[H]N(C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[C@@]1([H])SC(=O)N([H])C1=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]OC(=O)[C@@]([H])(N([H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C(F)C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C2=NC3=C(O2)C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1Cl)(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C(O[H])=C(C([H])=C2[H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C(Cl)=C(SC([H])([H])C([H])([H])C([H])([H])OC2=C(C3=C(C([H])=C2[H])C(=C([H])O3)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])SC1=NC(Cl)=C([H])C(=N1)N([H])C1=C([H])C([H])=C([H])C(=C1C([H])([H])[H])C([H])([H])[H] [H]N1OC(=O)[C@@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=NOC(=N2)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C(F)=C([H])C(F)=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=NOC(=N2)C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=NOC(=N2)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])[N+]([O-])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C(C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N1C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=NOC(=N2)C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=NOC(=N2)C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])OC3=C2C([H])=C([H])C([H])=C3[H])C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1=C(C(=C([H])C([H])=C1[H])C1=NOC([H])=N1)C1([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3C3=C2C([H])=NC([H])=C3[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3C3=C2C([H])=C([H])C(Br)=C3[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2([H])C3=C([H])C([H])=C([H])C([H])=C3OC3=C2C([H])=C([H])C([H])=C3[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@@]2([H])SC3=C(OC4=C2C([H])=C([H])C([H])=C4[H])C([H])=C([H])C([H])=C3[H])C([H])=C1[H] [H]N1C(=O)S[C@@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=NC([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C1\C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])(O[H])[C@]([H])(C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]2([H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N([H])C2=NC3=C(SC4=C2C([H])=C([H])C([H])=C4[H])C([H])=C([H])C([H])=C3[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C([H])=C3[H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3OC3=C2C([H])=C([H])C([H])=C3[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C1=NC([H])=C([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C(F)(F)F)C(F)(F)F)C1=C(C(=C([H])C([H])=C1[H])C1=NOC([H])=N1)C1([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])OC(=O)C1=C([H])C([H])=C(N=C=O)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C(C(=C([H])C([H])=C1[H])C1=NOC([H])=N1)C1([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C(C([H])=C1C(F)(F)F)C(F)(F)F)(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1C(F)(F)F)C(F)(F)F)(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(\C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])O2)C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])=C(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])O2)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])O2)C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])=C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])=C(C2=C([H])C([H])=C(Br)C([H])=C2[H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(\C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(\C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C(OS(=O)(=O)C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C(C3=C(C([H])=C2[H])C(=NO3)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(SC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C(Cl)=C1[H] [H]OC(=O)C(C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])=C(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(ON=C2C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])C(C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C(C([H])=C(SC([H])([H])C2=C(N=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])C2=C(N=C(O2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C(N=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C(N=C(O2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=C(N=C(O2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]N1C(=O)S[C@@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C(Cl)C(=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)S[C@@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C(F)C(=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C(C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C(F)=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])C2=C(N=C(S2)C2=C([H])C([H])=C(C(F)=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C2=C(N=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(Cl)=C(SC([H])([H])C([H])([H])C([H])([H])OC2=C(C3=C(C([H])=C2[H])C(=NO3)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C(Cl)=C(SC([H])([H])C([H])([H])C([H])([H])OC2=C(C(O[H])=C(C([H])=C2[H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]O\N=C(\C1=C(O[H])C(=C(OC([H])([H])C([H])([H])C([H])([H])SC2=C(Cl)C([H])=C(C([H])=C2[H])C([H])([H])C(=O)O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C(N=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)[C@@](OC1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C(Cl)=C(SC([H])([H])C([H])([H])C([H])([H])OC2=C(C3=C(C([H])=C2[H])C(=NO3)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C(Cl)=C(SC([H])([H])C([H])([H])C([H])([H])OC2=C(C(O[H])=C(C([H])=C2[H])C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C(Cl)=C(SC([H])([H])C([H])([H])C([H])([H])OC2=C(C3=C(C([H])=C2[H])C(=C([H])O3)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C2=NOC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C(C2=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C(C2=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C(C2=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C(C2=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=NO2)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C(C([H])=C(C([H])=C1C([H])([H])[H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C(C([H])=C(C([H])=C1Cl)C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C(C2=C(C([H])=C1Cl)C(=NO2)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@](OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@](OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C2=NC3=C(SC4=C2C([H])=C([H])C([H])=C4[H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C(C2=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]OC(=O)[C@]([H])(OC1=C(C2=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C(C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)S[C@@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)O[C@@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)O[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C(C2=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1 [H]OC(=O)[C@]([H])(OC1=C(C(O[H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C(C(O[H])=C(C([H])=C1Cl)C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C(C([H])=C(C([H])=C1C([H])([H])[H])C(=O)OC([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]OC1=C([H])C([H])=C(OC2=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C(=C([H])C([H])=C3[H])[C@]3([H])SC(=O)N([H])C3=O)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C(C([H])=C3[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)S[C@@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C(N=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1[H] [H]N1C(=O)O[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)O[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)S[C@@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)O[C@@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)S[C@@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N1C(=O)O[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(SC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(N([H])C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C#CC2=C([H])C([H])=C(C#C\C([H])=C(/[H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[C@]([H])(OC([H])([H])C([H])([H])[H])C(=O)O[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=NN(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=NN(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=NN(C(=O)N1C([H])([H])[H])C([H])([H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=NN(C(=O)N1C([H])([H])C([H])([H])O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC(C(=O)O[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=NN(C(O[H])=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=NN(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=NN(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=NN(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)O[C@@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C#CC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C#CC2=C([H])C(C#C\C([H])=C(/[H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[C@]([H])(OC([H])([H])C([H])([H])[H])C(=O)O[H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(\C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(\C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=C(/[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[C@]([H])(OC([H])([H])C([H])([H])[H])C(=O)O[H])\C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@](OC1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@](OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@](OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@](OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@](OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@](OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@](OC1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(OC4=C([H])C([H])=C(Cl)C([H])=C4[H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@](OC1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=NN(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=NN(C(=O)N1C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(OC4=C([H])C([H])=C(F)C([H])=C4[H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(OC4=C([H])C([H])=C(F)C([H])=C4[H])C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@](OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])S2)C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(F)C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@](OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@](OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@](OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(\N=C(\C(\[H])=C(/O[H])C1=C([H])C([H])=C([H])C([H])=C1[H])/C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])OC2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N3[H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])=C(OC([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C(=O)OC([H])([H])[H])C(=O)OC([H])([H])[H])C([H])=C2[H] [H]OC(=O)[C@]1(OC2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])OC2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])(C(=O)OC([H])([H])[H])C(=O)OC([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C#CC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C#CC([H])([H])C([H])([H])OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]N1C2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])(C(=O)OC([H])([H])[H])C(=O)OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])OC2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N3[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])OC2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C12)C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])OC2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/C#CC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C1\C([H])([H])[C@]2([H])[C@]([H])(O[H])C([H])([H])[C@@]([H])(C(\[H])=C(/[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]2([H])C1([H])[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C12)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C12)C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C12)C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@](OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C2=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(OC([H])([H])[H])=NO2)C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C2=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@](OC1=C(C2=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C(C2=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3Cl)C([H])=C2C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(OC4=C([H])C([H])=C(F)C([H])=C4[H])C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])C(F)(F)F)=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(SC(F)(F)F)C([H])=C3Cl)C([H])=C2C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3Cl)C(F)(F)F)C([H])=C2C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3Cl)=C([H])C([H])=C2C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3Cl)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]4(C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C3Cl)C([H])=C2C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])OC3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3Cl)C([H])=C2C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3Cl)C([H])([H])C(F)(F)F)C([H])=C2C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(OC(F)(F)F)C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(OC([H])([H])C4([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C3[H])C([H])=C2C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C(=C([H])C([H])=C3Cl)C(F)(F)F)C([H])=C2C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3Cl)C([H])([H])C(F)(F)F)C([H])=C2C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3Cl)C([H])=C2C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3Cl)C([H])([H])C([H])([H])C(F)(F)F)C([H])=C2C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(SC(F)(F)F)C([H])=C3C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(OC1=C(C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C(C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C2N(C(=O)OC2=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C(C([H])=C1Cl)C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C2C(=O)N(OC2=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C3Cl)C([H])=C2C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1([H])OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C3Cl)C([H])=C2C1([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C2N(C(=O)OC2=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C2N(C(=O)OC2=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]OC(=O)[C@@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3Cl)C([H])([H])C(F)(F)F)C([H])=C2C1([H])[H])C(F)(F)F [H]OC(=O)[C@@]([H])(C1([H])C([H])([H])C1([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C(Cl)C([H])=C(Cl)C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C(F)=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N3N=C(C([H])=C3C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C2N(C(=O)OC2=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C2C(=O)N(OC2=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C2N(C(=O)OC2=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C(Cl)C([H])=C(C([H])=C1Cl)C(=O)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C2C(=O)N(OC2=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C(Cl)C([H])=C2N(C(=O)OC2=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C2N(C(=O)OC2=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C(C([H])=C(C([H])=C1C([H])([H])[H])C(=O)C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C2N(C(=O)OC2=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(OC2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N1C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(OC2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C2=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C2N1C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(OC2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C2=C([H])C([H])=C([H])C([H])=C2N1C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C(F)C([H])=C([H])C([H])=C3F)C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C([H])OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(SC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(OC([H])([H])C4([H])C([H])([H])C4([H])[H])C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(OC(F)(F)F)C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C(=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C(=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C(F)(F)F)[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C(F)(F)F)C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C4=C(S3)C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H] [H]O[C@]([H])(C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(Cl)C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=NOC(=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C(=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C(F)=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C(F)C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C(Br)=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]O[C@@]([H])(C1=C([H])C([H])=C([H])N=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C(F)=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3Cl)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C(F)C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(OC([H])([H])[H])C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C1(C2=C([H])C(=C(O[C@@]([H])(C(=O)O[H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])OC3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3Cl)C([H])=C2C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C4=C(C([H])=C3[H])C([H])([H])C([H])([H])O4)C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]O[C@@]([H])(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])C([O-])=O [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C(N2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C3C(N([H])C([H])=C3C(=O)C(F)(F)F)=C1C([H])([H])C([H])([H])C([H])([H])[H])=C2[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C([H])N2[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C3=C(C([H])=C1[H])C(=NO3)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])=C2[H] [H]N1N=NC(=N1)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC1=C(C3=C(C([H])=C1[H])C(=NO3)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])=C2[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC1=C(C3=C(C([H])=C1[H])C(C#N)=C([H])N3[H])C([H])([H])C([H])([H])C([H])([H])[H])=C2[H] [H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]O[C@]([H])(C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([O-])=O [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])C([H])([H])OC1=C(C3=C(C([H])=C1[H])C(=NO3)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])=C2[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC1=C(C3=C(C([H])=C1[H])C(=NO3)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])=C2[H] [H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=C(C([H])=C2[H])C(=C([H])C(O3)(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])=C1[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C3=C(C([H])=C2[H])C(=C([H])C(=O)O3)C(F)(F)F)C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=C(C([H])=C2Cl)C(=C([H])C(=O)O3)C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(OS(=O)(=O)C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(OC2=C([H])C([H])=C(Cl)C(=C2[H])C(F)(F)F)C2=C([H])C(Cl)=C([H])C([H])=C2N1C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(OC2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C2=C([H])C(OC3=C([H])C([H])=C([H])N3[H])=C([H])C([H])=C2N1C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(OC2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C2=C([H])C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]O[C@@]([H])(C1=C([H])C([H])=C([H])N=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])C([O-])=O [H]O[C@@]([H])(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H] [H]O[C@@]([H])(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H] [H]O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=C(C([H])=C2[H])C(=C([H])C(=O)O3)C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=C(C([H])=C2Cl)C(=C([H])C(O3)(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C12 [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])O3)C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C4=C(OC([H])([H])O4)C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=NOC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C(=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C(Cl)=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C(=C(F)C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C([H])([H])OC3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C(F)(F)F)C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C3=NOC(=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2C([H])([H])C1([H])[H] [H]O[C@@]([H])(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])C([O-])=O [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C(C(=O)C([H])([H])[H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC1=C(C3=C(C([H])=C1[H])C(=NO3)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC2=C(C3=C(C([H])=C2[H])C(=NO3)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C(=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C2=C(C([H])=C1[H])N(N=N2)C([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(N([H])C([H])([H])C([H])([H])C([H])([H])OC2=C(C3=C(C([H])=C2[H])C(=NO3)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C3=C(C([H])=C2[H])C(=NO3)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C3=C(C([H])=C2[H])C(=NO3)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C(Cl)=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1C(F)(F)F)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC1=C(C3=C(C([H])=C1[H])C(=NO3)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])=C2[H] [H]OC(=O)C([H])([H])C1=C([H])C2=C(C([H])=C1[H])N(N=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=C([H])O2)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C4=C([H])C([H])=C(C([H])=C4C([H])=C3[H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C12 [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C4=C([H])C([H])=C(C([H])=C4C([H])=C3[H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C([H])C([H])=C12 [H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=NC(O[H])=C([H])C(=C3C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C3=C(C([H])=C2[H])C(=C([H])C(=O)O3)C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(C([H])=C3[H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(C([H])=C3[H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C12 [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C4=C([H])C([H])=C(C([H])=C4C([H])=C3[H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C4=C([H])C([H])=C(C([H])=C4C([H])=C3[H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C4=C([H])C([H])=C(C([H])=C4C([H])=C3[H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C12 [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(C([H])=C3[H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C4=C([H])C([H])=C(C([H])=C4C([H])=C3[H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C12 [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(Cl)=C(C([H])=C1[H])C1=NOC(=C1C([H])([H])OC([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[N+]([O-])=O)C(F)(F)F)C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(Cl)=C(C([H])=C1[H])C1=NOC(=C1C(=O)N([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(Cl)=C(C([H])=C1[H])C1=NOC(=C1C(=O)N([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])N(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C(C2=C1[H])C([H])([H])[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(Cl)=C(C([H])=C1[H])C1=NOC(=C1C(=O)N([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[N+]([O-])=O)C(F)(F)F)C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C2C(=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C2C(=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C#C[H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])C2=C(SC(=N2)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C2=NC([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C2=C(C([H])=C([H])N2C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C([H])=C(C([H])=C([H])C3=C2C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=NC([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=NC([H])=C(OC([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])C(=O)OC([H])([H])[H])=C(C([H])=C1OC([H])([H])C([H])([H])C([H])([H])OC1=C(C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C2C(=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=NC([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@](OC([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=NC([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C(=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=NC([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=N1 [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=NC([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=NC([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=NC([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=NC([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C2=C(C([H])=C([H])N2C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C([H])=C(C([H])=C([H])C3=C2C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C(=C([H])C2=C1[H])C([H])([H])[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]OC(=O)[C@@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]OC(=O)[C@@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(OC([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)OC1=C([H])N=C([H])C([H])=N1 [H]OC(=O)[C@](OC([H])([H])C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])[H])N=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)OC1=C([H])N=C([H])C([H])=N1 [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=NC([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])N(C2=C([H])C([H])=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C(N=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(OC([H])([H])C(=O)OC([H])([H])[H])C([H])=C2[H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(N=C2[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1OC([H])([H])C(=O)OC([H])([H])[H] [H]OC1=C(C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(OC([H])([H])C(=O)OC([H])([H])[H])C([H])=C2[H])=C([H])C([H])=C1C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])N=C1[H] [H]OC(=O)C1(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])N=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])N=C1[H] [H]OC(=O)[C@@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])N=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(F)C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C(C([H])=NC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C(C([H])=NC(=N3)C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])SC([H])=N2)C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])S2)C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1C([H])([H])C([H])([H])[H] [H]N([H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])OC([H])=N2)C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C(F)(F)F)C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C(F)(F)F)C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])SC([H])=C2[H])C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=NC([H])=C([H])O2)C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])O2)C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=NC([H])=C(C([H])=C3[H])C3=NC(=C([H])S3)C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C(C([H])=NC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(Cl)C([H])=C2[H])C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C(C([H])=NC(=N3)C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=NC([H])=C(C([H])=C3[H])C3=NC(OC([H])([H])C([H])([H])[H])=C([H])S3)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C(C([H])=NC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C(C([H])=NC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C([H])C(=NC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=NC([H])=C(C([H])=C3[H])C3=NC(=C(S3)C(=O)C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]OC(=O)C1(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])N=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]OC(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C(C([H])=NC(=N3)C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C(F)(F)F [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])N=C1[H] [H]OC(=O)[C@](OC([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C([H])N=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C(OC3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])=C2C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=NC([H])=C(C([H])=C3[H])C3=NC(=C(S3)C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C(C([H])=NC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=NC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C(C([H])=NC(=N3)C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C(C([H])=NC(=N3)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C(C([H])=NC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C(F)C([H])=NC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C(C([H])=NC(=N3)C3=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(O1)C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C2=C([H])C(C#CC3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C(C#CC3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C2=C([H])C(\C([H])=C(/[H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C(\C([H])=C(/[H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C2=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C2=C([H])C(Br)=C([H])C(Br)=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C2=C([H])C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C2=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C(OC([H])([H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C2=C([H])C(OC(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C(OC(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@]([H])(OC2=C([H])C([H])=C(C([H])=C2[H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@]([H])(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@]([H])(OC([H])([H])C([H])=C([H])[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(OC(=S)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(OC(=S)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(OC(=S)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C(F)=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(OC([H])([H])C([H])([H])C2([H])[H])=C(SC([H])([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])C2=C([H])C([H])=C([H])C(F)=C2OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C2=C1C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C(SC([H])([H])C3=C([H])C([H])=C(OC([H])([H])C4=C([H])C([H])=C(OC([H])([H])[H])C([H])=C4[H])C([H])=C3[H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C(SC([H])([H])C3=C([H])C([H])=C(OC([H])([H])C4=C([H])C([H])=C(C([H])=C4[H])C(F)(F)F)C([H])=C3[H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C(Cl)=C(SC([H])([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(OC(=S)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C2=C1C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C(SC([H])([H])C3=C([H])C([H])=C(OC([H])([H])C4=C([H])C([H])=C(OC(F)(F)F)C([H])=C4[H])C([H])=C3[H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C(SC([H])([H])C3=C([H])C([H])=C(OC([H])([H])C4=C(C([H])=C(F)C([H])=C4[H])C(F)(F)F)C([H])=C3[H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])C1=C([H])OC2=C([H])C(OC([H])([H])C3=C(N=C(S3)C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])[H])=C([H])C([H])=C12 [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C(SC([H])([H])C3=C([H])C([H])=C(OC([H])([H])C4=C(Cl)C([H])=C([H])C(Cl)=C4[H])C([H])=C3[H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])C1=C([H])SC2=C([H])C(OC([H])([H])C3=NOC(=C3[H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C([H])C(=C12)C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])SC2=C([H])C(OC([H])([H])C3=NOC(=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C([H])C([H])=C12 [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C([H])C(OC([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C([H])C([H])=C12 [H]OC(=O)C(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])OC2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C([H])C([H])=C12 [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(\[H])[C@@]([H])(C#CC2=C([H])C([H])=C(S2)C([H])([H])[H])C2=C([H])C3=C(OC(=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(\[H])[C@@]([H])(C#CC2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])OC2=C([H])C(OC([H])([H])C3=NOC(=C3[H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(OC(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])SC2=C([H])C(OC([H])([H])C3=NOC(=C3[H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C([H])C([H])=C12 [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(OC4=C([H])C([H])=C(C([H])=C4[H])C(F)(F)F)C([H])=C3[H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])C1=C([H])SC2=C([H])C(OC([H])([H])C3=NOC(=C3[H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C([H])C(Cl)=C12 [H]OC(=O)C([H])([H])C1=C([H])SC2=C([H])C(OC([H])([H])C3=C(N=C(S3)C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])[H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C([H])C(OC([H])([H])C3=C(N=C(S3)C(F)(F)F)C([H])([H])[H])=C([H])C([H])=C12 [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)OC([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])SC2=C([H])C(OC([H])([H])C3=C(N=C(S3)C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])[H])=C(C([H])=C12)C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(OC(=S)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(OC(=S)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(OC(=S)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC(=S)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(O[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C([H])C(OC([H])([H])C3=NOC(=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C([H])C([H])=C12 [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2O[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C(O[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C([H])C(SC([H])([H])C3=C(N=C(S3)C(F)(F)F)C([H])([H])[H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])C1=C([H])SC2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C([H])C([H])=C12 [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])C([H])(C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C1OC([H])([H])OC1=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(OC([H])([H])C([H])([H])C2([H])[H])=C(SC([H])([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])SC2=C([H])C(OC([H])([H])C3=NOC(=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C([H])C(=C12)C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])OC2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C([H])C([H])=C12 [H]OC(=O)C([H])([H])C1=C([H])OC2=C([H])C(OC([H])([H])C3=NOC(=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C([H])C([H])=C12 [H]OC(=O)C([H])([H])C1=C([H])SC2=C([H])C(OC([H])([H])C3=NOC(=C3[H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C(C([H])=C12)C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])SC2=C([H])C(OC([H])([H])C3=NOC(=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C([H])C(Cl)=C12 [H]OC(=O)C([H])([H])C1=C([H])SC2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C([H])C([H])=C12 [H]OC(=O)C([H])([H])C1=C([H])SC2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C(C([H])=C12)C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])SC2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C([H])C([H])=C12 [H]OC(=O)C([H])([H])C1=C([H])SC2=C([H])C(OC([H])([H])C3=C(N=C(S3)C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])[H])=C([H])C(Cl)=C12 [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C2=C([H])C(=C([H])C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C2=C([H])C(=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C2=C([H])C(OC([H])([H])C(F)(F)F)=C([H])C(OC([H])([H])C(F)(F)F)=C2[H])C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@]([H])(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C(SC([H])([H])C3=C([H])C([H])=C(OC([H])([H])C4=C([H])C([H])=C(C([H])=C4[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C3[H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C#N)C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(SC(=N3)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@]([H])(OC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@@]([H])(C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])OC([H])([H])C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(SC(=N3)C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(SC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@@]([H])(OC([H])([H])OC([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC2=C([H])C(=NC(C#CC([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C2[H])C#CC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@]([H])(OC([H])([H])C(=O)O[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@]([H])(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(SC(=N3)C3=C([H])C([H])=C([H])C(F)=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(SC(=N3)C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@]([H])(O[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@@]([H])(OC([H])([H])SC([H])([H])[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C(SC([H])([H])C3=C([H])C([H])=C(OC([H])([H])C4=C([H])C([H])=C(Cl)C([H])=C4[H])C([H])=C3[H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C(SC([H])([H])C3=C([H])C([H])=C(OC([H])([H])C4=C([H])C([H])=C(C([H])=C4[H])C(F)(F)F)C([H])=C3[H])C([H])=C1C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C(OC([H])([H])[H])=C(SC([H])([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(SC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(SC(=N3)C3=C([H])C([H])=C4OC([H])([H])OC4=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(SC(=N3)C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C(F)(F)F)C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C(F)=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2F)C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C3=C(N2[H])C([H])=C([H])C(Br)=C3[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C(F)=C2[H])[C@]([H])(N([H])C(=O)C2=C(C3=C(C([H])=C([H])C(Cl)=C3[H])N2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1C([H])([H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2OC([H])([H])[H])C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C3=C(C([H])=C([H])C(Cl)=C3[H])N2C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C(C3=C(N2[H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=N\OC([H])([H])[H])\C1=C([H])C2=C(C([H])=C1[H])N(C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(OC([H])([H])C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C3=C(C([H])=C(C([H])=C3[H])C(=N/OC([H])([H])[H])\C3=C([H])C([H])=C([H])C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]O\N=C(\C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C(=O)OC([H])([H])[H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C2=C(C([H])=C1[H])N(C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C(=O)OC([H])([H])[H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H] [H]O\N=C(\C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(OC([H])([H])C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NOC(=N1)C([H])([H])OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C(F)(F)F)C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(S1)C([H])=C([H])C(OC([H])([H])[H])=C2[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C(F)(F)F)C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2F)C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2C([H])([H])[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C3=C(N2[H])C([H])=C(Cl)C(Cl)=C3[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C3=C(N2[H])C([H])=C([H])C([H])=C3Cl)C([H])=C1C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2C([H])([H])[H])C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2C([H])([H])C([H])([H])[H])C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])C(F)(F)F)C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NOC(=N1)C([H])([H])OC([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C(F)(F)F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C(S1)C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C(F)(F)F)C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C(F)(F)F)C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C(F)(F)F)C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C3=C(N2[H])C([H])=C(Cl)C([H])=C3[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(SC1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]([H])(N(C(=O)N([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])[H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])S(=O)(=O)C(F)(F)F [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2F)C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2F)C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2Br)C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C3=C(N2[H])C(Br)=C([H])C([H])=C3[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(SC(=N3)C3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C(F)C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2F)C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C3=C(N2[H])C([H])=C([H])C(Cl)=C3[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@@]([H])(C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])[S@@](=O)C([H])([H])[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]C1=C([H])C(=C([H])C([H])=C1F)C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(OC(=O)[C@@]([H])(C(=O)OC([H])([H])[H])C2([H])[H])=C1[H] [H]C1=C([H])C(F)=C([H])C(=C1[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C(=O)OC([H])([H])[H])C(=O)OC2=C1[H] [H]C1=C([H])C(F)=C([H])C(=C1[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(OC(=O)[C@@]([H])(C(=O)OC([H])([H])[H])C2([H])[H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(OC(=O)[C@@]([H])(C(=O)OC([H])([H])[H])C2([H])[H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C(=O)OC([H])([H])[H])C(=O)OC2=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(OC(=O)[C@]([H])(C(=O)OC([H])([H])[H])C2([H])[H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C(=O)OC([H])([H])[H])C(=O)OC2=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(OC(=O)[C@@]([H])(C(=O)OC([H])([H])[H])C2([H])[H])=C1[H] [H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C(=O)OC([H])([H])[H])C(=O)OC2=C1[H] [H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(OC(=O)[C@]([H])(C(=O)OC([H])([H])[H])C2([H])[H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C(=O)OC([H])([H])[H])C(=O)OC2=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(OC(=O)[C@]([H])(C(=O)OC([H])([H])[H])C2([H])[H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C(=O)OC([H])([H])[H])C(=O)OC2=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(OC(=O)[C@]([H])(C(=O)OC([H])([H])[H])C2([H])[H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(OC(=O)[C@@]([H])(C(=O)OC([H])([H])[H])C2([H])[H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C(=O)OC([H])([H])[H])C(=O)OC2=C1[H])C(F)(F)F [H]C1=C([H])C(=C([H])C(=C1[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(OC(=O)[C@@]([H])(C(=O)OC([H])([H])[H])C2([H])[H])=C1[H])C(F)(F)F [H]C1=C([H])C(=C([H])C([H])=C1F)C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C(=O)OC([H])([H])[H])C(=O)OC2=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C(F)=C2[H])[C@]([H])(N([H])C(=O)C2=C(C3=C(S2)C([H])=C([H])C(Cl)=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1C([H])([H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2Cl)C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2C([H])([H])[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2OC2=C([H])C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2C([H])([H])[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C(C3=C(C([H])=C([H])C(Cl)=C3[H])N2C([H])([H])[H])C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2F)C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1F)C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])[H])C([H])=C1F)C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1F)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])[H])C([H])=C1F)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1F)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C(F)=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1F)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C(F)=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(S3)C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(S3)C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=N\OC([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])\C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=N\OC([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])\C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NO[C@@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NO[C@@]([H])(C2=C([H])C([H])=C(I)C([H])=C2[H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NO[C@@]([H])(C2=C([H])C([H])=C(Br)C([H])=C2[H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NO[C@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=N\OC([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])\C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C3C(F)(F)F)C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C([H])C(Cl)=C3Cl)C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C(C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])[H])C2=C(S1)C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]OC(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])SC2=NN=C(N2C([H])([H])C([H])([H])[H])C2=C([H])C3=C(O2)C(OC([H])([H])[H])=C([H])C([H])=C3[H])C([H])=C1[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C(=NN1C([H])([H])C([H])=C([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C(Cl)C([H])=C3Cl)C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C(Cl)=C([H])C([H])=C3Cl)C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C(Cl)=C([H])C(Cl)=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C([H])S3)C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])N=C([H])C([H])=N3)C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=NC([H])=C([H])C([H])=N3)C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C(=NN1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C(=NN1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C(=NN1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C(=NN1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=N\OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])\C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])OC([H])=C1[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C(=NN1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])N(C([H])=C1C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1=C([H])N(C([H])=C1C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])N(C([H])=C1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])N(N=C1C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=NN(C([H])=C1C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])N(N=C1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N/OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N/OC([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1 [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]OC(=O)[C@]([H])(OC1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C(Br)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])=C([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C(=NN1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])=C([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Br [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(=C([H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])OC([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=NN(N=C1C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=NN(N=C1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=NN(N=C1C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=NN(N=C1C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=NN(N=C1C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=NN(N=C1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=NN(N=C1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C2C(=C([H])C([H])=C1[H])N(C([H])([H])C([H])([H])C([H])([H])OC1=C(C3=C([H])C([H])=C(C([H])=C3C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C2N(C([H])([H])C([H])([H])C([H])([H])OC3=C(C4=C([H])C([H])=C(C([H])=C4C([H])=C3[H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C2C(=C([H])C([H])=C1[H])N(C([H])([H])C([H])([H])C([H])([H])OC1=C(C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C(=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C(F)(F)F)C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C(F)(F)F)C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])SC2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])SC2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O[C@@]1([H])C([H])=C([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])[C@@]([H])(N([H])C(=C(\[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)\C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(SC1=NC(N([H])C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])=C([H])C(Cl)=N1)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O[C@]1([H])C(C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O[C@]1([H])C(I)=C([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C2C(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C2C(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C2C(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C12)C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C([H])([H])N2C([H])=C([H])N=C2C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C([H])([H])N2C(=NC(=C2C([H])([H])[H])C([H])([H])[H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C([H])([H])N2C(=NC3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C([H])([H])N2C(=NC3=C2C([H])=C([H])C([H])=C3[H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C([H])C(\C([H])=C(/[H])N2C(=NC3=C2C([H])=C([H])C([H])=C3[H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])\[N+]([O-])=O [H]OC(=O)[C@@]([H])(OC([H])([H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C3=C(C([H])=C(C([H])=C3[H])C(=N\OC([H])([H])[H])\C3=C([H])C([H])=C([H])C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C3=C(C([H])=C(C([H])=C3[H])C(=N\OC([H])([H])C3([H])C([H])([H])C3([H])[H])\C3=C([H])C([H])=C([H])C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C3=C(C([H])=C(C([H])=C3[H])C(=N\OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])\C3=C([H])C([H])=C([H])C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C3=C(C([H])=C(C([H])=C3[H])C(=N\OC([H])([H])C([H])=C([H])[H])\C3=C([H])C([H])=C([H])C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)C1(OC2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])N2C3=C([H])C(OC(F)(F)F)=C([H])C([H])=C3C(C(=O)C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@](OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C2C(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C(OC([H])([H])[H])=C(F)C([H])=C1[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(SC1=C([H])C([H])=C(Cl)S1)(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(SC1=NC2=C([H])C(Br)=C([H])C([H])=C2S1)(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=NC2=C([H])C(Br)=C([H])C([H])=C2S1)C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=NC2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=NC2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2S1)C([H])([H])[H] [H]OC1=C([H])C([H])=C2C(=O)C(=C([H])OC2=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]C1=C([H])C([H])=C(O[C@](C(=O)OC([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C4=C([H])C([H])=C([H])C(=C4N=C3C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(/[H])C1=C([H])C([H])=C(O[C@@]([H])(C([O-])=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C#CC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)C1=C([H])C([H])=C(O[C@@]([H])(C([O-])=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] CC1=C(CCOC2=CC=C(C[C@H](N3CCN(CC3)S(=O)(=O)C3=CC=CC=C3N(O)=O)C(O)=O)C=C2)N=C(O1)C1=CC=CC=C1 [H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=C(\[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])\C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C(=C(Cl)C([H])=C2[H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C(=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C3C(=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C(=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1)(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1)(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C([H])O1)(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1)(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1)(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C(=O)N([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1)(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C(=O)N([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])O1)(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])C1=C([H])C([H])=C([H])O1)(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(N=C(O2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(SC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(F)C([H])=C2F)=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(F)C(Cl)=C2[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])[C@]([H])(C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])[C@]([H])(C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C([H])SC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])[C@]([H])(C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])[C@]([H])(C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]([H])(C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C(=C([H])C([H])=C1F)C([H])([H])[H])[C@]([H])(C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(F)C(OC([H])([H])[H])=C1[H])[C@]([H])(C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C([H])SC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C([H])SC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C([H])SC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C([H])SC(=N2)C2=C([H])C([H])=C([H])C(Cl)=C2[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C([H])SC(=N2)C2=C([H])C([H])=C([H])C([H])=C2Cl)=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C(C([H])=C(C([H])=C1[H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(C2=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C(F)C([H])=C(C([H])=C2[H])C(F)(F)F)=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])SC2=NC(=C(S2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])SC2=NC(=C(S2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C1=C(C([H])=C([H])C(=C1[H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C(C([H])=C1[H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])C(F)(F)F [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(O2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(O2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)[C@@]([H])(C1=C([H])C([H])=C([H])C(SC2=NC(=C(S2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(O2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])N=C(OC([H])(C([H])([H])[H])C([H])([H])[H])N=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(O2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])N=C(N=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(O2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(O2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])SC2=NC(=C(S2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(Cl)=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])SC2=NC(=C(S2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(Cl)=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])SC2=NC(=C(S2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(Cl)=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])SC2=NC(=C(S2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(O2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])N=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(O2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C(N=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])N=C(N=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C(N([H])C(=O)[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C(=C1C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C1C([H])([H])[H])C([H])=C(C([H])=C2[H])C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] CCCCOC1=C(CNC(=O)C2=C(F)C=C(C=C2)C(F)(F)F)C=C(C=C1)C1=CC(=CN=C1)C(O)=O CCCCOC1=C(CNC(=O)C2=C(F)C=C(C=C2)C(F)(F)F)C=C(C=C1)C1=C(C)C(=CN=C1C)C(O)=O [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C(=N\OC([H])([H])C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])\C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C(=N\OC([H])([H])C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])\C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C(=N\OC([H])([H])C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])\C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C(=N\OC([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])\C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C(=N\OC([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])\C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N1C(=S)S\C(=C(/[H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2[H])C1=O [H]OC(=O)C([H])([H])C([H])([H])N1C(=S)S\C(=C(/[H])C2=C([H])N(N=C2C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1=O [H]OC(=O)C([H])([H])C([H])([H])N1C(=S)S\C(=C(\[H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C([H])C([H])=C2[H])C1=O [H]OC(=O)C([H])([H])C([H])([H])N1C(=S)S\C(=C(\[H])C2=C(F)C([H])=C(F)C([H])=C2[H])C1=O [H]\C(=C1\SC(=S)N(C1=O)C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])N1C(=S)S\C(=C(/[H])C2=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C2[H])C1=O CC1=C(C[Se]C2=CC=C(OCC(O)=O)C(C)=C2)SC(=N1)C1=CC=C(C=C1)C(F)(F)F CC(OC1=CC=C([Se]CC2=C(C)N=C(S2)C2=CC=C(C=C2)C(F)(F)F)C=C1C)C(O)=O CCC(OC1=CC=C([Se]CC2=C(C)N=C(S2)C2=CC=C(C=C2)C(F)(F)F)C=C1C)C(O)=O CC1=C(C[Se]C2=CC=C(OCC(O)=O)C(C)=C2)SC(=N1)C1=CC(F)=C(C=C1)C(F)(F)F CC(OC1=CC=C([Se]CC2=C(C)N=C(S2)C2=CC(F)=C(C=C2)C(F)(F)F)C=C1C)C(O)=O CCC(OC1=CC=C([Se]CC2=C(C)N=C(S2)C2=CC(F)=C(C=C2)C(F)(F)F)C=C1C)C(O)=O [H]OC(=O)C([H])([H])OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@@]1([H])C(=O)N([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C([H])([H])N2C([H])=C([H])C([H])=C2C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C([H])([H])N2C([H])=C([H])C([H])=C2C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)C(OC1=C([H])C2=C(C([H])=C1[H])C(=NO2)C([H])([H])C([H])([H])C1=C(OC(=N1)C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C2=C(C([H])=C1[H])C(=NO2)C([H])([H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C2=C(C([H])=C1[H])C(=NO2)C([H])([H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C2=C(C([H])=C1[H])C(=NO2)C([H])([H])C([H])([H])C1=C(OC(=N1)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C2=C(C([H])=C1[H])C(=NO2)C([H])([H])C([H])([H])C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C2=C(C([H])=C1C([H])([H])[H])C(=NO2)C([H])([H])C([H])([H])C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(SC1=NC2=C([H])C(Cl)=C([H])C([H])=C2S1)C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])=C([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])S2)C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C(OC(=N2)C2=C([H])SC([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C(OC(=N2)C2=C(C([H])=C([H])S2)C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(S2)C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(S2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])S2)C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])SC([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C(C([H])=C([H])S2)C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(S2)C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(S2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C(F)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C(F)=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C(F)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C(F)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C2C([H])=C([H])C3=C([H])C([H])=C([H])C4=C([H])C([H])=C(C([H])=C1[H])C2=C34)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(F)OC1=C([H])C([H])=C(SC([H])([H])C2=C(N=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)[C@@]([H])(F)OC1=C([H])C([H])=C(SC([H])([H])C2=C(N=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(F)OC1=C([H])C([H])=C(SC([H])([H])C2=C(N=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(\[H])=C(/[H])\C(\[H])=C(/[H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(\[H])=C(/[H])C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C([H])([H])C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C(C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C(SC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C(N=C(O2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C(N=C(S2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C(N=C(S2)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C(N=C(S2)C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C(N=C(S2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C(N=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C(N=C(S2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C(N=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N([H])C(=O)C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])O[C@]([H])(C([H])([H])N([H])C(=O)C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N([H])C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)[C@@]1([H])N(C(=O)C(\[H])=C(/[H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C(\[H])=C(/[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2C1([H])[H] [H]OC(=O)[C@@]1([H])N(C(=O)C(\[H])=C(/[H])\C(\[H])=C(/[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C(\[H])=C(/[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C2[H])C1([H])[H] [H]OC(=O)[C@@]1([H])N(C(=O)C(\[H])=C(/[H])\C(\[H])=C(/[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C(\[H])=C(/[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C2[H])C1([H])[H] [H]OC(=O)[C@@]1([H])N(C(=O)[C@@]1([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]1([H])N(C(=O)[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])N(C(=O)[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H] [H]OC(=O)[C@@]1([H])N(C(=O)[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)[C@@]1([H])N(C(=O)[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])N(C(=O)[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])N(C(=O)[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1([H])N(C(=O)[C@]1([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1([H])N(C(=O)[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])N(C(=O)[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)[C@@]1([H])N(C(=O)[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C(F)=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(SC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C(F)(F)F)C([H])([H])O1)C([H])([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])C2=NSC(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])C2=C([H])C(=NS2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C1(OC2=C([H])C([H])=C(SC([H])([H])C3=NC(=NS3)C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1(OC2=C(C([H])=C(SC([H])([H])C3=NC(=NS3)C3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3[H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(SC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(C(Cl)=C2[H])C([H])([H])[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(OC(F)(F)F)C(Cl)=C2[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(C(F)=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(OC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(OC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(SC([H])([H])C([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(SC([H])([H])C([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(SC([H])([H])C2=NSC(=N2)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(SC([H])([H])C2=NSC(=N2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(SC([H])([H])C2=NSC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(SC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(C(Cl)=C2[H])C([H])([H])[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(SC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(SC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(SC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(OC(F)(F)F)C(Cl)=C2[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(SC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(SC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C(C([H])=C(SC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])C2=NOC(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])C2=C([H])C(=NO2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(SC([H])([H])C2=NSC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(SC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(SC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(C(F)=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(SC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])C2=C([H])SN=C2C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])O[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])C([H])([H])N(C2=NC([H])=C([H])C(=N2)C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])C(=C([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])C(=C([H])N(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])C(=C([H])N(C2=NC([H])=C([H])C(=N2)C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C(C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])N(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])N(C(=O)OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C(C2=C([H])C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])N(C(=O)OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C(C2=C([H])C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])N(C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=C(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])N(C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])N(C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])N(C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=N\OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)\C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=N\OC([H])([H])C1=C([H])C([H])=C(I)C([H])=C1[H])\C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=N\OC([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])\C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=N\OC([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])\C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=N\OC([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])\C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NO[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]OC(=O)C1=C(C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])N(C2=NC([H])=C([H])C(=N2)C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])N1C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N([H])C(=O)N([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)C2=C([H])C(Cl)=C([H])C([H])=C2O[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@](OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(\C([H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C(O[H])=C1C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(\C([H])=C(/[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C([H])C(O[H])=C1C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(\C([H])=C(/[H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)=C([H])C(O[H])=C1C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(\C([H])=C(/[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C(O[H])=C1C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(\C([H])=C(/[H])C2=C([H])C(F)=C([H])C(F)=C2[H])=C([H])C(O[H])=C1C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(\C([H])=C(/[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C(O[H])=C1C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C(O[H])=C(C(O[H])=C2[H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C(\C([H])=C(/[H])C2=C([H])OC([H])=C2[H])=C([H])C(O[H])=C1C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(\C([H])=C(/[H])C2=C([H])SC([H])=C2[H])=C([H])C(O[H])=C1C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(SC1=NC2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2S1)C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)[C@]([H])(SC1=NC2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2S1)C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)[C@]([H])(SC1=NC2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)[C@]([H])(SC1=NC2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)[C@]([H])(SC1=NC2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)[C@]([H])(SC1=NC2=C([H])C(Cl)=C([H])C([H])=C2S1)C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]OC1=C([H])C(\C([H])=C(/[H])C2=C([H])C([H])=C(C([H])=O)C([H])=C2[H])=C([H])C(O[H])=C1C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])C1(Cl)Cl)(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(Cl)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H] [H]OC(=O)C1=C([H])C(Cl)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C(Cl)=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(Cl)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(S[C@]([H])(C2=C(N=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(S[C@]([H])(C2=C(N=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(S[C@]([H])(C2=C(N=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2Br)C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C(F)(F)F [H]OC(=O)C1=C([H])C(Cl)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C(Br)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(Cl)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2OC([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(Br)C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C(F)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C(Cl)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]OC(=O)C1=C([H])C(Cl)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2C([H])([H])[H] [H]OC(=O)C1=C([H])C(Cl)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C(=C([H])C([H])=C2[H])C(=O)O[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C(Cl)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C(OC([H])([H])C(=O)O[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C(Cl)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C(=C1C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N(C1=C([H])C([H])=C([H])C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C(=C1C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N(C1=C([H])C([H])=C([H])C(C2=C([H])C([H])=C([H])C(Cl)=C2[H])=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C(=C1C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N(C1=C([H])C([H])=C([H])C(=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(N([H])C(=O)C2=NN(C(=C2C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)=C([H])C([H])=C1[H] [H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C([H])C(OC(C(=O)OC([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]OC1=C([H])C([H])=C(N([H])C(=O)C2=NN(C(=C2C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])=C1[H] [H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(OC(C(=O)OC([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] COC1=C(C\C=C(/C)CCC=C(C)C)C(O)=C(C(O)=O)C(CCC2=CC=CC=C2)=C1 OC(=O)C(CC1=CC=CC=C1)OC1=CC=C(C=C1)C1=CC=CC=C1CCC1=CC=CC=C1 CCCCCC1=CC=CC=C1C1=CC=C(OC(CC2=CC=CC=C2)C(O)=O)C=C1 CCCC1=CC=CC=C1C1=CC=C(OC(CC2=CC=CC=C2)C(O)=O)C=C1 CC(C)C1=CC=CC=C1C1=CC=C(O[C@H](CC2=CC=CC=C2)C(O)=O)C=C1 COC1=CC=CC=C1C1=CC=C(O[C@@H](CC2=CC=CC=C2)C(O)=O)C=C1 OC(=O)[C@H](CC1=CC=CC=C1)OC1=CC=C(C=C1)C1=CC=CC=C1C1=CC=CC=C1 OC(=O)[C@H](CC1=CC=CC=C1)OC1=CC=C(C=C1)C1=CC=CC=C1C(F)(F)F OC(=O)[C@H](CC1=CC=CC=C1)OC1=CC=C(C=C1)C1=CC=CC=C1F CC1=CC=CC=C1C1=C(C)C=C(O[C@@H](CC2=CC=CC=C2)C(O)=O)C=C1 CC1=CC=CC=C1C1=CC=C(O[C@@H](CC2=CC=CC=C2)C(O)=O)C=C1 CC1=CC(=CC=C1)C1=CC=C(OC(CC2=CC=CC=C2)C(O)=O)C=C1 CC1=CC=C(C=C1)C1=CC=C(O[C@@H](CC2=CC=CC=C2)C(O)=O)C=C1 CC1=CC=CC(C)=C1C1=CC=C(O[C@@H](CC2=CC=CC=C2)C(O)=O)C=C1 CC1=CC(OC(CC2=CC=CC=C2)C(O)=O)=CC(C)=C1C1=CC=CC=C1 CC1=CC(=CC(C)=C1O[C@@H](CC1=CC=CC=C1)C(O)=O)C1=CC=CC=C1 CC1=C(C=CC(O[C@@H](CC2=CC=CC=C2)C(O)=O)=C1)C1=CC=CC=C1