[H]N([H])C1=NON=C1C1=NC2=C([H])N=C([H])C(C(=O)N3C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])=C2N1C([H])([H])C([H])([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])N=C([H])C(C(=O)N([H])[C@]3([H])C([H])([H])N([H])C([H])([H])C([H])([H])C3([H])[H])=C2N1C([H])([H])C([H])([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])N=C([H])C(OC([H])([H])C3([H])C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])=C2N1C([H])([H])C([H])([H])[H] [H]N([H])C1=NON=C1C1=NC2=C(N=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N([H])[H])=C2N1C([H])([H])C([H])([H])[H])C1=C([H])OC([H])=C1[H] [H]N([H])C1=NON=C1C1=NC2=C(N=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N([H])[H])=C2N1C([H])([H])C([H])([H])[H])C1=C([H])N([H])C([H])=C1[H] [H]N([H])C1=NON=C1C1=NC2=C(N=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N([H])[H])=C2N1C([H])([H])C([H])([H])[H])C1=C([H])N([H])N=C1[H] [H]N([H])C1=NON=C1C1=NC2=C(N=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N([H])[H])=C2N1C([H])([H])C([H])([H])[H])C#CC1([H])C([H])([H])C1([H])[H] [H]OC(C#CC1=C2N=C(N(C2=C(OC([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])=N1)C([H])([H])C([H])([H])[H])C1=NON=C1N([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C#CC1=C2N=C(N(C2=C(OC([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])=N1)C([H])([H])C([H])([H])[H])C1=NON=C1N([H])[H] [H]OC([H])([H])C([H])([H])C#CC1=C2N=C(N(C2=C(OC([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])=N1)C([H])([H])C([H])([H])[H])C1=NON=C1N([H])[H] [H]N([H])C1=NON=C1C1=NC2=C(N=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N([H])[H])=C2N1C([H])([H])C([H])([H])[H])C#CC([H])([H])N([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])N=C([H])C(OC3([H])C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])=C2N1C([H])([H])C([H])([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])N=C([H])C(C(=O)N([H])C([H])([H])C([H])([H])N([H])C([H])([H])[H])=C2N1C([H])([H])C([H])([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])N=C([H])C(C(=O)N3C([H])([H])C([H])([H])[C@@]([H])(N([H])[H])C3([H])[H])=C2N1C([H])([H])C([H])([H])[H] [H]N([H])C1=NON=C1C1=NC2=C(N=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N([H])[H])=C2N1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])N1[H] [H]N([H])C1=NON=C1C1=NC2=C([H])N=C([H])C(=C2N1C([H])([H])C([H])([H])[H])C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])N=C([H])C([H])=C2N1C([H])([H])C([H])([H])[H] [H]N(C1=C2C([H])=C([H])N=C([H])C2=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C([H])N=C([H])C2=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C([H])C2=C([H])N=C([H])C([H])=C12)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])C([H])=C([H])C3=C([H])N=C([H])C([H])=C23)C1([H])[H] [H]N(C1=C2C([H])=C([H])N=C([H])C2=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C([H])N=C([H])C2=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C([H])N=C([H])C2=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C([H])C2=C([H])N=C([H])C([H])=C12)[C@]1([H])C([H])([H])N(C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])C([H])=C([H])C3=C([H])N=C([H])C([H])=C23)C1([H])[H] [H]N(C1=C([H])C([H])=C([H])C2=C([H])N=C([H])C([H])=C12)[C@]1([H])C([H])([H])N(C([H])([H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C([H])C2=C([H])N=C([H])C([H])=C12)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C([H])N=C([H])C2=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C([H])N=C([H])C2=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N=C2[H] [H]N(C1=C2C([H])=C([H])N=C([H])C2=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])C([H])=C([H])C3=C([H])N=C([H])C([H])=C23)C1([H])[H] [H]N(C1=C([H])C([H])=C([H])C2=C([H])N=C([H])C([H])=C12)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C(Cl)C([H])=C2N([H])C(=O)N([H])C3=NC(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C1[H])=C(N=C3[H])C#N)C([H])([H])C1=C([H])N=C([H])S1 [H]N([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C(Br)=C(S1)C1=C2C([H])=C([H])N([H])C2=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N(C1=C(N([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(=O)C1=O)C1=C([H])C([H])=NC([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]([H])(N([H])C1=C(N([H])C2=C([H])C([H])=NC([H])=C2[H])C(=O)C1=O)C(=O)N([H])[H] [H]N([H])C1=NN([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC(=N1)N([H])C([H])([H])[H])N1C([H])([H])[C@@]([H])(C(=O)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(=C(N=C1[H])C1=C([H])OC([H])=C1[H])C1=C([H])C2=C(N([H])N=C2C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N([H])[C@@]1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N([H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(OC2([H])C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])=NC(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]N(C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])N([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])N([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(=NC(=N1)N(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C([H])([H])[H])N([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])N([H])[C@]([H])(C([H])([H])[H])C1([H])[H])N([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])[H])N([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=C([H])C(=NC(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(N([H])C2([H])C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])=C([H])C(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(=NC(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1C([H])([H])[H])C1=C(C#N)C([H])=NC([H])=C1\C([H])=C(/[H])C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(=C(N=C1[H])C1=C([H])SC([H])=C1[H])C1=C([H])C2=C(N([H])N=C2C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(=C(N=C1[H])C1=C([H])C([H])=C([H])S1)C1=C([H])C2=C(N([H])N=C2C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(=C(N=C1[H])C1=C([H])OC([H])=C1[H])C1=C([H])C2=C(N([H])N=C2C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C#CC1=C(C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(O1)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C2C(C([H])=C([H])C2([H])[H])=C1C([H])([H])[H] [H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(=C(N=C1[H])C1=C([H])C([H])=C([H])O1)C1=C([H])C2=C(N([H])N=C2C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(Cl)C([H])=C1C1=C(C([H])=C(OC([H])([H])[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=N1)C1=C([H])C2=C(N([H])N=C2C([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(F)C([H])=C1C1=C(C([H])=C(OC([H])([H])[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=N1)C1=C([H])C2=C(N([H])N=C2C([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C(OC([H])([H])[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=N1)C1=C([H])C2=C(N([H])N=C2C([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C([H])=C1C1=C(C([H])=C(OC([H])([H])[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=N1)C1=C([H])C2=C(N([H])N=C2C([H])([H])[H])C([H])=C1[H] [H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(=C([H])N=C1[H])C1=C([H])C2=C(N([H])N=C2C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(\C(=N/C#N)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2C(=C([H])N3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H])C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]N(\C(=N/C#N)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2C(=C([H])N3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C(Br)=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2C(=C([H])N3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C(Br)=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2C(=C([H])N3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC(=O)N(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]OC(C#CC1=C2N=C(N(C2=C(OC([H])([H])[C@@]2([H])C([H])([H])N([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=N1)C([H])([H])C([H])([H])[H])C1=NON=C1N([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=N1)N(C([H])=C2C1=C([H])C(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3S2)=C2N([H])N=C([H])C2=C1[H])C([H])([H])C([H])([H])N([H])[H] [H]N(\N=C1/C(=O)N([H])N=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])N=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])N=C1C1=C([H])N=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])[C@]2([H])C(=O)N=C([H])C([H])=C12 [H]N1C([H])([H])C([H])([H])C([H])([H])N([C@@]([H])(C([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C(=C([H])N=C2[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1C([H])([H])[H])C1=C(C([H])=NC([H])=C1C#N)C1=C([H])C2=C([H])C(=C([H])C([H])=C2O1)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C1N=C([H])C([H])=C2C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(=C([H])C([H])=C2S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(=C([H])C([H])=C2S1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(=C([H])C([H])=C2S1)C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(=C([H])C([H])=C2S1)C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(=C([H])C([H])=C2S1)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(=C([H])C([H])=C2S1)C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2SC(=C(C2=C1[H])C([H])([H])[H])C1=NC(=NC([H])=C1[H])N([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2SC(=C(C2=C1[H])C([H])([H])[H])C1=NC(=NC([H])=C1[H])N([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C([H])=C([H])C([H])=C2S1)C([H])([H])[H] [H]OC1=C([H])C(OC2=C([H])C([H])=C3SC(=C(C3=C2[H])C([H])([H])[H])C2=NC(=NC([H])=C2[H])N([H])[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(N([H])C2=C([H])C([H])=C3SC(=C(C3=C2[H])C([H])([H])[H])C2=NC(=NC([H])=C2[H])N([H])[H])=C([H])C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(=C([H])C([H])=C2S1)[C@]([H])(N([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@@]([H])(N([H])[H])C1=C([H])C([H])=C2SC(=C(C2=C1[H])C([H])([H])[H])C1=NC(=NC([H])=C1[H])N([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(=C([H])C([H])=C2S1)[C@]([H])(N([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(=C([H])C([H])=C2S1)[C@]([H])(N([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(=C([H])C([H])=C2S1)[C@]([H])(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(=C([H])C([H])=C2S1)[C@]([H])(N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(=C([H])C([H])=C2S1)C([H])([H])N([H])[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(=C([H])C([H])=C2S1)[C@@]([H])(N([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(=C([H])C([H])=C2S1)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(=C([H])C([H])=C2S1)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1Cl)C(=O)N([H])C([H])=C2[H] [H]N([H])[C@]([H])(C(=O)N([H])C1=C([H])C2=C(C([H])=C1Cl)C(=O)N([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1Cl)C(=O)N([H])C([H])=C2[H] [H]N(C(=O)[C@@]([H])(N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1Cl)C(=O)N([H])C([H])=C2[H] [H]N(C(=O)[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1Cl)C(=O)N([H])C([H])=C2[H] [H]N(C(=O)C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1Cl)C(=O)N([H])C([H])=C2[H] [H]N([H])[C@]([H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C(N2C([H])=C([H])SC2=N1)C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1([H])C([H])([H])C1([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C(=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])C([H])=C2N(C(=NC2=C1[H])C1=NON=C1N([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C(N([H])C(=O)C([H])([H])[H])=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NON=C1C1=NC(=C([H])N1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NON=C1C1=NC(=C([H])N1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1=C(C#N)C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2N(C(=NC2=C1[H])C1=NON=C1N([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C(N([H])[H])=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C(=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)OC([H])([H])[H] [H]N([H])C1=NON=C1C1=NC(C#N)=C([H])N1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C(OC([H])([H])[C@@]([H])(C3=NC4=C(S3)C([H])=C(C([H])=C4[H])C3=C([H])N([H])N=C3[H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1N=C([H])C(=C1[H])C1=C([H])C2=C(N=C(S2)C(=O)N(C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N1N=C([H])C(=C1[H])C1=C([H])C2=C(N=C(S2)C(=O)N(C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C2C([H])=C([H])N([H])C2=NC([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=C1[H])C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H] [H]N([H])C1=NC([H])=C(N=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N([H])C1=NC([H])=C(N=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H] [H]N([H])C1=NC([H])=C(N=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C2=C1C([H])=NN2[H] [H]N([H])C1=NC([H])=C(N=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(N([H])N=C2[H])C([H])=C1[H] [H]N(C1=NC([H])=C(N=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C([H])N=C(N(C([H])([H])[H])C([H])([H])[H])C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC(=C([H])N=C2N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC(=C([H])N=C2N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1([H])C([H])([H])C([H])([H])N(C2=NC(=C([H])N=C2N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=NC(=C([H])N=C2N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=NC(=C([H])N=C2N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=NC(=C([H])N=C2N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])N=C12)C1=C([H])N=C(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])N=C12)C1=C([H])N=C(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C1([H])C([H])([H])C([H])([H])N(C2=NC(=C([H])N=C2N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC(=C([H])N=C2N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC(=C([H])N=C2N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C([H])N=C(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC(=C([H])N=C2N([H])[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H])C1=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])N([H])N=C1[H] [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C(C2=C([H])N([H])N=C2[H])C(F)=C1[H] [H]N(C(=O)[C@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C(C2=C([H])N([H])N=C2[H])C(F)=C1[H] [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H])C1=C(OC([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])N([H])N=C1[H] [H]N(C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C23)=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C1N=C([H])N=C2C1=C([H])N(N=C1[H])[C@]([H])(C([H])([H])C#N)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C(F)=C12 [H]C1=NC(=O)C(=C2C([H])=C([H])C(SC3=C(F)C([H])=C(F)C([H])=C3[H])=NN12)C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C(=O)C1=C(O[C@@]([H])(C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C(S1)N1C([H])=NC2=C1C([H])=C(C([H])=C2[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2OC(C(=O)N([H])C2=N1)(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=NC(=N1)N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C([H])([H])[H])[C@]1([H])C([H])([H])[C@@]2([H])O[C@@](N3C4=C(C([H])=C([H])C([H])=C4[H])C4=C3C3=C(C5=C(C([H])=C([H])C([H])=C5[H])N23)C2=C4C([H])([H])N([H])C2=O)(C([H])([H])[H])[C@]1([H])OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=NC([H])=NC(N([H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]N([H])C1=NC([H])=C(C([H])=C1O[C@@]([H])(C1=C(Cl)C([H])=C([H])C(F)=C1Cl)C([H])([H])[H])C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C(C(=N1)N([H])C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1N=C(\C([H])=C(/[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N1C([H])=C([H])C2=C1N=C([H])N=C2N(C([H])([H])[H])[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C#N)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])N=C(OC3=C([H])C(N([H])C(=O)C4=C([H])C([H])=C(OC([H])([H])C([H])([H])N5C([H])([H])C([H])([H])OC([H])([H])C5([H])[H])C([H])=C4[H])=C([H])C([H])=C3[H])C([H])=C2N1C([H])([H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])N([H])C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C2C([H])=C(F)C([H])=C3[H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1=C(C([H])=NC(=N1)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C(F)=C1F [H]N(C1=NC(N([H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(O[H])=C2C(=O)C([H])=C(OC2=C1[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])O[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12 [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C(C([H])=C2N1[H])C1=C([H])N([H])N=C1[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C(C([H])=C2N1[H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C([H])C([H])=C2C([H])=C(N([H])C2=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(=C1[H])C1=C([H])C([H])=C2C([H])=C(N([H])C2=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])N=C(C([H])=C2N1[H])C1=C([H])N([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])N=C(C([H])=C2N1[H])C1=C(N([H])N=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])N=C(C([H])=C2N1[H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C(N=C2N1[H])C1=C([H])N([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C(N=C2N1[H])C1=C(N([H])N=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C(N=C2N1[H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N([H])C2=NC(=C([H])C([H])=C12)C1=C([H])N([H])N=C1[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N([H])C2=NC(=C([H])C([H])=C12)C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])N([H])N=C1[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])N([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])N([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1[H] [H]N(C(=O)C1=C([H])N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])N([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H] [H]N(C(=O)C1=C([H])N([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])N([H])N=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])N([H])N=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])N([H])N=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])N([H])N=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N(C(=O)C1=C([H])N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])N([H])N=C1[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C(N=C2N1[H])C1=C([H])N([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C(N=C2N1[H])C1=C([H])N([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C(N=C2N1[H])C1=C([H])N([H])N=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=NC2=C([H])C(=C([H])C([H])=C2S1)C1=NN([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([H])C1=C(C([H])=C([H])C([H])=N1)C(=O)C1=NC(=C([H])C([H])=C1C(F)(F)F)N1C([H])([H])C([H])([H])N([H])[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=NN1[H])C1=NC(=NC(=C1[H])N1C([H])([H])C([H])([H])O[C@]([H])(C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])N([H])[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=NN1[H])C1=NC(=NC(=C1[H])N1C([H])([H])[C@@]([H])(C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])N([H])[H] [H]N([H])C1=NN([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC(=N1)N([H])[H])N1C([H])([H])[C@]([H])(OC([H])([H])[C@@]1([H])C([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NN([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=NC(=N1)N([H])[H] [H]N([H])C1=NN([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC(=N1)N([H])[H])N([H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C2C([H])=C([H])N([H])C2=NC([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C2C([H])=C(N([H])C2=NC([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N([H])[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N([H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC([H])=C2C([H])=C([H])C(O[C@]3([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C2=C1[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C(O[C@]3([H])C([H])([H])N([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C1=O [H]N([H])C1=C2C([H])=C([H])C([H])=C(C2=C([H])C([H])=N1)S(=O)(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N([H])C([H])([H])C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N([H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N([H])C1=C2C([H])=C([H])C(O[C@]3([H])C([H])([H])N([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C2=C([H])C([H])=N1 [H]N([H])C1=C2C([H])=C([H])C(OC3([H])C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])=C([H])C2=C([H])C([H])=N1 [H]N([H])C1=C2C([H])=C([H])C(O[C@@]3([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C2=C([H])C([H])=N1 [H]N([H])C1=NC([H])=C([H])C2=C1C([H])=C([H])C(OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])=C2[H] [H]OC1=C2C([H])=C([H])C([H])=C(C2=C([H])C([H])=N1)S(=O)(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(OC2=C([H])C3=C([H])C([H])=NC([H])=C3C([H])=C2[H])C1([H])[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C(O[C@]3([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C1=O [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(OC2=C([H])C3=C(C([H])=C2[H])C(=O)N([H])C([H])=C3[H])C1([H])[H] [H]N(C([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(OC2=C([H])C3=C(C([H])=C2[H])C(=O)N([H])C([H])=C3[H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(OC2=C([H])C3=C(C([H])=C2[H])C(=O)N([H])C([H])=C3[H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC2=C([H])C3=C(C([H])=C2[H])C(=O)N([H])C([H])=C3[H])C1([H])[H] [H]N1C([H])=C([H])C2=C(C([H])=C(C(O[C@]3([H])C([H])([H])N([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])[H])C1=O [H]N1C([H])=C(C2=C(C([H])=C([H])C(O[C@]3([H])C([H])([H])N([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C1=O)C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(OC2=C([H])C3=C(C([H])=C2[H])C(=O)N([H])C([H])=C3[H])C1([H])[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C(OC3([H])C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])=C2[H])C1=O [H]N([H])C1=NN([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC(=N1)N([H])[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N([H])C1=NN([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC(=N1)N([H])[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N([H])C1=NN([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC(=N1)N([H])[H])N1C([H])([H])[C@]([H])(C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]N([H])C1=NN([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC(=N1)N([H])C([H])([H])[H])N1C([H])([H])[C@@]([H])(C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N([H])C1=NN([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC(=N1)N([H])C([H])([H])[H])N1C([H])([H])[C@]([H])(OC([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NN([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC(=N1)N([H])[H])C([H])([H])[H] [H]N([H])C1=NN([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(OC([H])([H])[H])=NC(=N1)N([H])[H] [H]N([H])C1=NN([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC(=N1)N([H])[H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NN([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC(=N1)N([H])[H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OS(=O)(=C([H])[H])C1=C([H])C2=C(C([H])=C1[H])[N+]1=C(C3=C([H])C4=C5N(C6=C([H])C([H])=C(C([H])=C6C5(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C5=C([H])C([H])=C([H])C6=C([H])N=C([H])C([H])=C56)C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C(=O)N([H])[H])C([H])([H])C([H])([H])[C@]4([H])O[C@@]3([H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(N([H])N=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC([H])([H])[C@@]([H])(N([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C2=C(N([H])N=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(N([H])N=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C2=C(N([H])N=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C2=C(N([H])N=C2[H])C([H])=C1[H] [H]OC([H])([H])[C@@]([H])(N([H])C(=O)N([H])C1=C([H])C2=C(N([H])N=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])N1N=C([H])C(=C1[H])C1=C([H])N=C(N([H])[H])C2=C1SC([H])=C2C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])=C1[H] COC1=CC=C(C=C1)[C@@H]1CN(C)C[C@H]1C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 NCC1=CC=C(C=C1)C(=O)NC(C1=CC=C(Cl)C=C1)C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 ClC1=CC=C(C=C1)[C@@H]1CNC[C@H]1C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 COC1=C2N=C(NC(=O)C2=CC(=C1)C1=CNN=C1)C(N)C1=CC=CC(Cl)=C1 NC(C1=CC=CC(Cl)=C1)C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 COC1=CC=C(C[C@H](N)C2=NC3=CC=C(C=C3C(=O)N2)C2=CNN=C2)C=C1 COC1=C2N=C(NC(=O)C2=CC(=C1)C1=CNN=C1)[C@H](N)CC1=CC=CC(F)=C1 N[C@H](CC1=CC=C(F)C=C1)C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 O=C1NC(=NC2=CC=C(C=C12)C1=CNN=C1)[C@@H]1CNC[C@H]1C1=CC=CC=C1 COC1=CC=C(C=C1)C(N)C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 COC1=CC(CN(CCN2CCCCC2)C(=O)NC2=CC=C(C=C2)C2=CNN=C2)=CC=C1 COC1=CC(CN(CCN2CCCC2)C(=O)NC2=CC=C(C=C2)C2=CNN=C2)=CC=C1 COC1=CC(=CC=C1)C(CCO)NC(=O)NC1=CC=C(C=C1)C1=CNN=C1 COC1=CC(CN(CCN(C)C)C(=O)NC2=NC=C(C=C2)C2=CNN=C2)=CC=C1 OCCC(NC(=O)NC1=CC=C(C=C1)C1=CNN=C1)C1=CC=CC(F)=C1 CN(C)CCC(NC(=O)NC1=CC=C(C=C1)C1=CNN=C1)C1=CC=CC=C1 COC1=CC(CN(CCN(C)C)C(=O)NC2=CC=C(C=C2)C2=CNN=C2)=CC=C1 COC1=CC(CN(CCO)C(=O)NC2=CC=C(C=C2)C2=CNN=C2)=CC=C1 CCN(CC1=CC=CC(OC)=C1)C(=O)NC1=CC=C(C=C1O[C@H]1CCN(C)C1)C1=CNN=C1 COC1=CC(CN(C)C(=O)NC2=CC=C(C=C2)C2=CNN=C2)=CC=C1 COC1=CC(CN(CCN2CCOCC2)C(=O)NC2=CC=C(C=C2)C2=CNN=C2)=CC=C1 OCCN(CC1=CC=CC=C1)C(=O)NC1=CC=C(C=C1)C1=CNN=C1 [H][C@]12C[C@H]([C@H](OC)[C@@](C)(O1)N1C3=CC=CC=C3C3=C1C1=C(C4=C(C=CC=C4)N21)C1=C3CNC1=O)N(C)C(=O)C1=CC=CC=C1 [H][C@@]12C[C@@](O)(CO)[C@](C)(O1)N1C3=C(C=CC=C3)C3=C1C1=C(C4=C(C=CC=C4)N21)C1=C3CNC1=O NC1(CCN(CC1)C1=NC=NC2=C1C=CN2)C(=O)N[C@@H](CCO)C1=CC=C(Cl)C=C1