[H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=C(C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])[C@]2([H])C([H])([H])C([H])=C([H])C([H])([H])[C@]2([H])C1=O)C([H])([H])C([H])([H])[C@]1([H])O[C@@]([H])(C([H])([H])C([H])([H])C2=C(F)C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=C(C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])[C@]2([H])C([H])([H])C([H])=C([H])C([H])([H])[C@]2([H])C1=O)C([H])([H])C([H])([H])[C@]1([H])O[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(OC(=O)[C@@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])[C@@]2([H])C(=O)OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C(=O)N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1I)[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C(Br)=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] CCCC[Sn](CCCC)(CCCC)C1=CC=CC(=C1)C1CC2CCC(C1C(=O)OC)N2C [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C2([H])[H] [H]N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C2([H])[H] [H]C1=C([H])C(=C([H])C(I)=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]OC1=C2C(=C([H])C([H])=C1C([H])([H])[H])[C@@]([H])(O[C@@]([H])(C2([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])N([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(O[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1I)C([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(I)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)[C@@]([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(I)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(I)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)C([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(O[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])(O[C@@]1([H])C([H])([H])[C@@]3([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C21 [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C(Br)C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C(I)C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1I)[C@@]1([H])C([H])([H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])N2C(SC3=C([H])C([H])=C(Cl)C([H])=C3[C@]([H])(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C2([H])[H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])OC(=O)C([H])([H])C([H])([H])SC([H])([H])C([H])([H])SC([H])([H])[H] CN1C2CCC1[C@@H](COC(=O)CC[S+]1CC[S+](C)[Re]1(Br)(C=O)(C=O)C=O)[C@H](C2)C1=CC=C(F)C=C1 [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]([H])(C2([H])[H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]([H])(C2([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])=C(C([H])=C2[H])[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]([H])(C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C(=C1[H])C(=O)OC([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C1=C(C(=O)OC([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]([H])(C2([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]([H])(C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C(=C1[H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)[C@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC1=C([H])C([H])=C([H])C([H])=C1C(=O)OC([H])([H])[H] [H]\C(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])=C1\C([H])([H])N2C3([H])C([H])([H])C([H])([H])[C@]2([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@]1([H])C3([H])[H] [H]\C(C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])=C1\C([H])([H])N2C3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@]1([H])C3([H])[H] [H]\C(C1=C([H])C([H])=C([H])C([H])=C1[H])=C1\C([H])([H])N2C3([H])C([H])([H])C([H])([H])[C@]2([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@]1([H])C3([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(OC([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])[C@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[C@]2([H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C1=C([H])C(I)=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] CN1CC[C@@H]([C@H](CCC[N+]23CCS[Re]22(=O)SCCN2CC3)C1)C1=CC=C(Cl)C=C1 CN1CC[C@@H]([C@H](CCC[N+]23CCS[Re]22(=O)SCCN2C(=O)C3)C1)C1=CC=C(Cl)C=C1 [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@@]1(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1(O[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]O[C@@]1(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]O[C@@]1(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]O[C@@]1(C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]O[C@@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1Cl)[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1(O[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])[C@]1([H])OC(=O)O[C@]2(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]12[H] [H]N([H])C1=C([H])C(C#N)=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(Cl)=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(F)(F)F [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])O[C@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C2C(=C([H])C(I)=C1[H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]2([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H] [H]N(C([H])(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])[H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H] [H]N([C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3[H])=C1[H])C([H])([H])C2([H])[H] [H]O[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]1([H])C(C(=O)OC([H])([H])[H])=C(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C2([H])[H] [H]O[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]O[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C2([H])[H] [H]O[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C1[H])[C@@]2([H])C(=O)OC([H])([H])[H] [H]O[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C1[H])C2([H])[H] [H]O[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C2([H])[H] [H]O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]1([H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]2([H])C(=O)OC([H])([H])[H] [H]O[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])[C@@]2([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]2([H])C(=O)OC([H])([H])[H] [H]O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]1([H])C([H])([H])[C@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]2([H])C(=O)OC([H])([H])[H] [H]O[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]1([H])C(C(=O)OC([H])([H])[H])=C(C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]O[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]O[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])C(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])=C2C(=O)OC([H])([H])[H] [H]O[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]O[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]1([H])C(C(=O)OC([H])([H])[H])=C(C1=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C1[H])C2([H])[H] [H]N1C(=O)C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2Cl)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C([H])([H])OC(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3[H])=C1[H])C([H])([H])C2([H])[H] [H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]O[C@]1(N2C(=NC([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@@]1(N2C(=NC([H])([H])C2([H])[H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C12)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]O[C@@]1(N2C(=NC([H])([H])C([H])([H])C2([H])[H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=N1)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC(=C([H])C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])O1 [H]C1=C([H])C([H])=C(C#CC([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C3=C([H])C([H])=C(F)C([H])=C3[H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(SC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(OC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@@]1(N2C(=NC([H])([H])C2([H])[H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]\C(=C(\[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1 [H]\C(=C(\[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C(C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C3=C([H])C([H])=C(F)C([H])=C3[H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]1(N2C(=N[C@]3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]23[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(\C([H])=C(/[H])I)C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(I)C([H])=C1[H])C2([H])[H] [H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C(=C([H])C(=C12)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@]1(N2C(=NC([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]O[C@@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C(Cl)=C(Cl)C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C(F)C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])C1=NC([H])([H])C([H])([H])N1[C@@]2([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H] [H]O[C@]1(N2C(=NC([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])C1=NC([H])([H])C([H])([H])C([H])([H])N1[C@@]2(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C([H])=C3OC([H])([H])OC3=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1(O[H])N2C(=NC([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C(C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)[C@@]1([H])N([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])SC([H])=C1[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(/[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C(=C1Cl)C([H])([H])[H])[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]1([H])OC([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])[C@@]1([H])[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C2([H])[H] [H]N(C([H])([H])[H])C([H])([H])[C@]1([H])[C@@]([H])(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C2([H])[H] [H]N(C([H])([H])[H])C([H])([H])[C@]1([H])[C@@]([H])(C2=C([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3C([H])=C2[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C2([H])[H] [H]C1=C([H])C(=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)[C@@]1([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C2([H])[H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])[C@@]1([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])[C@@]([H])(C#N)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]1([H])OC([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])[C@@]([H])(C(=O)OC([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]1([H])OC([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]([H])(C([H])([H])OC2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(C#N)=C2[H])[C@@]1([H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(OC1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])S1 [H]C1=C([H])C(=C([H])C(Cl)=C1[H])[C@@]1([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C2=C([H])C([H])=C(F)C([H])=C12)[C@@]1([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C2([H])[H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] COC(=O)C1C2CCC(CC1C1=CC=C(Cl)C(Cl)=C1)N2CCC[N+]12CCS[Re]11(=O)SCCN1C(=O)C2 COC(=O)C1C2CCC(CC1C1=CC=C3C=CC=CC3=C1)N2CCC[N+]12CCS[Re]11(=O)SCCN1C(=O)C2 CCC(=O)C1C2CCC(CC1C1=CC=C(Cl)C(Cl)=C1)N2CCC[N+]12CCS[Re]11(=O)SCCN1C(=O)C2 COC(=O)C1C2CCC(CC1C1=CC=C(F)C=C1)N2CCC[N+]12CCS[Re]11(=O)SCCN1C(=O)C2 CCC(=O)C1=C(CC2CCC1N2CCC[N+]12CCS[Re]11(=O)SCCN1C(=O)C2)C1=CC=C(F)C=C1 COC(=O)C1=C(CC2CCC1N2CCC[N+]12CCS[Re]11(=O)SCCN1C(=O)C2)C1=CC(Cl)=C(Cl)C=C1 CCC(=O)C1C2CCC(CC1C1=CC=C(F)C=C1)N2CCC[N+]12CCS[Re]11(=O)SCCN1C(=O)C2 CCC(=O)C1=C(CC2CCC1N2CCC[N+]12CCS[Re]11(=O)SCCN1C(=O)C2)C1=CC(Cl)=C(Cl)C=C1 COC(=O)C1=C(CC2CCC1N2CCC[N+]12CCS[Re]11(=O)SCCN1C(=O)C2)C1=CC=C(F)C=C1 COC(=O)C1=C(CC2CCC1N2CCC[N+]12CCS[Re]11(=O)SCCN1C(=O)C2)C1=CC2=CC=CC=C2C=C1 CON(C)C(=O)C1C2CCC(CC1C1=CC=C(F)C=C1)N2CCC[N+]12CCS[Re]11(=O)SCCN1C(=O)C2 [H]OC1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1[H])[C@@]1([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C2([H])[H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(O[H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])[H] [H]OC1=C(O[H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])[C@]1([H])[C@@]([H])(C2=C([H])C3=C([H])C([H])=C(F)C([H])=C3C([H])=C2[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1I)C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C1=C(C(=O)OC([H])([H])[H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1I)C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(C(=O)OC([H])([H])[H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])S1)C1=C([H])C([H])=C([H])C(=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C(I)=C([H])C([H])=C1[H])C2([H])[H] [H]C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C([H])C(=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]\C(I)=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(\C([H])=C(\[H])Br)C([H])=C1[H])C2([H])[H] [H]C1=C([H])C([H])=C(OC(=O)[C@@]2([H])[C@@]3([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]C(=C(Br)Br)C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]\C(Br)=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C(Br)Br)C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])C([H])([H])C([H])([H])F)[C@@]([H])(C1=C([H])C([H])=C(Br)C([H])=C1[H])C2([H])[H] [H]N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])F)[C@]([H])(C1=C([H])C([H])=C(Br)C([H])=C1[H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])F [H]N([H])C1=C(OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(I)=C1[H] [H]N([H])C1=C(C([H])=C([H])C(I)=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(I)=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C1=C(OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(I)=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])C([H])([H])F [H]N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])F)[C@]([H])(C1=C([H])C([H])=C(I)C([H])=C1[H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N([H])C1=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C([H])([H])C([H])=C([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])F [H]N([H])C1=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C([H])([H])C([H])([H])F)C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C1=C([H])C(N([H])[H])=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])F [H]N([H])C1=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C1=C([H])C(N([H])[H])=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])C1=C([H])C(N([H])[H])=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(I)=C([H])C(=C1[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C([H])=C([H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C(=O)[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C#N)C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(C(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1I)C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C#CC([H])([H])[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(C(=O)[C@]([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C([H])=C([H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C(=O)C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC1=C(O[H])C([H])=C(C([H])=C1[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])N(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])[N+]([O-])=O [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1(C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]O[C@]1(C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]O[C@@]1(C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])(C1=C2C([H])=C([H])C([H])=C1[H])C1=C([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C1=C2C([H])=C([H])C(=C1[H])C1=C([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1(C(=O)N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1(C(=O)N(C2=C([H])C([H])=C(F)C(F)=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1C(=O)OC([H])([H])[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])OC1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C2N=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C(C2=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N(C2=C([H])C([H])=C([H])C(F)=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1(C(=O)N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1(C(=O)N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1(C(=O)N(C2=C([H])C(F)=C([H])C(F)=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1(C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1(C(=O)N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1(C(=O)N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1(C(=O)N(C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1(C(=O)N(C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]OC([H])([H])C1=C([H])C(N([H])[H])=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C([H])([H])[H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]N([H])C1=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(C([H])=C([H])[H])=C1[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(N([H])[H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])[S@](=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])N(C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])[C@]([H])(OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C(=C(C([H])=C1[H])C1=C2C([H])=C([H])C(C([H])=C2OC2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=[N+](C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])S([O-])(=O)=O)C([H])([H])C([H])([H])OC(=O)[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C2=C([H])C(=C(C([H])=C2[H])C2=C3C([H])=C([H])C(C([H])=C3OC3=C([H])C(=C([H])C([H])=C23)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=[N+](C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])S([O-])(=O)=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C2([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C2=C(C([H])=C3C([H])=C4C([H])=C([H])C(C([H])=C4C(C3=C2[H])(C([H])([H])[H])C([H])([H])[H])=[N+](C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C2([H])[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)N([H])C([H])([H])[H] [H]N([H])C(=O)C1=C2C(=C([H])C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C(C#N)=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])C([H])([H])[S@](=O)C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=C([H])C([H])=C1C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])N(C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C2C(=C1[H])[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C2C(=C1[H])[C@]([H])(N([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]2([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C2C(=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])[S@](=O)C([H])([H])[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])[N+]([O-])=O [H]N(C(=O)C1=C2C(=C([H])C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N([H])C(=O)C1=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C2C(=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])C(=O)OC([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(Cl)C([H])=C([H])C(Cl)=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C2C(=C1[H])[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])N1N=NC([H])=C1[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])[S@@](=O)C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C(O[11C]([H])([H])[H])C([H])=C2[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2N=C([H])C(=O)N(C2=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C2C(=C1[H])[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]OC(=O)C1=C2C(=C([H])C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C(C([H])=C2[H])[C@@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])[C@]2([H])C([H])([H])OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=O [H]N1C2=C([H])C([H])=C(C([H])=C2[H])[C@]2([H])C([H])([H])[C@]3([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C3([H])[H])[C@@]2([H])C([H])([H])OC(=O)C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C([H])C([H])=C3C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C1=O [H]N1C2=C([H])C([H])=C(C([H])=C2[H])[C@@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])[C@]2([H])C([H])([H])OC(=O)C([H])([H])C([H])([H])SC([H])([H])C([H])([H])C1=O [H]N1C2=C([H])C([H])=C(C([H])=C2[H])[C@]2([H])C([H])([H])[C@]3([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C3([H])[H])[C@]2([H])C([H])([H])OC(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C1=O [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])C([H])([H])N([H])S(=O)(=O)C([H])([H])[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C1=C([H])C([H])=C2C(=C1[H])[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N([H])C(=O)C([H])([H])C1=C([H])C([H])=C2C(=C1[H])[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])N1N=C([H])N=C1[H] [H]N(C(=O)C1=C([H])C([H])=C2C(=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])[H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C(C([H])=C2[H])[C@@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])[C@]2([H])C([H])([H])OC(=O)C([H])([H])C([H])([H])C(=O)C([H])([H])C([H])([H])C1=O [H]N([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C(OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])N(C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])[C@]2([H])N(C3=NC(=C([H])C([H])=C3C2([H])[H])C([H])([H])OC([H])([H])C2([H])C([H])([H])C2([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C1N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[C@]1([H])[C@@]3([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C([H])([H])[C@@]21[H] [H]C1=C([H])C2=C([H])C([H])=C1N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[C@]1([H])[C@]3([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C3([H])[H])C([H])([H])[C@]21[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C(=C1[H])[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C2C(=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])[H] [H]N([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])C(F)(F)F)C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=C2[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] COC1=CC=C(C=C1)[C@H](CN(C)C)[Si]1(O)CCCCC1 [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])SC([H])([H])[C@]2([H])N([H])C(=O)N([H])[C@]12[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])SC([H])([H])[C@]2([H])N([H])C(=O)N([H])[C@]12[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C([H])=C1C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C3([H])[H] [H]C([H])=C1C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(I)C([H])=C1[H])C3([H])[H] [H]\C(C(=O)OC([H])([H])[H])=C1/C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C3([H])[H] [H]C([H])=C1C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(Br)C([H])=C1[H])C3([H])[H] [H]\C(C(=O)OC([H])([H])[H])=C1/C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C3([H])[H] [H]C([H])=C1C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C3([H])[H] [H]\C(C(=O)OC([H])([H])[H])=C1/C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(Br)C([H])=C1[H])C3([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)[C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])[C@]([H])(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C3=C(C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])O1)C1=C(OC([H])([H])[H])N=C(N=C1OC([H])([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2F)C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])SC([H])([H])[C@]2([H])N([H])C(=O)N([H])[C@]12[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])C(=O)C([H])([H])[H])C(=O)C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C(=C([H])C(=C1[H])C(=O)C([H])([H])[H])C(=O)C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])F)C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])C(=O)C([H])([H])[H])C(=O)C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C(=C([H])C(=C1[H])C(=O)C([H])([H])[H])C(=O)C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])C(=O)C([H])([H])[H])C(=O)C([H])([H])[H] [H]N=C(N([H])[H])N1C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C(=C([H])C(=C1[H])C(=O)C([H])([H])[H])C(=O)C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C([H])([H])[H] [H]N([H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C(=C([H])C(=C1[H])C(=O)C([H])([H])[H])C(=O)C([H])([H])[H] [H]C([H])=C([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])C(=O)C([H])([H])[H])C(=O)C([H])([H])[H] [H]C#CC([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C(=C([H])C(=C1[H])C(=O)C([H])([H])[H])C(=O)C([H])([H])[H] [H]C([H])=C([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C(=C([H])C(=C1[H])C(=O)C([H])([H])[H])C(=O)C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])[C@]3([H])C([H])([H])[H])C([H])=C2C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C(\C([H])=C(/[H])I)=C1[H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1SC([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(F)C([H])([H])C3([H])[H])C([H])=C2C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1SC([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C2C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]N1[C@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C2([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C(C(=O)OC([H])([H])C([H])([H])[H])=C(C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])=C(C([H])=C2[H])C1=C(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C1=C(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C1=C(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])=C(C([H])=C2[H])C1=C(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1I)[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=C(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[N+]([O-])=O [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C(C(=O)OC([H])([H])C([H])([H])[H])=C(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])[C@]1([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(Cl)C(=C([H])C([H])=C2[H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C(\C([H])=C(/[H])Br)=C1[H])C2([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C(F)=C([H])C([H])=C2[H])C(F)(F)F)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C2([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C(Cl)=C([H])C([H])=C2[H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(F)C(F)=C(F)C([H])=C2[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C(C#N)=C([H])C([H])=C12)C1=C([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C#CC1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N([H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C([H])=C([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N([H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N1[C@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C(F)=C1[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C(=C([H])C2=C([H])C(C#N)=C([H])C([H])=C12)[C@]1([H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(C#CC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C([H])=C1OC1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(C#CC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(F)C([H])([H])C2([H])[H])=C([H])C([H])=C1OC1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C1([H])[H] [H]C1=NC([H])=C(C([H])=C1[H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])[C@]2([H])N(C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C2=C([H])C([H])=C(C#N)C([H])=C12)[C@]1([H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(C#CC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C([H])=C1OC1=C([H])C(=C(SC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(C#CC([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1OC1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(SC2=C(N([H])[H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(SC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])F)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(F)=C1[H] [H]OC1=C([H])C([H])=C(SC2=C(N([H])[H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(SC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(SC2=C([H])C([H])=C(OC([H])([H])C([H])([H])F)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(Br)=C1[H] [H]N([H])C1=C(SC2=C([H])C([H])=C(OC([H])([H])C([H])([H])F)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(Cl)=C1[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1=C(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1=C(C(=O)OC([H])([H])C(F)(F)F)C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(SC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])F)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(Br)=C1[H] [H]N([H])C1=C(SC2=C([H])C([H])=C(OC([H])([H])C([H])([H])F)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(SC2=C(N([H])[H])C([H])=C(Br)C([H])=C2[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])OC(=O)C1=C(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@]([H])(C(=O)OC([H])([H])C([H])([H])F)[C@@]([H])(C1=C([H])C([H])=C(\C([H])=C(\[H])I)C([H])=C1[H])C2([H])[H] [H]N(C(=O)C1=C(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]C1=C([H])C([H])=C(O1)C([H])([H])OC(=O)C1=C(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1=C(C(=O)N(OC([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1=C(C(=O)OC([H])([H])C([H])([H])F)C([H])([H])C([H])([H])C1([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(OC(=O)C2=C(C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(OC(=O)C2=C(C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(S1)C([H])([H])OC(=O)C1=C(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])F [H]C1=C([H])C([H])=C(OC(=O)C2=C(C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])OC1=C([H])C([H])=C(SC2=C(N([H])[H])C([H])=C(F)C([H])=C2[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(SC([H])([H])[H])=C([H])C([H])=C1SC1=C([H])C([H])=C(C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C([H])=C(SC2=C([H])C([H])=C(SC([H])([H])[H])C([H])=C2[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C([H])=C(SC2=C([H])C([H])=C(SC([H])([H])[H])C([H])=C2[H])C(=C1[H])C([H])([H])N([H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C([H])=C(SC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(I)=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C([H])C([H])=C([H])C(O[11C]([H])([H])[H])=C2C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(I)=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C([H])C([H])=C(O[11C]([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(Br)=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C([H])C([H])=C([H])C(O[11C]([H])([H])[H])=C2C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(Br)=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C([H])C([H])=C(O[11C]([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(F)=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C([H])C([H])=C([H])C(O[11C]([H])([H])[H])=C2C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(F)=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C([H])C([H])=C(O[11C]([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(C([H])=C2[H])C2([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(Br)C([H])=C2[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]C1=C([H])C(SC([H])([H])[H])=C([H])C([H])=C1OC1=C([H])C([H])=C(Br)C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(SC([H])([H])[H])=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(SC([H])([H])[H])=C([H])C([H])=C1OC1=C([H])C([H])=C(F)C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(Cl)C(Cl)=C2[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C([H])C(Cl)=C2[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(SC2=C([H])C([H])=C(SC([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(SC2=C([H])C([H])=C([H])C(Cl)=C2[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(SC2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1SC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C(=C1[H])C(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]OC1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])OC1=C([H])C([H])=C(SC2=C(N([H])[H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C(F)=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C(Cl)=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C(=C(SC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C(Cl)=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C(=C(SC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C(=C(SC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C1=C([H])C(N([H])[H])=C(SC2=C([H])C([H])=C(F)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C1=C([H])C(N([H])[H])=C(SC2=C([H])C([H])=C(Br)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C1=C([H])C(N([H])[H])=C(SC2=C([H])C([H])=C(I)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C(SC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])F)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(SC2=C([H])C([H])=C(OC([H])([H])C([H])([H])F)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(F)=C1[H] [H]N(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])OC1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N1C([H])=C(C2=C([H])C(C#N)=C([H])C([H])=C12)[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C(C#N)=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C3=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C(C#N)=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C3=C(C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C1=C(ON=C1C([H])([H])[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C(N=NN1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(N=NN1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C#C[C@]2([H])[C@]3([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C3([H])[H])C([H])([H])[C@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C#CC1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]C1=C([H])C([H])=C(C#C[C@]2([H])[C@]3([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C3([H])[H])C([H])([H])[C@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C#C[C@]2([H])[C@]3([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C3([H])[H])C([H])([H])[C@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]C#C[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C#C[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C(=C(Br)Br)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C(=C(Br)Br)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C1=C(C(=NO1)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=C(ON=C1C([H])([H])[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C1=C(C(=NO1)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(ON=C1C([H])([H])[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(ON=C1C([H])([H])[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C1=C(ON=C1C([H])([H])[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C1=C(ON=C1C([H])([H])[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(ON=C1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C(ON=C1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(ON=C1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C(ON=C1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(ON=C1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(ON=C1C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C(ON=C1C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(ON=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(ON=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])[C@@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H] [H]N([H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H] [H]N(C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(OC2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N([H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(OC2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N([H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]([H])(OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])[C@@]1([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C1([H])[H] [H]N([H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C1([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C(=C2[H])C([H])([H])[H])[S@](=O)C([H])([H])[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])S1 [H]N(C([H])([H])[H])C([H])([H])[C@]1([H])OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])OC1=C([H])C([H])=C([H])C(Cl)=C1C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])[C@]1([H])OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])OC1=C([H])C([H])=C([H])C([H])=C1SC([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])SC2=C(C([H])=C([H])C([H])=C2[H])[C@]1([H])OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]O[C@]1(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]1([H])OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]O[C@@]1(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]1([H])SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]O[C@@]1(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])OC1=C([H])C([H])=C([H])C([H])=C1F [H]O[C@@]1(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])OC1=C([H])C([H])=C([H])C(=C1C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])OC1=C([H])C([H])=C([H])C(F)=C1C([H])([H])[H] [H]O[C@@]1(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])OC1=C([H])C([H])=C(F)C([H])=C1C([H])([H])[H] [H]OC1=C(C(O[C@@]2([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[C@@]2(O[H])C([H])([H])N([H])C([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(O[C@@]2([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[C@@]2(O[H])C([H])([H])N([H])C([H])([H])[H])C(=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(Cl)C(Cl)=C(Cl)C([H])=C2[H])C1([H])[H] [H]N(C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C2C(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])[C@]1([H])OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])OC1=C([H])C([H])=C([H])C(=C1C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(SC([H])([H])[H])C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)S(=O)(=O)C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])S(=O)(=O)C(F)(F)F)C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)OC([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(SC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])=O)C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C1([H])[H] [H]N1C([H])=C([H])C2=C1C([H])=C(C([H])=C2[H])[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])N=C12)[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@](C2=C([H])C([H])=C3SC([H])=C([H])C3=C2[H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]C1=C([H])C(=C([H])C(F)=C1OC([H])([H])[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C(Br)=C1OC([H])([H])[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C(Br)C(OC([H])([H])[H])=C(Br)C([H])=C1[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C(I)=C1OC([H])([H])[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C(I)C(OC([H])([H])[H])=C(I)C([H])=C1[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])C([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC1([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC1([H])C([H])([H])C([H])([H])C1([H])[H] [H][C@@]12CC[C@]([H])([C@H]([C@H](C1)C1=CC=C(OC)C=C1)C(=O)OCCC1=CC=C(C=C1)N(O)=O)N2C [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])C([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])C([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1Br)C([H])([H])C([H])([H])OC(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])C([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C(Br)C([H])=C(C([H])=C1Br)C([H])([H])C([H])([H])OC(=O)[C@]1([H])C2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1I)C([H])([H])C([H])([H])OC(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])C([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C(I)C([H])=C(C([H])=C1I)C([H])([H])C([H])([H])OC(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])C([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C(ON=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])C([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C(=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]N(C1=C([H])C(=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@]1([H])O[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C2=C(OC([H])([H])[H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])[C@]2([H])C([H])([H])[C@]2(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])F)[C@]([H])(C1=C([H])C(\C([H])=C(\[H])I)=C([H])C([H])=C1[H])C2([H])[H] [H]N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])F)[C@]([H])(C1=C([H])C(\C([H])=C(\[H])Br)=C([H])C([H])=C1[H])C2([H])[H] [H]N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])C([H])([H])F)[C@]([H])(C1=C([H])C(\C([H])=C(\[H])I)=C([H])C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])C([H])([H])C([H])([H])F)[C@@]([H])(C1=C([H])C(\C([H])=C(\[H])Br)=C([H])C([H])=C1[H])C2([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C#N)C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C(=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1[H])[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1[H])[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C(C#N)=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C(=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@@](C2=C([H])C([H])=C3N(C([H])=C([H])C3=C2[H])C([H])([H])[H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC2=C([H])C3=C([H])C(C#N)=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(Br)C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC2=C([H])C3=C([H])C([H])=C(C#N)C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(C([H])([H])OC2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(OC([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])C2=C([H])C3=C([H])C([H])=C(C#N)C([H])=C3C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N([H])C([H])([H])[C@]1([H])O[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@]1([H])O[C@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@]1([H])O[C@]([H])(C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])C2=C([H])C3=C([H])C([H])=C(F)C([H])=C3C([H])=C2[H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C([H])([H])[C@]1([H])O[C@]([H])(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@]1([H])O[C@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@]1([H])O[C@]([H])(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])O[C@]([H])(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@]1([H])O[C@@]([H])(C([H])([H])C([H])([H])C2=C(F)C(F)=C(F)C(F)=C2F)C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])[C@]1([H])O[C@@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])[C@]1([H])O[C@@]([H])(C([H])([H])C([H])([H])C2=C([H])C(=C(F)C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]1([H])O[C@@]([H])(C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C(N=C(S1)C([H])([H])[H])C#CC1=C([H])C(F)=C([H])C(=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(C#N)=C1[H])C1=C([H])C([H])=C([H])C(F)=C1[H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(C#N)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C(N=C(S1)C([H])([H])[H])C#CC1=C([H])C([H])=C(C(F)=C1[H])C1=C([H])C([H])=C([H])N=C1[H] [H]O[C@@]([H])(C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])[H] [H]O[C@]([H])([C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])N([H])[H] [H]O[C@]([H])([C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C(=O)N(N=C2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]O[C@]([H])([C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@]([H])([C@]([H])(C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])O[C@]([H])(C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)C(F)(F)F [H]O[C@@]([H])([C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(F)(F)F [H]C([H])=C([H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])OC1=C(C#N)C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])OC1=C(C#N)C(Cl)=C([H])C([H])=C1[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@]([H])(C([H])([H])OC1=C2N([H])C(=O)N([H])C2=C([H])C([H])=C1[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@]1(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N2[C@]3([H])C([H])([H])C([H])([H])C2([H])[C@@]1([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C3([H])[H] [H]O[C@]1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])N2[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@@]1([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C3([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)[C@@]1([H])C([H])([H])C2([H])N3C([H])([H])C(=O)[C@]1([H])[C@@]3([H])C([H])([H])C2([H])[H] [H]O[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N2[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@@]1([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C3([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])[C@@]1([H])C([H])([H])[C@]2([H])N3C([H])([H])C([H])([H])[C@@]([H])(C2([H])[H])[C@@]3([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])[C@@]1([H])C([H])([H])C2([H])N3C([H])([H])C(=O)[C@]1([H])[C@@]3([H])C([H])([H])C2([H])[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]O[C@]1(OC([H])([H])C(N(C([H])([H])[H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]O[C@]1(OC([H])([H])C(N(C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N([H])C([H])([H])[C@]1([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1(C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])[C@](C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])=C([H])[H])C([H])([H])C([H])=C([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]C#CC([H])([H])N(C(=O)[C@@]1(C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])[C@@]1([H])C([H])([H])N([H])[H])C([H])([H])C#C[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])=C([H])[H])C([H])([H])C(F)=C([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)[C@@]1([H])N([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2SC([H])=C([H])C2=C1[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C(C2=C([H])C(C#N)=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])N=C(C([H])=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C(F)C(F)=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C(C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C(Cl)C([H])=C([H])C(Cl)=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@@]([H])(OC1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@@]([H])(OC1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@@]([H])(OC1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=NC([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@@]([H])(OC1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C1([H])[H])[C@]([H])(OC1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@@]([H])(OC1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@@]([H])(OC1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([C@@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(I)C([H])=C(C([H])=C1[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(I)=C1N=[N+]=[N-])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(C1([H])[H])[C@]([H])(OC1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1SC([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1SC(F)(F)F)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C(Br)=C1SC([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C(Br)=C1[S@](=O)C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1[S@](=O)C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(SC([H])([H])C([H])([H])[H])C([H])=C1[H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1SC([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])F)[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1SC([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])F)[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C([H])=C([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C2([H])[H] [H]C([H])=C([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(SC([H])([H])C([H])([H])[H])C([H])=C1[H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1SC([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N(C(=O)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]N(C(=O)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(N([H])C(=O)[C@]2([H])[C@]3([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C3([H])[H])C([H])([H])[C@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]N(C(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]C1=C(N=NN1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC(=O)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])OC(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])N(N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(N=NN1C([H])([H])C([H])([H])OC(=O)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])OC(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]N(C(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]N(C(=O)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H])C1=C([H])C([H])=C(N([H])C(=O)[C@]2([H])[C@]3([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C3([H])[H])C([H])([H])[C@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])SC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]N(C(=O)[C@@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]2([H])[C@]3([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C3([H])[H])C([H])([H])[C@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])SC([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C(F)C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C(F)C(F)=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])[C@@]([H])(OC1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])S1 [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=C(C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])[C@@]2([H])C([H])([H])C([H])=C([H])C([H])([H])[C@@]2([H])C1=O)C([H])([H])C([H])([H])[C@@]([H])(OC1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])S1 [H]N1C([H])([H])C([H])([H])C([H])(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC([H])([H])C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C(\C([H])=C3/SC([H])([H])C([H])([H])N(C3=O)C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C(F)=C([H])C([H])=C3[H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C([H])C(F)=C2F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C([H])C(F)=C3[H])C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C([H])C(F)=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]2([H])SC([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C2=O)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]OC1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])SC(Cl)=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C(OC3=C([H])C(F)=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(C(Cl)=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(C(F)=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(F)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])[H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C2=NC([H])=C([H])C([H])=N2)C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])OC1=C(C#N)C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C#N)C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])OC1=C(C#N)C(Cl)=C([H])C([H])=C1[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(C#N)=C(OC([H])([H])[C@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[C@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H])[C@]12O[C@]3([H])[C@@]4([H])[C@]5([H])[C@]([H])([C@@]14[H])[C@@]1([H])C([H])([H])[C@]5([H])[C@]3([H])[C@@]21[H] [H]N(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2=C([H])C(F)=C([H])C([H])=C2N(C2=C([H])C([H])=C([H])C([H])=C2[H])S1(=O)=O [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C([H])C([H])=C2[H])S1(=O)=O [H]N(C([H])([H])[C@@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])S1)C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C(F)C([H])=C2[H])S1(=O)=O [H]O[C@@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C(F)=C([H])C([H])=C2F)S1(=O)=O [H]O[C@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])S1(=O)=O [H]O[C@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C(F)C([H])=C([H])C([H])=C2F)S1(=O)=O [H]O[C@@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C(F)C([H])=C2F)S1(=O)=O [H]O[C@@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C([H])C([H])=C2F)S1(=O)=O [H]O[C@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C([H])C([H])=C2[H])S1(=O)=O [H]N(C([H])([H])[H])C([H])([H])C(=O)C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C([H])C([H])=C2F)S1(=O)=O [H]O[C@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])S1(=O)=O [H]N(C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])[C@@]1(OC1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])S1 [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C(OC(F)(F)F)C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])(F)F)C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC(F)(F)F)C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])C1=C(OC(F)(F)F)C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(Cl)=C([H])C(=C1[H])C(=O)[C@@]([H])(N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(Cl)=C([H])C(=C1[H])C(=O)[C@@]([H])(N(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C(Br)C(=C1[H])C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(Cl)=C([H])C(=C1[H])C(=O)[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])=C(N=C1[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C(C(Cl)=C1[H])C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(Cl)=C([H])C(=C1[H])C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Br)=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C(F)=C1[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]O[C@]1(OC([H])([H])C(N(C([H])([H])[H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([C@]([H])(C(=O)C1=C([H])C(F)=C([H])C(F)=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C2OC([H])([H])C([H])([H])C2=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])[H])C(F)=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1F [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])(F)F)C([H])=C([H])C([H])=C1F [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])(F)F)C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C(OC([H])(F)F)C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C(F)(F)F)C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C2=C([H])C([H])([H])OC([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C(F)C(F)=C2[H])S1(=O)=O [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C([H])C([H])=C2F)S1(=O)=O [H]N([H])C1=C(OC2=C([H])C(OC([H])([H])C([H])([H])F)=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])F)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C(OC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])F)=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C#CC([H])([H])F)[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N([H])C1=C(SC2=C([H])C(F)=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C(OC2=C([H])C(F)=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C(OC2=C([H])C([H])=C(F)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])F)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])F)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C(Cl)C([H])=C([H])C([H])=C3F)N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C([H])C([H])=C3F)N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C([H])C([H])=C3Cl)N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])[H])N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C([H])C([H])=C3C(F)(F)F)N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C([H])C(Cl)=C3Cl)N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C([H])C(F)=C3F)N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C(C([H])=C3F)C([H])([H])[H])N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C(Cl)C([H])=C3Cl)N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C(F)C([H])=C3F)N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C(F)=C([H])C([H])=C3Cl)N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3F)N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C(F)C([H])=C([H])C([H])=C3F)N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C(C([H])=C([H])C([H])=C3F)C([H])([H])[H])N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C(OC3=C([H])C([H])=C([H])C([H])=C3Cl)N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C(OC3=C(Cl)C([H])=C([H])C([H])=C3F)N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(F)=C([H])C(=C1[H])C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(SC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(SC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(SC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(SC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(SC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C(C#N)=C([H])C([H])=C12)C([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C2=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]2([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(Br)=C([H])C(=C1[H])C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Br)=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]\C(=C(\[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(Br)C([H])=C1[H])C2([H])[H])C([H])([H])F [H]\C(=C(\[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(I)C([H])=C1[H])C2([H])[H])C([H])([H])F [H]\C(=C(\[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C2([H])[H])C([H])([H])F [H]\C(=C(\[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H])C([H])([H])F [H]\C(=C(\[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C2([H])[H])C([H])([H])F [H]C1=NN(N=N1)[C@@]([H])(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=NN(N=N1)[C@@]([H])(C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(N1N=NC([H])=N1)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(N1N=NC(=N1)C([H])([H])[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(N1N=NC(=N1)N1N=C([H])C([H])=N1)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(N1N=NC([H])=N1)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N([H])N1C(=O)C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(C#N)=C2[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(F)=C2[H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H] CCCCN1CCC(COC(=O)C2=C3OCCOC3=C(NC)C(Cl)=C2)CC1 [H]C1=C([H])C([H])=C(C(N=[N+]=[N-])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C(I)=C([H])C([H])=C1[H] [H]C1=C([H])C(N=[N+]=[N-])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C(I)=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C(I)=C1[H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C(N=[N+]=[N-])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]C1=C([H])C([H])=C(O[C@@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])C([H])=C1[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(Cl)=C([H])C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C(Cl)C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(Br)=C([H])C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(I)=C([H])C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(F)=C([H])C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O)C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(C#N)=C([H])C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(=C([H])C(F)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(=C([H])C(C#N)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C2([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C1=C(C#N)C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]C1=C(ON=C1C([H])([H])[H])[C@]1([H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(ON=C1C([H])([H])[H])[C@]1([H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(ON=C1C([H])([H])[H])[C@]1([H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C(ON=C1C([H])([H])[H])[C@]1([H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]C1=C(ON=C1C([H])([H])[H])[C@]1([H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])[C@]2([H])S[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])[C@]2([H])S[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])[C@]2([H])S[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]C1=C(ON=C1C([H])([H])[H])C1=C(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@]2([H])S[C@@]1([H])C([H])([H])C2([H])[H] [H]C1=C(ON=C1C([H])([H])[H])C1=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@]2([H])S[C@@]1([H])C([H])([H])C2([H])[H] [H]C1=C(ON=C1C([H])([H])[H])C1=C(C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])[C@]2([H])S[C@@]1([H])C([H])([H])C2([H])[H] [H]C1=C(ON=C1C([H])([H])[H])C1=C(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])[C@]2([H])S[C@@]1([H])C([H])([H])C2([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]2([H])S[C@@]1([H])C([H])([H])C2([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@]2([H])S[C@@]1([H])C([H])([H])C2([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@]2([H])S[C@@]1([H])C([H])([H])C2([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])[C@]2([H])S[C@@]1([H])C([H])([H])C2([H])[H] [H]C1=C([H])C(F)=C([H])C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]1([H])[C@@]2([H])[C@@]3([H])C([H])([H])[C@]4([H])[C@@]5([H])C([H])([H])[C@]([H])([C@]2([H])[C@@]35[H])[C@]14[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H])[C@]1([H])[C@@]2([H])[C@@]3([H])C([H])([H])[C@]4([H])[C@@]5([H])C([H])([H])[C@]([H])([C@]2([H])[C@@]35[H])[C@]14[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])[C@]1([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]N(C([H])([H])[H])[C@]1([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]C1=C(ON=C1C([H])([H])[H])C1=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]2([H])S[C@@]1([H])C([H])([H])C2([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])[C@]2([H])S[C@@]1([H])C([H])([H])C2([H])[H] [H]N1C([H])([H])C([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2F)C1([H])[H] [H]N1C([H])([H])C([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])=C([H])C([H])=C2F)C1([H])[H] [H]N1C([H])([H])C([H])(OC2=C(OC3=C(Cl)C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2F)C1([H])[H] [H]N1C([H])([H])C([H])(OC2=C(OC3=C(C([H])=C([H])C([H])=C3F)C([H])([H])[H])C([H])=C([H])C([H])=C2F)C1([H])[H] [H]N1C([H])([H])C([H])(OC2=C(OC3=C(F)C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2F)C1([H])[H] [H]N1C([H])([H])C([H])(OC2=C(OC3=C(Cl)C([H])=C([H])C([H])=C3Cl)C([H])=C([H])C([H])=C2F)C1([H])[H] [H]N1C([H])([H])C([H])(OC2=C(OC3=C(C([H])=C([H])C([H])=C3Cl)C([H])([H])[H])C([H])=C([H])C([H])=C2F)C1([H])[H] [H]N1C([H])([H])C([H])(OC2=C(OC3=C([H])C([H])=C([H])C(Cl)=C3Cl)C([H])=C([H])C([H])=C2F)C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(OC2=C(OC3=C(Cl)C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(OC2=C(OC3=C(C([H])=C([H])C([H])=C3F)C([H])([H])[H])C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2F)C1([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N(C([H])([H])[H])[C@@]1([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H] [H]N([H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2F)C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])=C([H])C([H])=C2F)C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(OC2=C(OC3=C(C([H])=C([H])C([H])=C3F)C([H])([H])[H])C([H])=C([H])C([H])=C2F)C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(OC2=C(OC3=C(Cl)C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2F)C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(OC2=C(OC3=C(Cl)C([H])=C([H])C([H])=C3F)N=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])(OC2=C(OC3=C(Cl)C([H])=C([H])C([H])=C3F)N=C([H])C([H])=C2[H])C1([H])[H] [H]N([H])[C@]1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H] [H]C1=C([H])C([H])=C(C(N=[N+]=[N-])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(I)C([H])=C1[H] [H]C1=C([H])C(N=[N+]=[N-])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(I)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1I)[C@@]([H])(C(=O)OC([H])([H])[H])[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C(N=[N+]=[N-])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C(I)=C([H])C([H])=C1[H] [H][C@@]1(CCCCN1)[C@H](C(=O)OC)C1=CC=C(I)C=C1 [H]N(C([H])([H])[H])C([H])([H])C1(C2=C([H])C([H])=C(F)C(F)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C1(C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C1(C2=C([H])C([H])=C([H])S2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C1(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1(C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1(C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])[H])C([H])([H])C1(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(F)C(Cl)=C([H])C(=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C(F)=C([H])C(=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(Cl)=C([H])C(=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1(C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H])[C@]1([H])[C@@]2([H])[C@@]3([H])C([H])([H])[C@]4([H])[C@@]5([H])C([H])([H])[C@]([H])([C@]2([H])[C@@]35[H])[C@]14[H] [H]N([H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(N([H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1I)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C([N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(F)=C([H])C(=C1[H])C([H])([H])N(C([H])([H])[H])[C@]1([H])[C@@]2([H])[C@@]3([H])C([H])([H])[C@]4([H])[C@@]5([H])C([H])([H])[C@]([H])([C@]2([H])[C@@]35[H])[C@]14[H] [H]\C(I)=C(\[H])C([H])([H])N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C2([H])[H] [H]C1=C(F)C(F)=C([H])C(=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C1(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1(C2=C([H])C([H])=C(F)C(Cl)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C(F)(F)F)C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(F)=C([H])C(=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F [H]N(C([H])([H])[H])C([H])([H])C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C1(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C1(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C1(C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C1(C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C1(C2=C([H])C([H])=C(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C1(C2=C([H])C([H])=C([H])S2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C1(C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])O[C@@]([H])(C1([H])[H])[C@]([H])(OC1=C(F)C(F)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])O[C@@]([H])(C1([H])[H])[C@]([H])(OC1=C([H])C([H])=C([H])C2=C1OC([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])O[C@@]([H])(C1([H])[H])[C@]([H])(OC1=C(Cl)C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])O[C@]([H])(C1([H])[H])[C@]([H])(OC1=C(OC([H])([H])[H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])O[C@]([H])(C1([H])[H])[C@]([H])(OC1=C(C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])O[C@@]([H])(C1([H])[H])[C@]([H])(OC1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])O[C@]([H])(C1([H])[H])[C@]([H])(OC1=C(Cl)C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])O[C@]([H])(C1([H])[H])[C@@]([H])(OC1=C(OC([H])([H])[H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])O[C@]([H])(C1([H])[H])[C@]([H])(OC1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])O[C@]([H])(C1([H])[H])[C@]([H])(OC1=C(OC([H])([H])C([H])([H])[H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C(Cl)C([H])=C1[H])N2C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])N(C2=NC(=C([H])C([H])=C2C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]OC1=C(O[H])C([H])=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C1C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(Cl)=C3Cl)C([H])([H])C1([H])[H])C([H])=C2[H] [H]N(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=C(/[H])C([H])=C1C([H])=C([H])C(=O)C([H])=C1[H])\C1=C([H])C([H])=C([H])C([H])=C1F [H]C1=C2C(ON=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3OC([H])([H])[H])C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C(F)=C1[H] [H]C(=C1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3OC3=C2C([H])=C(Cl)C([H])=C3[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C2([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]\C(=C1\C2=C([H])C([H])=C([H])C([H])=C2SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]12C3=C([H])C([H])=C([H])C([H])=C3[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C2([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[C@]1([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]O[C@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])[C@@]12C3=C([H])C([H])=C([H])C([H])=C3[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C2([H])[H] [H]N([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])N2C(=O)N(N=C2C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C2C(N([H])C([H])=C2C2=NC(=NC([H])=C2[H])N([H])[H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])O[C@]([H])(C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3N(C3=C([H])C([H])=C([H])C([H])=C3[H])S2(=O)=O)C1([H])[H] [H]N1C([H])([H])C([H])([H])O[C@@]([H])(C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3N(C3=C([H])C([H])=C([H])C([H])=C3[H])S2(=O)=O)C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])[C@@]([H])(OC([H])([H])[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C([H])C([H])=C2[H])S1(=O)=O [H]C1=C(SC2=C([H])C([H])=C([H])C([H])=C12)C1(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])O[C@]([H])(C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3N(C3=C([H])C([H])=C([H])C([H])=C3F)S2(=O)=O)C1([H])[H] [H]N1C([H])([H])C([H])([H])O[C@]([H])(C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3N(C3=C([H])C([H])=C(F)C([H])=C3[H])S2(=O)=O)C1([H])[H] [H]N1C([H])([H])C([H])([H])O[C@]([H])(C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3N(C3=C([H])C([H])=C(F)C([H])=C3F)S2(=O)=O)C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])C([H])([H])[18F])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N([H])[C@@]([H])(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(N([H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])[C@@]([H])(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(N([H])[H])C([H])([H])[H] [H]N(C1=NC(SC([H])([H])[H])=NC(N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[N+]([O-])=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]\C(=C(\[H])[C@@]1([H])N(C([H])([H])[H])[C@@]([H])(C(\[H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(\I)C(F)(F)F)C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C2([H])[H] [H]\C(=C(\I)C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C2([H])[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([C@@]([H])(C(=O)C1=C([H])C(I)=C(N=[N+]=[N-])C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C(C([H])=C(C([H])=N2)C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(F)=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=C([H])C([H])=NC(Br)=C1[H])C([H])([H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=C([H])N=C(Br)C([H])=C1[H])C([H])([H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NC(Br)=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=NC(F)=C([H])C([H])=C1[H] [H]N(C(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=NC(Br)=C1[H] [H]N(C(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])N=C(Br)C([H])=C1[H] [H]N(C(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=NC(Br)=C([H])C([H])=C1[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])O[C@@]([H])(C1([H])[H])[C@@]([H])(OC1=C(SC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])S1(=O)=O [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2C([H])([H])[H])C(=C1[H])C([H])([H])N([H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1Cl)N1C([H])([H])C([H])([H])C([H])([H])S1(=O)=O [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1Cl)C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2Cl)C(=C1[H])C([H])([H])N([H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1Cl [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(F)C([H])=C1Cl [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(Cl)C([H])=C2OC([H])([H])[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(F)C([H])=C2Cl)=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(Cl)C([H])=C2F)=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(Cl)C([H])=C2Cl)=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H] [H]O[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])C(C1=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C1[H])=C2C(=O)OC([H])([H])[H] [H]N1C([H])([H])C([H])([H])O[C@@]([H])(C1([H])[H])[C@@]([H])(SC1=C(OC([H])([H])C([H])([H])C([H])([H])F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])O[C@@]([H])(C1([H])[H])[C@@]([H])(OC1=C(C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])O[C@@]([H])(C1([H])[H])[C@@]([H])(SC1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])=C([H])[H])C([H])([H])C([H])=C([H])[H])C1=C([H])SC([H])=C1[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Br)S1 [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C(=O)N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])OC(=O)C([H])([H])C([H])([H])C(=O)OC([H])([H])[C@]1([H])[C@]2([H])S[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])OC(=O)C([H])([H])C([H])([H])C(=O)OC([H])([H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])OC(=O)C([H])([H])C([H])([H])C(=O)OC([H])([H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)[C@@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])OC(=O)C([H])([H])C([H])([H])C(=O)OC([H])([H])[C@]1([H])[C@]2([H])S[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])OC(=O)C([H])([H])C([H])([H])C(=O)OC([H])([H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=NC([H])=C(C(OC2=C([H])C([H])=C(Cl)C([H])=C2Br)=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([3H])([3H])[3H])C([H])([H])C([H])([H])C1=C(OC([3H])([3H])[3H])C([H])=C(I)C(OC([H])([H])[H])=C1[H] [H]C1=NC([H])=C(C(OC2=C([H])C([H])=C(Cl)C([H])=C2C([H])([H])[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C(OC2=C([H])C([H])=C(Cl)C([H])=C2OC([H])([H])[H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C(C(OC2=C([H])C([H])=C(Cl)C([H])=C2Cl)=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C(OC2=C([H])C([H])=C(Cl)C([H])=C2C([H])([H])[H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=C(C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])[C@]2([H])C([H])([H])C([H])=C([H])C([H])([H])[C@]2([H])C1=O)C([H])([H])C([H])([H])[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(ON=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(ON=C1C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])O[C@@]([H])(C1([H])[H])[C@@]([H])(SC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])O[C@@]([H])(C1([H])[H])[C@@]([H])(OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])O[C@@]([H])(C1([H])[H])[C@@]([H])(OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])O[C@@]([H])(C1([H])[H])[C@@]([H])(OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC(=C([H])C(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NC(=C([H])C(OC2=C(C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C(OC2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])=C(N=C1[H])C([H])([H])[H] [H]C1=NC(=C([H])C(OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NC(=C([H])C(OC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C(OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])=C(N=C1[H])C([H])([H])[H] [H]C1=NC(=C([H])C(OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NC(=C([H])C(OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C(OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(N=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C(OC2=C(C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C(N=C1[H])C([H])([H])[H] [H]C1=C([H])C(Cl)=C(OC2=C(C([H])=NC(=C2[H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C(OC2=C(C([H])=NC(=C2[H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C(SC([H])([H])[H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C(OC2=C(SC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])=C(N=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C(OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C(N=C1[H])C([H])([H])[H] [H]C1=NC(=C([H])C(OC2=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C(OC2=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])=C(N=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C(OC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])=C(N=C1[H])C([H])([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C(=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]C1=C(ON=C1C([H])([H])[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C(=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C(=C(Cl)C([H])=C1[H])C([H])([H])[H])C2([H])[H] [H]N1C2=C(N=C1[C@]1([H])[C@]3([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C3([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C(ON=C1C([H])([H])C([H])([H])[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC1([H])C([H])([H])C([H])([H])C1([H])[H] [H][C@@]1(CCCCN1)[C@H](C(=O)OC)C1=CC=C(C=C1)[N+]([O-])=O [H][C@@]1(CCCCN1)[C@H](C(=O)OC)C1=CC=C(N)C=C1 [H]N([H])C1=C(I)C([H])=C(C([H])=C1[H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]1([H])N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(N=[N+]=[N-])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C(I)=C(N=[N+]=[N-])C([H])=C1[H] [H]OC([H])([H])C1=C([H])C([H])=C(C([H])=N1)C1=C2C(OC([H])([H])[C@@]([H])(N([H])C(=O)C3=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C3[H])C2([H])[H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C1=C([H])C([H])=C2C(Cl)=C(OC([H])([H])[H])C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C(O[H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C1=C([H])SC2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2S1)C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]\C(I)=C(\[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[18F])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C2([H])[H] [H]\C([125I])=C(\[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[18F] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[18F] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[18F] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[18F])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])[18F])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2N=C(SC2=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(F)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(F)=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(S1)C([H])([H])OC([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]N([H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])[C@@]([H])(OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C3([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])C1=C([H])C([H])=C([H])C(C#N)=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C#N)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C2=C([H])C([H])=C3N(C([H])=C([H])C3=C2[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C2=C([H])C([H])=C3SC([H])=C([H])C3=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)N([C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1N=C([H])C2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=C2C2=C([H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C1[H] [H]C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])N(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])N(C(=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])N=C(S1)C1=C([H])C(=C([H])C([H])=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C(SC(=N1)C1=C([H])C([H])=C([H])C(Br)=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C(OC2=C1C([H])=C([H])C([H])=C2[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C2=C(N=C(O2)C2=C(C(=O)OC([H])([H])[H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])C([H])=C1[H] [H]C1=C([H])C2=C(N=C(S2)C2=C(C(=O)OC([H])([H])[H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])C([H])=C1[H] [H]C1=C(SC2=C1C([H])=C([H])C([H])=C2[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1C2=C(C([H])=C1C1=C(C(=O)OC([H])([H])[H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])C1([H])[H])C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C([H])=C(S1)C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C(O1)C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])N(C(=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])N=C(S1)C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C(OC(=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(SC(=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(N(C(=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C2N(C(=O)C3=C2C([H])([H])[C@]2([H])O[C@@]3([H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])N(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H])C([H])([H])[H] [H]C1=C([H])N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C(O1)C1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C(S1)C1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])N(C(=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H])C([H])([H])[H] [H]C1=C([H])N=C(S1)C1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H] [H]C1=C(OC2=C1C([H])=C([H])C([H])=C2[H])[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H] [H]C1=C(SC2=C1C([H])=C([H])C([H])=C2[H])[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N1C2=C(C([H])=C1[C@]1([H])C([H])([H])[C@]3([H])O[C@@]([H])(C([H])([H])C3([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C([H])=C([H])C([H])=C2[H] [H]C1=C(SC(=C1[H])[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(OC(=C1[H])[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(S1)[C@@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H] [H]N1C([H])([H])C([H])(C1([H])[H])[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(F)=C(Cl)C([H])=C1[H] [H]N1C([H])([H])C([H])(C1([H])[H])[C@@]([H])(OC1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N1C([H])([H])C([H])(C1([H])[H])[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N1C([H])([H])C([H])(C1([H])[H])[C@@]([H])(OC([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N1C([H])([H])C([H])(C1([H])[H])[C@]([H])(OC([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]C1=C(OC2=C1C([H])=C(C([H])=C2[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)N1C([H])=C(C2=C([H])C(Cl)=C([H])C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)N1C([H])=C(C2=C([H])C(Cl)=C([H])N=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=O)C2=C(N=C1[C@]([H])(N1C([H])([H])C([H])(OC3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])[H])N(N=C2[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C(=O)C2=C(N=C1[C@]([H])(N1C([H])([H])C([H])(OC3=C([H])C([H])=C(F)C([H])=C3[H])C1([H])[H])C([H])([H])[H])N(N=C2[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C2=C(C(=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1([H])[H] OCC[C@]1(CCCNC1)C1=CC2=C(O1)C=CC=C2 OCC[C@]1(CCCNC1)C1=CC(Cl)=C(Cl)C=C1 OCC[C@]1(CCCCNC1)C1=CC(Cl)=C(Cl)C=C1 COCCN1CC=CC[C@@H](C1)C1=CC(Cl)=C(Cl)C=C1 OCCN1CC=CC[C@@H](C1)C1=CC(Cl)=C(Cl)C=C1 ClC1=C(Cl)C=C(C=C1)C1CCCCNC1 C1NCC(CC=C1)C1=CC2=C(O1)C=CC=C2 ClC1=CC=CC(=C1)C1CNCC=CC1 ClC1=CC=C(C=C1)C1CNCC=CC1 FC1=C(Cl)C=C(C=C1)C1CNCC=CC1 CC1=C(Cl)C=CC(=C1)C1CNCC=CC1 CC1=C(Cl)C=C(C=C1)C1CNCC=CC1 C1NCC(CC=C1)C1=CC2=CC=CC=C2C=C1 ClC1=C(Cl)C=C(C=C1)[C@H]1CNCC=CC1 CN1CCC2=C(C1)C=CC=C2C(=O)NCC1(CCCCC1)N1CCN(CC1)C1=CC=CC=C1 CCN(CC)C1=CC=C2C(OC3=CC(C=CC3=C2C2=C(C=C(C=C2)S(=O)(=O)NCCCCCC(=O)NCCN2[C@@H]3CC[C@@H]2[C@H]([C@H](C3)C2=CC(Cl)=C(Cl)C=C2)C(=O)OC)S([O-])(=O)=O)=[N+](CC)CC)=C1