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[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC(=NC(=C1[H])N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(O1)C([H])([H])[H]
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[H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)N1C([H])([H])C(=C([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1F)C([H])([H])[H]
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[H]N(C(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC3=NC4=C([H])C([H])=C([H])C([H])=C4S3)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])OC(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC3=NC4=C([H])C([H])=C([H])C([H])=C4S3)C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]N([H])[C@]([H])(C(=O)N1C([H])([H])C(=C([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1F)C1([H])C([H])([H])C1([H])[H]
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[H]N1C(=O)C(C2=NN(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C(C1=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(C(=O)C([H])([H])C([H])([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]O[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]N1C(=O)C(C2=NN(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C(C1=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]N1C(=O)C(C2=NN(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C(C1=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]N1C(=O)C(C2=NN(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C(C1=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N1C(=O)C(C2=NN(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C(C1=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])N=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N1C(=O)C(C2=NN(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C(C1=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C2=C(N=C1[H])C([H])=C([H])C([H])=C2[H]
[H]C1=C([H])C([H])=C(C(F)=C1[H])S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H]
[H]C1=NN(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C#N)S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H]
[H]C1=C([H])N(N=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=O)OC2=C([H])C([H])=C(Cl)C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C([H])([H])[C@@]11C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NN([H])N=N1
[H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])C([H])=C(C2=C([H])C(F)=C([H])C([H])=C2F)C([H])([H])N1C(=O)[C@@]([H])(N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])C([H])=C(C2=C([H])C(F)=C([H])C([H])=C2F)C([H])([H])N1C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])C([H])=C(C2=C([H])C(F)=C([H])C([H])=C2F)C([H])([H])N1C(=O)[C@@]([H])(N([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])C([H])=C(C2=C([H])C(F)=C([H])C([H])=C2F)C([H])([H])N1C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])[C@@]2([H])N(C3=C(C(Cl)=C([H])C([H])=C3C2([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])C([H])=C(C2=C([H])C(F)=C([H])C([H])=C2F)C([H])([H])N1C(=O)[C@@]([H])(O[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(N2C(=O)[C@@](C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])C3(C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]1(C(=O)N(C([H])([H])C1([H])[H])[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])C3(C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(N2C(=O)[C@]([H])(C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])C3(C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(N2C(=O)[C@]([H])(C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])C3(C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@](N2C(=O)[C@]([H])(C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C([H])([H])C2([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(N2C(=O)[C@@](C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C(=O)N(C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@](N2C(=O)[C@]([H])(C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])C2([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@](N2C(=O)[C@@](C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)(C([H])([H])[H])C([H])([H])C2([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]N(C(=O)[C@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C(=O)N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(N2C(=O)[C@]([H])(C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C(C#N)C(=O)N(C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=O)N(C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C([H])=C([H])C([H])=C(C(=O)N3C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C4=C(F)C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])C2=N1
[H]C1=C([H])C([H])=C(C(F)=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(O[C@@]([H])(C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])[C@@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])[C@]1([H])O[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)C([H])([H])[C@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])[C@@]([H])(O[C@@]([H])(C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=NN=C2N1C([H])([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(O[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)[C@@]1([H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])O[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H]
[H]C1=C([H])N2C(=N1)C([H])([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(O[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N1C(=O)C([H])([H])C([H])([H])[C@]([H])(O[C@@]([H])(C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])[C@@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]1([H])C([H])([H])[H]
[H]OC1=NN=C2N1C([H])([H])C([H])([H])[C@]([H])(O[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H]
[H]C1=C([H])N2C(=N1)C([H])([H])C([H])([H])[C@]([H])(O[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H]
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[H]C1=C([H])C(=C([H])C([H])=C1F)[C@@]1([H])C([H])([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])[C@]1([H])O[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)[C@@]1([H])C([H])([H])C(=O)N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]1([H])O[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H]
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[H]N(C1=NC(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(N([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C4OC([H])([H])OC4=C3[H])C([H])([H])C2([H])[H])=C2C([H])=C(Cl)C([H])=C([H])C2=N1
[H]N(C1=NC(=O)N(C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=O)N(C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(=O)N(C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=O)N(C2=C1C([H])=C(OC([H])(F)F)C([H])=C2[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(F)=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C([H])C([H])=C([H])C(C3=C([H])C([H])=C([H])C([H])=C3S(=O)(=O)N3C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C4=C(F)C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])=C2C([H])=C1[H]
[H]N(C1=C([H])C(=O)N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=O)N(C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C2=C([H])C(F)=C([H])C(F)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N1C(=O)[C@]2(C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H]
[H]N(C1=NC(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C12)C([H])([H])C(F)(F)F)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])C([H])=C4OC([H])([H])OC4=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C1=C([H])C(=O)N(C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C(C(=O)OC([H])([H])[H])C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(=O)N(C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(\[H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=NC2=C([H])C([H])=C(Cl)C([H])=C2C(N([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C4OC([H])([H])OC4=C3[H])C([H])([H])C2([H])[H])=C1C#N
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[H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(O[C@@]([H])(C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])[C@]1(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]2([H])C1=NN=NN1C([H])([H])[H]
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[H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)[C@]1(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]2([H])C1=NN(N=N1)C([H])([H])[H]
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[H]N(C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1OC([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])N([H])[C@]1(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]N(C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1OC1([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])N([H])[C@@]1(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@@]2([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])[H]
[H]N(C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C(OC(F)(F)F)=C1[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1OC1([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])N([H])[C@@]1(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]2([H])C1=NN([H])N=N1
[H]OC([H])([H])[C@@]1([H])C([H])([H])[C@]2(N([H])[C@]1([H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1OC1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1OC1([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])N([H])[C@]1(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@]2([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@]1([H])C([H])([H])[C@@]2(N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1OC1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])N([H])[C@@]1(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]N(C(=O)[C@]1([H])C([H])([H])[C@@]2(N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1OC1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=NN([H])C(=N1)[C@]1([H])C([H])([H])[C@@]2(N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1OC1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=NC(=O)C1=C([H])C([H])=C([H])C(Cl)=C1C([H])([H])C([H])([H])C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])[H])N([H])[H]
[H]N(C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1OC1([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])N([H])[C@]1(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
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[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
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[H]N(C([H])([H])C([H])([H])C(C1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])N(C(=O)N2C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H]
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[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C(C#N)C([H])=C3[H])C([H])([H])[C@]12[H])C1=C([H])C(=C(F)C([H])=C1[H])C(F)(F)F
[H]N([H])C1=NOC2=C1C([H])=C([H])C(=C2[H])[C@@]12C([H])([H])[C@]1([H])[C@]([H])(N(C(=O)N([H])C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]N(C(=O)C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@]1(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N1C([H])([H])C([H])([H])[C@]2(C(=O)N([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(Cl)=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C(C#N)=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC2=C(C([H])=C([H])C([H])=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(F)=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)S(=O)(=O)N1C([H])([H])C([H])([H])C(F)(C([H])([H])C([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C(F)C([H])=C1F)C([H])([H])C([H])([H])C1=C([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)N2C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])[H])C2([H])[H])C([H])([H])[H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C(O1)C([H])=C(Cl)C(Cl)=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C([H])C([H])=C(OC([H])(F)F)C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C([H])C([H])=C(C#N)C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])C([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(OC([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])=C1[H])C(=O)N([H])C1=NC([H])=C(Cl)C([H])=C1[H]
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[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(N2C([H])([H])C([H])([H])C([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)N([H])C1=NC([H])=C(Cl)C([H])=C1[H]
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[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1
[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C(=O)N([H])C1=NC([H])=C(Cl)C([H])=C1[H]
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[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(SC2=C([H])C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])[H])C([H])=C1[H])C(=O)N([H])C1=NC([H])=C(Cl)C([H])=C1[H]
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[H]OC(=O)C([H])([H])N(C(=N[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])C1=NC([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]N=C(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C(=NN2C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2C#N)C([H])([H])[H])C([H])=C1[H]
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[H]N=C(N1C([H])([H])C([H])([H])C([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(Cl)C([H])=C1OC([H])([H])[H])C(=O)N([H])C1=NC([H])=C(Cl)C([H])=C1[H]
[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(SC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C(=O)N([H])C1=NC([H])=C(Cl)C([H])=C1[H]
[H]N(N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C2C([H])=C([H])C([H])=C(F)C2=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C2C([H])=C([H])C([H])=C(F)C2=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C2C([H])=C([H])C([H])=C(F)C2=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C([H])C([H])=C(Br)C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C([H])([H])N1C([H])([H])C(=O)N(C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C([H])C(F)=C([H])C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C(O1)C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3SC([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C3=C([H])C(OC([H])([H])C4=NOC(=N4)C4=C([H])C([H])=C(Cl)C([H])=C4[H])=C([H])C([H])=C3C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]2([H])C3=C([H])C(OC([H])([H])C4=NOC(=N4)C4=C([H])C([H])=C(Cl)C([H])=C4[H])=C([H])C([H])=C3C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C3=NOC(=N3)C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C2C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]2([H])C3=C([H])C(OC([H])([H])C4=NOC(=N4)C4=C(F)C([H])=C([H])C([H])=C4[H])=C([H])C([H])=C3C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C3=C([H])C(OC([H])([H])C4=NOC(=N4)C4=C(F)C([H])=C([H])C([H])=C4[H])=C([H])C([H])=C3C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(F)=C(C([H])=C1[H])C1=NC(=NO1)C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H]
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[H]\C(=C(\[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)[S@@](=O)C1=C([H])C([H])=C([H])C([H])=C1F
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[H]N1N=C(C2=C([H])SC(C#CC([H])([H])OC3=C(Cl)C([H])=C([H])C([H])=C3[H])=C2[H])C2=C1C1=C(C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]N1N=C(C2=C([H])SC(C#CC([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C2=C1C1=C([H])C([H])=C(C([H])=C1C2([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])C([H])=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1N=C(C2=C([H])SC(C#CC([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C2=C1C1=C(C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H]
[H]C1=NC2=NC([H])=C(N=C2N=C1[H])N1C([H])([H])C([H])([H])[C@]([H])(C2=C(F)C([H])=C(F)C(F)=C2[H])[C@@]([H])([N+]([H])([H])[H])C1([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C4=C(N=C(S4)C([H])([H])C([H])([H])[H])C([H])=C3C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(N=C(S5)C([H])([H])C([H])([H])[H])C([H])=C4C([H])([H])C3([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C4=C(N=C(S4)C([H])([H])[H])C([H])=C3C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])[C@@]([H])(N3C([H])([H])C([H])([H])C4=C([H])C5=C(C([H])=C4C([H])([H])C3([H])[H])C([H])([H])N(C5=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(C([H])=C4C([H])([H])C3([H])[H])C([H])([H])N(C5=O)C([H])(C([H])([H])[H])C([H])([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C(N(N=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C([H])C([H])=C([H])C3=C([H])N=C(C([H])=C13)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N1C(=O)C([H])([H])OC2=C1C([H])=C1C(=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=NN=C(N2C([H])([H])[H])C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C2=C(OC([H])([H])C1([H])[H])C([H])=C1C(=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=NN=C(N2C([H])([H])[H])C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(C([H])=C4C([H])([H])C3([H])[H])N(C(=O)C([H])([H])O5)C([H])([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]N1C(=O)C([H])([H])OC2=C1C([H])=C1C(=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=NN=C(N2C([H])([H])[H])C2=C(N=C([H])O2)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1N=C(C2=C([H])SC(C#CC([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C2=C1C1=C([H])C([H])=C(C([H])=C1C2([H])[H])C([H])([H])N1C([H])=NC([H])=C1[H]
[H]N1N=C(C2=C([H])SC(C#CC([H])([H])OC([H])([H])C([H])([H])OC([H])([H])[H])=C2[H])C2=C1C1=C(C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C2=O
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(OC(=N5)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(Br)=C4C([H])([H])C3([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(OC(=N5)C([H])([H])C([H])([H])[H])C(Br)=C4C([H])([H])C3([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(OC(=N5)C([H])([H])[H])C(Br)=C4C([H])([H])C3([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]N([H])C(=O)C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2(OO[C@@]3(O2)[C@@]2([H])C([H])([H])[C@]4([H])C([H])([H])[C@@]([H])(C([H])([H])[C@@]3([H])C4([H])[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2(OO[C@@]3(O2)[C@@]2([H])C([H])([H])[C@]4([H])C([H])([H])[C@@]([H])(C([H])([H])[C@@]3([H])C4([H])[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1N=C(C2=C([H])SC(C#CC([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C2=C1C1=C([H])C([H])=C(C([H])=C1C2([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1N=C(C2=C([H])SC(C#CC([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C2=C1C1=C([H])C([H])=C(C([H])=C1C2([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1N=C(C2=C([H])SC(C#CC([H])([H])[H])=C2[H])C2=C1C1=C(C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]N1N=C(C2=C([H])SC(C#CC([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C2=C1C1=C([H])C([H])=C(C([H])=C1C2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1N=C(C2=C([H])SC(C#CC([H])([H])OC3=C([H])N=C([H])C([H])=C3[H])=C2[H])C2=C1C1=C(C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]N(C(=O)N([H])C([H])([H])C#CC1=C([H])C(=C([H])S1)C1=NN([H])C2=C1C([H])([H])C1=C2C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#CC1=C([H])C(=C([H])S1)C1=NN([H])C2=C1C([H])([H])C1=C2C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1N=C(C2=C([H])SC(C#CC([H])([H])OC3=C([H])C(Cl)=C([H])C([H])=C3[H])=C2[H])C2=C1C1=C(C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C(=NN2N=C(N=C12)C(F)(F)F)N1C([H])([H])C([H])([H])[C@]([H])(C2=C(F)C([H])=C(F)C(F)=C2[H])[C@@]([H])([N+]([H])([H])[H])C1([H])[H]
[H]N1N=C(C2=C([H])SC(C#CC([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C2[H])C2=C1C1=C([H])C([H])=C(C([H])=C1C2([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1(C([H])=C(C2=C([H])C(F)=C([H])C([H])=C2F)C([H])([H])N1C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1N=C(C2=C([H])SC(C#CC([H])([H])C([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C2=C1C1=C(C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1(C(=NN2C3=C([H])C(F)=C([H])C([H])=C3OC([H])([H])[C@@]12[H])C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@@]2(C(=NN3C4=C([H])C(F)=C([H])C([H])=C4OC([H])([H])[C@@]23[H])C(=O)C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(C(=NN2C3=C([H])C(F)=C([H])C([H])=C3OC([H])([H])[C@@]12[H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1(C(=NN2C3=C([H])C(Cl)=C([H])C([H])=C3OC([H])([H])[C@@]12[H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(C(=NN2C3=C([H])C(=C([H])C([H])=C3OC([H])([H])[C@@]12[H])C([H])([H])[H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(C(=NN2C3=C([H])C(F)=C([H])C([H])=C3OC([H])([H])[C@@]12[H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(C(=NN2C3=C([H])C(F)=C([H])C([H])=C3OC([H])([H])[C@@]12[H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(C(=NN2C3=C([H])C(Cl)=C([H])C([H])=C3OC([H])([H])[C@@]12[H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(C(=NN2C3=C([H])C(=C([H])C([H])=C3OC([H])([H])[C@@]12[H])C([H])([H])[H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(C(=NN2C3=C([H])C(Cl)=C([H])C([H])=C3OC([H])([H])[C@@]12[H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C2OC(=NC2=C1[H])N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NSC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])N2N=C([H])N=C2[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N
[H]N(C(=O)[C@]1(C([H])([H])C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@](C(=O)N([H])C([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
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[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])[N+]([O-])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]C1=C(C(=NN1C1=NC([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C2(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
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[H]C1=NC(=C(C(=O)N2C([H])([H])C([H])([H])C(N3C([H])([H])C([H])([H])C([H])(N(C4=C([H])C([H])=C([H])C([H])=C4[H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)C2=C([N+]([O-])=C([H])N=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C(OC([H])([H])[H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC2=C1C([H])=C([H])C([H])=C2[H]
[H]C1=C(N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(Cl)=C([H])C([H])=C2N1C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@@]1([H])OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]O[C@]1([H])C2=NC([H])=C([H])C([H])=C2C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]O[C@]1([H])C2=C([H])C([H])=C([H])C(=C2C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])[H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@]1([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]O[C@]1([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])C2([H])[H])C1([H])[H]
[H]O[C@]1([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C(Cl)C([H])=C([H])C([H])=C3Cl)C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NSC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NN=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(N=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C(=N3)N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]N1C(=NN=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(N=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C(=N3)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]N1C(=NN=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(C([H])=NC(=N3)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=[N+]([O-])C([H])=C1[H]
[H]N1C(=NN=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(C([H])=NC(=N3)N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=[N+]([O-])C([H])=C1[H]
[H]N1C(=NN=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(C([H])=NC(=N3)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])N([H])C(=O)C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=N2)C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C(=N3)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=NN=C(N3[H])C3=C([H])N([H])C(=O)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC([H])=C(C([H])=C1[H])C1=NN=C(N1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(C([H])=NC(=N3)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=N2)C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C(=N3)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=NN=C(N3[H])C3=C([H])N=C(N([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC([H])=C(C([H])=C1[H])C1=NN=C(N1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(C([H])=NC(=N3)N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=NN=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(C([H])=NC(=N3)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=N1
[H]N1C(=NN=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])C([H])=C3[H])C([H])([H])C1([H])[H])C1=C([H])N=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1C(=NN=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])C([H])=C3[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])N=C1[H]
[H]C1=C(C([H])=C2C([H])=C(Cl)C([H])=C([H])C2=N1)N1C([H])([H])C([H])([H])C([H])(C2=NC(=NO2)C2=C([H])C([H])=C(F)C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]N1C(=NN=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(C([H])=NC(=N3)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]N1C(=NN=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC([H])=C(C([H])=C1[H])C1=NN=C(N1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(N=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C(=N3)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NN=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(N=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C(=N3)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=N1
[H]N(C(=O)C1=C([H])C([H])=C([H])O1)[C@@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(Cl)=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)C([H])=C1[H])C1=NC([H])=NC2=C([H])C([H])=C([H])C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C12
[H]N(C1=C([H])C(=C(OC2=C([H])N=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C([H])C(O[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C12
[H]N(C(=O)C([H])([H])OC1=C([H])C(Cl)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C(Cl)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=O)N(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=O)N(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=O)N(C([H])=NC2=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])N=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])OC([H])([H])[H]
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[H]C1=NC(=C([H])C([H])=C1[H])C1=NC2=C(C([H])=C([H])C(F)=C2[H])N1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=NC(=C([H])C([H])=C1[H])C1=NC2=C(C([H])=C([H])C(F)=C2[H])N1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])SC([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=NC(=C([H])C([H])=C1[H])C1=NC2=C(C([H])=C([H])C(F)=C2[H])N1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])N2C(=NC3=C2C([H])=C([H])C(F)=C3[H])C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H]
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[H]N(C(=O)C([H])([H])OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=NC(=N1)C1=C([H])C([H])=C(O1)C([H])([H])[H])N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=NC(=N1)C1=C([H])C([H])=C(O1)C([H])([H])[H])N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])N=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C(OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])S(=O)(=O)N([H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1F)C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[C@]([H])(O[H])C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[C@]([H])(O[H])C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C(F)=C(Cl)C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C1=C(N=C(N=C1OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C#N)N([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC2=NC(=NC(N([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]4(C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])=C2C(=O)N([H])C([H])([H])[H])C#N)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N=C(N=C1OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C#N)N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2(OC([H])([H])C([H])([H])O2)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(N=C(N=C1OC([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C#N)N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2(C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(N=C(N=C1OC1([H])C([H])([H])C(N([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H])C#N)N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2(C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(N=C(N=C1OC([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C#N)N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2(C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H])N1C(=O)C2=C([H])C(Cl)=C([H])C([H])=C2N=C1C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H])N1C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2N=C1C([H])([H])[H]
[H]C1=C([H])C(Cl)=C2N=C(N(C(=O)C2=C1[H])C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(C2=NN=C(O2)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]C1=C([H])C(N2C([H])([H])C([H])([H])N(C(=O)C3=C([H])C(=C([H])C([H])=C3OC([H])([H])C3([H])C([H])([H])C3([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C2([H])[H])=C(F)C([H])=C1C#N
[H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(Cl)C(Cl)=C2[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(SC([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(Cl)C(Cl)=C2[H])=C1[H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C(OC2=C([H])C(=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C(F)(F)F
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]C1=C(OC2=C([H])C([H])=C(C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(Br)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])N([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(Cl)C(=C1[H])C([H])([H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C2N=C(N(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])C(=O)C2=C1[H])C([H])([H])[H])C(F)(F)F
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N1C(=O)C2=C([H])C([H])=C(C([H])=C2N=C1C([H])([H])[H])C(F)(F)F
[H]C1=C([H])C(Cl)=C2C(=O)N(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N1C(=O)C2=C([H])C([H])=C(F)C([H])=C2N=C1C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N1C(=O)C2=C([H])C(F)=C([H])C([H])=C2N=C1C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(C(Cl)=C1[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(Cl)C(=C1[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(F)C(=C1[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(F)C(Cl)=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(Cl)C(F)=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C(C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C(=C1[H])C([H])([H])N([H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C(F)(F)F
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(Cl)C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(F)=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(F)C(Cl)=C1[H]
[H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C(F)(F)F)C([H])([H])[H]
[H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(OC([H])([H])[H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C(F)(F)F
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(=C1[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@]([H])(F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N([H])C(=O)C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2C(=O)N(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])C(=NC2=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=O)N(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])C(=NC2=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C1([H])[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C2C(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(Cl)C(Cl)=C(Cl)C([H])=C2[H])C1([H])[H]
[H]N(C(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C2C1=O)C1=C([H])C([H])=C([H])C(\C([H])=C(\C2=NC(=NO2)C([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C1[H])C1=C(Cl)C([H])=NC([H])=C1Cl
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@](C(=O)OC([H])([H])[H])(C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=NC([H])=C([H])C([H])=C2C1=O)C1=C(Cl)C([H])=NC([H])=C1Cl
[H]C1=C([H])C(=C2N=C(N(C(=O)C2=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N1C(=O)C2=C([H])C([H])=C(C([H])=C2N=C1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C2C(=O)N(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])C(=NC2=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C(=C2[H])C(=O)C([H])([H])[H])C2=NC([H])=C([H])C([H])=C2C1=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C(=C2[H])C(=O)C([H])([H])[H])C2=NC([H])=C([H])C([H])=C2C1=O)C1=NC([H])=C([H])C(Cl)=C1Cl
[H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C2[H])C2=NC([H])=C([H])C([H])=C2C1=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C(SC([H])([H])[H])C([H])=C2[H])C2=NC([H])=C([H])C([H])=C2C1=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)C([H])([H])[H])C2=NC([H])=C([H])C([H])=C2C1=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@@]2([H])OC([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1Cl)C(=O)N1C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])C(Cl)=C1[H]
[H]C1=NN=C(O1)C1=NC([H])=C(OC([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])C(Cl)=C1[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])N=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C(=O)N1C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C(=O)N1C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=O)N(C(=NC2=C1[H])C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=O)N(C(=NC2=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2N=C1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2N=C1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
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[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]2(C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])S1
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(C([H])([H])N(C(=O)C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])[C@@]2(C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])S1
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[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(C([H])([H])N(C3=NC([H])=C([H])C([H])=N3)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1
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[H]C1=C([H])C([H])=C2C(=O)N(C3=C([H])C([H])=C(O[C@@]4([H])C([H])([H])C([H])([H])[C@@]([H])(N5C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C([H])([H])C4([H])[H])C([H])=C3[H])C(=NC2=C1[H])C([H])([H])[H]
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[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(C([H])([H])N(C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])SC([H])=C1[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])N(C([H])=N1)C([H])([H])[H]
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[H]C1=C([H])C(Cl)=C2N=C(N(C(=O)C2=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
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[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(C([H])([H])N([H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(N([H])C(=O)N([H])C2=O)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(N([H])C([H])([H])N([H])C2=O)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])N([H])C2=O)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(C([H])([H])N(C([H])([H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1
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[H]N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C3=C([H])C([H])=C(F)C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C2=C([H])N=C([H])N2C([H])([H])C2=C([H])C(OC3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])N3C(=O)[C@@]1([H])C([H])([H])C3([H])[H])=C(C#N)C([H])=C2[H]
[H]N1C([H])([H])C2=C([H])N=C([H])N2C([H])([H])C2=C([H])C(OC3=C([H])C(=C([H])C(Cl)=C3[H])C([H])([H])N3C(=O)[C@@]1([H])C([H])([H])C3([H])[H])=C(C#N)C([H])=C2[H]
[H]N1C([H])([H])C2=C([H])N=C([H])N2C([H])([H])C2=C([H])C(OC3=C([H])C(=C([H])C([H])=C3[H])[C@]([H])(N3C(=O)[C@@]1([H])C([H])([H])C3([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])=C(C#N)C([H])=C2[H]
[H]N1C([H])([H])C2=C([H])N=C([H])N2C([H])([H])C2=C([H])C(OC3=C([H])C(=C([H])C([H])=C3[H])[C@]([H])(N3C(=O)[C@@]1([H])C([H])([H])C3([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])=C(C#N)C([H])=C2[H]
[H]N1C([H])([H])C2=C([H])N=C([H])N2C([H])([H])C2=C([H])C(OC3=C([H])C([H])=C([H])C(=C3[H])C3=C([H])C([H])=C([H])C([H])=C3N3C(=O)[C@@]1([H])C([H])([H])C3([H])[H])=C(C#N)C([H])=C2[H]
[H]N1C([H])([H])C2=C([H])N=C([H])N2C([H])([H])C2=C([H])C(OC3=C([H])C4=C(C([H])=C([H])C([H])=C4C([H])=C3[H])N3C(=O)[C@]1([H])C([H])([H])C3([H])[H])=C(C#N)C([H])=C2[H]
[H]N1C([H])=NN=C1C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(C([H])([H])OC2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1([H])[H]
[H]N([H])C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C(C(=O)N2C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])C2=C([H])C3=C([H])C([H])=C(C#N)C([H])=C3C([H])=C2[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1([H])[H]
[H]N1N=C(N=C1C1=NC([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C2=NN=C(N2C([H])=C3[H])C([H])([H])Cl)C([H])([H])C1([H])[H]
[H]N1N=C(N=C1C1=NC([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C2=NN=C(N2C([H])=C3[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=NN=C2N1C([H])=C([H])C1=C2C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=NN([H])C(=N2)C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NN=C2N1C([H])=C([H])C1=C2C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=NN([H])C(=N2)C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1N=C(N=C1C1=NC([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]O[C@@](C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2(C3=C([H])C([H])=C(C([H])=C3[H])C(=O)N([H])[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C(F)(F)F
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(C2=C(C([H])=NN2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(N(C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C2([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(N2C(=NN=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(C2=NC(=NO2)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)C1([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NN=C1C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N1N=C([H])C(=N1)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C(F)(F)C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C1=C(Cl)C([H])=C(C(=O)N([H])C([H])([H])[C@]2([H])OC([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C2([H])[H])C(OC([H])([H])C([H])([H])[H])=C1[H]
[H]N1C(=N[C@](C2=C([H])C([H])=C(F)N=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]1([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H]
[H]N1C(=N[C@](C2=C([H])C([H])=C(F)N=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]1([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=N1)C#N
[H]N1C(=N[C@](C2=C([H])C([H])=C(F)N=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]1([H])C([H])([H])[H])C1=NC([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]N1C(=N[C@](C2=C([H])C([H])=C(F)N=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]1([H])C([H])([H])[H])C1=NC([H])=C([H])C(Cl)=C1[H]
[H]N1N=C([H])C([H])=C1C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]C1=NC(=NO1)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C(F)(F)F
[H]OC([H])([H])C(F)(F)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]OC(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N1N=C(C(=C1[H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(N2C([H])=C(N([H])C2=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C#C[C@@]2([H])N(C(=O)[C@@]([H])(C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])S(=O)(=O)N1C([H])([H])C([H])(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1
[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1
[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1
[H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])N([H])N=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=N[C@](C2=C([H])C([H])=C(OC([H])([H])[H])N=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]1([H])C([H])([H])[H])C1=NC([H])=C([H])C(C#N)=C1[H]
[H]N([H])C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2OC([H])([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C(C(=O)N2C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[C@]1([H])C2=C(OC1([H])[H])C([H])=C([H])C([H])=C2[H]
[H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])S(=O)(=O)N1C([H])([H])C([H])(OC2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H]
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[H]N([H])C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C(C(=O)N([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=N2)(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C(Cl)=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C2=C(N([H])C3=C2C([H])=C([H])C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
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[H]OC(C1=C([H])C([H])=C([H])N=C1[H])(C1=C([H])C([H])=C([H])N=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]O[C@](C(=O)N([H])[C@@]1([H])C2=C([H])C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)(C([H])([H])[H])C(F)(F)F
[H]O[C@@]([H])(C([H])([H])C(=O)N([H])[C@@]1([H])C2=C([H])C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C(F)(F)F
[H]OC([H])([H])C(F)(F)C(=O)N([H])[C@@]1([H])C2=C([H])C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
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[H]N(C(=O)C1=NN([H])C([H])=C1C([H])([H])[H])[C@@]1([H])C2=C([H])C(=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C1=NN([H])C(=C1C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C2=C([H])C(=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C1=C([H])N([H])N=C1[H])[C@@]1([H])C2=C([H])C(=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C1=C([H])N([H])N=C1C([H])([H])[H])[C@@]1([H])C2=C([H])C(=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C1=C(N([H])N=C1C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C2=C([H])C(=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C1=NN([H])C(=N1)C([H])([H])[H])[C@@]1([H])C2=C([H])C(=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C1=NN([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@@]1([H])C2=C([H])C(=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C(N([H])N=C2[H])C([H])=C1[H])[C@@]1([H])C2=C([H])C(=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])[C@@]1([H])C2=C([H])C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N(C(=O)C1=NN([H])C(=C1[H])C([H])([H])[H])[C@@]1([H])C2=C([H])C(=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]O[C@]([H])(C(=O)N([H])[C@@]1([H])C2=C([H])C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])[H]
[H]OC(C(=O)N([H])[C@@]1([H])C2=C([H])C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)(C([H])([H])[H])C([H])([H])[H]
[H]OC1(C(=O)N([H])[C@@]2([H])C3=C([H])C(C4=C([H])C([H])=C(Cl)C([H])=C4[H])=C(N=C3OC(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]O[C@]([H])(C(=O)N([H])[C@@]1([H])C([H])([H])C(O[C@]2([H])N([H])[C@@]([H])([C@@]3([H])C([H])([H])C([H])([H])[C@@]([H])(Cl)C([H])([H])[C@@]3([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[C@]12[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(Cl)C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F
[H]N1C(=O)N(C2=C([H])C(=C([H])C(C3=C([H])C([H])=C(F)C([H])=C3F)=C2C1([H])[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]N([H])C1=C([H])C2=C(C([H])=C([H])C(=O)N2C2=C(F)C([H])=C([H])C([H])=C2F)C(=N1)C1=C([H])C([H])=C(F)C([H])=C1F
[H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])C2=C(C3=C([H])C([H])=C(F)C([H])=C3C([H])=C2[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)C([H])([H])[H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1([H])[H]
[H]N(C(=O)OC([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])OC1([H])[H])C1=C([H])N2N=C([H])N=C(N([H])C3=C([H])C4=C(C([H])=C3[H])N(N=C4[H])C([H])([H])C3=C([H])C(F)=C([H])C([H])=C3[H])C2=C1C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C1=C([H])C([H])=NC2=C1N=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C(F)=C([H])C(F)=C1[H]
[H]N(C1=C([H])C([H])=NC2=C1N=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C(=NS1)C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C#N)C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]O[C@@]1([H])[C@]([H])(O[C@]2([H])[C@@]([H])(C([H])([H])[H])[C@]([H])(O[C@]3([H])O[C@@]([H])(C([H])([H])[H])[C@]([H])(O[H])[C@@](OC([H])([H])[H])(C([H])([H])[H])C3([H])[H])[C@]([H])(C(=O)O[C@]([H])(C([H])([H])C([H])([H])[H])[C@](O[H])(C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(C([H])([H])[H])[C@@]([H])(O[H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]2(O[H])C([H])([H])[H])C([H])([H])[H])O[C@]([H])(C([H])([H])[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])OC1=C(C#N)C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
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[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[C@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])=C1[H]
[H]N(N1C(=O)N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C2([H])C([H])([H])C2([H])[H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(N1C(=O)N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(N1C(=O)N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(N1C(=O)N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C1=NC2=C([H])C(=C([H])C([H])=C2O1)S(=O)(=O)C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C2OC(=NC2=C1[H])N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])[H])=C(F)C(OC([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N1N=C(C(OC2=C([H])C(C#N)=C([H])C(C#N)=C2[H])=C1C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(N1C(=O)N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C2[H])C([H])([H])C([H])([H])[C@]3([H])OC([H])([H])C2=C([H])C(F)=C([H])C([H])=C2C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]C1=NC(F)=C([H])C2=C1C1(OC2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C(F)C(F)=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]N([H])C1=C(N([H])C(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(C([H])=C2[H])[C@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]2([H])C(=O)N([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N(C(=O)[C@@]2([H])C([H])([H])N(C3=NC([H])=NC([H])=C3[H])C([H])([H])[C@]2([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]O[C@@]1(C2([H])C([H])([H])C2([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N(C(=O)[C@@]2([H])C([H])([H])N(C3=C([H])C([H])=C([H])N=N3)C([H])([H])[C@]2([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]O[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N(C(=O)[C@@]2([H])C([H])([H])N(C3=NN=C([H])C([H])=C3[H])C([H])([H])[C@]2([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]O[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N(C(=O)[C@@]2([H])C([H])([H])N(C3=C([H])N=C([H])C([H])=C3[H])C([H])([H])[C@]2([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]O[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N(C(=O)[C@@]2([H])C([H])([H])N(C3=NC([H])=C([H])C([H])=C3[H])C([H])([H])[C@]2([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]O[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N(C(=O)[C@@]2([H])C([H])([H])N(C([H])([H])[C@]2([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]O[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])N([H])C([H])([H])[C@@]2([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]N([H])C1=C(N([H])C(=O)C(\[H])=C(/[H])C2=C([H])C(F)=C(C([H])=C2[H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]2([H])C(=O)N([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=NN(C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1F
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])(F)F)C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])(F)F)C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C(OC([H])(F)F)C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC(F)(F)F)C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])C1=C(OC(F)(F)F)C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C(OC(F)(F)F)C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=NN(C([H])=C1C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NN(C([H])=C1C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])N(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=NN(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])N(C([H])=N1)C1([H])C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C(F)C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1F
[H]N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1[H]
[H]O[C@]([H])(C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C2C([H])=C([H])C([H])=C(C2=N1)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H]
[H]OC([H])([H])N([H])C(=O)[C@@]1([H])C2=C([H])C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C(N=C2N(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N1C(=NC2=NC([H])=C(Br)C(N3C([H])([H])C([H])([H])N(C([H])([H])C4=NOC(=C4[H])C([H])([H])[H])C([H])([H])C3([H])[H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C(N3C([H])([H])C([H])([H])N(C([H])([H])C4=NOC(=C4[H])C([H])([H])[H])C([H])([H])C3([H])[H])C(Cl)=C([H])N=C12)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])C(=O)N([H])[C@@]1([H])C2=C([H])C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]C1=C([H])C(=C([H])C2=C1N1C(=N2)C([H])([H])[C@]([H])(C2=C(F)C([H])=C(F)C(F)=C2[H])[C@@]([H])([N+]([H])([H])[H])C1([H])[H])C(F)(F)F
[H]N(C1=C([H])C2=C(C([H])=C1[H])N1C(=N2)C([H])([H])[C@]([H])(C2=C(F)C([H])=C(F)C(F)=C2[H])[C@@]([H])([N+]([H])([H])[H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C1=C([H])C(=C([H])C([H])=N1)C([H])([H])[H])C1=NC(=NC2=C1N(N=C2C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])N([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC3=C(N(N=C3C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C(=N2)N([H])C2=C([H])C(=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=NN(C(=C1C([H])([H])[H])C1=C([H])C(F)=C([H])C(F)=C1[H])C([H])([H])C([H])([H])C#N)[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(F)C1([H])[H]
[H]C1=C([H])C(Cl)=C(C([H])=C1F)C([H])([H])N(C1=C([H])C(Cl)=C(C#N)C([H])=C1[H])[C@]1([H])C([H])([H])N(C(=O)C1([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])N(C1=C([H])C(Cl)=C(C#N)C([H])=C1[H])[C@]1([H])C([H])([H])N(C(=O)C1([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1F)C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H]
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[H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)N([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])N(C([H])=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N2C([H])=C([H])C([H])=C2[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)N(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)N(C1=C([H])C([H])=C(Br)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H]
[H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=NC([H])=C(N=C1[H])[C@@]([H])(C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])[H]
[H]C1=NC([H])=C(N=C1[H])[C@@]([H])(C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C([H])([H])[H]
[H]C1=NC(OC([H])([H])[H])=C(N=C1[H])[C@@]([H])(C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(OC([H])([H])[H])=C(N=C1[H])[C@@]([H])(C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C([H])([H])[H]
[H]C1=NC(OC([H])([H])[H])=C(N=C1[H])[C@@]([H])(C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(F)=C([H])C([H])=C12)C([H])([H])[H]
[H]C1=C([H])N=C(S1)[C@@]([H])(C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])N=C(S1)[C@@]([H])(C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(F)=C([H])C([H])=C12)C([H])([H])[H]
[H]C1=C([H])C([H])=C(N=N1)C([H])([H])C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C12
[H]C1=NC(=NC([H])=C1[H])C([H])([H])C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]C1=NC([H])=C(N=C1[H])[C@@]([H])(C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H]
[H]C1=NC(OC([H])([H])[H])=C(N=C1[H])[C@@]([H])(C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H]
[H]C1=C([H])N=C(S1)[C@@]([H])(C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H]
[H]C1=C(N=C(S1)[C@@]([H])(C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])[H]
[H]C1=NC([H])=C(N=C1[H])C([H])([H])C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])[H]
[H]C1=NC([H])=C(N=C1[H])C([H])([H])C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12
[H]C1=NC([H])=C(N=C1[H])C([H])([H])C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C12
[H]C1=NC([H])=C(N=C1[H])C([H])([H])C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(F)=C([H])C([H])=C12
[H]C1=NC(OC([H])([H])[H])=C(N=C1[H])C([H])([H])C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C12
[H]C1=C([H])C([H])=C(N=N1)C([H])([H])C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(F)=C([H])C([H])=C12
[H]C1=NC(OC([H])([H])[H])=C(N=C1[H])C([H])([H])C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(F)=C([H])C([H])=C12
[H]C1=NC([H])=C(N=C1[H])C([H])([H])C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]C1=NC(OC([H])([H])[H])=C(N=C1[H])C([H])([H])C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]C1=C([H])C([H])=C2C(=C1[H])C(=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C([H])([H])C1=C([H])N=C([H])C(=N1)C([H])([H])[H]
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[H]N(C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H])C1=NC(=NC2=C1N(N=C2C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C(F)(F)F)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
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[H]N(C1=NC([H])=NC([H])=C1[H])C1=NC(=NC2=C1N(N=C2C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C(F)(F)F)N1C([H])([H])C([H])([H])N([H])[C@]([H])(C([H])([H])[H])C1([H])[H]
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[H]C1=C(OC2=C1C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C#N)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C2=C([H])C([H])=C(N=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])N=C(S1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NC([H])=C(C([H])=C1[H])C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C(C([H])=C([H])C(Cl)=N1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C2=C([H])C([H])=C(N=C12)C1=C(N=C(C(C#N)=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C(=C([H])O1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])S1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C(C2=NC3=C([H])C([H])=C(C([H])=C3C([H])=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C(=NC(=N1)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(O1)C([H])=C([H])C(=C2[H])C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]C1=C([H])C2=C(S1)C([H])=C([H])C(=C2[H])C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1N=C([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1C2=C(C([H])=C1C(F)(F)F)C([H])=C(C([H])=C2[H])C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]C1=C(N=C(S1)C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N=C1[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C(N=C(S1)C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N=C1[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[C@]1([H])OC([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3N=C2[C@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C(N=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C(N=C(S1)C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C(SC(=C1[H])C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C1=C([H])C([H])=C(S1)C([H])([H])[H]
[H]C1=NN(C(=C1C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]C1=NN(C(=C1C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])N=N1
[H]C1=C(ON=C1Br)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C2=C([H])C([H])=C(N=C12)C1=C(C(=O)OC([H])([H])C([H])([H])[H])C(=NO1)C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C(ON=C1C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(O[C@]2([H])C([H])([H])N(C(=O)C([H])([H])[H])[C@@]([H])(C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])=C([H])C(F)=C1[H]
[H]N1C([H])([H])[C@@]([H])(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])[C@@]([H])(OC2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(C#N)=C([H])C(OC2=NC([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H]
[H]C1=C([H])C(Cl)=C([H])C(OC2=NC([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H]
[H]C1=C(C([H])=C([H])C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])=N1)C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C([H])C(=N1)C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(F)=C([H])C(OC2=NC([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C(=O)O[H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C(=O)O[H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C(=O)O[H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C(=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])SC([H])=C1[H]
[H]N1C([H])([H])[C@@]([H])(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])[C@@]([H])(OC2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])[C@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N2[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]N(C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C(=O)O[H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C(=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C([H])C(=N1)C1=NC(=C(S1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NC([H])=C(C([H])=C1[H])C1=NC(=C(S1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
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[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=NOC(=C1C([H])([H])[H])C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
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[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C([H])C(=N1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C2=C([H])C([H])=C(N=C12)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
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[H]C1=C([H])C([H])=C(S1)C1=NC(=C(S1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
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[H]C1=C([H])N=C2C([H])=C(C([H])=C([H])C2=N1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C2=C([H])C([H])=C(N=C12)C1=C([H])C([H])=C2OC([H])([H])OC([H])([H])C2=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C(SC(=C1[H])C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C#N
[H]N=C(OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C1=NC(=C(S1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C(N=C(S1)C([H])([H])[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C(N=C(S1)C1=NOC(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C2N=C([H])C(C3=NC4=C([H])C([H])=C(C([H])=C4C([H])=C3[H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])[H])=C(N2N=C1C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C([H])C([H])=C2[H])S1(=O)=O
[H]C1=C([H])C2=C(O1)C([H])=C([H])C(=C2[H])C1=NC([H])=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]C1=C([H])C2=C(S1)C([H])=C([H])C(=C2[H])C1=NC([H])=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
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[H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])C1=NC([H])=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1C2=C(C([H])=C1C(F)(F)F)C([H])=C(C([H])=C2[H])C1=NC([H])=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=NC([H])=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C1=NC([H])=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]C1=C([H])C2=C(O1)C([H])=C([H])C(=C2[H])C1=C([H])N=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]C1=C([H])C2=C(S1)C([H])=C([H])C(=C2[H])C1=C([H])N=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1N=C([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])N=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])N=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1C2=C(C([H])=C1C(F)(F)F)C([H])=C(C([H])=C2[H])C1=C([H])N=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C([H])N=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]OC([H])([H])C(=O)N([H])C1=C(OC2=NC(C3=C([H])C([H])=C([H])C([H])=C3Cl)=C(C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)C(O[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(O1)C([H])=C([H])C(=C2[H])C1=NN=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]C1=C([H])C2=C(S1)C([H])=C([H])C(=C2[H])C1=NN=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
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[H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])C1=NN=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1C2=C(C([H])=C1C(F)(F)F)C([H])=C(C([H])=C2[H])C1=NN=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=NN=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C1=NN=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1C2=C(C([H])=C1C([H])([H])[H])C([H])=C(C([H])=C2[H])C1=NN=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C1=NC(=NC(=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C#N
[H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(=NC(=N1)C#N)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(=NC(=N1)C#N)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(=N3)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N(C1=C([H])C([H])=C(Br)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C4=C(C([H])=C3C([H])([H])C2([H])[H])C(=NO4)C([H])([H])[H])N1C([H])([H])[H])C(F)(F)F
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(C([H])=C4C([H])([H])C3([H])[H])C(=NO5)C([H])([H])C([H])([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=NC(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N(C1=C([H])C([H])=C(Br)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N(C1=C([H])C([H])=C(Br)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N(C1=C([H])C([H])=C(Br)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)N(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)N(C1=NC([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(C3=C(N2N=C1SC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H])=C1[H]
[H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])=C1[H]
[H]C1=C([H])C(OC([H])([H])[H])=C2C(O[C@@]([H])(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])[C@]([H])(C([H])([H])[H])S2(=O)=O)=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]1([H])OC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2S(=O)(=O)[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]1([H])OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2S(=O)(=O)[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C(OC([H])([H])[H])=C2O[C@@]([H])(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])[C@]([H])(C([H])([H])[H])S(=O)(=O)C2=C1[H]
[H]C1=C([H])C(OC([H])([H])[H])=C2O[C@@]([H])(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])[C@]([H])(C([H])([H])[H])S(=O)(=O)C2=C1[H]
[H]C1=C([H])C([H])=C2C(O[C@@]([H])(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])[C@]([H])(C([H])([H])[H])S2(=O)=O)=C1[H]
[H]C1=C([H])C([H])=C2S[C@@]([H])(C([H])([H])[H])[C@]([H])(OC2=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2S[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]([H])(OC2=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])SC2=C([H])C([H])=C([H])C([H])=C2O[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=NC(=C([H])N1C([H])([H])[H])C(=O)N(C([H])([H])C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F)[C@]1([H])C([H])([H])[C@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]2([H])C1([H])[H]
[H]C1=C([H])C([H])=C2SC(=C(OC2=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(OC(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])=C(C([H])([H])[H])S2(=O)=O)=C1[H]
[H]N1C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])(N(C(=O)C3=C([H])N(C([H])=N3)C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C(OC(F)(F)F)=C3[H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]N1C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])(N(C(=O)C3=C([H])N(C([H])=N3)C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C(F)C(=C3[H])C(F)(F)F)C([H])([H])[C@@]2([H])C1([H])[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])(N(C(=O)C3=C([H])N(C([H])=N3)C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C(OC(F)(F)F)=C3[H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])(N(C(=O)C3=C([H])N(C([H])=N3)C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C(OC(F)(F)F)=C3[H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]C1=NC(=C([H])N1C([H])([H])[H])C(=O)N(C([H])([H])C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1[H])[C@]1([H])C([H])([H])[C@]2([H])C([H])([H])N(C([H])([H])C([H])([H])C(F)(F)F)C([H])([H])[C@]2([H])C1([H])[H]
[H]C1=NC(=C([H])N1C([H])([H])[H])C(=O)N(C([H])([H])C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1[H])[C@]1([H])C([H])([H])[C@]2([H])C([H])([H])N(C([H])([H])[C@]([H])(F)C([H])([H])[H])C([H])([H])[C@]2([H])C1([H])[H]
[H]C1=NC(=C([H])N1C([H])([H])[H])C(=O)N(C([H])([H])C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1[H])[C@]1([H])C([H])([H])[C@]2([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[C@]2([H])C1([H])[H]
[H]C1=NC(=C([H])N1C([H])([H])[H])C(=O)N(C([H])([H])C1=C([H])C([H])=C(F)C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]2([H])C1([H])[H]
[H]C1=NC2=C(N=C(O2)N2C([H])([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])C([H])=C1Cl
[H]C1=C([H])C(F)=C(C([H])=C1[H])C1=NC2=C(OC(=N2)N2C([H])([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])C([H])=C1[H]
[H]N1C([H])([H])[C@@]2([H])[C@]([H])(C([H])([H])OC([H])([H])C([H])([H])[H])[C@@]2(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C1([H])[H]
[H]N1C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])(N(C(=O)C3=C([H])N(C([H])=N3)C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C(F)C(OC4([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C3[H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]C1=NC2=C(OC(=N2)N2C([H])([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])C([H])=C1Br
[H]C1=NC2=C(OC(=N2)N2C([H])([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])C([H])=C1Cl
[H]C1=NC2=C(OC(=N2)N2C([H])([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])C([H])=C1F
[H]N(C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N(C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])C(\[H])=C(/[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N1C(=NC2=C(N3C([H])([H])C([H])([H])N(C([H])([H])C4=NOC(=C4[H])C([H])([H])[H])C([H])([H])C3([H])[H])C(Br)=C([H])N=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C(N3C([H])([H])C([H])([H])N(C([H])([H])C4=NOC(=C4[H])C([H])([H])[H])C([H])([H])C3([H])[H])C(Cl)=C([H])N=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])[C@@]([H])(C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])[C@@]([H])(C1=C(OC2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])C(C(=O)N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H]
[H]N([C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])C(C(=O)N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H]
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[H]N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(Cl)=C1[H])[C@]([H])(N([H])C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=NC(=C(S1)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])N1C([H])([H])[H])C(=O)N(C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])[C@]2([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[C@]12[H]
[H]C1=NC(=C([H])N1C([H])([H])[H])C(=O)N(C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])[C@]2([H])C([H])([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])[C@]12[H]
[H]C1=NC(=C([H])N1C([H])([H])[H])C(=O)N(C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])[C@]2([H])C([H])([H])N(C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[C@]12[H]
[H]C1=NC(=C([H])N1C([H])([H])[H])C(=O)N(C([H])([H])C1=C([H])C(Cl)=C(F)C([H])=C1[H])C([H])([H])[C@@]1([H])[C@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]12[H]
[H]N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C(=C([H])N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C1[H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=NC(=C(O1)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=NC(=C(O1)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=NC(=C(O1)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=NC(=C(O1)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H]
[H]N(C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=NC(=C(O1)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]N(C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=NC(=C(O1)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C#N
[H]N(C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=NC(=C(O1)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=NC(=C(O1)C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=NC(=C(O1)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C(F)(F)F
[H]N(C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])SC1=NC(=C(O1)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=N2)C(F)(F)F)C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=N2)C(F)(F)F)C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=N2)C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]OC([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])OC([H])([H])[H])C([H])([H])N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(O2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])N([H])C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(O2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]OC1=C([H])C(Cl)=C([H])C([H])=C1C([H])([H])N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]OC1=C([H])C(Cl)=C([H])C(Cl)=C1C([H])([H])N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])N1C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C(N=C3[H])C3=C([H])N=C(OC([H])([H])[H])C([H])=C3[H])N(C2=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C(N=C3[H])C3=C([H])N=C(OC([H])([H])[H])C([H])=C3[H])N(C2=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])C2=C1N=C(N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(O3)C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C(Cl)=C1[H])C([H])([H])N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])[C@]([H])(C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])N=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C(N=C3[H])C3=C([H])N=C(OC([H])([H])[H])C([H])=C3[H])N(C2=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])N([H])C1=NC2=C(C([H])=C(N=C2[H])C2=C([H])N=C(OC([H])([H])[H])C([H])=C2[H])N(C1=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])[H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C(N=C3[H])C3=C([H])N=C(OC([H])([H])[H])C([H])=C3[H])N(C2=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N1C2=NC([H])=C(C([H])=C2C([H])([H])C2=C(C(C#N)=C([H])C([H])=C2[H])C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])[C@@]2([H])C([H])([H])[C@]([H])(OC3=C([H])C([H])=C([H])C([H])=C3C3=C([H])C([H])=C([H])N=C3[H])[C@]([H])(C2([H])[H])C1([H])[H]
[H]OC1=C([H])N=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1O[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@]1([H])C([H])([H])N([H])C2([H])[H]
[H]N1C([H])([H])[C@@]2([H])C([H])([H])[C@]([H])(OC3=C([H])C([H])=C([H])C([H])=C3C3=C(F)C([H])=C([H])N=C3[H])[C@]([H])(C2([H])[H])C1([H])[H]
[H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(N(C(=C1C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(N(C(=C1C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C(N([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N([H])C(=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N(C(=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N(C(=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N(C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(OC([H])(F)F)C([H])=N1
[H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C([H])N=C(OC([H])([H])[H])N=C1[H]
[H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1F)C1=C([H])N=C(OC([H])([H])[H])N=C1[H]
[H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1Cl)C1=C([H])N=C(OC([H])([H])[H])N=C1[H]
[H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])N=C(OC([H])([H])[H])N=C1[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N([H])C(=O)C1=C([H])C(=C(N=C1[H])C1=NC2=NC([H])=C([H])C(N([H])C3=NC([H])=C(C([H])=C3[H])C(F)(F)F)=C2N=C1[H])C(F)(F)F
[H]C1=NN(C(=C1C([H])([H])N1C([H])([H])C([H])(OC2=C(F)C([H])=C([H])C([H])=C2OC([H])([H])[H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C([H])C([H])=N1
[H]N([H])C(=O)C1=C([H])C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C([H])N=C1[H]
[H]N([H])C(=O)C1=NC(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C([H])C(F)=C1[H]
[H]N([H])C(=O)C1=C([H])C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C(C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1O[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C(=C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C(F)=C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])N=C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])C([H])=C1[H]
[H]OC1=C([H])C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])C(S[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C(N([H])[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=NC([H])=C1[H]
[H]OC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])N1[C@@]([H])(C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C([H])C(Cl)=C([H])C([H])=C2N1[C@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C(=C([H])C(F)=C12)C(=O)[C@@]1(N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1(C(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=NN(C(=O)C([H])=C2[H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C(S4)C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C([H])C([H])=C1[H]
[H]C1=NN(C2=C1C([H])=C(C([H])=C2[H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C1=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=NN(C2=C([H])C([H])=C(C([H])=C12)N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C1=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NN(C2=C1C([H])=C(C([H])=C2[H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C1=O)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])N2N=C([H])C3=C2C([H])=C([H])C(=C3[H])N2C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C2=O)C([H])([H])C1([H])[H]
[H]C1=NN(C2=C1C([H])=C(C([H])=C2[H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C1=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1N=C([H])C2=C1C([H])=C([H])C(=C2[H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C1=O
[H]OC([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])N2N=C([H])C3=C2C([H])=C([H])C(=C3[H])N2C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C2=O)C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NN(C2=C1C([H])=C(C([H])=C2[H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C1=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])OC([H])([H])[H]
[H]N1C(=NC([H])([H])C1([H])[H])C([H])([H])N1N=C([H])C2=C1C([H])=C([H])C(=C2[H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C1=O
[H]C1=NN(C2=C1C([H])=C(C([H])=C2[H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C1=O)C([H])([H])C1=NC([H])([H])C([H])([H])N1C([H])([H])[H]
[H]OC(C1=C(C2=C([H])C([H])=C(C([H])=C2S1)C([H])([H])N1N=NC(=C1[H])[C@@](O[H])(C([H])([H])C([H])([H])[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C1=C(C2=C([H])C([H])=C(C([H])=C2S1)C([H])([H])N1N=NC(=C1[H])[C@@](O[H])(C([H])([H])C([H])([H])[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]O[C@](C1=C([H])N(N=N1)C([H])([H])C1=C([H])C([H])=C2C(SC(C(=O)C([H])([H])[H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])(C([H])([H])C([H])([H])[H])C(F)(F)F
[H]N(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])N([H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])N([H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N([C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([C@@]1([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1F)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)N=C1[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
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[H]C1=C([H])C([H])=C2C(=C1[H])C(=O)N(N=C2C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C(=O)N(N=C2C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C2C(=O)N(N=C(C2=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C2C(=C1[H])C(=O)N(N=C2C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C2C(=C1[H])C(=O)N(N=C2C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C2C(=C1[H])C(=O)N(N=C2C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=N1)C(=O)N(N=C2C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=N1)C(=O)N(N=C2C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=N1)C(=O)N(N=C2C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=O)N(N=C(C2=N1)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=O)N(N=C(C2=N1)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=O)N(N=C(C2=N1)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])N=C2C(=N1)C(=O)N(N=C2C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C2C(=C1[H])C(=O)N(N=C2C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(C1=C([H])C(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(C([H])=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C(F)=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C(F)=C([H])C(=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C(=O)N1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C(=O)N1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C([H])C(=O)N1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C([H])C(=O)N1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[C@]2([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[C@]2([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(O[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C1=O)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N1C(=NC2=C(C3=C(S2)C([H])([H])C([H])([H])C3([H])[H])C1=O)C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H]
[H]N([H])C1=NC(=NC2=C1C([H])=C([H])C([H])=C2[H])C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H]
[H]\C(=C(\[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(=C(\[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])[H]
[H]N([H])C1=NC(=NC(=N1)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H]
[H]N([H])C1=NC(=NC2=C1C(=C(S2)C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H])C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H]
[H]N([H])C1=NC(=NC2=C1C1=C(O2)C([H])=C([H])C([H])=C1[H])C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H]
[H]N(C1=NC(=NC2=C1C1=C(S2)C([H])([H])C([H])([H])C1([H])[H])C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(=NC2=C1C1=C(S2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H]
[H]N1C(=NC2=C(C([H])=C([H])C(=C2[H])C(F)(F)F)C1=O)C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H]
[H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H]
[H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=NC(=C([H])C(C#N)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H]
[H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=NC(=C([H])C([H])=C1[H])C1=C(C#N)C([H])=C([H])C([H])=C1[H])C2([H])[H]
[H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(=C([H])C(C#N)=C1[H])C1=C(C#N)C([H])=C([H])C([H])=N1)C2([H])[H]
[H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(=C([H])C(C#N)=C1[H])C1=C([H])C([H])=C([H])C([H])=N1)C2([H])[H]
[H]N([H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])[H])[C@]1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H]
[H]N(C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C2=NC3=C(N2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C(=O)N(C2=C3C([H])=C([H])C(C#N)=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]C1=C([H])C(=C([H])C2=C1C(=O)OC2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C(OC(F)(F)F)=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C(=C([H])C2=C1C(=O)OC2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])[H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C(=C([H])C([H])=C1C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H]
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[H]C1=C([H])C(=C([H])C2=NON=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C2=NON=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C3=NON=C3C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C(=C([H])C2=C1C(=O)OC2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C(=C(C#N)C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C2=C1C(=O)OC2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C(OC3([H])C([H])([H])C3([H])[H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C2=C1C(=O)OC2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C(SC([H])([H])[H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C(=C([H])C2=C1C(=O)OC2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C(Br)=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C2=C1C(=O)OC2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]N(C1=NN2C(=NC([H])=C2C2=C([H])C([H])=C([H])C(OC(F)(F)F)=C2[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1(N2C([H])([H])C([H])([H])C([H])(N3C(=NC4=C3C([H])=C([H])C([H])=C4[H])N3C([H])([H])[C@]4([H])C([H])([H])N([H])C([H])([H])[C@]4([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]([H])(N1C(=NC2=C([H])C(F)=C(Cl)C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]([H])(N1C(=NC2=C([H])C(F)=C(F)C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H]
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[H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(C([H])=C(C#N)C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=NN([H])C(=C1[H])C1=NC([H])=C([H])C([H])=C1[H]
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[H]O[C@@](C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=N1)(C([H])([H])[H])C([H])([H])C1=NC(=C([H])N1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
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[H]N([C@]1([H])C([H])([H])C([H])([H])[C@](C(=O)N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])OC([H])([H])[H]
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[H]N(C(=O)C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(N1C(=NC3=C1C([H])([H])C([H])([H])N(C1=NC([H])=C([H])N=C1[H])C3([H])[H])C([H])([H])[H])C2([H])[H]
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[H]N(C([H])([H])C1=NC(=C([H])N=C1[H])C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=C([H])C(=C([H])N=C1[H])C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=NC(=C([H])C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=C([H])C(=NC([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=C([H])C(=C([H])N=C1[H])C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=C([H])C(=C([H])N=C1[H])C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C(=C([H])N=C1[H])C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H]
[H]N(C1=C([H])C(=C([H])N=C1[H])C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C(=C([H])N=C1[H])C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H])[C@]1([H])C([H])([H])OC([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=NC([H])=C([H])N=C1[H])C([H])([H])C1=C([H])C(=C([H])N=C1[H])C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N(C1=N[C@]3(C4=C(C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])N21)C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C1=C2N([H])C([H])([H])[C@]3([H])N(C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])C3=C(C4=C(N3C(C([H])=C1[H])=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C4=O)C([H])([H])[H]
[H]N([H])C(=O)C1=C2N([H])C([H])([H])[C@]3([H])N(C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])C3=C(C4=C(N3C(C([H])=C1[H])=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C4=O)C([H])([H])[H]
[H]N([H])C(=O)C1=C2N([H])C([H])([H])[C@]3([H])C([H])([H])[N@](C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])C3=C(C4=C(N3C(C([H])=C1[H])=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C4=O)C([H])([H])[H]
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[H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C3=C(OC2(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
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[H]N(C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
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[H]N([H])C(C(=O)N1C([H])([H])C2=NC(=C(N([H])C3=C([H])C([H])=C(F)C([H])=C3[H])N2C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N1C([H])([H])C2=NC(=C(N([H])C3=C([H])C([H])=C(F)C([H])=C3[H])N2C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(F)=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N1C([H])([H])C2=NC(=C(N([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])N2C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N1C([H])([H])C2=NC(=C(N([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])N2C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N1C([H])([H])C2=NC(=C(N([H])C3=C([H])C([H])=C(F)C(F)=C3[H])N2C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N1C([H])([H])C2=NC(=C(N([H])C3=C([H])C([H])=C(Cl)C(F)=C3[H])N2C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])N1C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C1=C([H])N(N=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H]
[H]C1=NC(=C([H])N1C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C1=C([H])N(N=N1)C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])[H]
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[H]N([C@]1([H])C([H])([H])C([H])([H])[C@](C(=O)N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])OC([H])([H])[C@]1([H])C([H])([H])C([H])([H])[H]
[H]O[C@]1([H])C([H])([H])OC([H])([H])C([H])([H])[C@]1([H])N([H])[C@]1([H])C([H])([H])C([H])([H])[C@](C(=O)N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C(=O)[C@]2(C([H])([H])C([H])([H])[C@@]([H])(N3C([H])([H])C([H])([H])[C@@]4([H])C([H])([H])OC([H])([H])C([H])([H])[C@]34[H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]N1C([H])([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C#CC([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C2=NC([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@]1([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@]1([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C2=NC([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@]1([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@]1([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@]1([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C2=NC([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@]1([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@]1([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C(=N2)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@]1([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C#CC([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C2=NC([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C2=C([H])N3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C(=N2)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C2=NC([H])=C3C([H])=C([H])C([H])=C([H])C3=C2C#N)C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=NC([H])=C2C#N)C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C#CC([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C2=C(C#N)C([H])=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(C(Br)=C(OC([H])([H])C([H])([H])C([H])([H])[H])S2)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])[C@]1([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(=O)N(C([H])=N3)C([H])([H])C2=C([H])C([H])=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])SC([H])=N2)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])SC([H])=N2)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])SC([H])=N2)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N1N=C(C(=C([H])C1=O)C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C(=C(C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C(=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1[H])[C@]([H])(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)[C@]([H])(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C2=C([H])C(F)=C([H])C(F)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C(F)(F)F
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C(F)(F)F)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C(F)(F)F)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])N(C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C([H])C(=N1)C(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C(C([H])=C1[H])C(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]C1=C(OC2([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C2([H])[H])C([H])=C2C(OC3(C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])=C1[H]
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[H]N(C([H])([H])C1=NC2=C(OC([H])([H])C(=O)N2[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C(F)C([H])=NC3=C([H])C([H])=C(OC([H])([H])[H])N=C23)C([H])([H])C1([H])[H]
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[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
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[H]C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3N=C2[C@]2([H])C([H])([H])N(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
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[H]N1C([H])([H])C([H])([H])O[C@]([H])(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C(=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])S[C@]([H])(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C1([H])[H]
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[H]OC(=O)[C@@]1([H])N(C(=O)[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
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[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])S1(=O)=O
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[H]N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2C([H])([H])[H])C(=C1[H])C([H])([H])N([H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1Cl)N1C([H])([H])C([H])([H])C([H])([H])S1(=O)=O
[H]N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2Cl)C(=C1[H])C([H])([H])N([H])C([H])([H])[H]
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[H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2OC([H])([H])[H])C(=C1[H])C([H])([H])N([H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2OC([H])([H])[H])C(=C1[H])C([H])([H])N([H])C([H])([H])[H]
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[H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(Cl)C([H])=C2Cl)=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
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[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])[C@]([H])(N([H])[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1
[H]N(C1=NC([H])=NN2C([H])=C(C3=NN=C(O3)C([H])([H])[H])C(=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(N=C1[H])N([H])C(=C2[H])C([H])([H])[H]
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[H]C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C1(O2)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C([H])C([H])=C3[H])C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C([H])C([H])=C3[H])C(=C2[H])C2=C([H])C([H])=C([H])C(=C2[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C([H])C([H])=C3[H])C(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2(OC3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H]
[H]N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C([H])C([H])=C3[H])C(=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C([H])C([H])=C3[H])C(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C([H])C([H])=C3[H])C(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C([H])C([H])=C3[H])C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NN(C2=C1[C@]1(O[C@@]2([H])OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NN(C2=C1[C@]1(O[C@]2([H])OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=NN1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=NN1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=NN1[H])C1=C([H])C([H])=C([H])C(F)=C1[H]
[H]N([H])S(=O)(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O
[H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C2=NC3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C1(C#N)C([H])([H])C1([H])[H]
[H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C2=NC(=C([H])S2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1(C#N)C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C(F)C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])OC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])C3=C2C([H])=C([H])C(F)=C3[H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C1C(F)=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])OC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C([H])C(F)=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])OC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])C3=C2C([H])=C([H])C([H])=C3F)C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])C3=C2C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C([H])=N3)C([H])([H])C([H])([H])C2=O)C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2F)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])OC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])OC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C2=O)C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])C3=C2C(F)=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])ON2C(=O)C([H])([H])C([H])([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])N(C(=O)C([H])=C([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C(=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])N(C(=O)C([H])=C([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])N(C(=O)C([H])=C([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(C#N)C([H])=C(F)C(=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C([H])=C2OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(C#N)C([H])=C(F)C(=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C([H])=C2OC([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(C#N)C([H])=C(F)C(=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C([H])=C2OC([H])([H])C(F)(F)F)S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(C#N)C([H])=C(F)C(=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C([H])=C2O[C@]([H])(C([H])([H])[H])C(F)(F)F)S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C#N)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C([H])=C2O[C@@]([H])(C([H])([H])[H])C(F)(F)F)S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(O[C@@]([H])(C([H])([H])[H])C(F)(F)F)C(=C([H])C(=C1[H])S(=O)(=O)C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2F)C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C2=C(C([H])=C([H])N2C2=NC3=C(C#N)C([H])=NN3C(N([H])C3([H])C([H])([H])C3([H])[H])=C2[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C1=NOC(=N1)[C@@]1([H])C([H])([H])N(C(=O)C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1[H])C1=NOC(=N1)[C@@]1([H])C([H])([H])N(C(=O)C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N1C([H])=C(N=C1[C@]1([H])N([H])C(C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2[H])C1([H])[H])(C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(N=C1[C@]1([H])N([H])C(C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2[H])C1([H])[H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(N=C1[C@]1([H])N([H])[C@]([H])(C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(N=C1[C@]1([H])N([H])[C@@]([H])(C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(N=C1[C@]1([H])N([H])[C@]([H])(C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2[H])C1([H])[H])[C@]1([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(N=C1[C@]1([H])N([H])[C@]([H])(C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])SC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(N=C1[C@]1([H])N([H])[C@]([H])(C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2[H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[S@+]([O-])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(N=C1[C@]1([H])N([H])[C@]([H])(C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(N=C1[C@]1([H])N([H])[C@]([H])(C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(N=C1[C@]1([H])N([H])[C@]([H])(C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(N=C1[C@]1([H])N([H])[C@]([H])(C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]1([H])N([H])[C@@]([H])(C2=NC(=C([H])N2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C1N([H])C1=C([H])C([H])=C([H])C([H])=C21)C([H])([H])[H]
[H]N1C([H])=C(N=C1[C@]1([H])N([H])[C@]([H])(C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C1([H])[H]
[H]N(C(=O)C1=NN(N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C1([H])[H]
[H]N(C(=O)C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])C([H])=NC([H])=C3[H])=C2C1([H])[H]
[H]N(C(=O)C1=NN(N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])C([H])=NC([H])=C3[H])=C2C1([H])[H]
[H]N(C(=O)C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])N=C(OC([H])([H])[H])N=C3[H])=C2C1([H])[H]
[H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N2[H])C1=C([H])C([H])=NC2=C1C([H])=C([H])C(Cl)=C2[H]
[H]N=C(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1
[H]N(C(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])C([H])=NC([H])=C3[H])=C2C1([H])[H]
[H]N(C(=O)C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C1([H])[H]
[H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])N=C([H])N=C3[H])=C2C1([H])[H]
[H]C1=C(OC(=C1[H])C1=C([H])C([H])=C([H])N=C1[H])C1=NOC(=N1)[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]N1C(=O)OC2=C1C([H])=C([H])C(=C2[H])C1=NN(C2=C([H])C([H])=C(C#N)C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)[C@@]1([H])N(N=C(C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F
[H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N1C2=NC([H])=C([H])C(=N2)C2=C([H])C(OC([H])([H])C([H])([H])\C([H])=C([H])\C([H])([H])OC([H])([H])C3=C([H])C1=C([H])C([H])=C3OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=NC([H])=C2[H]
[H]N1C2=NC([H])=C([H])C(=N2)C2=C([H])C([H])=C(S2)C([H])([H])OC([H])([H])\C([H])=C([H])\C([H])([H])OC([H])([H])C2=C([H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C(C([H])=N1)N1C([H])([H])[C@]2([H])N(C([H])([H])[H])C([H])([H])[C@]2([H])C1([H])[H]
[H]OC1=NC([H])=NC(=C1[H])N1C(=O)N(C(=O)C11C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])[H])=NC([H])=N2)C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])[H])=NC([H])=N2)C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC(=O)C1=C(Cl)C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])[H])=NC([H])=N2)C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC1=NC([H])=NC(=C1[H])N1C(=O)N(C(=O)C11C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=NC([H])=NC(=C1[H])N1C(=O)N(C(=O)C11C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NOC(=N1)C([H])([H])OC([H])([H])[H]
[H]OC1=NC([H])=NC(=C1[H])N1C(=O)N(C(=O)C11C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C([H])C([H])=C1[H]
[H]OC1=NC([H])=NC(=C1[H])N1C(=O)N(C(=O)C11C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C(S1)C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])[H])=NC([H])=N2)C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N1N=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])[H])=NC([H])=N2)C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC1=NC([H])=NC(=C1[H])N1C(=O)N(C(=O)C11C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NN1[H]
[H]N1N=C([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])[H])=NC([H])=N2)C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC1=NC([H])=NC(=C1[H])N1C(=O)N(C(=O)C11C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C2SC([H])=NC2=C1[H]
[H]C1=NC(=C([H])C(OC([H])([H])[H])=N1)N1C(=O)N(C(=O)C11C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])[H])=NC([H])=N2)C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])[H])=NC([H])=N2)C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])C(OC([H])([H])[H])=N1)N1C(=O)N(C(=O)C11C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C(=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)N1C(=O)N(C2=C([H])C(OC([H])([H])[H])=NC([H])=N2)C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C2=C([H])C([H])=C(C([H])=C2[H])N2C(=O)N(C3=C(OC([H])([H])[H])N=C([H])C([H])=N3)C3(C2=O)C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C3([H])[H])C(=C1[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C2=C([H])C([H])=C(C([H])=C2[H])N2C(=O)N(C3=NC([H])=C([H])N=C3C([H])([H])[H])C3(C2=O)C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C3([H])[H])C(=C1[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C2=C([H])C([H])=C(C([H])=N2)N2C(=O)N(C3=NC([H])=C([H])N=C3[H])C3(C2=O)C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C3([H])[H])C(=C1[H])C([H])([H])[H]
[H]OC(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])[H])=NC([H])=N2)C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N1N=C([H])C2=C([H])C([H])=C(C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])[H])=NC([H])=N2)C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C2=C([H])C([H])=C(C([H])=C2[H])N2C(=O)N(C3=NC([H])=C([H])N=C3[H])C3(C2=O)C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C3([H])[H])C(=C1[H])C([H])([H])[H]
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[H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
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[H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C(OC([H])([H])[H])C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])N=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=NC([H])=C(C([H])=C1C1=C([H])C([H])=C(N=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]OC(=O)C1=C([H])C(=C2C([H])=C([H])C([H])=C([H])N2C1=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C(=C2C([H])=C([H])C([H])=C([H])N2C1=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C1=NN([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=C(Cl)C([H])=NC(=N1)N([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=N1)C([H])([H])[H]
[H]C1=C([H])C(=C([H])O1)C1=C([H])C2=C(O[C@@]3(C2([H])[H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]3([H])C([H])([H])C2([H])[H])N=C1[H]
[H]N(C(=O)C1=NC(C#N)=C([H])N1[H])C1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=NC([H])=C(C#N)N1[H])C1=C(C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=NC(C#N)=C([H])N1[H])C1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C#N)C2=C1N=C(SC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])N=C2C1=C([H])C(OC([H])([H])[H])=C(C#N)C([H])=C1Cl
[H]N(C(=O)N(C([H])([H])C1=C([H])SC([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C(N=C(Cl)C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(OC([H])([H])[H])C(=O)N(C([H])([H])C1=C([H])SC([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C(Cl)N=C(Cl)C([H])=C1C([H])([H])[H]
[H]N(OC([H])([H])[H])C(=O)N(C([H])([H])C1=C([H])SC([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C(N=C(Cl)C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(N=C(Cl)C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C2=C([H])SC([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C2=C(F)C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C(=C12)C([H])([H])[H])C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C(F)=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C(F)C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C(F)(F)C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C(C([H])=N1)C(F)(F)F)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N1C([H])=C(C#N)C2=C1N=C(SC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])N=C2C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1Cl
[H]N1C([H])=C(C#N)C2=C1N=C(SC([H])([H])[H])N=C2C1=C([H])C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C(Cl)C([H])=C1Cl
[H]N1C([H])=C(C#N)C2=C1N=C(SC([H])([H])[H])N=C2C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(Cl)C([H])=C1Cl
[H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]C1=C([H])N(C([H])=N1)C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N1C(=O)N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(N([H])C(=O)C([H])([H])OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2N=C2SC(=C([H])C2=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])OC3=C(OC2([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(\Cl)=C(/C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=NC(=C([H])N2[H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N1C2=C(C([H])=C([H])C([H])=C2[H])C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]C1=C([H])C(=NC(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C(=O)C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
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[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@](OC(=O)C([H])([H])C([H])([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2C(=C1O[H])C1=C3C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]3([H])C2([H])[H]
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[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@@]3([H])C([H])([H])[C@@]3(C3=C([H])C([H])=C(Cl)C([H])=C3F)C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@@]3([H])C([H])([H])[C@@]3(C3=C([H])C([H])=C([H])C(OC(F)(F)F)=C3[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C(C([H])=C([H])C(=N1)C([H])([H])[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@]3([H])C([H])([H])[C@]3(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C2([H])[H])N1C([H])([H])[H]
[H]C1=NC(=C([H])N=C1C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@]3([H])C([H])([H])[C@]3(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@]3([H])C([H])([H])[C@]3(C3=C([H])C([H])=C(Br)C([H])=C3[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3([H])C([H])([H])[C@]3(C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@@]3(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[C@@]3([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3([H])C([H])([H])[C@]3(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@@]3(C4=C([H])C([H])=C(C([H])=C4[H])C(F)(F)F)C([H])([H])[C@@]3([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3([H])C([H])([H])[C@]3(C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@@]3(C4=C([H])C([H])=C([H])C(=C4[H])C(F)(F)F)C([H])([H])[C@@]3([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])[C@@]3(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C(F)(F)F)[C@@]12C([H])([H])[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C(N=C(S1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H]
CN1C(SCCCN[C@@H]2CC[C@@]3(CC23)C2=CC=C(C=C2)C(F)(F)F)=NN=C1C1=C(C)N=CO1
[H]N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C(N=C([H])O1)C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])[C@]12[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C(N=C([H])O1)C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C(C([H])=C3F)C(F)(F)F)C([H])([H])[C@]12[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3(C4=C(C([H])=C([H])C(Br)=C4[H])C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3(C4=C(C([H])=C(OC([H])([H])[H])C([H])=C4[H])C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3(C4=C(OC([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3(C4=C(C(Br)=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3(C4=C(C([H])=C([H])C(Br)=C4[H])C([H])([H])C3([H])[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(Cl)=C([H])C2=C1[C@@]1(C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC3=NN=C(N3C([H])([H])[H])C3=C(N=C(S3)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3(C4=C(C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H][C@]12CC[C@]([H])(C[C@@H](C1)C1=CC=C(C=C1)C(C)(C)C)N2CCCSC1=NN=C(N1C)C1=C(C)N=CO1
[H][C@]12CC[C@]([H])(C[C@@H](C1)C1=CC=C(C=C1)C(F)(F)F)N2CCCSC1=NN=C(N1C)C1=C(C)N=CO1
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])[C@]([H])(C2=C(F)C([H])=C(C([H])=C2[H])C(F)(F)F)C3([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C(N=C([H])O1)C([H])([H])[H])[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])[C@]2(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C(F)(F)F)[C@@]12C([H])([H])[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C(N=C(O1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H]
CN1C(SCCCN2CCC3CC3(CC2)C2=CC=C(C=C2)C(F)(F)F)=NN=C1C1=CN=NC=C1
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3(C4=C(C([H])=C(Br)C([H])=C4[H])C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3(C4=C(C(OC([H])([H])[H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3(C4=C(C([H])=C(Br)C([H])=C4[H])C([H])([H])C3([H])[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(Cl)=C([H])C2=C1C([H])([H])C([H])([H])[C@]21C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=NN=C(N2C([H])([H])[H])C2=C(N=C(S2)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(F)=C([H])C2=C1C([H])([H])C([H])([H])[C@]21C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=NN=C(N2C([H])([H])[H])C2=C(N=C(S2)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C3([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3(C4=C(C([H])=C([H])C(OC([H])([H])[H])=C4[H])C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(C(=O)N([H])[C@]1([H])C([H])([H])[C@@]2([H])N([H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@@]([H])(C(=O)N([H])[C@]1([H])C([H])([H])[C@@]2([H])N([H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC([H])([H])C(=O)N(C4=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]N1C(=O)C([H])([H])OC2=C(C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C4OC([H])([H])C(=O)N(C4=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]N1C(=O)C([H])([H])OC2=C1C([H])=C([H])C(=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C4=C(C([H])=C3[H])N(C(=O)C([H])([H])O4)C([H])([H])[H])C([H])([H])C2([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C3OC([H])([H])C(=O)N(C3=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C3OC([H])([H])C(=O)N(C3=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C3OC([H])([H])C(=O)N(C3=C([H])C([H])=C2[H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C3OC([H])([H])C(=O)N(C3=C([H])C([H])=C2[H])C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C3OC([H])([H])C(=O)N(C3=C([H])C([H])=C2[H])C([H])([H])C([H])(F)F)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C2OC([H])([H])C(=O)N(C2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(F)=C([H])C3=NC(=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C2OC([H])([H])C(=O)N(C2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(F)=C([H])C3=NC(=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C3OC([H])([H])C(=O)N(C3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C3OC([H])([H])C(=O)N(C3=C([H])C([H])=C2[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C2OC([H])([H])C(=O)N(C2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(F)=C([H])C3=NC(=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C2OC([H])([H])C(=O)N(C2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(F)=C([H])C3=NC(=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]N1C(=O)C([H])([H])OC2=C(C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C3=NC(=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C([H])([H])OC2=C([H])C([H])=C(C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@@]3([H])C([H])([H])[C@@]3(C3=C([H])C([H])=C(C#N)C([H])=C3[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@@]3([H])C([H])([H])[C@@]3(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@]3([H])C([H])([H])[C@]3(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C2([H])[H])N1C([H])([H])[H]
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[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@@]3([H])C([H])([H])[C@@]3(C3=C([H])C([H])=C([H])C([H])=C3C(F)(F)F)C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C([H])C([H])=C([H])C3=NC(=C([H])C([H])=C13)C([H])([H])[H])C2([H])[H]
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[H]C1=NC([H])=C(C([H])=N1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@]3([H])C([H])([H])[C@]3(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C2([H])[H])N1C([H])([H])[H]
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[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@@]3([H])C([H])([H])[C@@]3(C3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@]3([H])C([H])([H])[C@]3(C3=C([H])C([H])=C(C([H])=C3C([H])([H])[H])C(F)(F)F)C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C3=C([H])C([H])=C([H])C([H])=C3N(C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C([H])=C(C([H])=C1[H])C1(C([H])([H])C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])[C@]([H])(N2C4=C(N=C2C([H])([H])[H])C([H])=C([H])C([H])=C4[H])C3([H])[H])C([H])([H])C([H])([H])N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]N(C([H])([H])C1=C([H])N=C([H])N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C([H])C3=NC([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
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[H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])N(C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])[C@]1([H])C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]OC(=O)C1=C(OC2=C([H])C([H])=C(Cl)C([H])=C2N([H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])=C([H])C([H])=C1[H]
CNC(=O)C1=C2COC3=C(CCN4CCN(CC4)C4=C5C=CC(C)=NC5=CC=C4)C=CC=C3N2C=N1
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[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C3([H])C([H])([H])C3(C3=C([H])C([H])=C([H])C(=C3[H])S(F)(F)(F)(F)F)C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])SC(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])N3C(=O)OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C3=C([H])C(Cl)=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C3=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C3=C([H])C(C#N)=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C3=C([H])C(Cl)=C([H])C(F)=C3[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C3=C([H])C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2S1)N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C3=C([H])C([H])=C4SC(=NC4=C3[H])C([H])([H])[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C([H])([H])C3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C([H])([H])C3=C(Cl)C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C([H])([H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C2([H])[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(I)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([11C]#N)=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]C1=C([H])C(OC(F)(F)F)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]C1=C(F)C(C#N)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(SC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N1C(=O)N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(S1)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]34C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[C@@]23[H])C4(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]23C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]23C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]C1=C([H])C(=C([H])C([H])=C1N1C(=O)N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]23C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]23C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]23C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)N1C(=O)N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]23C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC(=NC4=C3C([H])([H])C2([H])[H])C([H])([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])S1)C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])[C@]2([H])C([H])([H])N(C(=O)[C@]3([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])[C@]12[H]
[H]N1C(=NC2=C([H])C(OC(F)(F)F)=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=C([H])C([H])=C(F)C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C([H])C(=C([H])C([H])=C12)C(F)(F)F)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=C([H])C([H])=C([H])C([H])=N3)C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C([H])C(OC(F)(F)F)=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C([H])C(OC(F)(F)F)=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=C([H])C([H])=C([H])C([H])=N3)C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C([H])C(=C([H])C([H])=C12)C(F)(F)F)N1C([H])([H])C([H])([H])C2(OC(=O)N(C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2N=C1[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=C([H])C([H])=C([H])C(=N3)C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C([H])C(C#N)=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=C([H])C([H])=C(F)C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])C2(OC(=O)N(C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C([H])C(OC(F)(F)F)=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=C([H])C([H])=C([H])N=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C([H])C(OC(F)(F)F)=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=C([H])C([H])=C([H])C([H])=C3F)C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C([H])C(OC(F)(F)F)=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=C([H])C([H])=C([H])C(F)=N3)C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2N=C1[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]C1=C(N2C(=O)N(C([H])([H])C([H])([H])N3C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H]
[H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2O1)N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(OC(F)(F)F)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1[H])N1C(=O)N(N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])[C@]3([H])C([H])([H])C([H])([H])[C@]([H])(C2([H])[H])[C@@]3([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])C([H])([H])N3C(=O)N(C4=C([H])C([H])=C([H])C(Cl)=C4[H])C([H])([H])C3([H])[H])C([H])([H])[C@@](C([H])([H])[H])(C2([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])N3C(=O)N(C4=C([H])C([H])=C([H])C(Cl)=C4[H])C([H])([H])C3([H])[H])C([H])([H])[C@]([H])(C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=O)N(C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C([H])([H])C1([H])[H])C1([H])C([H])([H])OOC1([H])[H])C([H])([H])[C@@]12C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=O)N(C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]23C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C1=C2C([H])=C([H])C(O[C@]3([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C2=C([H])C([H])=N1
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[H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])C1=NOC(=N1)C1=C([H])C(C#N)=C(OC([H])(C([H])([H])[H])C([H])([H])[H])N=C1[H]
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[H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C2C([H])=C([H])C([H])=C(C2=C([H])C([H])=N1)S(=O)(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N1N=C([H])C2(C1([H])[H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C2OC([H])([H])OC2=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]23C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])N=C(N=C1N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])N([H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])N=C(N=C1N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])N([H])C([H])([H])C([H])([H])N([H])[H]
[H]N([H])C(=O)C1=C([H])N=C(N=C1N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])N([H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])N=C(N=C1N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])N([H])C1([H])C([H])([H])N([H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])N=C(N=C1N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])N([H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C(N=C(N=C1[H])N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])[H])N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C(N=C(N=C1[H])N([H])[C@]1([H])C([H])([H])C([H])([H])OC([H])([H])[C@]1([H])N([H])[H])N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
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[H]N([H])C(=O)C1=C([H])N=C(N=C1N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])N([H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C(N=C(N=C1[H])N([H])[C@]1([H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])[C@]1([H])N([H])[H])N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C(N=C(N=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C1([H])[H])N([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]N([H])C(=O)C1=C(N=C(N=C1[H])N([H])[C@]1([H])C([H])([H])C(F)(F)C([H])([H])C([H])([H])[C@]1([H])N([H])[H])N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
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[H]O[C@@]1(C2=C([H])C([H])=C(C([H])=N2)C2=NC([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])[C@]([H])(N([H])[C@]2([H])C([H])([H])N(C(=O)C3([H])C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C(=C4[H])C(F)(F)F)C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(Cl)=C(Cl)C([H])=C1OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H]
[H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(O1)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(O1)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(O1)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1F)C1=NN=C(O1)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C2=NN=C(O2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C2=NN=C(O2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=C1[H])C(F)(F)F
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[H]N([H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H]
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[H]C1=NC(=C([H])N1C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=N1)C([H])([H])C(=O)N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C(F)(F)F)C([H])([H])[H]
[H]C1=NC(=C([H])N1C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=N1)C([H])([H])C(=O)N(C1=C([H])C([H])=C2OC(F)(F)OC2=C1[H])C([H])([H])C(F)(F)F)C([H])([H])[H]
[H]C1=NC(=C([H])N1C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=N1)C([H])([H])C(=O)N(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C(F)(F)F)C([H])([H])[H]
[H]N1C(=O)[C@@]([H])(N2N=NC(=C2[H])C2=C([H])C(OC([H])([H])[H])=C(C([H])=C2[H])N2C([H])=NC(=C2[H])C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H]
COC1=C(C=CC(=C1)C1=CN(N=N1)C1CC(CCNC1=O)[Si](C)(C)C)N1C=NC(C)=C1
[H]C1=NC(=C([H])N1C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=N1)[C@]1([H])C(=O)N(C([H])([H])[C@]23C([H])([H])[C@@]4([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C4([H])[H])C2([H])[H])C3([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
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[H]C1=NC(=C([H])N1C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=N1)[C@]1([H])C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])N1C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=N1)[C@]1([H])C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@@]([H])(C1([H])[H])C(F)(F)F)C([H])([H])[H]
[H]C1=NC(=C([H])N1C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=N1)[C@]1([H])C(=O)N(C([H])([H])C(F)(F)F)C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])N1C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=N1)C([H])([H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=NC(=C([H])N1C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=N1)C([H])([H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C(=NC([H])=N2)N(C(=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C(=NC([H])=N2)N(C([H])=C3C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C(Cl)=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC(=N2)C(F)(F)F)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C1=NN=C(O1)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@@]([H])(C1=NC2=C([H])C(Cl)=C([H])C([H])=C2C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3([H])C([H])([H])C4=C(C5=C([H])C(=C([H])C([H])=C5N4[H])C(F)(F)F)[C@]([H])(C([H])([H])[H])[C@@]3([H])C2([H])[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
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[H]OC(=O)C1(C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3([H])C([H])([H])C4=C(C5=C([H])C(=C([H])C([H])=C5N4[H])C(F)(F)F)[C@]([H])(C([H])([H])[H])[C@@]3([H])C2([H])[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC(=O)C1(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3([H])C([H])([H])C4=C(C5=C([H])C(=C([H])C([H])=C5N4[H])C(F)(F)F)[C@]([H])(C([H])([H])[H])[C@@]3([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C(F)=C2F)C([H])([H])C1([H])[H]
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[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C2=C(N=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(N([H])C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC1(C([H])([H])C([H])([H])N(C2=NC(=C3C([H])=C(N([H])C(=O)C(\[H])=C(/[H])C4=C([H])C([H])=C(C([H])=C4[H])C([H])(F)F)C([H])=C([H])C3=N2)C([H])([H])[H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]OC1([H])C([H])([H])C([H])([H])N(C2=NC(=C3C([H])=C(N([H])C(=O)C(\[H])=C(/[H])C4=C([H])C([H])=C(OC(F)(F)F)C([H])=C4[H])C([H])=C([H])C3=N2)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1(C([H])([H])C([H])([H])N(C2=NC(=C3C([H])=C(N([H])C(=O)C(\[H])=C(/[H])C4=C([H])C([H])=C(Cl)C([H])=C4[H])C([H])=C([H])C3=N2)C([H])([H])[H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(O1)N([H])C([H])([H])C([H])([H])C([H])([H])N1[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]N(C1=NN2C([H])=C3C(=NC2=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C3([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])(C1([H])[H])[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(F)=C(Cl)C([H])=C1[H]
[H]N1C([H])([H])C([H])(C1([H])[H])[C@@]([H])(OC1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N1C([H])([H])C([H])(C1([H])[H])[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N1C([H])([H])C([H])(C1([H])[H])[C@@]([H])(OC([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N1C([H])([H])C([H])(C1([H])[H])[C@]([H])(OC([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C1=NOC(=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C1=C([H])C(=NO1)C1=C([H])C([H])=C(F)C([H])=C1Br
[H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C1=C([H])C(=NO1)C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C1=C([H])C(=NO1)C1=C([H])C([H])=C(F)C([H])=C1Cl
[H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C1=C(Br)C(=NO1)C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C1=C(Br)C(=NO1)C1=C([H])C([H])=C([H])C(=C1C([H])([H])[H])C([H])([H])[H]
[H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C1=C(Br)C(=NO1)C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C1=C(Br)C(=NO1)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C1=NOC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H]
[H]ON([H])C(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(F)C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]ON([H])C(=O)[C@]([H])(OC1=C([H])C(=C(F)C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]ON([H])C(=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@@]([H])(OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
CC1=CC(N[C@H](CCCCNCC2=CC=C(F)C=C2)C(=O)NO)=CC(C)=C1F
[H]ON([H])C(=O)[C@]([H])(N([H])C1=C([H])C(=C(F)C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]ON([H])C(=O)[C@]([H])(OC1=C([H])C(=C(F)C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C(C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(F)C([H])=C1C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C(C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(Cl)C([H])=C1C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]N(C(=O)C1=C([H])C(F)=C(C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=NN=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=NC3=C(S2)C([H])=C([H])C(F)=C3[H])C([H])([H])C1([H])[H]
[H]C1=NN=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NOC(=N2)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NN=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(F)=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]C1=NN=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=NC([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]C1=NN=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C(F)=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2F)S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]C1=C([H])C(F)=C([H])C2=C1SC(=N2)C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])[C@@]([H])(F)C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(C(Cl)=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N1N=C([H])C(=C1[H])C1=C([H])N=C(N([H])[H])C2=C1SC([H])=C2C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C#N)C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]C1=C(N(N=C1OC([H])([H])C([H])([H])N1C([H])([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])[C@@]([H])(F)C1([H])[H])C(F)(F)F
[H]C1=NN=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=NC3=C(S2)C([H])=C([H])C(F)=C3[H])C([H])([H])[C@]1([H])F
[H]C1=NN=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[C@]1([H])OC([H])([H])[H]
[H]C1=NN=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[C@]1([H])F
[H]C1=NN=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=NC3=C(S2)C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(C#N)C([H])=C([H])C(=N1)C1=NOC(=N1)C1=C([H])C(C#N)=C([H])C(F)=C1[H]
[H]C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])=NN1C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]C1=C(N(N=C1OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H]
[H]C1=C(N(N=C1OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H]
[H]C1=C(N(N=C1OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H]
[H]N(C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)N1C([H])=C(C2=C([H])C(Cl)=C([H])C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)N1C([H])=C(C2=C([H])C(F)=C([H])C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=N[C@@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C(N([H])C(=O)C2=NC([H])=C(Cl)C([H])=C2[H])=C([H])C([H])=C1[H])C1=C([H])N(C(=O)C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=N[C@@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C(C#CC2([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H])C1=C([H])N(C(=O)C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=N[C@@](C2=C([H])C(F)=C([H])C(F)=C12)(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C(C#CC([H])([H])[H])=C1[H])C1=C([H])N(C(=O)C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=N[C@@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C(C#CC([H])([H])[H])=C1[H])C1=C([H])N(C(=O)C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=N[C@@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C(F)=C1[H])C1=C([H])N(C(=O)C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=N[C@@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])N=C1[H])C1=C([H])C(=C(OC([H])([H])[H])C(C#N)=C1[H])C([H])([H])[H]
[H]N([H])C1=N[C@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C(=C(OC([H])([H])[H])C(=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])N=C1[H]
[H]N([H])C1=N[C@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])N=C1[H]
[H]N([H])C1=N[C@@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C(=NC([H])=C1[H])C([H])(F)F)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C(C#CC([H])([H])[H])=C1[H]
[H]N([H])C1=N[C@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C(=NC([H])=C1[H])C([H])(F)F)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])N=C1[H]
[H]N([H])C1=N[C@@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C(OC([H])([H])[H])=NC([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])N=C1[H]
[H]N([H])C1=N[C@@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C(=NC([H])=C1[H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])N=C1[H]
[H]N([H])C1=N[C@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])N=C1[H])C1=C([H])C(=NC(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=N[C@@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C(=NC([H])=C1[H])C(F)(F)F)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C(C#N)=C1[H]
[H]N([H])C1=N[C@@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C(F)=C1[H]
[H]N([H])C1=N[C@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])N=C1[H]
[H]N([H])C1=N[C@@](C2=C([H])C([H])=C([H])C([H])=C12)(C1=C([H])C(=NC([H])=C1[H])C(F)(F)F)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])N=C1[H]
[H]C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N=C(N([H])[H])N([H])C(=O)C1=C([H])C(=C(C([H])=C1C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]N=C(N([H])[H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=N2)N2C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C2=O)C([H])([H])[C@]1([H])C1=C([H])C(F)=C([H])C([H])=C1F
[H]N([H])[C@@]1([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=N2)N2C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C2=O)C([H])([H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1F
[H]N(C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C2=C1N=C(N2C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C1=C([H])C([H])=C(C([H])=N1)N1C([H])=NC(=C1[H])C([H])([H])[H])C1=C2N=C(N(C2=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C1=C([H])N=C(N2C([H])=NC(=C2[H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C2N=C(N(C2=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C1=NC(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C2=C1N=C(N2C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C(N(N=C1C([H])([H])[H])C([H])([H])[H])C1=NC2=C(O1)C([H])=C1C(=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=NN=C(N2C([H])([H])[H])C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C4=C(N=C(O4)C(F)(F)C(F)(F)F)C([H])=C3C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C4=C(N=C(O4)C([H])([H])C4([H])C([H])([H])C4([H])[H])C([H])=C3C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(N=C(O5)C(F)(F)C([H])([H])[H])C([H])=C4C([H])([H])C3([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(N=C(O5)C([H])([H])C(F)(F)F)C([H])=C4C([H])([H])C3([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(N=C(O5)C(F)(F)F)C([H])=C4C([H])([H])C3([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(F)=C1F)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C4=C(N=C(O4)C([H])([H])C([H])([H])[H])C([H])=C3C([H])([H])C2([H])[H])N1C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C4=C(N=C(O4)C([H])([H])C([H])([H])[H])C([H])=C3C([H])([H])C2([H])[H])N1C([H])([H])[H])C(F)(F)F
[H]C1=C([H])C(=C([H])C([H])=C1C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C4=C(N=C(O4)C([H])([H])[H])C([H])=C3C([H])([H])C2([H])[H])N1C([H])([H])[H])C(F)(F)F
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(N=C(O5)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C4C([H])([H])C3([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C4=C(N=C(O4)C4([H])C([H])([H])C4([H])[H])C([H])=C3C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(N=C(O5)C5([H])C([H])([H])C5([H])[H])C([H])=C4C([H])([H])C3([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C4=C(N=C(O4)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C3C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(N=C(O5)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C4C([H])([H])C3([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=NC2=C(O1)C([H])=C1C(=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=NN=C(N2C([H])([H])[H])C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC2=C(O1)C([H])=C1C(=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=NN=C(N2C([H])([H])[H])C2=C(N=C([H])O2)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])[C@@]([H])(N3C([H])([H])C([H])([H])C4=C([H])C5=C(OC(=N5)C(F)(F)F)C(Br)=C4C([H])([H])C3([H])[H])C([H])([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])[C@@]([H])(N3C([H])([H])C([H])([H])C4=C([H])C5=C(OC(=N5)C(F)(F)F)C(=C4C([H])([H])C3([H])[H])C([H])([H])[H])C([H])([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])[C@@]([H])(N3C([H])([H])C([H])([H])C4=C([H])C5=C(OC(=N5)C([H])([H])C([H])([H])[H])C(=C4C([H])([H])C3([H])[H])C([H])([H])[H])C([H])([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(OC(=N5)C([H])([H])C([H])([H])[H])C(=C4C([H])([H])C3([H])[H])C([H])([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(OC(=N5)C([H])([H])C([H])([H])[H])C(Br)=C4C([H])([H])C3([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C4=C(OC(=N4)C(F)(F)F)C(Br)=C3C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C4=C(OC(=N4)C([H])([H])[H])C(Br)=C3C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(OC(=N5)C([H])([H])[H])C(=C4C([H])([H])C3([H])[H])C([H])([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])[C@@]([H])(N3C([H])([H])C([H])([H])C4=C([H])C5=C(OC(=N5)C([H])([H])C([H])([H])[H])C(Br)=C4C([H])([H])C3([H])[H])C([H])([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(OC(=N5)C(F)(F)F)C(Br)=C4C([H])([H])C3([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
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[H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C(C([H])=C3C([H])([H])C2([H])[H])C2=NC([H])=C(O2)C([H])([H])[H])N1C([H])([H])[H]
[H]C1=C([H])N(C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C(C([H])=C3C([H])([H])C2([H])[H])C2=NC([H])=C(O2)C([H])([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C(ON=C1C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C2([H])[H])C([H])([H])[H]
[H]C1=C(ON=C1C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C([H])C3=C(N=C(C(=N3)C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C2([H])[H])C([H])([H])[H]
[H]C1=C(N(N=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=NC([H])=C(N=C1[H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]C1=C(N(N=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C2([H])[H]
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[H]C1=C([H])C([H])=C([H])C(=N1)C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
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[H]N(C1=NC([H])=C([H])C2=C1C1=C([H])C([H])=C([H])C([H])=C1N2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C([H])=C([H])C3=NC3=C(N2[H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C1([H])[H]
CC(OC1=C(CC2CC2)C=CC=C1)C1=NCCN1
[H]N(C1=C([H])C(OC([H])([H])[H])=C2N=NN(C2=N1)C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
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CC(C)(C)NC(=O)C1=CNC2=C1N=C(C=N2)C1=C2CCCCN2C=N1
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CC(C)(C)NC(=O)C1=CNC2=C1N=C(C=N2)C1=NN(CCC(O)CO)C2=C1C=C(OC(F)F)C=C2
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CC(C)(C)NC(=O)C1=CNC2=C1N=C(C=N2)C1=NN(CCCN2CCOCC2)C2=C1C=C(OC(F)F)C=C2
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CC(C)(C)NC(=O)C1=CNC2=C1N=C(C=N2)C1=NNC2=C1C=CC=C2C(C)(C)O
COC1=CC(NC2=NC=C(F)C(NC3=NC4=C(OC(C)(C)C(=O)N4COP(O)(O)=O)C=C3)=N2)=CC(OC)=C1OC
COC1=CC(=CC=C1)N1CCN(C[C@H](O)COC2=CC=C(C=C2)C(F)(F)F)CC1
O[C@H](COC1=CC=C(F)C=C1)CN1CCN(CC2=CC=C(Cl)C(Cl)=C2)CC1
O[C@H](COC1=CC=C(F)C=C1)CN1CCN(CC2=CC=C(Cl)C=C2)CC1
O[C@H](COC1=CC=C(Cl)C=C1)CN1CCN(CC2=C(F)C=CC=C2Cl)CC1
O[C@H](COC1=CC=C(Cl)C=C1)CN1CCN(CC2=CC=C(Cl)C=C2)CC1
O[C@@H](COC1=CC=C(C=C1)C(F)(F)F)CN1CCN(CC2=CC=C(Cl)C(Cl)=C2)CC1
COC1=CC=CC=C1N1CCN(C[C@@H](O)COC2=CC=C(C=C2)C(F)(F)F)CC1
[H]OC([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C2C(N=C(N=C2N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])N2C([H])([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])=N1
COC1=C(CO)C=C(C=C1)C1=CC=C2C(=N1)N=C(N=C2N1CCOC[C@@H]1C)N1CC[C@@H](O)C1
C[C@H]1CN(C[C@@H](C)O1)C1=NC2=NC(=CC=C2C(=N1)N1CCOC[C@@H]1C)C1=CC=CC=C1
CCOC(=O)N1[C@H]2CC[C@@H]1C[C@@H](CN1CC[C@@H](C1)N1C(=O)CC3=C1C=CC=C3)C2
CCOC(=O)N1CCC(O)(CN2CC[C@@H](C2)N2C(=O)CC3=C2C=CC=C3)CC1
CCOC(=O)N1CCC(C)(CN2CC[C@@H](C2)N2C(=O)CC3=C2C=CC=C3)CC1
[H][C@@]12COC3=CC(=CC=C3N1C(=O)O[C@H]2CNC(C)=O)C1=CC=C(N=C1)C#N
COCCN1CC=CC[C@@H](C1)C1=CC(Cl)=C(Cl)C=C1
ClC1=C(Cl)C=C(C=C1)C1CCCCNC1
CC(C)(C)NC(=O)NCCN1CCCC(C1)NC(=O)C1=CC(Cl)=CC(Cl)=C1
CC(C)(C)NC(=O)NCCN1CCC(C1)NC(=O)C1=CC(Cl)=CC(Cl)=C1
CC(C)(C)NC(=O)NCCN1CCC(CNC(=O)C2=CC(Cl)=CC(Cl)=C2)C1
CC(C)(C)NC(=O)NCCN1CCCC(CNC(=O)C2=CC(Cl)=CC(Cl)=C2)C1
CC(C)(C)NC(=O)NCCN1CCN(CC(=O)NC2=CC(Cl)=CC(Cl)=C2)CC1
COC1=CC=C(C=C1C1=CC(NC2=CC(OC)=C(C=C2)N2CCOCC2)=NC=C1)C#N
COC1=C(C=CC(NC2=NC=CC(=C2)C2=CC(=CC=C2)C#N)=C1)N1CCOCC1
COC1=C(C=CC(NC2=NC=CC(=C2)C2=CC(=CC=C2)C#N)=C1)N1CCN(C)CC1
COC1=CC=C(C=C1)C(CCCN)(C1=CC=CC=C1)C1=CC=CC=C1
CC(C)[C@@H](N(CCCN)C(=O)C1=CC=C(C)C=C1)C1=C(CC2=CC=CC=C2)C(=O)C2=CC=C(Cl)C=C2O1
[H][C@]12CCC[C@]1(C[C@@H](C2)NC1CCOCC1OC)C(=O)N1CCC2=C(C1)C=C(OC(F)(F)F)C=C2
FC(F)(F)C1=CC=C2N=CN=C(NCC(=O)NC3CN(C3)[C@H]3CC[C@H](CC3)C3=C(C=CC=C3)C#N)C2=C1
OC1=C(C=CC=C1)[C@@H]1CC[C@@H](CC1)N1CC(C1)NC(=O)CNC1=NC=NC2=CC=C(C=C12)C(F)(F)F
FC(F)(F)C1=CC=C2N=CN=C(NCC(=O)NC3CN(C3)[C@H]3CC[C@H](CC3)C3=CC=CC=N3)C2=C1
NC1=C(N=CC=C1)[C@@H]1CC[C@@H](CC1)N1CC(C1)NC(=O)CNC1=NC=NC2=CC=C(C=C12)C(F)(F)F
FC(F)(F)C1=CC=C2N=CN=C(NCC(=O)NC3CN(C3)[C@H]3CC[C@H](CC3)C3=CC=CC=C3)C2=C1
COCCC(NC(=O)C1(N)CCN(CC1)C1=NC=NC2=C1C=CN2)C1=CC=C(Cl)C=C1
NC1(CCN(CC1)C1=NC=NC2=C1C=CN2)C(=O)NC(CC1=CC=CC=C1)C1=CC=C(Cl)C=C1
NC1(CCN(CC1)C1=NC=NC2=C1C=CN2)C(=O)NC(C1=CC=CC=C1)C1=CC=C(Cl)C=C1
CCC(NC(=O)C1(N)CCN(CC1)C1=NC=NC2=C1C=CN2)C1=CC=C(Cl)C=C1
C[C@H](NC(=O)C1(N)CCN(CC1)C1=NC=NC2=C1C=CN2)C1=CC=C(Cl)C=C1
[H]N([H])C1(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2C([H])=C([H])N3[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
CC1=CC=C(OCCCC2=CC=CC(CCCOC3=CC=C(C)C=C3)=[N+]2C)C=C1
CC1=CC=C(C=C1)C#CCOCC1=CC=CC(COCC#CC2=CC=C(C)C=C2)=[N+]1C
CC1=CC=C(CCCOCC2=CC=CC(COCCCC3=CC=C(C)C=C3)=[N+]2C)C=C1
CC1=CC=C(OCCCC2=CC(N)=CC(CCCOC3=CC=C(C)C=C3)=N2)C=C1
C[N+]1=C(CCC2=CC=CC=C2)C=CC=C1CCC1=CC=CC=C1
C(CC1=CC=CC(CCC2=CC=CC=C2)=N1)C1=CC=CC=C1
C[N+]1=C(COC2=CC=CC=C2)C=CC=C1COC1=CC=CC=C1
C(OC1=CC=CC=C1)C1=CC=CC(COC2=CC=CC=C2)=N1
C[N+]1=C(CCCOC2=C(Cl)C=CC=C2)C=CC=C1CCCOC1=CC=CC=C1Cl
C[N+]1=C(CCCOC2=CC(Cl)=CC=C2)C=CC=C1CCCOC1=CC=CC(Cl)=C1
C[N+]1=C(CCCOC2=CC=C(Cl)C=C2)C=CC=C1CCCOC1=CC=C(Cl)C=C1
C[N+]1=C(C=CC=C1C#CC1=CC=CC=C1Cl)C#CC1=C(Cl)C=CC=C1
C[N+]1=C(C=CC=C1C#CC1=CC=CC(Cl)=C1)C#CC1=CC(Cl)=CC=C1
C[N+]1=C(C=CC=C1C#CC1=CC=C(Cl)C=C1)C#CC1=CC=C(Cl)C=C1
COC1=CC=C(C=C1)C#CC1=CC=CC(C#CC2=CC=C(OC)C=C2)=[N+]1C
C[N+]1=C(C=CC=C1C#CC1=CC=C(C=C1)C1=CC=CC=C1)C#CC1=CC=C(C=C1)C1=CC=CC=C1
C[N+]1=C(C=CC=C1C#CC1CCCCC1)C#CC1CCCCC1
C[N+]1=C(C=CC=C1C#CC1=CC=CC=C1)C#CC1=CC=CC=C1
CC1=CC=C(OCCCC2=CC=CC(C#CCOC3=CC=C(C)C=C3)=[N+]2C)C=C1
CCCCCCCCC1=CC=CC(CCCCCCCC)=[N+]1C
CC1=CC=C(CCOCCCC2=CC=CC(CCCOCCC3=CC=C(C)C=C3)=[N+]2C)C=C1
CC1=CC=C(CCC2=CC=CC(CCC3=CC=C(C)C=C3)=[N+]2C)C=C1
CC1=CC=C(C=C1)C#CC1=CC=CC(C#CC2=CC=C(C)C=C2)=[N+]1C
CC1=CC=C(CCOCC2=CC=CC(COCCC3=CC=C(C)C=C3)=[N+]2C)C=C1
CC1=CC=C(COCC2=CC=CC(COCC3=CC=C(C)C=C3)=[N+]2C)C=C1
CC1=CC=C(OCC2=CC=CC(COC3=CC=C(C)C=C3)=[N+]2C)C=C1
[O-]S(=O)(=O)C(F)(F)F.CC1=CC=C(CC2=CC=[N+](C)C(COC3=CC=C(C)C=C3)=C2)C=C1
CC1=CC=C(C=C1)S([O-])(=O)=O.CC1=CC=C(CC2=CC=CC(COC3=CC=C(C)C=C3)=[N+]2C)C=C1
CC1=CC=C(CC2=CC=NC(COC3=CC=C(C)C=C3)=C2)C=C1
CC1=CC=C(CC2=CC=CC(COC3=CC=C(C)C=C3)=N2)C=C1
ClC1=CC=C(OCCCC2=CC=CC(CCCOC3=CC=C(Cl)C=C3)=N2)C=C1
CN(CCOC1=CC=C(C)C=C1)CCC1=CC=C(C)C=C1
COC1=CC=C(OCCCC2=CC=CC(CCCOC3=CC=C(OC)C=C3)=[N+]2C)C=C1
C[N+]1=C(CCCOC2=CC=CC=C2)C=CC=C1CCCOC1=CC=CC=C1
CN1CCC(COCC2=NC(=CC(=C2)C(F)(F)F)C2CC2)(CC1)C1=CC=CC(F)=C1
CN1CCC(COCC2=NC(=CC(=C2)C(F)(F)F)C2CC2)(CC1)C1=CC=CC(Cl)=C1
CN1CCC(COCC2=NC(=CC(=C2)C(F)(F)F)C2CC2)(CC1)C1=CC=C(Cl)C=C1
CN1CCC(COCC2=NC(=CC(=C2)C(F)(F)F)C2(F)CC2)(CC1)C1=CC=C(F)C=C1
FC(F)(F)C1=CC(COCC2(CCNCC2)C2=CC=CC=C2)=NC(=C1)C1CC1
CN1CCC(COCC2=NC(=CC(=C2)C(F)(F)F)C2CC2)(CC1)C1=CC=CC=C1
COC1=CC(=CC(COCC2(CCN(C)CC2)C2=CC=C(F)C=C2)=N1)C(F)(F)F
CN1CCC(COCC2=NC(=CC(=C2)C(F)(F)F)N2CCC(CC2)C#N)(CC1)C1=CC=C(F)C=C1
CN1CCC(COCC2=NC(=CC(=C2)C(F)(F)F)N2CCC(C2)C#N)(CC1)C1=CC=C(F)C=C1
CN1CCC(COCC2=NC(=CC(=C2)C(F)(F)F)N2CC=CC2)(CC1)C1=CC=C(F)C=C1
CN1CCC(COCC2=NC(=CC(=C2)C(F)(F)F)N2CCCC2)(CC1)C1=CC=CC=C1
FC(F)(F)C1=CC(COCC2(CCNCC2)C2=CC=CC=C2)=NC(=C1)N1CCCC1
CC(C)CN(CC(C)C)C1=CC(=CC(COCC2(CCN(C)CC2)C2=CC=C(F)C=C2)=N1)C(F)(F)F
CCC(CC)NC1=CC(=CC(COCC2(CCN(C)CC2)C2=CC=C(F)C=C2)=N1)C(F)(F)F
CN(C)C1=CC(=CC(COCC2(CCNCC2)C2=CC=C(F)C=C2)=N1)C(F)(F)F
CN1CCC(COCC2=NC(Cl)=CC(=C2)C(F)(F)F)(CC1)C1=CC=C(F)C=C1
FC(F)(F)C1=CC(COCC2(CCNCC2)C2=CC=CC=C2)=CC(Cl)=C1
COC1=CC(CN2CCC3=CC4=C(C=C3CC2)N=C(N)S4)=CC=C1
COC1=CC=C(CN2CCC3=CC4=C(C=C3CC2)N=C(N)S4)C=C1
NC1=NC2=C(S1)C=C1CCN(CC3=CC(F)=CC=C3)CCC1=C2
NC1=NC2=C(S1)C=C1CCN(CC3=CC=C(F)C=C3)CCC1=C2
NC1=NC2=C(S1)C=C1CCN(CC3=CC=CC=C3)CCC1=C2
CCNC1=NC(C(N)=O)=C2CN(CCC2=N1)C(=O)CCC1=CC=C(OC(F)(F)F)C=C1
CCNC(=O)NC1=CC=C(C=C1)C1=NC2=C(CCN(C2)C(C)C)C(=N1)N1CCOC[C@@H]1C
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C(N4C([H])=C([H])C(=C([H])C4=N3)C(F)(F)F)C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C(N4C([H])=C(C([H])=C([H])C4=N3)C([H])([H])[H])C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4N=C(OC4=C3C([H])([H])C2([H])[H])C(F)(F)C([H])([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C(N4C([H])=C(C([H])=C([H])C4=N3)C(F)(F)F)C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C(N4C([H])=C(C([H])=C([H])C4=N3)C(F)(F)F)C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C(N4C([H])=C([H])C(=C([H])C4=N3)C(F)(F)F)C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])N2C(=NC3=C2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=NN=C(N2C([H])([H])[H])C2=C([H])C([H])=C([H])C4=NC(=C([H])C([H])=C24)C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C1[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C(N4C([H])=C(Cl)C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C(N4C([H])=C([H])C(=C([H])C4=N3)C([H])([H])[H])C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4N=C(SC4=C3C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4N=C(SC4=C3C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4N=C(SC4=C3C([H])([H])C2([H])[H])C([H])([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4N=C(OC4=C3C([H])([H])C2([H])[H])C(F)(F)C([H])([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4N=C(OC4=C3C([H])([H])C2([H])[H])C(F)(F)F)N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4N=C(OC4=C3C([H])([H])C2([H])[H])C(F)(F)F)N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC(=NC4=C3C([H])([H])C2([H])[H])C2=C([H])C(=NN2C([H])([H])[H])C([H])([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C(N(N=C1C([H])([H])[H])C([H])([H])[H])C1=NC2=C3C(=C([H])C([H])=C2O1)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C([H])C([H])=C([H])C2=NC(=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])C3([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C4N=C(OC4=C([H])C(Cl)=C3C([H])([H])C2([H])[H])C([H])([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C2OC(=NC2=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C(N=C(S1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C(F)(F)F
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC(=NC4=C3C([H])([H])C2([H])[H])C(F)(F)F)N1C([H])([H])[H]
[H]C1=NC(=C(C([H])=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC(=NC4=C3C([H])([H])C2([H])[H])C(F)(F)F)N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C(C([H])=C([H])C(=N1)C([H])([H])[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC(=NC4=C3C([H])([H])C2([H])[H])C(F)(F)F)N1C([H])([H])[H]
[H]C1=NC(=C([H])N=C1C([H])([H])[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC(=NC4=C3C([H])([H])C2([H])[H])C(F)(F)F)N1C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC(=NC4=C3C([H])([H])C2([H])[H])C(F)(F)C(F)(F)F)N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC(=NC4=C3C([H])([H])C2([H])[H])C(F)(F)C(F)(F)F)N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC(=NC4=C3C([H])([H])C2([H])[H])C(F)(F)C([H])([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC(=NC4=C3C([H])([H])C2([H])[H])C(F)(F)F)N1C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC(=NC4=C3C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC(=NC4=C3C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[H])N1C([H])([H])[H])C([H])([H])[H]
COC1=CC2=C(C=CN=C2C=C1)C1CN(C2CCN(CC3=CC(C)=C(C)C=C3)CC2)C(=O)O1
[H]N1C2=C(C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(N3C(=O)O[C@]([H])(C4=C5C([H])=C(OC([H])([H])[H])C([H])=C([H])C5=NC([H])=C4[H])C3([H])[H])C([H])([H])C1([H])[H])C([H])=C([H])C([H])=C2[H]
Cl.CN1CCN(CCCCN2C(=O)CN(\N=C\C3=CC=C(O3)C3=CC=C(Cl)C=C3)C2=O)CC1