[H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1[C@]([H])(C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1Cl)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C([H])([H])C(F)(F)F [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)C1=C(OC(F)(F)F)C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C([H])([H])C(F)(F)C(F)(F)F [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1[C@@]([H])(C([H])([H])[H])C(F)(F)F [H]N(C(=O)[C@]([H])(N([H])C(=O)C1(C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C(F)=C1F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)C1(C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)C1(C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=C(F)C([H])=C([H])C(F)=C1F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)C1(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)C1(C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)C1(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])N=C(OC([H])([H])[H])N=C1[H] [H]OC([H])([H])C1=C([H])C([H])=C(C([H])=N1)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])OC([H])([H])C(F)(F)F)C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(N=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1Cl)C1=C([H])N=C(OC([H])([H])[H])N=C1[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(OC([H])([H])[H])N=C1[H] [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C([H])([H])OC([H])([H])C(F)(F)F)C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(N=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])OC([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(N=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(OC([H])(F)F)C([H])=N1 [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1F)C1=C([H])N=C(OC([H])([H])[H])N=C1[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(OC([H])([H])[H])C([H])=N1 [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C([H])([H])OC([H])([H])C(F)(F)F)C([H])([H])C([H])([H])C1=C(C2=C([H])N=C(OC([H])([H])[H])C([H])=N2)C(=C([H])C([H])=C1F)C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C2=C([H])N=C(OC([H])([H])[H])N=C2[H])C(=C([H])C([H])=C1F)C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C([H])([H])OC([H])([H])C(F)(F)F)C([H])([H])C([H])([H])C1=C(C(OC([H])([H])[H])=C([H])C([H])=C1F)C1=C([H])N=C(OC([H])([H])[H])C([H])=N1 [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1C#N)C1=C([H])N=C(OC([H])([H])[H])N=C1[H] [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C([H])([H])OC([H])([H])C(F)(F)F)C([H])([H])C(F)(F)C1=C(C([H])=C([H])C([H])=C1F)C1=C([H])N=C(OC([H])([H])[H])C([H])=N1 [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C([H])([H])OC([H])([H])C(F)(F)F)C([H])([H])C(F)(F)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(OC([H])([H])[H])C([H])=N1 [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C(F)(F)C1=C(C([H])=C([H])C([H])=N1)C1=C([H])N=C(OC([H])([H])[H])N=C1[H] [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C([H])([H])OC([H])([H])C(F)(F)F)C([H])([H])C(F)(F)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(OC([H])([H])[H])N=C1[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C2=C([H])N=C(OC([H])([H])[H])N=C2[H])C(=C([H])C([H])=C1F)C([H])([H])[H] [H]N(C(=O)C1=NC([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(N=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C(F)(F)F [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C(F)(F)F)C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(N=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C([H])N=C(OC([H])([H])[H])N=C1[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(N=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C([H])([H])OC([H])([H])C(F)(F)F)C([H])([H])C([H])([H])C1=C(C(F)=C([H])C([H])=C1F)C1=C([H])N=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C([H])([H])OC([H])([H])C(F)(F)F)C([H])([H])C([H])([H])C1=C(C(F)=C([H])C([H])=C1F)C1=C([H])N=C(OC([H])([H])[H])C([H])=N1 [H]N(C(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C1([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C1([H])[H] [H]N(C(=O)C1=NN(N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C1([H])[H] [H]N(C(=O)C1=NN(N=C1C([H])([H])[H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])C([H])=C([H])C([H])=N3)=C2C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])C([H])=C([H])N=C3[H])=C2C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])C([H])=NC([H])=C3[H])=C2C1([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])C([H])=NC([H])=C3[H])=C2C1([H])[H] [H]OC([H])([H])C1=C([H])C([H])=C(C([H])=N1)C1=C2C(OC([H])([H])[C@@]([H])(N([H])C(=O)C3=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C3[H])C2([H])[H])=C([H])C([H])=C1[H] [H]OC([H])([H])C1=C([H])C(=C([H])C([H])=N1)C1=C2C(OC([H])([H])[C@@]([H])(N([H])C(=O)C3=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C3[H])C2([H])[H])=C([H])C([H])=C1[H] [H]OC([H])([H])C1=C([H])C([H])=C(C([H])=N1)C1=C2C(OC([H])([H])[C@@]([H])(N([H])C(=O)C3=C([H])N=C(OC([H])([H])C([H])([H])OC([H])([H])C(F)(F)F)C([H])=C3[H])C2([H])[H])=C([H])C([H])=C1[H] [H]O[C@]([H])(C1=C([H])C([H])=C(C([H])=N1)C1=C2C(OC([H])([H])[C@@]([H])(N([H])C(=O)C3=C([H])N=C(OC([H])([H])C([H])([H])OC([H])([H])C(F)(F)F)C([H])=C3[H])C2([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=NN(N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])C([H])=NC([H])=C3[H])=C2C1([H])[H] [H]N(C(=O)C1=NN(N=C1C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])C([H])=C([H])N=C3[H])=C2C1([H])[H] [H]N(C(=O)C1=NN(N=C1C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])C([H])=C([H])N=C3[H])=C2C1([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])N=C(OC([H])([H])[H])N=C3[H])=C2C1([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])N=C(OC([H])([H])[H])N=C3[H])=C2C1([H])[H] [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C([H])([H])OC([H])([H])C(F)(F)F)[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])N=C(OC([H])([H])[H])N=C3[H])=C2C1([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])N=C(N=C3[H])C([H])([H])[H])=C2C1([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])N=C(OC([H])([H])[H])C([H])=N3)=C2C1([H])[H] [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C([H])([H])OC([H])([H])C(F)(F)F)[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])N=C(C([H])=N3)C([H])([H])[H])=C2C1([H])[H] [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C([H])([H])OC([H])([H])C(F)(F)F)[C@@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])N=C(OC([H])([H])[H])C([H])=N3)=C2C1([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])C([H])=C([H])N=C3[H])=C2C1([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C1([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])C(F)=C(OC([H])([H])[H])N=C3[H])=C2C1([H])[H] [H]OC([H])([H])C1=C(C([H])=C(C([H])=N1)C1=C2C(OC([H])([H])[C@@]([H])(N([H])C(=O)C3=C([H])N=C(OC([H])([H])C([H])([H])OC([H])([H])C(F)(F)F)C([H])=C3[H])C2([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])N=C([H])N=C3[H])=C2C1([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])N=C(C([H])=N3)C([H])([H])[H])=C2C1([H])[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C(F)C([H])=N1)C([H])([H])C1=C([H])C(=C(F)C([H])=C1[H])C(F)(F)F [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C(F)C([H])=N1)C([H])([H])C1=C([H])C(OC(F)(F)F)=C(F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C(F)C([H])=N1)C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H] [H]OC1=C2C(=O)N(C([H])([H])C([H])([H])C3=NC([H])=C([H])C([H])=C3[H])[C@]([H])(C(=O)N([H])C([H])([H])C3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3[H])C2=C([H])C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C(F)C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C(=C12)C([H])([H])[H])C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C(F)=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@@]1(N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C(F)C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C(F)(F)C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C(C1=C([H])C([H])=C([H])C([H])=N1)(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C(C([H])=N1)C(F)(F)F)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C#N)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)[C@]([H])(C([H])([H])[H])C([H])([H])C#N)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])OC([H])([H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1([H])C([H])([H])C(F)(F)C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C(F)(F)C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(C#N)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N=C(OC([H])(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(F)(F)F [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]OC([H])([H])[C@]([H])(N([H])C(=O)C1=NC([H])=C([H])C([H])=C1[H])C(=O)N([H])C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]OC([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H])C([H])([H])O[H] [H]OC([H])([H])[C@@]([H])(O[H])C(=O)N([H])C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N(C([H])([H])[C@@]1([H])C([H])([H])[C@]11C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[C@]1([H])C([H])([H])[C@]11C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])[C@]11C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C2=C([H])C([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])[C@]11C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])[C@]11C([H])([H])C([H])([H])N(C2=C([H])C(F)=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C(=C1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C2C(=O)N(C([H])([H])C([H])([H])C3=NC([H])=C(F)C([H])=N3)[C@@]([H])(C(=O)N([H])C([H])([H])C3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3[H])C2=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C(ON=C1C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=NC(OC([H])([H])C([H])([H])OC([H])([H])C(F)(F)F)=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C1=C([H])N=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C([H])C([H])=C1[H])C1=C(ON=C1C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])N=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(ON=C1C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N(C1=C(ON=C1C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N=C(OC2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)N(C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N=C(OC2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1Cl)C1=C(ON=C1C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C(F)C([H])=C([H])C([H])=C1Cl)C1=C(ON=C1C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C(F)C([H])=C([H])C([H])=C1Cl)C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1F)C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])OC([H])([H])[H] [H]C1=C([H])C(F)=C(C(Cl)=C1[H])C([H])([H])OC(=O)N(C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(Cl)=C(C2=NOC(=C2N(C(=O)OC([H])([H])C2=C([H])N=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H] [H]N(C(=O)OC([H])([H])C1=C([H])N=C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])N=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1Cl)C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C(F)C([H])=C([H])C([H])=C1Cl)C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N(C(=O)N(C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N=C(OC2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C(ON=C1C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C([H])C([H])=C1[H])C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1Cl)C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C(F)C([H])=C([H])C([H])=C1Cl)C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N([H])C1=C([H])N=C([H])C(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=NC([H])=NC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C2[H])=C1[H] [H]N([H])C1=C([H])C([H])=C([H])C(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=C([H])N=C([H])C(N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C2[H])=C1[H] [H]N([H])C1=C([H])C([H])=NC(N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C2[H])=C1[H] [H]N([H])C1=NN=C([H])C(N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C2[H])=C1[H] [H]N([H])C1=C([H])N=NC(N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C2[H])=C1[H] [H]N([H])C1=C([H])N=C([H])C(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=NC(=NS1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=NC(OC2=C([H])C([H])=C(OC3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C2[H])=N1 [H]N([H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]N([H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C2([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=NSC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H] [H]N([H])C1=C([H])N=C([H])C(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=C([H])N=C([H])C(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=C([H])N=C([H])C(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C([H])N=C([H])C(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C2([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C1=C([H])N=C([H])C(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=C([H])N=C([H])C(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C(=NC([H])=N2)N(C(=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=NC([H])=C([H])C([H])=C4F)C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=NC([H])=C([H])N=C4[H])C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=N4)C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=N4)C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1F [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=N4)C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1F [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=N4)C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC(=N2)C(F)(F)F)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=NC([H])=C([H])C([H])=C4C([H])([H])[H])C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])[C@]([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=NC([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])N=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=NC([H])=C4[H])C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=NC(=C([H])C([H])=C4[H])C([H])([H])[H])C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=NC([H])=C(C([H])=C4[H])C([H])([H])[H])C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=NC([H])=C([H])C(=C4[H])C([H])([H])[H])C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=NC(F)=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=NC([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C(F)=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C(Cl)=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC(=N2)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=NN(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3N=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C(=NC([H])=N2)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C(=NC([H])=N2)N(C(=O)C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C(F)=C2F)C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2F)C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC(=C([H])O1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=NC(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1N=C([H])C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NN(C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])N(C(=N1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C(N=C(S1)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])N=C(S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C([H])N(C2=NC([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])SC([H])=N2)C([H])([H])C1([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C(=NC([H])=N2)N(C([H])=C3C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] CC(C)(C)C(=O)ON[C@H](CC1=CC=CC=C1)C(=O)N[C@@H]1CCC2=C(C=CC=C2)N(CC(F)(F)F)C1=O [H]N(C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]