(Cl)=C([H])C(Cl)=C2C(=O)[C@@](C1=O)(C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(Br)=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C([H])=C(Cl)S2)C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(Br)=C2[H])C1([H])[H] [H]N1C(Cl)=C(N2C([H])=C([H])S[C@@]12[H])S(=O)(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C(Cl)=C(N2C([H])=C([H])S[C@]12[H])S(=O)(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])[C@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C([H])([H])C2=C([H])C([H])=C(Cl)S2)C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C([H])([H])OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])N(C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])N([H])C1=C([H])C(N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])[N+]([O-])=O [H]N(C1=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(N(N=C1C([H])([H])[H])C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])[H] [H]N1C(=O)[C@](C(=O)C2=C([H])C([H])=C(Cl)C([H])=C12)(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C(=O)[C@@](C(=O)C2=C(Br)C([H])=C(Br)C([H])=C12)(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C(C#N)C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C([H])([H])OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C(Cl)C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N(N1C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C#N)C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N1C([H])([H])C([H])([H])N(C2=C([H])C(N3N=C(C([H])=C3C([H])([H])[H])C([H])([H])[H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(OC2=C(C([H])=C([H])C(=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])[N+]([O-])=O)C([H])=C1[H] [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C1=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O [H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C([H])C(Cl)=C([H])C(Cl)=C2C(=O)[C@](C1=O)(C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2C1=O)C([H])([H])[H] [H]N1C2=C([H])C(Cl)=C([H])C(Cl)=C2C(=O)[C@](C1=O)(C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H] [H]N1C(Cl)=C(N2C([H])=C([H])S[C@]12[H])S(=O)(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C(Br)=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C([H])=C(Br)C([H])=C2[H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C3N=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C3C(Cl)=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)[C@@](C(=O)C2=C(Cl)C([H])=C(OC([H])([H])[H])C([H])=C12)(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C(=O)[C@](C(=O)C2=C(Cl)C([H])=C(C([H])=C12)N(C([H])([H])[H])C([H])([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1SC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C(=C1C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=O)[C@](C(=O)C2=C([H])C(Cl)=C(Cl)C([H])=C12)(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C2=C([H])C(Cl)=C([H])C(Cl)=C2C(=O)[C@@](C1=O)(C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])[N+]([O-])=O)C([H])([H])[H] [H]N1C(=O)[C@](C(=O)C2=C(Cl)C([H])=C(Cl)C([H])=C12)(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2C1=O)C([H])([H])[H] [H]N1C(=O)[C@@](C(=O)C2=C(Cl)C([H])=C(Cl)C([H])=C12)(C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1C2=C([H])C(Cl)=C([H])C(Cl)=C2C(=O)[C@@](C1=O)(C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2C1=O)C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C(=O)[C@@](C(=O)C2=C(Br)C([H])=C(OC([H])([H])[H])C([H])=C12)(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C2=C([H])C(Cl)=C([H])C(Cl)=C2C(=O)[C@](C1=O)(C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[N+]([O-])=O)[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2C1=O)C([H])([H])[H] [H]N1C(=O)[C@@](C(=O)C2=C([H])C([H])=C([H])C([H])=C12)(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C2=C([H])C(Cl)=C([H])C(Cl)=C2C(=O)[C@](C1=O)(C1=C([H])C([H])=C(I)C([H])=C1[H])C([H])([H])[H] [H]N1C(=O)[C@](C(=O)C2=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C12)(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C(=O)[C@](C(=O)C2=C(Cl)C([H])=C(Cl)C([H])=C12)(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C(Br)=NC(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=O)[C@@](C(=O)C2=C([H])C(Br)=C([H])C(Br)=C12)(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC2=C([H])C([H])=C(Cl)C(Cl)=C2C([H])([H])N1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3SC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N1C2=C(C([H])=C(S2)C([H])([H])[H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=O)C([H])([H])C2=C1C([H])=C(Cl)C(=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(F)=C([H])C2=C1C(=NO2)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C(N=C3N(C2=O)C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C2=C([H])C(=C(C([H])=C2C([H])([H])C1([H])[H])C([H])([H])[H])C(F)(F)F)C1=C([H])N=C(OC2=C(N=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3O2)S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3O2)S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3O2)S(=O)(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3O2)S(=O)(=O)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3O2)S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3O2)S(=O)(=O)C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3O2)S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3O2)S(=O)(=O)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3O2)S(=O)(=O)C2=C(Cl)C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3O2)S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C(=C([H])C([H])=C3O2)S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])F)=C1OC([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])C(=C([H])C2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=C([H])C([H])=C2C(=C1[H])C(=C(C([H])([H])[H])C2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=C([H])C([H])=C2C(=C1[H])C(=C(C([H])([H])[H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])SC2=C1C([H])=C([H])C([H])=C2[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C(C([H])=C3O2)S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C(=C3O2)S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])S(=O)(=O)C1=C2N=C(OC2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])S(=O)(=O)C1=C2N=C(OC2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])S(=O)(=O)C1=C2N=C(OC2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])S(=O)(=O)C1=C2N=C(OC2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3O2)S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])S(=O)(=O)C1=C2N=C(OC2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C1=C(OC([H])([H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]N(C1=NN2C(N=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NN2C(N=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NN3C(N=C(C([H])=C3C([H])([H])[H])C([H])([H])[H])=C2S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NN2C(N=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1[S@](=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])[C@@]([H])(C([H])=C2C3=C([H])C([H])=C([H])C4=C3C(=C([H])N4[H])C([H])([H])[C@@]12[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C2C3=C1C([H])=C([H])C([H])=C3C1=C([H])[C@@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])N([H])[C@]1([H])C2([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]C1=C(C2=NC([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=NC([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]C1=C(C2=NC(Cl)=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=NC(=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=NC(=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]C1=C(C2=NC(=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=NC([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=NC([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=NC([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=NC([H])=C([H])C([H])=C12)S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]C1=C2OC([H])([H])OC2=C([H])C2=C1C1=C3C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])[C@@]3([H])C2([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]C1=C([H])C([H])=C2C(=N1)N(C(=C2S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])N1C2=NC([H])=C([H])C([H])=C2C(=C1C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(S1)S(=O)(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(Cl)SC(=C1[H])S(=O)(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])N2C(S1)=NC(Cl)=C2S(=O)(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1Cl [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C2=C(C([H])=C(C([H])=C2[H])C(F)(F)F)C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]C1=C([H])C(F)=C([H])C2=C1N(C1=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C(F)=C([H])C2=C1N(C1=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(F)=C([H])C2=C1N(C1=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C2=C1N(C1=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C2=C1N(C1=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]C1=C([H])C(=C([H])C2=C1N(C1=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C2=C1N(C1=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C2=C(C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]\C(=C(\N1C2=C(C([H])=C(F)C([H])=C2[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(\N1C2=C(C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(/[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])N1C2=C(C([H])=C(F)C([H])=C2[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]\C(=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)N1C2=C(C([H])=C(F)C([H])=C2[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]N1C(=NC2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N1C(=NC2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N1C([H])=NC2=C1C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(C([H])=C2N=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=NC2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N1C(=NC2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N1C(=NC2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N1C(=NC2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2N=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2N=C1C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N1C(=NC2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N1C2=C([H])C([H])=C(C([H])=C2N=C1C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])N([H])\N=C1\C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])N(C([H])([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(\N=C1\C2=C([H])C(N([H])S(=O)(=O)C3=C(Cl)N=C4SC([H])=C([H])N34)=C([H])C([H])=C2C([H])([H])C1([H])[H])C1=NC([H])([H])C([H])([H])N1[H] [H]N=C(N([H])[H])N([H])\N=C(\C1=C([H])N([H])C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C12)C([H])([H])[H] [H]N=C(N([H])[H])N([H])\N=C(\C1=C([H])N([H])C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])=C12)C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C(F)=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])N=C12 [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=C(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C1([H])[H] [H]C1=C(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2N1[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])N=C23)C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C(F)C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C(F)=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(Cl)=C2[H])C1([H])[H] [H]N=C(N([H])[H])N([H])\N=C1\C2=C([H])C(N([H])S(=O)(=O)C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=C3[H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N=C(N([H])[H])N([H])\N=C1\C2=C([H])C(N([H])S(=O)(=O)C3=C([H])C([H])=C4OC([H])([H])C([H])([H])N(C4=C3[H])C([H])([H])[H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N(\N=C1/C2=C([H])C(N([H])S(=O)(=O)C3=C([H])C([H])=C4OC([H])([H])C([H])([H])N(C4=C3[H])C([H])([H])[H])=C([H])C([H])=C2C([H])([H])C1([H])[H])C1=NC([H])([H])C([H])([H])N1[H] [H]N=C(N([H])[H])N([H])\N=C1\C2=C([H])C(N([H])S(=O)(=O)C3=C(Cl)N=C4SC([H])=C([H])N34)=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N=C(N([H])[H])N([H])\N=C1\C2=C([H])C(N([H])S(=O)(=O)C3=C(Cl)N=C4SC([H])=C([H])N34)=C([H])C([H])=C2C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])\N=C1\C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C(Cl)N=C4SC([H])=C([H])N34)C([H])=C2C([H])([H])C1([H])[H] [H]N=C(N([H])[H])N([H])\N=C1\C2=C([H])C(N([H])S(=O)(=O)C3=C(Cl)N=C4SC([H])=C([H])N34)=C([H])C([H])=C2C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H] [H]C1=C(C2=C([H])C(F)=C([H])C([H])=C2N1[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(Cl)=C2[H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N1C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])N=C23)C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C(F)C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C(Cl)=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C(Cl)C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C([H])C([H])=C3F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C([H])C3=C(N2N=C1SC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C3C(=C([H])N2N=C1SC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C3=C(N2N=C1SC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C3C(=C(N2N=C1SC([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C([H])C3=C(N2N=C1SC([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H] [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])C([H])([H])N1C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]C1=C([H])C(=C([H])C2=C1N(C1=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C([H])C(F)=C1[H])S(=O)(=O)C1=C([H])C2=C(N([H])C3=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])N(C1=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C([H])C(F)=C1[H])S(=O)(=O)C1=C([H])C2=C(N([H])C3=C2C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C3([H])[H])C([H])=C1[H] [H]N1C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]N1C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])N=C2[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NN2C([H])=C3C(=NC2=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H] [H]N(C1=NN2C(N=C([H])C3=C2C([H])([H])C([H])([H])C3([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NN2C(N=C([H])C3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NN2C(N=C(C3=C2C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C([H])C3=C(N2N=C1N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C3=C(N2N=C1N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NN3C(N=C(C4=C3C([H])([H])C([H])([H])C4([H])[H])C([H])([H])[H])=C2S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NN3C(N=C(C4=C3C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])[H])=C2S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C3N=C([H])C(=C([H])C3=C([H])C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C3C(=NC4=C(C([H])=NN24)S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C3N([H])N=C(C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C3N([H])N=C(C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C3N([H])N=C(C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=C(Cl)C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C3N([H])N=C(C3=C2[H])S(=O)(=O)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C3N([H])N=C(C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@]1([H])C([H])([H])N(C2=C([H])C([H])=C3N([H])N=C(C3=C2[H])S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1([H])C([H])([H])N(C2=C([H])C([H])=C3N([H])N=C(C3=C2[H])S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C1([H])[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N([H])[C@@]1([H])C([H])([H])N(C2=C([H])C([H])=C3N(N=C(C3=C2[H])S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])N(C2=C([H])C([H])=C3N(N=C(C3=C2[H])S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])N(C2=C([H])C([H])=C3N(N=C(C3=C2[H])S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])N(C2=C([H])C3=C(N(N=C3C([H])=C2[H])C([H])([H])[H])S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])N(C2=C([H])C3=C(N(N=C3C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])N(C2=C([H])C3=C(N(N=C3C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NN2C(N=C3C(=C2C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NN2C(N=C(C3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]\C(=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])N1C2=C(C([H])=C(F)C([H])=C2[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]\C(=C(\[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C2=C(C([H])=C(F)C([H])=C2[H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]12[H] [H]\C(=C(/[H])C1=C([H])C([H])=C(F)C([H])=C1[H])N1C2=C(C([H])=C(F)C([H])=C2[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]\C(=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C2=C(C([H])=C(F)C([H])=C2[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]\C(=C(/[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])N1C2=C(C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]\C(=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)N1C2=C(C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]\C(=C(/[H])C1=C([H])C([H])=C(F)C([H])=C1[H])N1C2=C(C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]\C(=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])N1C2=C(C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]\C(=C(\[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C2=C(C([H])=C(C([H])=C2[H])C([H])([H])[H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]12[H] [H]\C(=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C2=C(C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]\C(=C(\[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C2=C(C([H])=C([H])C([H])=C2[H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]12[H] [H]\C(=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C1=C([H])C(I)=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C1=C(C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(OC2=NC([H])=C(C([H])=C2[H])N(C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])=N1 [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1 [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(C#N)=C2[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N([H])N1C(=O)C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] CCCCN1CCC(COC(=O)C2=C3OCCOC3=C(NC)C(Cl)=C2)CC1 COC1=CC=C(NS(=O)(=O)C2=C(C)C3=C(S2)C=CC(Cl)=C3)C=C1N1CCN(CC1)S(=O)(=O)C1=CC=CC2=C(C=CC=C12)N(C)C COC1=CC=C(NS(=O)(=O)C2=C(C)C3=C(S2)C=CC(Cl)=C3)C=C1N1CCN(CCCCCCNS(=O)(=O)C2=CC=CC3=C(C=CC=C23)N(C)C)CC1 COC1=CC=C(NS(=O)(=O)C2=C(C)C3=C(S2)C=CC(Cl)=C3)C=C1N1CCN(CCCCCCCCNS(=O)(=O)C2=CC=CC3=C(C=CC=C23)N(C)C)CC1 COC1=CC=C(C=C1N1CCNCC1)N(S(=O)(=O)C1=C(C)C2=C(S1)C=CC(Cl)=C2)S(=O)(=O)C1=CC=CC2=C(C=CC=C12)N(C)C COC1=CC=C(C=C1N1CCNCC1)N(CCCCNS(=O)(=O)C1=CC=CC2=C(C=CC=C12)N(C)C)S(=O)(=O)C1=C(C)C2=C(S1)C=CC(Cl)=C2 COC1=CC=C(C=C1N1CCNCC1)N(CCCCCCCCNS(=O)(=O)C1=C2C=CC=C(N(C)C)C2=CC=C1)S(=O)(=O)C1=C(C)C2=C(S1)C=CC(Cl)=C2 CN(C)C1=C2C=CC=C(C2=CC=C1)S(=O)(=O)NCCCCCCCCOC1=CC=C(NS(=O)(=O)C2=C(C)C3=C(S2)C=CC(Cl)=C3)C=C1N1CCNCC1 COC1=CC=C(NS(=O)(=O)C2=C3C=CC=C(N(C)C)C3=CC=C2)C=C1N1CCNCC1 COC1=CC=C(C=C1N1CCNCC1)N(S(=O)(=O)C1=C2C=CC=C(N(C)C)C2=CC=C1)S(=O)(=O)C1=C2C=CC=C(N(C)C)C2=CC=C1 COC1=CC=C(NS(=O)(=O)C2=C3C=CC=C(N(C)C)C3=CC=C2)C=C1N1CCN(CCCCNS(=O)(=O)C2=C3C=CC=C(N(C)C)C3=CC=C2)CC1 COC1=CC=C(NS(=O)(=O)C2=C3C=CC=C(N(C)C)C3=CC=C2)C=C1N1CCN(CCCCCCNS(=O)(=O)C2=C3C=CC=C(N(C)C)C3=CC=C2)CC1 COC1=CC=C(NS(=O)(=O)C2=C3C=CC=C(N(C)C)C3=CC=C2)C=C1N1CCN(CCCCCCCCNS(=O)(=O)C2=C3C=CC=C(N(C)C)C3=CC=C2)CC1 COC1=CC=C(NS(=O)(=O)C2=CC=C(C=C2)C2=NC=C(O2)C2=CC=C(C=C2)N(C)C)C=C1N1CCNCC1 [H][C@]12CSC(CCCCC(=O)NCCCCCCN3CCN(CC3)C3=CC(NS(=O)(=O)C4=C(C)C5=C(S4)C=CC(Cl)=C5)=CC=C3OC)[C@@]1([H])NC(=O)N2 [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N1N=C(C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C12)S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C3N(N=C(C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])S(=O)(=O)C1=NN(C2=C([H])C([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C3N(N=C(C3=C2[H])S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])S(=O)(=O)C1=NN(C2=C([H])C([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])S(=O)(=O)C1=NN(C2=C([H])C([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C3N(N=C(C3=C2[H])S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])S(=O)(=O)C1=NN(C2=C([H])C([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C3N(N=C(C3=C2[H])S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C3N(N=C(C3=C2[H])S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1N=C(C2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N1N=C(C2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1N=C(C2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1N=C(C2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1F [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C2=C([H])C([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N1N=C(C2=C([H])C([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C2=C([H])C([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1N=C(C2=C([H])C([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1N=C(C2=C([H])C([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N1N=C(C2=C([H])C([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N(C1=C2C(N([H])N=C2S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C2C(N([H])N=C2S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C2N([H])N=C(C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C2C(N([H])N=C2S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2C(N([H])N=C2S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C2N([H])N=C(C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C2N([H])N=C(C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C1=C2N([H])N=C(C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2C(=O)C([H])([H])C1([H])[H] [H]C1=C([H])C(Cl)=C([H])C2=C1SC(=C2C([H])([H])[H])S(=O)(=O)N1C2=C([H])C(=C([H])C([H])=C2C(=O)C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C(=O)C([H])([H])[C@]1([H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C(=O)C([H])([H])[C@]1([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C(=O)C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C(=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C(=O)C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C2C(=C1[H])N(C([H])([H])C([H])([H])C2=O)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C(=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C(=O)C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C(Br)=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C(=O)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C3C(=C([H])C([H])=C2[H])N([C@@]([H])(C([H])([H])[H])C([H])([H])C3=O)S(=O)(=O)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C(=C([H])C([H])=C2C(=O)C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(C([H])=C2C(=O)C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C(=O)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C(=C([H])C([H])=C2C(=O)C([H])([H])[C@]1([H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C(Br)=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C(Br)=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C(Br)=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C(Br)=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Br [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C(Cl)=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C(Cl)=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Br [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C(Cl)=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C(Cl)C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C(Cl)C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C(Cl)C([H])=C2[H])N1S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C(Cl)C([H])=C2[H])N1S(=O)(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C(Cl)C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Br [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Br [H]N(C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2C(N([H])N=C2S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C2N([H])N=C(C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2C(N([H])N=C2S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C2N([H])N=C(C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2C(N([H])N=C2S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2C(N([H])N=C2S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C2N([H])N=C(C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2C(N([H])N=C2S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C2N([H])N=C(C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N([H])C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])[C@]([H])(C([H])([H])N([H])C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C2C(N([H])N=C2S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H] [H]N([H])C([H])([H])C([H])([H])N([H])C1=C2N([H])N=C(C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C1=C2C(N([H])N=C2S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2C(N([H])N=C2S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C2N([H])N=C(C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=NC(=NC([H])=C2C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N1C2=C(N=C3C([H])=C([H])C([H])=C([H])C3=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])=C([H])C(Cl)=C2[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2N=C2SC(=C([H])C2=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C(C(=O)N([H])C([H])([H])[C@]2([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C(=O)N1C2=C(C([H])=C3OC([H])([H])C4(C3=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C1=NOC(=N1)C([H])([H])[H] [H]N([H])C1=C(Cl)C([H])=C(C2=NN(C(=O)O2)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C2=C1OC([H])([H])C([H])([H])O2 [H]N1C(=O)C2=C(C([H])=C([H])C3=C2C1=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(C2=NSN=C2OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C1C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(Cl)=C3Cl)C([H])([H])C1([H])[H])C([H])=C2[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=C(/[H])C([H])=C1C([H])=C([H])C(=O)C([H])=C1[H])\C1=C([H])C([H])=C([H])C([H])=C1F [H]O[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C(C([H])=C1[H])C1=NOC(=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C(SC4=C2C([H])=C(C([H])=C4[H])C(F)(F)F)C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N1C(=C(C2=C1C([H])([H])C([H])([H])[C@]([H])(C2=O)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3SC3=C2C([H])=C(Cl)C([H])=C3[H])C([H])([H])C1([H])[H] [H]N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])N(C4=C([H])C([H])=C(Cl)C([H])=C34)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N(C3=C(SC2=C1[H])C([H])=C([H])C(SC([H])([H])[H])=C3[H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]\C(=C1\C2=C([H])C([H])=C([H])C([H])=C2SC2=C1C([H])=C(C([H])=C2[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N(C3=C(SC2=C1[H])C([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1Cl)C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3N(C([H])=C(Cl)C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3N(C([H])=C(Cl)C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3N(C([H])=C([H])C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3N(C([H])=C([H])C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3N(C([H])=C([H])C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2Br)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Br)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1Cl)C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])C1=C([H])C([H])=C([H])S1)C([H])=C2[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(OC1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])S1 [H]OC1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC(=C([H])C(=N1)C1=C([H])C([H])=C(F)C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C2C(ON=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3OC([H])([H])[H])C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C(F)=C1[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(Br)=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])C(F)(F)F [H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])C(F)(F)F [H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(C#N)C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])C([H])([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])C([H])([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(Br)C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])C(F)(F)F [H]C1=NC([H])=C(N=C1[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])C([H])([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(F)C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(F)C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1Cl)N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])N1N=C([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C(Cl)N(N=C1C([H])([H])[H])C([H])([H])[H])N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1[H])N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])[C@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)N1N=C([H])[C@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])N1N=C([H])[C@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])N1N=C([H])[C@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])\N1N=C([H])[C@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H])N1N=C([H])[C@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])N1N=C([H])[C@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])C(C([H])([H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])C2(C1([H])[H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])C(C([H])([H])F)(C([H])([H])F)C1([H])[H])C([H])([H])C([H])([H])[H] [H]C1=NN(\C(=N\S(=O)(=O)C2=C([H])C([H])=C([H])C(Cl)=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(\C(=N/S(=O)(=O)C1=C(F)C(Cl)=C([H])C([H])=C1[H])N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C(Cl)S1)N1N=C([H])[C@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])C2(C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])C2(C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])C2(C1([H])[H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12)N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])[C@@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])[H] [H]N(\C(=N/[S@](=O)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H])N1N=C([H])[C@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])[C@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C(=C1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3OC3=C2C([H])=C(Cl)C([H])=C3[H])C([H])([H])C1([H])[H] [H]O[C@@]12O[C@@](N([H])C(=O)[C@]3([H])C([H])=C4C5=C([H])C([H])=C([H])C6=C5C(=C(Br)N6[H])C([H])([H])[C@@]4([H])N(C([H])([H])[H])C3([H])[H])(C(=O)N1[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]21[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(C1=C([H])C([H])=C([H])C([H])=C1C([H])=C2[H])=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C1=C(N=C2N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1SC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2N(C3=C(SC2=C1[H])C([H])=C([H])C(=C3[H])[S@](=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([C@]1([H])C([H])([H])N(C([H])([H])[H])[C@]2([H])C([H])([H])C3=C([H])N(C4=C([H])C([H])=C([H])C(=C34)[C@@]2([H])C1([H])[H])C([H])([H])[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])[C@]2([H])C([H])([H])C3=C([H])N(C4=C([H])C([H])=C([H])C(=C34)[C@@]2([H])C1([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])C(=O)[C@]1([H])C([H])=C2C3=C([H])C([H])=C([H])C4=C3C(=C([H])N4C([H])([H])[H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(SC3=C(C([H])=C(Cl)C([H])=C3[H])[C@]([H])(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C2([H])[H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C(=N2)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]\C(C#N)=C1/C2=C([H])C([H])=C([H])C([H])=C2C(=C([H])C2=C1C([H])=C([H])C(Cl)=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])N2C(S1)=NC(=C(C2=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C(=C(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]\C(C#N)=C1\C2=C([H])SC([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])SC([H])=C12 [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(SN=C2N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)C([H])([H])C4(C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C3=O)C([H])([H])C2([H])[H])=C1[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(I)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(SC4=C([H])C([H])=C([H])C([H])=C4C([H])([H])[H])=C3[H])C([H])([H])[C@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(SC4=C([H])C([H])=C([H])C(=C4[H])C([H])([H])[H])=C3[H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(SC4=C([H])C([H])=C(C([H])=C4[H])C([H])([H])[H])=C3[H])C([H])([H])[C@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(SC4=C([H])C([H])=C([H])C([H])=C4OC([H])([H])[H])=C3[H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(SC4=C([H])C([H])=C([H])C(OC([H])([H])[H])=C4[H])=C3[H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(SC4=C([H])C([H])=C(OC([H])([H])[H])C([H])=C4[H])=C3[H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(SC4=C([H])C([H])=C([H])C([H])=C4F)=C3[H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(SC4=C([H])C([H])=C(F)C([H])=C4[H])=C3[H])C([H])([H])[C@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(SC4=C([H])C([H])=C([H])C([H])=C4C(F)(F)F)=C3[H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(SC4=C([H])C([H])=C([H])C(=C4[H])C(F)(F)F)=C3[H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(SC4=C([H])C([H])=C(C([H])=C4[H])C(F)(F)F)=C3[H])C([H])([H])[C@]2([H])C1([H])[H] [H]O[C@@]12O[C@@](N([H])C(=O)[C@@]3([H])C([H])([H])N(C([H])([H])[H])[C@]4([H])C([H])([H])C5=C([H])N([H])C6=C([H])C([H])=C([H])C(=C56)[C@@]4([H])C3([H])[H])(C(=O)N1[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]21[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C([H])([H])C2=C(C3=C([H])C([H])=C(C([H])=C3O2)S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1F [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C(F)=C([H])C(F)=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(F)=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C(Cl)C(Cl)=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(F)=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C(F)C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])N=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])N=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=NC2=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])N=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C2N=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C([H])=C2N=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])N=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C(C([H])=C([H])C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C(C([H])=C2C2=C1C([H])([H])[C@]1([H])N([H])[C@@]2([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(OC(F)(F)F)=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(C#N)=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=NN(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)N3C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])N=C2C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C2N=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])N=C2C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(SC([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(SC([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=NC([H])=C([H])C([H])=C2C([H])=C1[H] [H]C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C([H])C([H])=C2C([H])=C1[H])S(=O)(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]C1=NC2=C(C([H])=C([H])C([H])=C2C([H])=C1[H])S(=O)(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(OC3=C([H])C(=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])[C@]11C([H])([H])OC([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(OC3=C([H])C(=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])[C@]11C([H])([H])OC([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(OC3=C([H])C(=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C11C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(OC3=C([H])C(=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])[C@]1(C([H])([H])[H])C([H])([H])OC([H])([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(OC3=C([H])C(=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])[C@]1(C([H])([H])[H])C([H])(F)F [H]N1C([H])([H])C([H])([H])C2=C(OC3=C([H])C(=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(OC3=C([H])C(=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C1(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(OC3=C([H])C(=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C1(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C2=C(C3=C([H])C([H])=C(C([H])=C3O2)S(=O)(=O)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(C3=C([H])C([H])=C(C([H])=C3O2)S(=O)(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(C3=C([H])C([H])=C(C([H])=C3O2)S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(C3=C([H])C(=C([H])C([H])=C3O2)S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C3C(=NC4=C(C(SC([H])([H])[H])=NN24)S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C1=NN2C(N=C(C([H])=C2N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C(Cl)C(=NC2=C(C(=NN12)N([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C([H])=C(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])[H])C([H])=C2[H])=C([H])C(Br)=N1 [H]C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])N3C([H])([H])C([H])([H])C([H])([H])S3(=O)=O)C([H])([H])C2([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])C(=C(C([H])([H])[H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])C(=C(C([H])([H])[H])C2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C2=C(S1)C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C2\C(=C(\[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C(=C(C2=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C2C(=C1[H])C(=C(C([H])([H])[H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C([H])C(F)=C([H])C([H])=C2[C@](C1=O)(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(F)C([H])=C2[C@@]([H])(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([3H])([3H])[3H])C([H])([H])C([H])([H])C1=C(OC([3H])([3H])[3H])C([H])=C(I)C(OC([H])([H])[H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N([H])C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N([H])C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H])C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C1([H])[H] [H]N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC3=C(N=NN3C3=C2SC([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C1([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]12C([H])([H])[C@]3([H])C([H])([H])[C@](C([H])([H])[H])(C1([H])[H])C([H])([H])[C@@](C([H])([H])[H])(C3([H])[H])C2([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(Cl)=C1N=C2OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC(=C2[H])C(=O)N([H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(O[C@@]([H])(OC([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(O[C@]([H])(OC([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C23)C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(O[C@]([H])(OC([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C23)C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(O[C@]([H])(OC([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C23)C1([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]([H])(OC([H])([H])[H])O[C@@]21C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(O[C@@]([H])(OC([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(O[C@@]([H])(OC([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)C1([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])[C@]([H])(OC([H])([H])[H])O[C@@]21C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(O[C@@]([H])(OC([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)C1([H])[H] [H]N(C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1 [H]N(C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1 [H]N(C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2SC([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]N(C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1 [H]N(C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(F)=C(F)C([H])=C1[H] [H]N(C(=O)C1=C(F)C(F)=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1 [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1 [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1 [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1 [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1 [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C(Cl)=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1 [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1 [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C2N=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2SC([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(F)=C(F)C([H])=C1[H] [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(F)=C(F)C([H])=C1[H] [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1F [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C3C(=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1F [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2SC([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N([C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1 [H]N([C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1 [H]N([C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(=C([H])C(=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C2=C1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C(F)(F)F [H]C1=C([H])C(=C([H])C(=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(Cl)C([H])=C2C2=C1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C(F)(F)F [H]C1=C([H])C(=C([H])C(=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(Br)C([H])=C2C2=C1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C(F)(F)F [H]C1=C([H])C([H])=C(C([H])=C1[H])C(\Cl)=C(\C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C(Cl)C([H])=C1[H])N2C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]\C(=C1/C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])OC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C2([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(O[H])C([H])=C2S1 [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=C(\C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])\C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=C(\C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])Cl)\C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(\[H])=C2/C3=C(SC4=C2C([H])=C(Cl)C([H])=C4[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]C1=C([H])C(Cl)=C([H])C(=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(SC([H])([H])[H])C([H])=C2C2=C1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C(Cl)=C([H])C(=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(F)C([H])=C2C2=C1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]C1=C2N(C3=C(C2=C([H])C(SC([H])([H])[H])=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C2N(C3=C(C2=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C2N(C3=C(C2=C([H])C(F)=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C2N(C3=C(C2=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]C1=C2N(C3=C(C2=C([H])C(F)=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]C1=C2N(C3=C(C2=C([H])C(Cl)=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C(F)C([H])=C(F)C([H])=C2C2=C1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(SC([H])([H])[H])C([H])=C2C2=C1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C2=C1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(F)C([H])=C2C2=C1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(Cl)C([H])=C2C2=C1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(Br)C([H])=C2C2=C1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]N([H])[C@@]1([H])C([H])([H])C2=C(N([H])C3=C([H])C([H])=C(C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C3C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C3([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])S(=O)(=O)N1C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3C(=C21)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])C2=C([H])N(C3=C([H])C([H])=C([H])C(=C23)C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])[C@@]1([H])C([H])([H])C2=C(N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])C2=C(N(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])[C@@]1([H])C([H])([H])C2=C(N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])[C@@]1([H])C([H])([H])C2=C(N(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=C2N(C3=C(C2=C([H])C(Br)=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C(F)=C(F)C([H])=C1[H] [H]C1=C2N(C3=C(C2=C([H])C(Br)=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C(F)C(F)=C(F)C([H])=C1[H] [H]C1=C2N(C3=C(C2=C([H])C(Br)=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C(=C1[H])C(F)(F)F [H]C1=C2N(C3=C(C2=C([H])C(SC([H])([H])[H])=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C2N(C3=C(C2=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C2N(C3=C(C2=C([H])C(Br)=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C2N(C3=C(C2=C([H])C(F)=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C2N(C3=C(C2=C([H])C(Br)=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C2N(C3=C(C2=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C2N(C3=C(C2=C([H])C(SC([H])([H])[H])=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C2N(C3=C(C2=C([H])C(F)=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C2N(C3=C(C2=C([H])C(Cl)=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(F)=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C2=C1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(Cl)=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C2=C1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(Br)=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C2=C1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C(Br)=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(F)C([H])=C2C2=C1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C(Br)=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(Cl)C([H])=C2C2=C1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Br)C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C1=C([H])C(=NC2=C(C(SC([H])([H])[H])=NN12)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C1=NC2=C(C(SC([H])([H])[H])=NN2C(=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1SC([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NC2=C(C(SC([H])([H])[H])=NN2C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(F)C([H])=C1[H] [H]N(C1=NN2C([H])=C([H])C([H])=NC2=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NN2C([H])=C([H])C(=NC2=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NN2C(N=C([H])C([H])=C2C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NN2C(N=C(C([H])=C2C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])C(=NC2=C(C(=NN12)N([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NN2C([H])=C([H])C([H])=NC2=C1S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NN2C(N=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NN2C(N=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(C1=NN2C(N=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]C1=NC2=C(C(SC([H])([H])[H])=NN2C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C([H])=C([H])N2N=C1SC([H])([H])[H])C([H])([H])[H] [H]C1=NC2=C(C(SC([H])([H])[H])=NN2C(=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1SC([H])([H])[H])C([H])([H])OC([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1SC([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])[H] [H]C1=NC2=C(C(SC([H])([H])[H])=NN2C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]C1=NC2=C(C(SC([H])([H])[H])=NN2C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1SC([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=NC2=C(C(SC([H])([H])[H])=NN12)S(=O)(=O)C1=C([H])C(Cl)=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(C1=NN2C(N=C(C([H])=C2C([H])([H])OC([H])([H])[H])C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C1=NC2=C(C(=NN2C(=C1[H])C([H])([H])[H])N([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NN2C(N=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NN2C([H])=C([H])C([H])=NC2=C1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(C1=NN2C(N=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C(Cl)=C(F)C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C([H])=C(N2N=C1N([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2N(C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2N(C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1([H])C([H])([H])N(C(=O)[C@]2([H])C3=C([H])C([H])=C([H])C([H])=C3N(C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)C1([H])[H] [H]N([H])C([H])([H])C1([H])C([H])([H])N(C(=O)[C@]2([H])C3=C([H])C([H])=C([H])C([H])=C3N(C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)C1([H])[H] [H]N(C(=O)[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2N(C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C3=C([H])C([H])=C([H])C([H])=C3N(C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@@]2([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N1C([H])([H])C([H])([H])N(C(=O)[C@@]2([H])C3=C([H])C([H])=C([H])C([H])=C3N(C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2N(C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2N(C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2N(C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C(Cl)C([H])=C([H])C([H])=C12 [H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])[C@@]2([H])C([H])([H])C([H])([H])O[C@@]2([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C(=C([H])N=C12)C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=NSN=C12 [H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C2=C(S1)C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(S1)S(=O)(=O)N1C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(C(=O)N(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C([H])=C(OC([H])([H])[H])C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(C(=O)N(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(C(=O)N(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2N(C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C([H])=C(Cl)S2)C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C(Cl)N=C3SC([H])=C([H])N23)C1([H])[H] [H]C1=C([H])N2C(S1)=NC(Cl)=C2S(=O)(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])N2C(S1)=NC(Cl)=C2S(=O)(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C(Cl)N=C3SC([H])=C([H])N23)C1([H])[H] [H]C1=C([H])N2C(S1)=NC(Cl)=C2S(=O)(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(Cl)=C([H])C(Cl)=C1OC([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C(N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C1=NC([H])=C([H])C([H])=N1)C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(C([H])([H])N([H])[H])C([H])([H])C([H])([H])C2([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(C#N)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])N([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])N([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])N(C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])N([H])N=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])N=C([H])S2)C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C3=C2N=C([H])N3[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C([H])([H])N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OS(=O)(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C(=O)N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])N([H])C(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C(=O)N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(C(=O)N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C(F)(F)F [H]N([H])S(=O)(=O)N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])S(=O)(=O)N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(F)=C1[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])S1(=O)=O)C([H])([H])C([H])([H])C2([H])[H] [H]N(C1=NC([H])([H])C(=O)N1[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NC([H])=C([H])N1[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=O)C([H])([H])N(C([H])([H])[C@@]2([H])C3=C(C([H])=C(C([H])=C3[H])S(=O)(=O)C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2F)S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C(=O)N(C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(F)=C1[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(F)=C1[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(C([H])([H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H] [H]N([H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N1[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1([H])C([H])([H])N(C([H])([H])[C@@]2([H])C3=C(C([H])=C(C([H])=C3[H])S(=O)(=O)C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N([H])C(=O)N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2F)S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2F)S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C(=O)N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2F)S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NN2C([H])=C3C(=NC2=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C3([H])[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C2SN=C(\N=C(/[H])N(C([H])([H])[H])C([H])([H])[H])C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C2SN=C(\N=C(/[H])N(C([H])([H])[H])C([H])([H])[H])C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=C([H])C([H])=C2SN=C(\N=C(/[H])N(C([H])([H])[H])C([H])([H])[H])C2=C1[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N(C1=NN2C([H])=C3C(=NC2=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C3([H])[H])C([H])([H])[H] [H]N(C1=NN2C(N=C([H])C3=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C3([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NN2C(N=C([H])C3=C2C([H])([H])C([H])([H])N([H])C3([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NN2C(N=C3C(=C2C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NN2C(N=C(C3=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C3([H])[H])C([H])([H])[H])=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=NC2=C(C(SC([H])([H])[H])=NN2C2=C1C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1N=C([H])C(N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])=C(Cl)C1=O [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])N1N=C([H])C(N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])=C(Cl)C1=O [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C(=C([H])C([H])=C1[H])C([H])([H])N1N=C([H])C(N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])=C(Cl)C1=O)C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C3=C(C([H])=C([H])C([H])=C3[H])N2N=N1 [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C([H])C3=C(C([H])=C([H])C([H])=C3[H])N2N=N1 [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(SC([H])([H])C([H])([H])[H])C3=C(C([H])=C([H])C([H])=C3[H])N2N=N1 [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C(Cl)C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C(C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=NC3=C(N=NN3C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)C2=C([H])C(=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(N(C([H])([H])[H])C([H])([H])[H])C3=C(C([H])=C([H])C([H])=C3[H])N2N=N1 [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C3=C(C([H])=C([H])C([H])=C3[H])N2N=N1 [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])[H])C3=C(C([H])=C([H])C([H])=C3[H])N2N=N1 [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] CN1CCC(CC1)C1=CN(C2=CC=C(C=C12)C1=CN=CN=C1)C1=CC=C(F)C=C1 ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNS(=O)(=O)C2=CN=CC3=CC=CC=C23)CC1 ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNS(=O)(=O)C2=CC3=CC=CC=C3C=N2)CC1 ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNS(=O)(=O)C2=CC=CC3=CC=CN=C23)CC1 ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNS(=O)(=O)C2=CC3=NC=CC=C3C=C2)CC1 ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNS(=O)(=O)C2=CC3=CC=CN=C3C=C2)CC1 ClC1=CC=C2N=CC(=CC2=C1)S(=O)(=O)NCCCCN1CCN(CC1)C1=CC=CC(Cl)=C1Cl ClC1=C(Cl)C(=CC=C1)N1CCN(CCCNS(=O)(=O)C2=CC3=NC=CC=C3C=C2)CC1 ClC1=C(Cl)C(=CC=C1)N1CCN(CCCNS(=O)(=O)C2=CC3=CC=CN=C3C=C2)CC1 ClC1=CC=C2N=CC(=CC2=C1)S(=O)(=O)NCCCN1CCN(CC1)C1=CC=CC(Cl)=C1Cl