[H]N1C(=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[S@](=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C(=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C(=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C(=NN1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C(N([H])C1=NC([H])=C([H])C(=N1)C([H])([H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C2C([H])=C([H])N(C2=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(C#CC([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C([H])=C(C#CC([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C([H])=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N1C([H])=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])C([H])=C2N(C(=O)N(C2=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])C2=C(N=NN2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])=NC([H])=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C(F)=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C(F)C([H])=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@@]([H])(N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(C2=NC([H])=C([H])C([H])=C2N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C2=NC([H])=C([H])C([H])=C2O1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C2=NC([H])=C([H])C([H])=C2N1OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C2=NC([H])=C([H])C([H])=C2N1[C@]([H])(OC([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C2=NC([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C2=NC([H])=C([H])C([H])=C2N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1N=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=C(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H] [H]N1N=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=C(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1N=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1N=C(C(=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=NC(=C(O1)C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C2=C1N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])N1N=NN=C1C1=C([H])C([H])=C(F)C(=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C2=C1N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=NN=NN1C1=C([H])C([H])=C(F)C(=C1[H])C([H])([H])[H] [H]C1=NN(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]C1=NC(C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])=C(C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC2=C(C(=C(N2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C(OC([H])([H])[H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C(F)C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(OC2=C([H])C([H])=C([H])N=C2[H])=C([H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C1=C(N([H])[H])N(N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])N=C2C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C2=C([H])C([H])=NC([H])=C2C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C2=NC([H])=C([H])N=C2C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C2=C([H])N=C([H])N=C2C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C2C([H])=C(N(C2=NC([H])=N1)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(F)=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(F)=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(F)=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(F)=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]N(C1=NN=C2C([H])=C([H])C(=C([H])N12)C1=C(N=C([H])O1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@@]([H])(N1C2=C([H])C([H])=C([H])N=C2C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(C2=NC([H])=C([H])C([H])=C2N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])[H])C([H])([H])N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(C2=NC([H])=C([H])C([H])=C2N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C(C1=NN(C(N([H])C(=O)N([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NN=C2C([H])=C([H])C(=C([H])N12)C1=C(N=C([H])O1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]C1=NC(=C(O1)C1=C([H])N2C(OC([H])([H])C([H])([H])[H])=NN=C2C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]N1N=C(C(=C1[H])C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1F [H]C1=NOC(=C1C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1F [H]N1C([H])=NC(=C1C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1F [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(C#CC([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(C#CC([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(C#CC([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])S1 [H]N1C([H])=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[S@](=O)C([H])([H])[H] [H]N1C(=C([H])C(=C1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N1N=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C(F)C([H])=C1[H])C([H])([H])[H] [H]N1N=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N([H])C1=C(C([H])=NN1C1=C(F)C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC(=C(N1C([H])([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C([H])([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(N=C2SC([H])([H])C([H])([H])N12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]OC([H])([H])C#CC1=C([H])C([H])=C([H])C(=C1[H])C(=O)C1=C(N([H])[H])N(N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C(N=C(N1C([H])([H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C(N=C(N1C([H])([H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(F)F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])([H])C(F)(F)F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2=C([H])C([H])=NO2)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C([H])=NN=C2C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(OC([H])(C([H])([H])[H])C([H])([H])[H])=NN=C2C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2C#N)=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2C#N)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2C#N)=C1[H])C([H])([H])[H])C1=NOC([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2C#N)=C1[H])C([H])([H])[H])C1=NOC([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2C#N)=C1[H])C([H])([H])[H])C1=C([H])C([H])=NN1C([H])([H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])S(=O)(=O)N([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H] [H]OC1(C([H])([H])C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C(=O)C2=C(N([H])[H])N(N=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C1=C(N([H])[H])N(N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1OC([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C(F)=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])S1 [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])S1 [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])S1 [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])S1 [H]OC([H])([H])[C@@]([H])(O[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C1=C(N([H])[H])N(N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C(O[H])(C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C1=C(N([H])[H])N(N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])O[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])OC1=C([H])C(=C([H])C([H])=C1[H])C(=O)C1=C(N([H])[H])N(N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2C#N)=C1[H])C([H])([H])[H])C1=C([H])C([H])=NN1C([H])([H])C([H])([H])[H] [H]N([H])C1=NC(N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C#N)C(=N1)N([H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=NN1C([H])([H])C([H])([H])[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(=C(F)C([H])=C1[H])C([H])([H])[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(F)=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(F)=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(Cl)=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(Cl)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(Cl)=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(Cl)C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(F)=C(Cl)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(F)=C(F)C(F)=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(Br)=C(F)C([H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C2C#N)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C2C#N)N([H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC(N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C(C#N)C(=N1)N([H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])OC([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C2C#N)=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(N([H])C([H])([H])[H])=C2C#N)=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(N([H])C([H])([H])C([H])([H])C([H])([H])[H])=C2C#N)=C1[H])C([H])([H])[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(Cl)C(F)=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(Cl)C([H])=C(F)C(F)=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NN=C2C([H])=C([H])C(=C([H])N12)C1=C(N=C([H])O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C(C#N)C(=N1)N([H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1=NOC([H])=C1[H] [H]N([H])C1=NC(N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C#N)C(=N1)N([H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1=NOC([H])=C1[H] [H]N([H])C1=NC(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C(C#N)C(=N1)N([H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=NN1C([H])([H])C([H])([H])[H] [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])S1 [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C([H])C([H])=C([H])S1 [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])S1 [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])S1 [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C([H])S1 [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])S1 [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])S1 [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])S1 [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(C1=NN=C2C([H])=C([H])C(=C([H])N12)C1=C(N=C([H])O1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(N1C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=C1[H])C(=C(N2[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C3=C(C([H])=C2[H])N(C(=O)N3C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=NC(=C(N2C([H])([H])[H])C2=C([H])C3=C(C([H])=C2[H])N(C(=O)N3C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(C1=NN=C2C([H])=C([H])C(=C([H])N12)C1=C(N=C([H])O1)C1=C(F)C([H])=C([H])C(F)=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(F)=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C(N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1F [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C(F)=C([H])C(F)=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C(F)=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C(F)=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C(F)=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=NN1C1=C(F)C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C2=NC([H])=C([H])C([H])=C2N1[C@]([H])(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C2=NC([H])=C([H])C([H])=C2N1[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C2=NC([H])=C([H])C([H])=C2N1[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(C2=NC([H])=C([H])C([H])=C2N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C([H])O1)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(N([H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C([H])=C23)C(=O)OC([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)OC([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)OC([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)OC([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])C([H])([H])[H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)OC([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)OC([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])OC([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C4([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C4=C([H])C([H])=C([H])C([H])=N4)C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=C(C(=C1N1C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C(=C1N1C([H])([H])C([H])([H])N([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C(=C1N1C([H])([H])[C@@]([H])(N([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C(=C1N1C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@]1([H])C([H])([H])N(C2=C(C(=NN2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1([H])C([H])([H])C([H])([H])N(C2=C(C(=NN2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1N=C(C(=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1N=C(C(=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C(=C1N1C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(N([H])C(=O)C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(N([H])C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(N([H])C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(N([H])C(=O)OC([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N1N=C(C(=C1N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C(=C1N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(N([H])C(=O)OC([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NOC(=N1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N=C([H])C([H])=C1[H])N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N2[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(N([H])C2=C3C([H])=C([H])C(=C([H])C3=NC([H])=C2[H])C2=C([H])SC(=N2)C([H])=O)=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])N=C(N=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C(F)=C1[H])C(F)(F)F)C1=C([H])C(C(=O)N([H])C2=C([H])N=C(N=C2[H])N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C(N([H])C(=O)C2=C(C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])[H])=C1[H])C([H])([H])[H])C1=C([H])N=C(N=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C(N([H])C(=O)C2=C([H])C3=C(OC(F)(F)O3)C([H])=C2[H])=C1[H])C([H])([H])[H])C1=C([H])N=C(N=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(C(=O)N([H])C2=C([H])N=C(N=C2[H])N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C([H])C(C(=O)N([H])C2=C([H])N=C(N=C2[H])N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(Cl)C([H])=C([H])C(N([H])C(=O)C2=C([H])C3=C(OC(F)(F)O3)C([H])=C2[H])=C1[H])C1=C([H])N=C(N=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C(=C2[H])C2=NN=C(O2)C([H])([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(C(=O)N([H])C2=C([H])N=C(N=C2[H])N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C(N([H])C(=O)C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])=C1[H])C([H])([H])[H])C1=C([H])N=C(N=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C(N([H])C(=O)C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])N=C(N=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(N([H])C(=O)C2=C(C([H])=C([H])C(=C2[H])C(=O)N([H])C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=N1 [H]N(C(=O)C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C1=C([H])N=C(N=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=N1)C1=C(C([H])=C([H])C(N([H])C(=O)C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C(N([H])C(=O)C2=C(C([H])=C([H])C(N([H])C(=O)C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)=C2[H])C([H])([H])[H])C([H])=N1 [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C(C(=O)N([H])C2=C([H])N=C(N=C2[H])N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=N1)C1=C(C([H])=C([H])C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)=C1[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C(C(=O)N([H])C2=C([H])N=C(N=C2[H])N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C(N([H])C(=O)C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)=C1[H])C([H])([H])[H])C1=C([H])N=C([H])N=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(C([H])=C([H])C(N([H])C(=O)C2=C([H])C3=C(OC(F)(F)O3)C([H])=C2[H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])N=C(N=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C([H])=C2[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NC([H])=C([H])N1[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(N1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C(C(=O)N([H])C2=C([H])N=C(N=C2[H])N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C(C(=O)N([H])C2=C([H])N=C(N=C2[H])N([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C(N([H])C(=O)C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)=C1[H])C([H])([H])[H])C1=C([H])N=C(N=C1[H])N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C(N([H])C(=O)C([H])([H])[H])=C1[H])C([H])([H])[H])C1=C([H])N=C(N=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(ON=C1[H])C([H])([H])[H])C1=C([H])C(C(=O)N([H])C2=C([H])N=C(N=C2[H])N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(C#N)=C1[H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(F)C([H])=C(OC([H])([H])[H])C([H])=C1F)C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C(=C(C([H])=C1[H])C1=[N+]([O-])C([H])=C([H])C(C(=O)C2=C(F)C([H])=C(F)C([H])=C2[H])=C1N([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C(C([H])=C1[H])C1=[N+]([O-])C([H])=C([H])C(C(=O)C2=C(F)C([H])=C(F)C([H])=C2[H])=C1N([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(F)C([H])=C([H])C([H])=C1F)C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C([H])C([H])=C([H])C([H])=C1Cl)C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(Cl)C([H])=C([H])C([H])=C1[H])C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(Cl)C([H])=C([H])C([H])=C1[H])C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(Cl)C([H])=C([H])C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(Cl)C([H])=C([H])C([H])=C1[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C([H])C(Cl)=C([H])C([H])=C1[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C([H])C([H])=C([H])C2=C1OC([H])([H])O2)C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C(F)C([H])=C(F)C([H])=C1[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C([H])N=C(N=C2C([H])=C1[H])N([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C1=NC([H])=C([H])C2=C(N([H])C3=C(C([H])=C([H])C([H])=N3)C3=NC([H])=NC([H])=C3[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C1=NC([H])=C([H])C2=C(N([H])C3=C(C([H])=C([H])C([H])=N3)C3=NC([H])=NC([H])=C3[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NC([H])=C([H])C2=C(N([H])C3=C(C([H])=C([H])C([H])=N3)C3=NC([H])=NC(N([H])C([H])([H])[H])=C3[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NC([H])=C([H])C2=C(N([H])C3=C(C([H])=C([H])C([H])=N3)C3=NC([H])=NC(N([H])C([H])([H])[H])=C3[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=C([H])C([H])=C2C2=NC([H])=NC([H])=C2[H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]C#CC1=C([H])C([H])=C([H])C(N([H])C2=NC([H])=C([H])C3=C(N([H])C4=C(C([H])=C([H])C([H])=N4)C4=NC([H])=NC(N([H])C([H])([H])[H])=C4[H])C(=C([H])C([H])=C23)C([H])([H])[H])=C1[H] [H]N(C1=C([H])C2=C(SC(=N2)C([H])([H])[H])C([H])=C1[H])C1=NC([H])=C([H])C2=C(N([H])C3=C(C([H])=C([H])C([H])=N3)C3=NC([H])=NC(N([H])C([H])([H])[H])=C3[H])C(=C([H])C([H])=C12)C([H])([H])[H] [H]N(C1=NC([H])=C([H])C2=C(C3=C([H])C4=C([H])N=C(N=C4C([H])=C3[H])N([H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C([H])C2=C(C3=C([H])C4=C([H])N=C(N=C4C([H])=C3[H])N([H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H] [H]N(C1=NC([H])=C([H])C2=C(C3=C([H])C4=C(N=C(N=C4[H])N([H])C([H])([H])[H])C([H])=C3[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])C(C(=O)N2[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C2=C(N([H])C3=C(C([H])=C([H])C([H])=N3)C3=NC([H])=NC4=C3N=C([H])N4[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[S@](=O)C([H])([H])[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(Br)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[S@](=O)C([H])([H])[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H] [H]N1C(=C([H])C(C(=O)OC([H])([H])C([H])([H])[H])=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C(N1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C([H])=C([H])C([H])([H])OC1=C(C([H])=C([H])C([H])=C1[H])C1=C(N([H])C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C(Br)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)C1=C(N([H])C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C(N1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(=C(C([H])=C1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N1C([H])=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(Br)=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])C(=NO1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1=C([H])C(=NO1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])C(=NO1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C(=NO1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])C(=NO1)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])C(=NO1)C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C(C(=NO1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(Br)=C([H])C(Br)=C1[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])C(=NO1)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C(=NO1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])=C(F)C([H])=C1C([H])([H])[H])N(C(=O)N([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C(=O)C1=C(N([H])C(=O)N([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C1=C([H])C(N([H])C(=O)C([H])([H])[H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(Br)=C([H])C(Br)=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C1=C([H])C(F)=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C([H])([H])C(F)(F)F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C1=NC([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C([H])([H])C([H])([H])C#N)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C([H])([H])C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])OC(=O)C1=C(N([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(OC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C(N([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(N(C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C(N([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H] [H]N([H])C1=C([H])C(N([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C(S1)C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(N([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C(SC(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])OC(=O)C1=C(N([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C(N([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C1=C(OC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C(SC(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(OC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C(N(C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(C#N)C([H])=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C(N1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=NC(OC([H])([H])[H])=N1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C4OC([H])([H])OC4=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C(F)=C([H])C(F)=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C([H])C([H])=C3F)=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(C([H])=C3C([H])([H])[H])C([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C([H])C(F)=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C(=C([H])C([H])=C3C([H])([H])[H])C([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(C(=C3[H])C([H])([H])[H])C([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C([H])C(=C3C([H])([H])[H])C([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C(N1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C(=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C([H])=C1[H] [H]C1=NC(=C(N1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=N1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C(N([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C(OC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C(N(C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(N([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C(N([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C(N([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C(N([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C(N([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C(N(C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]OC1=C([H])C([H])=C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(F)C([H])=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1OC1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(Cl)C([H])=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C([H])C(=C3[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C([H])C([H])=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1OC1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(N([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C(OC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(N(C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C(C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(Cl)C(Cl)=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C([H])=C1OC1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])=NC(=C2C2=NC(OC([H])([H])[H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N([H])C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])=NC(=C2C2=NC(OC3=C([H])C([H])=C([H])C([H])=C3[H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=NC(OC([H])(C([H])([H])[H])C([H])([H])[H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])C(=O)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(F)(F)F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])=NC(=C2C2=NC(=NC([H])=C2[H])N([H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])=NC(=C2C2=NC(=NC([H])=C2[H])N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])=NC(=C2C2=NC(=NC([H])=C2[H])N([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C(N([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(SC([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])SC1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C(=NN3C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(SC2=C([H])C([H])=NC([H])=C2[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(=NN2C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(SC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(N([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(=NN2C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(SC2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C(=NN3C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(SC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1SC([H])([H])[H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])C2=C([H])C([H])=C([H])C(SC([H])([H])[H])=C2[H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])[S@](=O)C([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(=NC(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[S@](=O)C([H])([H])[H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2F)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C([H])([H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(OC([H])([H])[H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2F)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C(F)C([H])=C([H])C([H])=C2F)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(OC3([H])C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C1=C([H])C2=C(C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(OC([H])([H])[H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(OC3([H])C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C([H])C(F)=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(OC([H])([H])[H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2F)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2C([H])([H])[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2F)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C1=C([H])C2=C(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C(=O)N(C2=C([H])C(=C([H])C(C3=C([H])C([H])=C(F)C([H])=C3F)=C2C1([H])[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C([H])([H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2F)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C(=O)N(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C2N=C([H])N(C2=NC(=N1)C1=C(C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C(C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1F [H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C(C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C(C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C(C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(C(=NN1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C([H])=NC2=C1C([H])=C([H])C([H])=C2[H] [H]N1N=C(C2=C([H])C([H])=C([H])S2)C(=C1[H])C1=C([H])C([H])=NC2=C1C([H])=C([H])C([H])=C2[H] [H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12 [H]N1C([H])=C([H])C2=C([H])C(C(=O)N3C([H])([H])[C@]([H])(N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[C@]3([H])C([H])([H])[H])C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12 [H]N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)N1C([H])([H])[C@@]([H])(N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C(C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(N=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C(OC([H])([H])[H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1N=C([H])C(=C1C1=NC([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=NC2=C1C([H])=C([H])C([H])=C2[H] [H]N1N=C(C(=C1C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C1([H])[H] [H]N1N=C([H])C(=C1C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=NC2=C1C([H])=C([H])C([H])=C2[H] [H]N1N=C(C(=C1C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=NC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]C1=C(C(=NN1C([H])([H])[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1N=C([H])C(=C1C1=NC([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC2=C1C([H])=C([H])C([H])=C2[H] [H]N1N=C(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=N1)C1=C2C([H])=C([H])C([H])=C([H])C2=NC([H])=C1[H] [H]N1N=C([H])C(=C1C1=NC(Br)=C([H])C([H])=C1[H])C1=C([H])C([H])=NC2=C1C([H])=C([H])C([H])=C2[H] [H]N1N=C(C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]N1N=C([H])C(=C1C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=NC2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N1N=C([H])C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)C1=C([H])C(Cl)=C(N2C(=O)N([H])C([H])([H])C3=C2C([H])=C([H])C(SC2=C([H])C([H])=C(F)C([H])=C2[H])=N3)C(Cl)=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(C([H])=C(C([H])=C1Cl)C(=O)OC([H])([H])[H])C([H])([H])[H] [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1Cl)C(=O)OC([H])([H])[H] [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C([H])C([H])=C3C(F)(F)F)C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(N=C(SC3=C(C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1SC1=NC2=C(C([H])=C1[H])N(C(=O)N([H])C2([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(C([H])=C(C([H])=C1Cl)C(=O)C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(Cl)C([H])=C3Cl)C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(N=C(SC3=C(Cl)C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C(=O)OC1=C([H])C(Cl)=C(N2C(=O)N([H])C([H])([H])C3=C2C([H])=C([H])C(SC2=C([H])C([H])=C(F)C([H])=C2[H])=N3)C(Cl)=C1[H] [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(F)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3F)C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C1=NC2=C(C([H])=C1[H])N(C(=O)N([H])C2([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1F [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C(C([H])=C1Cl)C(=O)C([H])([H])[H] [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C(C([H])=C1Cl)C(F)(F)F [H]N1C(=O)N(C2=C(N=C(SC3=C(Cl)C([H])=C([H])C([H])=C3Cl)C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C(C([H])=C1Cl)C(=O)OC([H])([H])[H] [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]OC(=O)C1=C([H])C(Cl)=C(N2C(=O)N([H])C([H])([H])C3=C2C([H])=C([H])C(SC2=C([H])C([H])=C(F)C([H])=C2[H])=N3)C(Cl)=C1[H] [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])[H])C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)N(C2=C(N=C(SC3=C(Cl)C([H])=C([H])C(Cl)=C3[H])C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(C([H])=C(C([H])=C1Cl)[N+]([O-])=O)C([H])([H])[H] [H]N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C2=C(N=C(SC3=C(Cl)C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H] [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])[H] [H]N([H])C1=C([H])C(F)=C([H])C([H])=C1SC1=NC2=C(C([H])=C1[H])N(C(=O)N([H])C2([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H] [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1Cl)C(F)(F)F [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3Cl)C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2Cl)C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H] [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C([H])C([H])=C3Br)C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C1=NC2=C(C([H])=C1[H])N(C(=O)N([H])C2([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)N(C2=C(N=C(SC3=C(F)C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=C([H])C(C2=C3N(N=C2C2=C([H])C([H])=C([H])C(=N2)C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])=C2C([H])=C([H])C(Cl)=C([H])C2=N1 [H]C1=NC(=C([H])C([H])=C1[H])C1=NN2C(=C1C1=C3C([H])=C([H])C([H])=C([H])C3=NC([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])C1=NN2C(=C1C1=C3C([H])=C([H])C(SC([H])([H])C([H])([H])[H])=C([H])C3=NC([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=C([H])C(C2=C3N(N=C2C2=C([H])C([H])=C([H])C(=N2)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])=C2C([H])=C([H])C([H])=C([H])C2=N1 [H]C1=C([H])C(C2=C3N(N=C2C2=C([H])C([H])=C([H])C(=N2)C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])=C2C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C2=N1 [H]C1=NC(=C([H])C([H])=C1[H])C1=NN2C(=C1C1=C3C([H])=C([H])C(Cl)=C([H])C3=NC([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=C([H])C(C2=C3N(N=C2C2=C([H])C([H])=C([H])C(=N2)C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])=C2C([H])=C([H])C([H])=C([H])C2=N1 [H]C1=C([H])C(=NC(=C1[H])C1=NN2C(=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C2N(N=C1C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])C1=NN2C(=C1C1=C3C([H])=C([H])C(=C([H])C3=NC([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=NN2C(OC([H])([H])C2([H])[H])=C1C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=NC(OC2=C([H])C([H])=C([H])C([H])=C2[H])=NC(=C1[H])C1=NN2C(OC([H])([H])C([H])([H])C2([H])[H])=C1C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(OC2=C([H])C([H])=C([H])C([H])=C2[H])=NC(=C1[H])C1=NN2C(OC([H])([H])C2([H])[H])=C1C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(N(N=N1)C([H])([H])OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C(C(=NN1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=NN2C(OC([H])([H])C([H])([H])C2([H])[H])=C1C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=NN2C(OC([H])([H])C2([H])[H])=C1C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Br)C(N([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C(OC([H])([H])C([H])([H])[H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N([H])[C@]2([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N2C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N([H])[C@]2([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N([H])[C@]2([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=NC(=N1)N([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C([H])([H])C([H])([H])[H] [H]N(C1=NC(=NC(=N1)N([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N([H])[C@]2([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]2([H])C3(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])N1C(SC([H])([H])C([H])([H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])C([H])([H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])N1C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])(OC([H])([H])[H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])N1C(SC([H])([H])C([H])([H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])N1C(SC([H])([H])C([H])([H])C([H])([H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])[C@]1([H])OC(OC1([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])SC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N([H])[C@]2([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N([H])[H])N([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]2([H])C3(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]C#CC([H])([H])OC([H])([H])C([H])([H])N1C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])N1C([H])([H])C([H])([H])SC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C#CC([H])([H])OC([H])([H])C([H])([H])N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C([H])=C([H])C([H])([H])OC([H])([H])C([H])([H])N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])[H])C([H])([H])N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C23)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(Cl)C([H])=C(F)C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C1=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(N([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])=NC([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(N([H])C2=C([H])C([H])=NC(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=N2)=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC(Cl)=NC([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1F [H]C([H])=C([H])C([H])([H])N(C1=NC([H])=C([H])C(=N1)N([H])C1=C([H])C(N([H])C(=O)C2=C([H])C([H])=NC(=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(Cl)C([H])=C([H])C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC(OC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=NC([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C23)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C23)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC(=NC([H])=C2[H])N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=NC(=N1)N([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC(=NC(=N1)N([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N([H])[C@]2([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N2C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]2([H])C3(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N([H])[C@]2([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])N([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]2([H])C3(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]ON([H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N([H])[C@]2([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=NC([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])N=C([H])C([H])=C3[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C([H])C(N([H])C(=O)C2=C([H])C(=C([H])C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=NC([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=NC([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C(N([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C(F)=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=NC([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(N([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C(F)=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=NC([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])SC([H])=N3)C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=NC([H])=C3[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])SC(=N3)C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C(F)=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])SC(=N3)C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C(F)=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])SC([H])=N3)C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC(=NC([H])=C2[H])N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C23)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(Cl)=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=NC([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC(=NC([H])=C2[H])N(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC(SC([H])([H])[H])=NC([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])=C23)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])=NC([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC(OC([H])([H])[C@]3([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])=NC([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC(=C2[H])C(=O)N([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C(F)=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=NC([H])=C3[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=NC([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C(N1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=O)C(=C2C([H])=C([H])C(SC3=C(F)C([H])=C(F)C([H])=C3[H])=NN12)C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=NC([H])=C([H])C(=C1[H])C1=NN(N=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])OC([H])([H])C([H])([H])[H] [H]OC1=C(C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(N=C(N1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N([H])C(=N2)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(N=C(N1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(N=C(N1[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(N=C([H])N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)C(\C#N)=C1\SC2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]C1=C(Cl)C([H])=C(C(=N1)C1=C([H])N=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(F)(F)F [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(N=C([H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C2C([H])=C([H])C(N([H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])=C([H])C2=NN1[H] [H]N(C(=O)C1=C([H])C([H])=C(I)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(N=[N+]=[N-])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@@]1([H])N2C(=NC(=C2C2=C([H])C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(N=C(N1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C(N=C(N1[H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(N=C(N1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(N=C(N1[H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(N=C([H])N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(N=C(N1[H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(N=C(N1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C(=NN2[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=NN([H])C(=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN([H])C2=C1C([H])=C([H])C(N([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C(N([H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])=C([H])C2=NN1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(F)=C(N2C(=O)C([H])=C([H])C3=C2C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C3C2=C([H])C([H])=C(F)C([H])=C2F)C(F)=C1[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C1=C([H])C(=C([H])C2=C1C([H])=C([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(Cl)=C(N2C(=O)C([H])=C([H])C3=C2C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C3C2=C([H])C([H])=C(F)C([H])=C2F)C(Cl)=C1[H] [H]C1=C([H])C(Cl)=C(N2C(=O)C([H])=C([H])C3=C2C([H])=C(C([H])=C3C2=C([H])C([H])=C(F)C([H])=C2Cl)[C@@]2([H])C([H])([H])[C@@]3([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])C(Cl)=C1[H] [H]C1=C([H])C(Cl)=C(N2C(=O)C([H])=C([H])C3=C2C([H])=C(C([H])=C3C2=C([H])C([H])=C(F)C([H])=C2Cl)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H] [H]C1=C([H])C(Cl)=C(N2C(=O)C([H])=C([H])C3=C2C([H])=C(N=C3C2=C([H])C([H])=C(F)C([H])=C2F)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C1=C([H])C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C2=C1C([H])=C([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]OC(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])(C2=C([H])C3=C(C([H])=C([H])C(=O)N3C3=C(Cl)C([H])=C([H])C([H])=C3Cl)C(=C2[H])C2=C([H])C([H])=C(F)C([H])=C2Cl)C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C(Cl)=C(N2C(=O)C([H])=C([H])C3=C2C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C3C2=C([H])C([H])=C(F)C([H])=C2Cl)C(Cl)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]OC1=C(C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])O[H] [H]OC1=C(C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])O[H] [H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C(OC2=C([H])C([H])=C(F)C([H])=C2[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(=C([H])C(=N1)C([H])([H])[H])C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=N1)C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(C(=O)ON1C([H])([H])OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C(=O)C([H])([H])N1OC(=O)C(=C1C1=C([H])C([H])=NC(OC2=C([H])C([H])=C([H])C([H])=C2[H])=N1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C([H])=C1OC1=NC(=C([H])C([H])=N1)C1=C(C(=O)ON1C([H])([H])OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C(OC2=NC(=C([H])C([H])=N2)C2=C(C(=O)ON2C([H])([H])OC([H])([H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C(N([H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])=C([H])C2=NN1[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C(N([H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])=C([H])C2=NN1[H] [H]N(C1=C([H])C2=NN([H])C(=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C(N([H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])=C([H])C2=NN1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(Cl)=C(N2C(=O)C([H])=C([H])C3=C2C([H])=C(C([H])=C3C2=C([H])C([H])=C(F)C([H])=C2Cl)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C(=O)OC([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H] [H]C1=C([H])C(Cl)=C(N2C(=O)C([H])=C([H])C3=C2C([H])=C(C([H])=C3C2=C([H])C([H])=C(F)C([H])=C2Cl)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C1=NC(=C([H])C2=C1C([H])=C([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(F)=C(N2C(=O)C([H])=C([H])C3=C2C([H])=C(C([H])=C3C2=C([H])C([H])=C(F)C([H])=C2Cl)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(F)=C1[H] [H]C1=C([H])C(Cl)=C(N2C(=O)C([H])=C([H])C3=C2C([H])=C(N=C3C2=C([H])C([H])=C(F)C([H])=C2Cl)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C(N([H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])=C([H])C2=NN1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C(Cl)=C(N2C(=O)C([H])=C([H])C3=C2C([H])=C(C([H])=C3C2=C([H])C([H])=C(F)C([H])=C2F)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H] [H]C1=C([H])C(Cl)=C(N2C(=O)C([H])=C([H])C3=C2C([H])=C(C([H])=C3C2=C([H])C([H])=C(F)C([H])=C2Cl)C2=C([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(C1=C([H])C3=C(C([H])=C([H])C(=O)N3C3=C(Cl)C([H])=C([H])C([H])=C3Cl)C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1Cl)C2([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C([H])N([H])N=C1C1=C([H])C([H])=C([H])C([H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C(C([H])=C(C2=C([H])C3=C(C([H])=C([H])C(=O)N3C3=C(Cl)C([H])=C([H])C([H])=C3Cl)C(=C2[H])C2=C([H])C([H])=C(F)C([H])=C2Cl)C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(F)=N1)C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N([H])C1=NC(=C([H])C([H])=N1)C1=C(N=C2N1[C@]([H])(C([H])([H])OC([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C2N1[C@@]([H])(C([H])([H])OC([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=N1)C([H])([H])[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=N1)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=N1)N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)[C@@]1([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C([H])C(=NC([H])=C1[H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C([H])C(=NC([H])=C1[H])N([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C([H])C(=NC([H])=C1[H])N([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C(=C1[H])C1=C([H])C(=NC([H])=C1[H])N([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C([H])C(=NC([H])=C1[H])N([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C(=C1[H])C1=C([H])C(=NC([H])=C1[H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C([H])C(=NC([H])=C1[H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C2C([H])=C([H])C([H])=C3C2=NN1C([H])([H])C([H])([H])[N@@]1C([H])([H])[C@@]([H])(OC2=C4N=C3C(O[H])=NC4=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N1C(=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[S@+]([O-])C([H])([H])[H] [H]N([H])C1=C([H])C(F)=C(N([H])C2=C([H])C3=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])O3)C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(N([H])C2=C([H])C3=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])O3)C([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])O2)C1=C(Br)C([H])=C(Br)C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(Cl)=C1[H] [H]N([H])C1=C([H])C(N([H])[H])=C(N([H])C2=C([H])C3=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])O3)C([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])O2)C1=C([H])C([H])=C(F)C([H])=C1F [H]N([H])C1=C([H])C([H])=C(N([H])C2=C([H])C3=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C3([H])[H])C([H])=C1[H] [H]N([H])C1=C(N([H])C2=C([H])C3=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2OC3([H])[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])O3)=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])O2)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])=C2[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])O2 [H]N([H])C1=C(N([H])C2=C([H])C3=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])S3)C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C(F)=C([H])C([H])=C1N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])O2 [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C(C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1N1C(=O)N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C(C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(C2=C([H])C([H])=C3N=C(N=C([H])C3=C2[H])N([H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C(C2=C([H])C([H])=C3N=C(N=C([H])C3=C2[H])N([H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C(C2=C([H])C3=C([H])N=C(N=C3C([H])=C2[H])N([H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C(C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(N(C(C#N)=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C(C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(C2=C([H])C3=C([H])N=C(N=C3C([H])=C2[H])N([H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C2C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C1=C(C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C([H])N=C(N=C2C([H])=C1[H])N([H])C([H])([H])[H])C([H])([H])[H])C(F)(F)F [H]N([H])C1=NC([H])=C2C([H])=C(C([H])=C([H])C2=N1)C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=C(C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1N1C(=O)C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(F)(F)F [H]N(C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C(C2=C([H])C([H])=C3N=C(N=C([H])C3=C2[H])N([H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1OC1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F [H]N(C(=O)C1=C([H])C(C2=C([H])C([H])=C3N=C(N=C([H])C3=C2[H])N([H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(C(=C(Cl)C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C([H])N=C(N=C2C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C1=C(C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C1=C(C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]N(C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])C(F)(F)F)C1=C([H])C(C2=C([H])C([H])=C3N=C(N=C([H])C3=C2[H])N([H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C([H])=NC(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[S@](=O)C([H])([H])[H])=N1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(=O)C(C2=C([H])C([H])=C(F)C([H])=C2[H])=C(C2=C([H])C([H])=NC([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)C1=C([H])C(OC(F)(F)C([H])(F)F)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(OC2=NC([H])=C([H])C([H])=C2C2=NC([H])=NC(=N2)N([H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C([H])C(C#N)=C1[H])C([H])([H])C1=NC(=C(N1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C2N=C([H])C([H])=NC2=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(ON=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(ON=C1C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C(C([H])=C(Cl)C(=C2[H])C(=O)N2C([H])([H])C3=C(C(=NC([H])=N3)C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])N1C([H])([H])[H] [H]N1C(=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C2=C(N(N=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C(OC([H])([H])[H])C(=C2[H])C(=O)N2C([H])([H])C3=C([H])N=C(N3C([H])([H])C2([H])[H])C2=C(F)C([H])=C(F)C([H])=C2[H])N1C([H])([H])[H] [H]N1C([H])=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C1N=C(OC([H])([H])[H])C(=C2[H])C(=O)N1C([H])([H])C2=C(N(N=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C2N(C(=N1)C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1F)C2([H])[H] [H]C1=C2N(C(=N1)C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C3=C(C([H])=C1Cl)N(C([H])=C3C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]O[C@@]1([H])C([H])([H])N(C(=O)C(=O)C2=C([H])N([H])C3=C2C([H])=C(C(=O)N2C([H])([H])C4=C([H])N=C(N4C([H])([H])C2([H])[H])C2=C(F)C([H])=C(F)C([H])=C2[H])C(OC([H])([H])[H])=N3)C([H])([H])C1([H])[H] [H]N1C([H])=C(C(=O)N2C([H])([H])C3=C(N(N=C3[H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N1C([H])=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C2=C(N(N=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C2N(C(=N1)C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C3=C(C([H])=C1OC([H])([H])[H])N(C([H])=C3C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C2=C(C([H])=C(Cl)C(=C2[H])C(=O)N2C([H])([H])C3=C([H])N=C(N3C([H])([H])C2([H])[H])C2=C(F)C([H])=C(F)C([H])=C2[H])N1C([H])([H])[H] [H]N1C([H])=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C1N=C(OC([H])([H])[H])C(=C2[H])C(=O)N1C([H])([H])C2=C([H])N=C(N2C([H])([H])C1([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]C1=NN(C2=C1C([H])([H])N(C(=O)C1=C([H])C3=C(C([H])=C1Cl)N(C([H])=C3C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C2=C(N(N=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]1([H])C([H])([H])N(C(=O)C(=O)C2=C([H])N(C3=C2C([H])=C(C(=O)N2C([H])([H])C4=C([H])N=C(N4C([H])([H])C2([H])[H])C2=C(F)C([H])=C(F)C([H])=C2[H])C(OC([H])([H])[H])=N3)C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NN(C2=C1C([H])([H])N(C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C2([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C(Cl)C(=C2[H])C(=O)N2C([H])([H])C3=C(N(N=C3[H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])N1C([H])([H])[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C(=O)N1C([H])([H])C2=C(N(N=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C(Cl)C(=C2[H])C(=O)N1C([H])([H])C2=C([H])N=C(N2C([H])([H])C1([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N1C([H])=C([H])C2=C1N=C(OC([H])([H])[H])C(=C2[H])C(=O)N1C([H])([H])C2=C([H])N=C(N2C([H])([H])C1([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]C1=C2N(C(=N1)C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1F)C2([H])[H] [H]C1=C([H])C2=C(C([H])=C([H])C(=C2[H])C(=O)N2C([H])([H])C3=C(N(N=C3[H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])N1C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C([H])C(=C2[H])C(=O)N2C([H])([H])C3=C(N(N=C3[H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])N1C([H])([H])[H] [H]C1=NN(C2=C1C([H])([H])N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])C2([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]C1=NN(C2=C1C([H])([H])N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])C2([H])[H])C1=C(Cl)C([H])=C(F)C([H])=C1[H] [H]C1=NN(C2=C1C([H])([H])N(C(=O)C1=C([H])N(C3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C([H])C2=C1N=C(OC([H])([H])[H])C(=C2[H])C(=O)N1C([H])([H])C2=C(N(N=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C([H])C([H])=NN1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C(=NN1[H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(N=C(S2)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C([H])C([H])=NN1C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C(N=C([H])O1)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C(=NN1C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(N=C(S2)N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C([H])C([H])=NN1C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C([H])C([H])=NN1C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C(N=C([H])O1)C1=C(F)C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C(N=C([H])N1[H])C1=C(F)C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=NC(=C(O1)C1=C([H])C2=C(N=C([H])S2)C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C(N=C([H])N1[H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C([H])C([H])=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C(=NN1C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(N=C(S2)N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N1C(=O)C(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C(C2=C([H])C([H])=NC([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)N(C#CC([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C([H])C([H])=NN1C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C(N=C([H])O1)C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N2C(=O)[C@@]3([H])SC(=N[C@@]3([H])C2([H])[H])N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C(N=C(S1)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(S1)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C(=O)C2=C([H])N=C([H])N=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C1=C([H])N=C([H])N=C1[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C(N=C([H])O1)C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C(N=C([H])N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C([H])C([H])=NN1C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C(=NN1[H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(N=C(S2)N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C([H])C([H])=NN1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C(N=C([H])O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C([H])C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C([H])C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(C([H])=C([H])C(=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])=N1 [H]N(C(=O)C1=C([H])C(C(=O)N([H])C2=C([H])C([H])=C([H])N=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(C([H])=C([H])C(=C2[H])C(=O)N([H])C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=N1 [H]N(C(=O)C1=C([H])C(C(=O)N([H])C2=C([H])N=C(N=C2[H])N([H])C(=O)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(C([H])=C([H])C(=C2[H])C(=O)N([H])C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=N1 [H]N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(OC([H])([H])[C@@]2([H])OC([H])([H])C([H])([H])C2([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(OC([H])([H])C2=C([H])C([H])=C([H])S2)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(O[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])C(=C([H])C([H])=N2)C2=C(N=C(SC([H])([H])[H])N2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])[C@]([H])(N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@]([H])(N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])[H])C([H])([H])N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])C(=C([H])C([H])=N2)C2=C(N=C(SC([H])([H])[H])N2[H])C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)[C@@]([H])(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])OC([H])=C1[H])C1=C([H])C([H])=C(N(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])OC([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])OC([H])=C1[H])C1=C([H])C([H])=C(Cl)C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])OC([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1F)C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N=C(S1)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(S1)N([H])C([H])([H])C([H])([H])OC([H])([H])[H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(S1)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(S1)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(S1)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(S1)N([H])C1([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)N(C1=NC(=C([H])S1)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC(OC([H])([H])[H])=N1 [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC(=N1)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])=NC(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC(OC([H])([H])[H])=N1 [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])=NC(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC(=N1)N([H])C1([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])=NC(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC(=N1)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C1=C([H])C(C2=NN([H])C3=C2C([H])=C([H])C(=N3)N([H])C2=C(F)C([H])=C(F)C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])OC([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(S1)N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C(N([H])C(=O)C2=C([H])N=C(S2)N([H])C([H])([H])C([H])([H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N2C(=O)C3=C(N=C(S3)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C(N=C(S1)N([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N2C(=O)C3=C(N=C(S3)N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C(=O)C2=C([H])N=C(S2)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=NN1[H] [H]N(C(=O)C1=C([H])N=C(S1)N([H])C1([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C(=O)C2=C([H])N=C(S2)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=NOC([H])=C1[H] [H]N(C(=O)C1=C([H])C(N2C(=O)C3=C(N=C(S3)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(S1)N([H])C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C(=O)C2=C([H])N=C(S2)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=NN1C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(S1)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N2C(=O)C3=C(N=C(S3)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N2C(=O)C3=C(N=C(S3)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C(N([H])C(=O)C2=C([H])N=C(S2)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C1=NC(=C(N1[H])C1=C([H])C([H])=NC(OC([H])([H])[H])=N1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C1=NC(=C(N1[H])C1=C([H])C([H])=NC(=N1)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C1=NC(=C(N1[H])C1=C([H])C([H])=NC(=N1)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(=NC(=C1C1=C([H])C([H])=NC(OC([H])([H])[H])=N1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C(N1[H])C([H])([H])C1=C([H])C([H])=C([H])C(C#N)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C(N1[H])C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC(=C([H])C([H])=N1)C1=C(N=C(N1[H])C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C(N1[H])C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC(=C1C1=C([H])C([H])=NC(OC([H])([H])[H])=N1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC(=C1C1=C([H])C([H])=NC(=N1)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])=NC(=C1C1=C([H])C([H])=NC(OC([H])([H])[H])=N1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])=NC(=C1C1=C([H])C([H])=NC(=N1)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])=NC(=C1C1=C([H])C([H])=NC(=N1)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])=NC(=C1C1=C([H])C([H])=NC(=N1)N([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=NC(OC([H])([H])[H])=N1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=NC(=C(N1C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=NC(OC([H])([H])[H])=N1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C([H])([H])C1=C([H])C([H])=C([H])C(C#N)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C1=NC(=C(N1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C2N=C([H])C([H])=NC2=C1[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N(C([H])=N1)C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])=NC(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC(=N1)N([H])[H] [H]C1=NC(=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC(OC([H])([H])[H])=N1 [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=NC(=C(N1C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC(OC([H])([H])[H])=N1 [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N(C([H])=N1)C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N(C([H])=N1)C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC(=C([H])C([H])=N1)C1=C(N(C([H])=N1)C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])[H])C([H])([H])N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])[C@]([H])(N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]O[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])C(=C([H])C([H])=N2)C2=C(N=C(SC([H])([H])[H])N2C([H])([H])C([H])([H])OC([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(SC([H])([H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C([H])=C([H])N2N=C1C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C2N(N=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])=C([H])C([H])=C2F [H]C1=NC([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C(F)=C([H])N2N=C1C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C2N(N=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])=C([H])C([H])=C2C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C2C([H])=C(C([H])=C([H])N2N=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C(=C([H])N2N=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(Cl)=C1[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C(=C([H])N2N=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C(F)(F)F [H]C1=NC([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C(C#N)=C([H])N2N=C1C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C(Cl)=C([H])N2N=C1C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C([H])=C(Cl)N2N=C1C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C([H])=C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])N2N=C1C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])N2N=C1C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C([H])=C(OC([H])([H])C(F)(F)F)N2N=C1C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O\N=C(/C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C(OC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C2=C([H])N=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C(=O)C1=C(OC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C(=O)C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=NN=C([H])S1 [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C(N2C([H])=C([H])C([H])=C([H])C2=N1)C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C(=C(C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1=C([H])C(N([H])C(=O)C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])OC([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(N([H])C2([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])C(=O)OC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])P(=O)(OC([H])([H])C([H])([H])[H])OC([H])([H])C([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC(N([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])C(=O)OC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC(N([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(O[H])C([H])([H])C2([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC(N([H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])C(=O)OC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC(N([H])[C@]([H])(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC(N([H])[C@]([H])(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])[C@]([H])(O[H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])[C@]([H])(O[H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC(N([H])[C@]([H])(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])[C@]([H])(O[H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC(N([H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])SC([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]OC([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=NO1)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(SC([H])(C(=O)OC([H])([H])C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=NN(C2=C1C([H])=C([H])C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)=C2[H])C([H])([H])[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C(=NN=C4[H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N([H])C1=NSC2=C(C3=C([H])C4=C(C([H])=C3[H])C(=NN=C4[H])N3C([H])([H])C([H])([H])OC([H])([H])[C@]3([H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H] [H]N([H])C1=NN([H])C2=C(C3=C([H])C4=C(C([H])=C3[H])C(=NN=C4[H])N3C([H])([H])C([H])([H])OC([H])([H])[C@]3([H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C(=NN=C4[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=NN=C4[H])C(=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C(=NN=C4[H])N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C(=NN=C4[H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C(=NN=C4[H])N3C([H])([H])C([H])([H])OC([H])([H])[C@@]3([H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])[H] [H]N(C1=NOC2=C(C(Cl)=C([H])C([H])=C12)C1=C([H])C2=C(C([H])=C1[H])C(=NN=C2[H])N1C([H])([H])C([H])([H])OC([H])([H])[C@]1([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NOC2=C(C(Cl)=C([H])C([H])=C12)C1=C([H])C2=C(C([H])=C1[H])C(=NN=C2[H])N1C([H])([H])C([H])([H])OC([H])([H])[C@]1([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C(=NN=C4[H])N3C([H])([H])C([H])([H])OC([H])([H])[C@]3([H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H] [H]N([H])C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C(=NN=C4[H])N3C([H])([H])C([H])([H])OC([H])([H])[C@]3([H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C(=NN=C4[H])N3C([H])([H])C([H])([H])OC([H])([H])[C@]3([H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C(=NN=C4[H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C(=NN=C4[H])N3C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])[C@]3([H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C(=NN=C4[H])N3C([H])([H])C([H])([H])OC([H])([H])[C@]3([H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C(N2C([H])=C([H])C([H])=C([H])C2=N1)C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N(C1=NC([H])=C2C([H])=C(C([H])=C([H])C2=N1)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(N([H])C(=O)C2=C([H])C(=NC([H])=C2[H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1C([H])([H])[H] [H]N([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NOC(=N1)C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NOC(=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(I)=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NN([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(N([H])C(=O)C2=C([H])C(=NC([H])=C2[H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1C([H])([H])[H] [H]N([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NOC(=N1)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NOC(=N1)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])SC1=NC(=C(N1C([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])C(=O)OC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])[H])C(=O)N([H])C2([H])C([H])([H])C2([H])[H])C(=O)N1[H] [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])[H])C(=O)N([H])C2=C([H])C(=C([H])C([H])=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(=O)N1[H] [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C([H])C(N([H])C(=O)C3=C([H])C(=NC([H])=C3[H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C2C([H])([H])[H])C(=O)N1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C(=O)N([H])C(=NC2=C1[H])C1=C([H])C([H])=C([H])S1)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C(=O)N(C(=O)N([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C(=O)N(C(=O)N([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C(=O)N(C(=O)N([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C(=O)N(C(=O)N([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C(=O)N(N=NC2=C1[H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C(=O)C([H])=C(OC2=C1[H])C1=C([H])C([H])=C([H])S1)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N([H])C(=O)C([H])=C([H])C2=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N([H])C(=O)C([H])=C([H])C2=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N([H])C(=O)C([H])=C([H])C2=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C([H])=C([H])N([H])C(=O)C2=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C([H])=C([H])N([H])C(=O)C2=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C([H])=C([H])N([H])C(=O)C2=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C([H])=C([H])N([H])C(=O)C2=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C([H])=C([H])N=C([H])C2=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C([H])=C([H])N=C([H])C2=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C([H])=C([H])N=C([H])C2=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=NC2=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=NC2=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2ON=C(C2=C1[H])C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2ON=C(C2=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2ON=C(C2=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N([H])N=C2[H])C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N([H])N=C2[H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1=NOC2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N([H])C1=NOC2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1=NOC2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(N([H])C(=O)C2=C([H])C(=NC([H])=C2[H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1C([H])([H])[H] [H]N([H])C1=NOC2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(=NO2)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(=NO2)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(=NO2)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C([H])N=NC(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])=C2C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C([H])N=NC(C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C([H])N=NC(O[C@]([H])(C([H])([H])[H])C(F)(F)F)=C2C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C([H])N=NC(OC([H])(C([H])([H])[H])C([H])([H])[H])=C2C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C2=C([H])N=NC(N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C2C([H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C([H])N=NC(N3C([H])([H])C([H])([H])OC([H])([H])[C@]3([H])C([H])([H])[H])=C2C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C([H])N=NC(N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C2C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C([H])C(=C([H])C2=C([H])N=N1)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC([H])([H])[C@]([H])(O[H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC(N([H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C([H])N=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C2C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]OC([H])([H])[C@]([H])(O[H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC(N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])[C@]([H])(O[H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC(N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])[C@]([H])(O[H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC(N([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(N=C([H])C([H])=C1[H])C([H])([H])O2)C1=C([H])C([H])=C(F)C([H])=C1F [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NN3C(=NN=C3C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NN2C(=NN=C2C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(Cl)C([H])=C(N([H])C(=O)C2=C([H])C(N([H])C(=O)C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)=C([H])C([H])=C2Cl)C([H])=N1 [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C(N2C([H])=C([H])C([H])=C([H])C2=N1)C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C(N2C([H])=C([H])C([H])=C([H])C2=N1)C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(OC(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(=C(O1)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N1C([H])=C([H])C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N([H])C1=C([H])C(F)=C([H])C([H])=C1N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F [H]N(C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])=C2[H])C1=C([H])C([H])=C(F)C([H])=C1F [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(N=C([H])C([H])=C1[H])C([H])=C2[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(N=C([H])C([H])=C1[H])C([H])=C2[H])C1=C([H])C([H])=C(F)C([H])=C1F [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(N=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]N([H])C1=C([H])C(F)=C([H])C([H])=C1N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(N=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(N=C([H])C([H])=C1[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(C([H])=C([H])N=C1[H])C([H])=C2[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C([H])=N1)C([H])([H])C2([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(N=C([H])C([H])=C1[H])C([H])([H])O2 [H]N([H])C1=C([H])C(F)=C([H])C([H])=C1N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(N=C([H])C([H])=C1[H])C([H])([H])O2 [H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2[H])C1=C([H])C(=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C1OC([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C(O1)C([H])=C([H])C([H])=C2[H])C1=C([H])C(=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C1OC([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C1OC([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C1=C([H])N=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C#CC1=NC(=C(N1C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(N1[H])[S@](=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(N1[H])[S@](=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(N1[H])[S@](=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(N1[H])[S@](=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])(C([H])([H])[H])C([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(N1[H])[S@](=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(N1[H])[S@](=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(N1[H])[S@](=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(N1[H])[S@](=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(N1C([H])([H])[H])[S@](=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(N1[H])[S@](=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])(C([H])([H])[H])C([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=NC(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=C([H])C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=C([H])C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(N([H])C2=NC([H])=C3C([H])=C(C(=O)N(C3=N2)C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C1=C([H])C([H])=C(N([H])C2=NC([H])=C3C([H])=C(C(=O)N(C3=N2)C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(N([H])C2=NC([H])=C3C([H])=C(C(=O)N(C3=N2)C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(N([H])C2=NC3=C(C([H])=N2)C([H])=C(C(=O)N3C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C1[H] [H]OC([H])([H])C1=C([H])C([H])=C([H])C(N([H])C2=NC3=C(C([H])=N2)C([H])=C(C(=O)N3C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C1[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C(N([H])C2=NC([H])=C3C([H])=C(C(=O)N(C3=N2)C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C1[H] [H]N([H])C1=C([H])C([H])=C([H])C(N([H])C2=NC([H])=C3C([H])=C(C(=O)N(C3=N2)C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=NC([H])=C3C([H])=C(C(=O)N(C3=N2)C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C1[H] [H]OC1=C([H])C([H])=C(N([H])C2=NC3=C(C([H])=N2)C([H])=C(C(=O)N3C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]OC([H])([H])[C@@]1([H])O[C@]([H])(OC2=C([H])C([H])=C(N([H])C3=NC([H])=C4C([H])=C(C(=O)N(C4=N3)C([H])([H])[H])C3=C(Cl)C([H])=C([H])C([H])=C3Cl)C([H])=C2[H])[C@]([H])(O[H])[C@]([H])(O[H])[C@@]1([H])O[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(I)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(N([H])C2=NC([H])=NC3=C([H])C([H])=C(C([H])=C23)[N+]([O-])=O)C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C([H])=C(N([H])C(=O)N([H])C4=C([H])C(=NN4C4=C([H])C([H])=C([H])C(=C4[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C3[H])C2=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(N([H])C2=NC([H])=NC3=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])[H])C([H])=C23)C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C2=C(N=C([H])N=C2C([H])=C1[H])N([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(=NN2C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(N([H])C(=O)N([H])C4=C([H])C(=NN4C4=C([H])C([H])=C([H])C(=C4[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C3[H])C2=C1[H] [H]N([H])C1=C([H])C2=C(N=C([H])N=C2C([H])=C1[H])N([H])C1=C([H])C([H])=C([H])C(N([H])C(=O)N([H])C2=C([H])C(=NN2C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N([H])C1=C([H])C2=C(N([H])C3=C([H])C([H])=C(N([H])C(=O)N([H])C4=C([H])C(=NN4C4=C([H])C(=C([H])C([H])=C4[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C3[H])C([H])=C([H])N=C2C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(N([H])C2=C3C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])[H])C([H])=C([H])C3=NC([H])=C2[H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C2=C(N([H])C3=C([H])C([H])=C([H])C(N([H])C(=O)N([H])C4=C([H])C(=NN4C4=C([H])C([H])=C(C([H])=C4[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C3[H])C([H])=C([H])N=C2C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(N([H])C2=C3C([H])=C(C([H])=C([H])C3=NC([H])=C2[H])[N+]([O-])=O)=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(N([H])C2=C3C([H])=C([H])C([H])=C([H])C3=NC([H])=C2[H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(N([H])C2=C3C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])[H])C([H])=C([H])C3=NC([H])=C2[H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(C(=O)N3C([H])([H])[C@@]([H])(N(C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])[C@@]3([H])C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=C2N1C([H])([H])[H] [H]N([H])[C@]([H])(C([H])([H])N([H])C1=NC(C2=C([H])C([H])=NC([H])=C2[H])=C(C(=O)N1C([H])([H])[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])C(=C([H])C([H])=N2)C2=C(N=C3C([H])=C([H])C([H])=C([H])C3=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C2C([H])=C(Cl)C(Cl)=C([H])C2=N1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C2C([H])=C([H])C([H])=C([H])C2=N1)C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C2C([H])=C([H])C([H])=C([H])C2=N1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])C(=C([H])C([H])=N2)C2=C(N=C3C([H])=C(C(=C([H])C3=N2)C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])C(=C([H])C([H])=N2)C2=C(N=C3C([H])=C(Cl)C(Cl)=C([H])C3=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C2C([H])=C([H])C([H])=C([H])C2=N1)C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C2C([H])=C(C(=C([H])C2=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C2C([H])=C(C(=C([H])C2=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC2=NC(=C(N=C2C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(N=C2C([H])=C([H])C([H])=C([H])C2=N1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(N=C2C([H])=C(C(=C([H])C2=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(N=C2C([H])=C(OC([H])([H])[H])C([H])=C([H])C2=N1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C2C([H])=C(Cl)C(Cl)=C([H])C2=N1)C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C2C([H])=C([H])C([H])=C([H])C2=N1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C2N=C([H])C([H])=C([H])C2=N1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C2C([H])=C(C(=C([H])C2=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])N2C1=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(F)C([H])=C1F [H]C1=C([H])C(=C([H])N2C1=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])[S@](=O)C1=C([H])C([H])=C(F)C([H])=C1F [H]C1=C([H])C(=C([H])N2C1=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]N1N=C(N2C([H])=C(C([H])=C([H])[C@@]12[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1F)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1N=C(N2C([H])=C(C([H])=C([H])[C@@]12[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1F)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C2=NC([H])=C3C([H])=C(C(=O)N(C3=N2)C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(N([H])C2=NC([H])=C3C([H])=C(C(=O)N(C3=N2)C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(N([H])C2=NC([H])=C3C([H])=C(C(=O)N(C3=N2)C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]N(C(=O)C([H])([H])Cl)C1=C([H])C([H])=C(N([H])C2=NC([H])=C3C([H])=C(C(=O)N(C3=N2)C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]C1=C([H])C(SC2=C([H])C([H])=C(F)C([H])=C2F)=C([H])N2C1=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(SC2=C([H])C([H])=C(F)C([H])=C2F)=C([H])N2C1=NN=C2C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(SC2=C([H])C([H])=C(F)C([H])=C2F)=C([H])N2C1=NN=C2C1(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C([H])=C([H])C([H])([H])C(C1=NN=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3F)=C([H])N12)(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])C(C1=NN=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3F)=C([H])N12)(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(SC2=C([H])C([H])=C(F)C([H])=C2F)=C([H])N2C1=NN=C2C1=C([H])C([H])=C(F)C([H])=C1F [H]C1=C([H])C(SC2=C([H])C([H])=C(F)C([H])=C2F)=C([H])N2C1=NN=C2C1=C([H])C([H])=C(Br)C([H])=C1C([H])([H])[H] [H]C([H])=C([H])C1=C([H])C([H])=C(C2=NN=C3C([H])=C([H])C(SC4=C([H])C([H])=C(F)C([H])=C4F)=C([H])N23)C(=C1[H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(O[H])C1=C([H])C([H])=C(C2=NN=C3C([H])=C([H])C(SC4=C([H])C([H])=C(F)C([H])=C4F)=C([H])N23)C(=C1[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(C2=NN=C3C([H])=C([H])C(SC4=C([H])C([H])=C(F)C([H])=C4F)=C([H])N23)C(=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C1=NN=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3F)=C([H])N12)C(=O)OC([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=NN=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3F)=C([H])N12 [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=NN=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3F)=C([H])N12 [H]C1=C([H])C(SC2=C([H])C([H])=C(F)C([H])=C2F)=C([H])N2C1=NN=C2C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)OC([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C(=C1[H])C1=NN=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3F)=C([H])N12)C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=NN=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3F)=C([H])N12)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=NN=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3F)=C([H])N12)C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=NN=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3F)=C([H])N12)C([H])([H])[H] [H]OC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=NN=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3F)=C([H])N12)C([H])([H])[H] [H]C1=C([H])C(SC2=C([H])C([H])=C(F)C([H])=C2F)=C([H])N2C1=NN=C2C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3F)=C([H])N12 [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3F)=C([H])N12 [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3F)=C([H])N12)C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=NN=C3C([H])=C([H])C(SC4=C([H])C([H])=C(F)C([H])=C4F)=C([H])N23)C([H])([H])C1([H])[H] [H]C1=C([H])C(SC2=C([H])C([H])=C(F)C([H])=C2F)=C([H])N2C1=NN=C2C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(C2=NN=C3C([H])=C([H])C(SC4=C([H])C([H])=C(F)C([H])=C4F)=C([H])N23)C([H])([H])C1([H])[H] [H]C1=C([H])C(SC2=C([H])C([H])=C(Cl)C([H])=C2Cl)=C([H])N2C1=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(SC2=C([H])C([H])=C(F)C([H])=C2F)=C(Cl)N2C1=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(F)C([H])=C(F)C(SC2=C([H])N3C(=NN=C3C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2Cl)=C1[H] [H]C1=C(F)C([H])=C(F)C(SC2=C(Cl)N3C(=NN=C3C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2Cl)=C1[H] [H]C1=C(F)C([H])=C(F)C(SC2=C(Br)N3C(=NN=C3C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2Cl)=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(ON=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(ON=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(ON=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(ON=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(ON=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(ON=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(ON=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(N1[H])[S@](=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C(Br)C(=O)N(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1N=C([H])C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)=C(Br)C1=O [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C(Br)C(=O)N(N=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C1=C(Br)C(=O)N(N=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC1=C(Br)C(=O)N(N=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C1=C(Br)C(=O)N(N=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(Cl)=C(N2N=C([H])C(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C(Br)C2=O)C(Cl)=C1[H] [H]C1=C([H])C(Cl)=C(N2N=C([H])C(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3F)=C(Br)C2=O)C(Cl)=C1[H] [H]C1=C([H])C(Cl)=C(N2N=C([H])C(OC([H])([H])C3=C(F)C([H])=C(F)C([H])=C3F)=C(Br)C2=O)C(Cl)=C1[H] [H]C1=C([H])C(Cl)=C(N2N=C([H])C(OC([H])([H])C3=C([H])C([H])=C(F)C(F)=C3[H])=C(Br)C2=O)C(Cl)=C1[H] [H]C1=C([H])C(Cl)=C(N2N=C([H])C(OC([H])([H])C3=C([H])C([H])=C(F)C(F)=C3F)=C(Br)C2=O)C(Cl)=C1[H] [H]C1=C([H])C(Cl)=C(N2N=C([H])C(OC([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3F)=C(Br)C2=O)C(Cl)=C1[H] [H]C1=NC([H])=C(Cl)C(N2N=C([H])C(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3F)=C(Br)C2=O)=C1Cl [H]C1=C([H])C(F)=C(N2N=C([H])C(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3F)=C(Br)C2=O)C(F)=C1[H] [H]C1=NN(C(=O)C(Br)=C1OC([H])([H])C1=C([H])C([H])=C(F)C([H])=C1F)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1N=C([H])C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)=C(Br)C1=O)C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C#CC1=NC(=C(N1C#C[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])C1=C([H])C2=NC(=C(N2C(Cl)=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C(N([H])C2=NN=C([H])C3=C2C([H])=NN3C2=C([H])C([H])=C(F)C([H])=C2[H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C2=NN=C([H])C3=C2C([H])=NN3C2=C(F)C([H])=C(F)C([H])=C2[H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C(N([H])C2=NN=C([H])C3=C2C([H])=NN3C2=C(F)C([H])=C(F)C([H])=C2[H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C(N([H])C2=NN=C([H])C3=C2C([H])=NN3C2=C(F)C([H])=C(F)C([H])=C2[H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(OC2=NN=C([H])C3=C2C([H])=NN3C2=C(F)C([H])=C(F)C([H])=C2[H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C(OC2=NN=C([H])C3=C2C([H])=NN3C2=C(F)C([H])=C(F)C([H])=C2[H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C(N([H])C2=NN=C([H])C3=C2C([H])=NN3C2=C(F)C([H])=C([H])C(F)=C2[H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NN=C([H])C2=C1C([H])=NN2C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C(N([H])C2=NN=C([H])C3=C2C([H])=NN3C2=C(F)C([H])=C([H])C([H])=C2F)=C1[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(OC2=NN=C([H])C3=C2C([H])=NN3C2=C(F)C([H])=C([H])C([H])=C2F)=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NN=C(C2=C1C([H])=NN2C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NN=C(C2=C1C([H])=NN2C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(OC2=NN=C(C3=C2C([H])=NN3C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NN=C(C2=C1C([H])=NN2C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NN=C(C2=C1C([H])=NN2C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C(F)=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NN=C(C2=C1C([H])=NN2C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(OC2=NN=C(C3=C2C([H])=NN3C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])[H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NN=C(C2=C1C([H])=NN2C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C(N([H])C2=NN=C([H])C3=C2C([H])=NN3C2=C(Cl)C([H])=C([H])C([H])=C2[H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NN=C([H])C2=C1C([H])=NN2C1=C([H])C(F)=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C(N([H])C2=NN=C([H])C3=C2C([H])=NN3C2=C([H])C(F)=C([H])C([H])=C2[H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C(Cl)C(=O)N(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C(I)C(=O)N(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C(Br)C(=O)N1C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(F)=C([H])C(=C1[H])C([H])([H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C(Br)C1=O [H]C1=C([H])C(F)=C([H])C(=C1[H])C([H])([H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)=C(Br)C1=O [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C(C(=O)N(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C(C(=O)N(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C(=O)O\N=C(\C1=C([H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(F)=C([H])C(=C1[H])C([H])([H])N1C([H])=C([H])C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])=C(C#N)C1=O [H]C1=C([H])C(C#N)=C(C([H])=C1[H])C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C(=C([H])C(C#N)=C1[H])C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C(=C(F)C([H])=C1F)C([H])([H])OC1=C(Br)C(=O)N(C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]N([H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C(=C(F)C([H])=C1F)C([H])([H])OC1=C(Br)C(=O)N(C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C(F)C([H])=C1F)C([H])([H])OC1=C(Cl)C(=O)N(C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]\C(=N/C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]\C(=N/C([H])([H])[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)N1C(=O)C(Br)=C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]C1=NC(=C([H])N=C1N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])N=C(C([H])=N1)N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]C1=NC(=NC([H])=C1N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(Cl)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]O\N=C1/C(=O)N(C2=C([H])C([H])=C([H])C(=C12)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C2OC([H])([H])OC([H])([H])C2=C([H])C(F)=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C1=NC(=C(N1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C2=C([H])C([H])=C([H])N=C2C([H])=C1[H] [H]O\N=C1/C(=O)N(C2=C([H])C([H])=C([H])C(\C([H])=C(/[H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C12)C([H])([H])C1=C2OC([H])([H])OC([H])([H])C2=C([H])C(F)=C1[H] [H]O\N=C1/C(=O)N(C2=C([H])C([H])=C([H])C(=C12)C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])C1=C2OC([H])([H])OC([H])([H])C2=C([H])C(F)=C1[H] [H]O\N=C1/C(=O)N(C2=C([H])C([H])=C([H])C(C([H])=C([H])[H])=C12)C([H])([H])C1=C2OC([H])([H])OC([H])([H])C2=C([H])C(F)=C1[H] [H]O\N=C1/C(=O)N(C2=C([H])C([H])=C([H])C(=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C2OC([H])([H])OC([H])([H])C2=C([H])C(F)=C1[H] [H]O\N=C1/C(=O)N(C2=C([H])C([H])=C([H])C(=C12)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C2OC([H])([H])OC([H])([H])C2=C([H])C(F)=C1[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C(=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C(C(=NN2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(OC2=C([H])C(=O)N(C3=C2C([H])=NN3C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])([H])[H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C(F)C([H])=C([H])C(F)=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C(F)C([H])=C([H])C(F)=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(OC2=C([H])C(=O)N(C3=C2C([H])=NN3C2=C(F)C([H])=C([H])C(F)=C2[H])C([H])([H])[H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C(OC2=C([H])C(=O)N(C3=C2C([H])=NN3C2=C(F)C([H])=C([H])C(F)=C2[H])C([H])([H])[H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1F)C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(OC2=C([H])C(=O)N(C3=C2C([H])=NN3C2=C(F)C([H])=C([H])C([H])=C2F)C([H])([H])[H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N1N=C(C(=C1[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C(F)C([H])=C([H])C([H])=C2F)N(C1=O)C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C([H])N=NC(C3=C(F)C([H])=C([H])C([H])=C3[H])=C2C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C([H])C([H])=C(F)C([H])=C2F)N(C1=O)C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C([H])C([H])=C([H])C([H])=C2F)N(C1=O)C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(OC([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C([H])=C([H])C2=C1OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])SC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C([H])=C([H])C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])N(C(=O)C2=C([H])C3=C(OC([H])([H])C3([H])[H])C([H])=C2[H])C2=C([H])C([H])=NC(=N2)N([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])N(C(=O)C2=C([H])C3=C(OC([H])([H])C3([H])[H])C([H])=C2[H])C2=C([H])C([H])=NC(=N2)N([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C2=C(C(=NN2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C(C(=NN2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(C2=C(C(=NN2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C(C(=NN2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=NC([H])=N2)C([H])([H])C1([H])[H] [H]OC([H])([H])C(N1C([H])([H])C([H])([H])C([H])(C2=C(C(=NN2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=NC([H])=N2)C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C(C(=NN2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=NC([H])=N2)C([H])([H])C1([H])[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N1C([H])([H])C([H])([H])C([H])(C2=C(C(=NN2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=NC([H])=N2)C([H])([H])C1([H])[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(C2=C(C(=NN2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=NC([H])=N2)C([H])([H])C1([H])[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=NC([H])=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C(=C1[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])N(C1=O)C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)N(C1=O)C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=NC([H])=C([H])C([H])=C2C(F)(F)F)N(C1=O)C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C([H])C(F)=C([H])C([H])=C2F)N(C1=O)C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C([H])C([H])=C(F)C([H])=C2F)N(C1=O)C([H])([H])C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2C([H])([H])[H])C2=C(F)C([H])=C([H])C([H])=C2F)N(C1=O)C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C(F)C([H])=C([H])C([H])=C2F)N(C1=O)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(F)=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C(F)C([H])=C([H])C([H])=C2F)N(C1=O)C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C(F)C([H])=C([H])C([H])=C2F)N(C1=O)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C(F)C([H])=C([H])C([H])=C2F)N(C1=O)C([H])([H])[H])C([H])([H])[H])C1(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C(F)C([H])=C([H])C([H])=C2F)N(C1=O)C([H])([H])[H])C([H])([H])[H])C1=NOC([H])=C1[H] [H]N1C([H])=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(C(=O)N3C([H])([H])C([H])([H])C([H])(C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12 [H]C1=NC([H])=C([H])C(=C1[H])N(C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C(N1C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)N(C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)N(C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C(=C([H])C([H])=N1)N(C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)N(C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)N(C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)N(C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=NC(=N1)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=NC(=N1)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC(=C([H])C([H])=N2)N(C(=O)C2=C([H])C3=C(OC([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC(=C([H])C([H])=N2)N(C(=O)C2=C([H])C3=C(OC([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H] [H]OC([H])([H])C(N([H])C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=NC(=N1)N([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC(=C([H])C([H])=N2)N(C(=O)C2=C([H])C3=C(OC([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=NC(=N1)N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)N(C(=O)N1C([H])([H])C([H])([H])[C@]2([H])C([H])=C([H])C([H])=C([H])[C@]2([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])C(=C([H])C([H])=N2)C2=C(N([H])C(=O)N2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N([H])C(=O)N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N([H])C(=O)N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C(=O)N([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C2N1[C@]([H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C2=C1C(=O)\C(O2)=C(/[H])C1=C([H])N(C2=C1C(=C([H])C([H])=N2)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])O[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])(N([H])C1=NC([H])=C2C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3F)C(=O)N(C2=N1)C([H])([H])[H])C([H])([H])C([H])([H])O[H] [H]OC(=O)C1=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C(=C1[H])C1=NN([H])C2=C1C([H])=C([H])C(N([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])=C2[H] [H]N([H])C(=O)N(C1=NC(=C(C([H])=C1[H])C(=O)N([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N(C(=O)C1=C([H])C2=C(C([H])=NN2C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1OC1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(OC2=C([H])C(=O)N(C3=C2C([H])=NN3C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])[H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(OC2=C([H])C(=O)N(C3=C2C([H])=NN3C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])[H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1F)C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C(F)C([H])=C([H])C([H])=C2F)N(C1=O)C([H])([H])[H])C([H])([H])[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(N(N=C4[H])C4=C(F)C([H])=C([H])C([H])=C4F)N(C3=O)C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(C(=O)N3C([H])([H])C([H])([H])C([H])(C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])=C(Cl)C([H])=C12 [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(OC([H])([H])[H])C([H])=C([H])C(=C2[H])C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(Cl)C([H])=C3N(N=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C3=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(C([H])=C2C(C(=O)N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])=C1C([H])([H])[H])C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(C(=O)N3C([H])([H])C([H])([H])C([H])(C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2O1 [H]N1C([H])=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(C(=O)N3C([H])([H])C([H])([H])C([H])(C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])N=C12 [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(OC2=C3N([H])C(=O)N([H])C3=C([H])C([H])=C2[H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1[H])C1=C(F)C(F)=C(F)C(OC2=C3N([H])C(=O)N([H])C3=C([H])C([H])=C2[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(OC2=C3N([H])C(=O)N([H])C3=C([H])C([H])=C2[H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(=N1)C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C3=C(N=C([H])N(C3=O)C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(=N1)C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C3=C(N=C([H])N(C3=O)C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(=N1)C(F)(F)F)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C3=C(N=C([H])N(C3=O)C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(=N1)C(F)(F)F)C1=C([H])C([H])=C(F)C(Cl)=C1[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C3=C(N=C([H])N(C3=O)C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(=N1)C(F)(F)F)C1=C([H])C([H])=C(F)C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C3=C(N=C([H])N(C3=O)C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(=N1)C(F)(F)F)C1=C([H])C([H])=C(C(F)=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C3=C(N=C([H])N(C3=O)C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(=N1)C(F)(F)F)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C3=C(N=C([H])N(C3=O)C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(=N1)C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C(N([H])C2=C([H])C3=C(N=C([H])N(C3=O)C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(=N1)C(F)(F)F)C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C(N([H])C2=C([H])C3=C(N=C([H])N(C3=O)C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(=N1)C(F)(F)F)C1=C([H])C([H])=C(F)C(F)=C1[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C3=C(N=C([H])N(C3=O)C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(=N1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C3=C(N=C([H])N(C3=O)C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C3=C(N=C([H])N(C3=O)C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]C1=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(C(=O)N3C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]3([H])C([H])([H])[H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C(Cl)C([H])=C2N1C([H])([H])[H] [H]C1=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(C(=O)N3C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]3([H])C([H])([H])[H])[C@]3([H])C4=C(C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])[H])=C(Cl)C([H])=C2N1C([H])([H])[H] [H]C1=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(C(=O)N3C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]3([H])C([H])([H])[H])[C@@]([H])(C#N)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[H])=C(Cl)C([H])=C2N1C([H])([H])[H] [H]C1=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(C(=O)N3C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]3([H])C([H])([H])[H])[C@@](C#N)(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=C2N1C([H])([H])[H] [H]N1N=C(N2C([H])([H])[C@]([H])(N(C(=O)C3=C(Cl)C([H])=C4N(C([H])=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C4=C3[H])C([H])([H])[H])C([H])([H])[C@]2([H])C([H])([H])[H])C([H])([H])[H])C2=C1C(Cl)=C([H])C([H])=C2[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C([H])C(F)=C([H])C([H])=C1F)C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=C([H])C(=O)N(C3=C2C([H])=NN3C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=C([H])C(=O)N(C3=C2C([H])=NN3C2=C([H])C(F)=C([H])C([H])=C2F)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=C([H])C(=O)N(C3=C2C([H])=NN3C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C2=C([H])C(=O)N(C3=C2C([H])=NN3C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])[H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C(N([H])C2=C([H])C(=O)N(C3=C2C([H])=NN3C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]C1=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(C(=O)N3C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]3([H])C([H])([H])[H])[C@]([H])(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=C2N1C([H])([H])[H] [H]C1=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(C(=O)N3C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]3([H])C([H])([H])[H])C([H])(C3=C([H])C([H])=C(F)C([H])=C3[H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[H])=C(Cl)C([H])=C2N1C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=NC([H])=NC(N([H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=NC(=N2)C([H])([H])[H])N([H])C2=NC([H])=C(S2)C(=O)N([H])C2=C(Cl)C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)OC([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])=O)C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])N=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)C1=NOC(=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(=O)C1(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N([H])S(=O)(=O)C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(C(=O)C([H])([H])N([H])C(=O)C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1C(=O)OC([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1C([H])=C([H])C([H])=C([H])C1=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1C([H])=NC([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1C([H])=C([H])N=C1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1N=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1N=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1([H])C([H])([H])C([H])=C([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C(N([H])C2=NC(=C([H])C([H])=N2)C2=C([H])N=C([H])C([H])=C2[H])=C1[H])C([H])([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F [H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F [H]N(C(=O)N([H])C1=C([H])C(N([H])C2=NC(=C([H])C([H])=N2)C2=C([H])N=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC(=C2[H])C(=O)N([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N1C(N([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])=C1C([H])=C([H])C(=O)C([H])=C1[H] [H]N1C([H])=C(C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])[C@@]2([H])N(C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C([H])=C1SN(C2=C1C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N([H])[C@]([H])(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])N([H])C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N([H])C2=NC(=NC(=N2)N([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])[H])C(=O)N([H])OC([H])([H])[H])N([H])[C@]([H])(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C1=NC(=NC(=N1)N1C([H])=NC2=C1C([H])=C([H])C(=C2[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2OC(OC([H])([H])C2=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C1=NC(OC([H])([H])C([H])([H])[H])=NC(=N1)N1C([H])=NC2=C1C([H])=C([H])C(=C2[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C2OC(OC([H])([H])C2=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C1=NC(OC([H])([H])C([H])([H])[H])=NC(=N1)N1C([H])=NC2=C1C([H])=C(C([H])=C2[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C2OC(OC([H])([H])C2=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=NC(=NC(=N1)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2OC(OC([H])([H])C2=C1[H])(C([H])([H])[H])C([H])([H])[H])N1C([H])=NC2=C1C([H])=C([H])C(=C2[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=NC(=NC(=N1)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2OC(OC([H])([H])C2=C1[H])(C([H])([H])[H])C([H])([H])[H])N1C([H])=NC2=C1C([H])=C(C([H])=C2[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C(F)C([H])=C(C([H])=C1F)N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=C([H])C([H])=NN1C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=C([H])C([H])=NN1C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=NOC([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C([H])C([H])=N1)C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=NOC([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1F)C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=C([H])C([H])=NN1C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1F)C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=C([H])C([H])=NN1C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1F)C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=NOC([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=C([H])C([H])=NN1C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=NOC([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=C([H])C([H])=NN1C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=NOC([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C(=O)C2=C(N([H])C([H])([H])[H])N(N=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C1=NOC([H])=C1[H] [H]N(C(=O)C1=C(N([H])C([H])([H])C([H])([H])[H])N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C(=O)C2=C(N([H])C([H])([H])C([H])([H])[H])N(N=C2[H])C2=C([H])C([H])=C([H])C([H])=N2)=C(C([H])=C1[H])C([H])([H])[H])C1=NOC([H])=C1[H] [H]N(C(=O)C1=C([H])C(N([H])C(=O)C2=C(N([H])C([H])([H])C([H])([H])[H])N(N=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=NOC([H])=C1[H] CNC1=NC(=CC=N1)C1=CC=CN=C1OC1=CC=C(NC(=O)C2=CC(=CC=C2)C(F)(F)F)C=C1C CC1=CC=C(C=C1C(=O)NCC#N)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CC1=CC=C(C=C1C(=O)NCC1=CC=NC=C1)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CCN(CCN)C(=O)C1=CC(=CC=C1C)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CN1CCN(CCNC(=O)C2=CC(=CC=C2C)N2N=C(C=C2NC(=O)NC2=C3C=CC=CC3=CC=C2)C(C)(C)C)CC1 CC1=CC=C(C=C1C(=O)N[C@@H]1CS(=O)(=O)C[C@H]1O)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CC1=CC=C(C=C1C(=O)N(CCCN)C1CCCCC1)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CCN(CC)CCNC(=O)C1=CC(=CC=C1C)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CC(C)(C)C1=NN(C(NC(=O)NC2=CC=C(Cl)C=C2)=C1)C1=CC=CC(CN2C(=O)CNS2(=O)=O)=C1 CC1=CC=C(C=C1C(=O)NCCCO)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CC1=CC=C(C=C1C(=O)NCCCN1CCOCC1)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CC1=CC=C(C=C1C(=O)NCCCN1CCCC1)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CC(C)N(CCCN)C(=O)C1=CC(=CC=C1C)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CC1=CC=C(C=C1C(=O)NCC1=NC=NC=C1)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C COCCCN1CCC(CC1)NC(=O)C1=CC(=CC=C1C)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CC1=CC=C(C=C1C(=O)NCCNC1=CC=CC=C1)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CC(C)[C@H](CO)CNC(=O)C1=CC(=CC=C1C)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CN1C(=O)C(=CC2=CN=NC(C3=C(Cl)C=CC=C3)=C12)C1=CC(=NC=C1C)C(=O)NC1CC1 CN1C(=O)C(=CC2=CN=NC(C3=C(C=CC=C3)C(F)(F)F)=C12)C1=CC(=NC=C1C)C(=O)NC1CC1 CN1C(=O)C(=CC2=CN=NC(C3=C(C)C=C(F)C=C3)=C12)C1=CC(=NC=C1C)C(=O)NC1CC1 CN1C(=O)C(=CC2=CN=NC(C3=C(F)C=C(C=C3)C(F)(F)F)=C12)C1=CC(=NC=C1C)C(=O)NC1CC1 CN1C(=O)C(=CC2=CN=NC(C3=C(Cl)C=CC(F)=C3)=C12)C1=CC(=NC=C1C)C(=O)NC1CC1 CC(C)CC(CNC(=O)C1=CC(=CC=C1C)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C)C(N)=O CC1=CC=C(C=C1C(=O)NC1CCN(CCN2CCOCC2)CC1)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CCN(CCOC)C(=O)C1=CC(=CC=C1C)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CC1=CC=C(C=C1C(=O)NCCC1=CNC2=C1C=CC=C2)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CC1=CC=C(C=C1C(=O)NCCC1=CC=C(N)C=C1)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C COC1=CC=CC=C1CCNC(=O)C1=CC(=CC=C1C)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CC1=CC=C(C=C1C(=O)NCCC1=CCCCC1)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C COC1=CC=C(CCNC(=O)C2=CC(=CC=C2C)N2N=C(C=C2NC(=O)NC2=C3C=CC=CC3=CC=C2)C(C)(C)C)C=C1 CN1C(=O)C(NC2=CC=C(F)C=C2)=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12 CN1C(=O)C(NC2=CC=C(F)C=C2F)=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12 CN1C(=O)C(NC2=NC=C(F)C=C2)=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12 CN1C(=O)C(NC2=NC=C(F)C=C2F)=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12 CN1C(=O)C(OC2=CC=C(F)C=C2)=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12 CN1C(=O)C(OC2=CC=C(F)C=C2F)=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12 CN1C(=O)C(CC2=CC=C(F)C=C2)=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12 CN1C(=O)C(CC2=CC=C(F)C=C2F)=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12 CN1C(=O)C(=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12)C1=CC(=CC=C1C)C(O)=O CN1C(=O)C(=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12)C1=CC(=CC=C1C)C(N)=O CNC(=O)C1=CC=C(C)C(=C1)C1=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C2N(C)C1=O CN1C(=O)C(=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12)C1=CC(=CC=C1C)C(=O)NC1CC1 CN1C(=O)C(=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12)C1=CC(=CC=C1C)C(=O)NC1(C)CC1 CN1C(=O)C(=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12)C1=CC(=CC(F)=C1C)C(=O)NC1CC1 CN1C(=O)C(=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12)C1=CC(=CC=C1Cl)C(=O)NC1CC1 CN1C(=O)C(=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12)C1=CC(=NC=C1C)C(=O)NC1CC1 CN1C(=O)C(=CC2=CN=NC(C3=C(C)C=CC=C3)=C12)C1=CC(=NC=C1C)C(=O)NC1CC1 CCNC(=O)C1=CN2N=CN=C(NC3=C(C)C=CC(=C3)C(=O)NCC)C2=C1C CCNC(=O)C1=CC(NC2=NC=NN3C=C(C(=O)N[C@@H](C)C4=CC=CC=C4)C(C)=C23)=C(C)C=C1 CCCNC(=O)C1=CN2N=CN=C(NC3=C(C)C=CC(=C3)C(=O)NCCC)C2=C1C CCNC(=O)C1=CN2N=CN=C(NC3=C(C)C=CC(=C3)C(=O)NC(C)C)C2=C1C CCCCNC(=O)C1=CC(NC2=NC=NN3C=C(C(=O)NCC)C(C)=C23)=C(C)C=C1 CCNC(=O)C1=CN2N=CN=C(NC3=C(C)C=CC(=C3)C(=O)NCCOC)C2=C1C CNC(=O)C1=CN2N=CN=C(NC3=C(C)C=CC(=C3)C(=O)NC3CC3)C2=C1C [H]N(C(=O)C1=C([H])N2N=C([H])N=C(N([H])C3=C([H])C(=C([H])C([H])=C3C([H])([H])[H])C(=O)N([H])C3([H])C([H])([H])C3([H])[H])C2=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] C[C@H](NC(=O)C1=CN2N=CN=C(NC3=C(C)C=CC(=C3)C(=O)NC3CC3)C2=C1C)C1=CC=CC=C1 CC[C@H](C)NC(=O)C1=CN2N=CN=C(NC3=C(C)C=CC(=C3)C(=O)NC3CC3)C2=C1C COCCNC(=O)C1=CN2N=CN=C(NC3=C(C)C=CC(=C3)C(=O)NC3CC3)C2=C1C CC1=C2N(C=C1C(=O)N[C@@H](CO)C1=CC=CC=C1)N=CN=C2NC1=C(C)C=CC(=C1)C(=O)NC1CC1 C[C@H](NC(=O)C1=CN2N=CN=C(NC3=C(C)C=CC(=C3)C(=O)NC3=CC=CC=C3)C2=C1C)C1=CC=CC=C1 CCNC(=O)C1=CN2N=CN=C(NC3=C(C)C=CC(=C3)C(=O)NC3=NC=CS3)C2=C1C CCNC(=O)C1=CN2N=CN=C(NC3=C(C)C=CC(=C3)C(=O)NC3=NC=C(C)S3)C2=C1C CCNC(=O)C1=CN2N=CN=C(NC3=C(C)C=CC(=C3)C(=O)NC3=NC=CO3)C2=C1C CCNC(=O)C1=CN2N=CN=C(NC3=C(C)C=CC(=C3)C(=O)NC3=NOC=C3)C2=C1C [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=NOC([H])=C1[H] CC(C)NC1=NC=C(S1)C1=NC(=NC=C1)C1=CC=CC=C1Cl CCCNC1=NC=C(S1)C1=CC(=NC(N)=N1)C1=C(F)C=CC=C1 CCCNC1=NC=C(S1)C1=CC(=NC(C)=N1)C1=C(F)C=CC=C1 CCCNC1=NC=C(S1)C1=CC(=NC(=N1)C1CC1)C1=C(F)C=CC=C1 CCCNC1=NC=C(S1)C1=CC=NC(=N1)C1CC1 CCCNC1=NC=C(S1)C1=CC=NC(=N1)C1=CC=CC=N1 CCCNC1=NC=C(S1)C1=CC(=NC(=N1)C1=CC=CC=N1)C1=CC=C(F)C=C1 CCCNC1=NC=C(S1)C1=CC(=NC(=N1)C1=CC=CC=N1)C1=C(F)C=CC=C1 CCCNC1=NC=C(S1)C1=CC(=NC(=N1)C1=CC=CC=N1)C1=C(Cl)C=CC=C1 CCCNC1=NC=C(S1)C1=CC(=NC(=N1)C1=CC=CC=N1)C1=C(OCC)C=CC=C1 CCCNC1=NC=C(S1)C1=CC(=NC(=N1)C1=CC=CC=N1)C1=C(Cl)C=C(F)C=C1 CCCNC1=NC=C(S1)C1=CC(=NC(=N1)C1=CC=CC=N1)C1=C(Cl)C=C(OCC)C=C1 NC1=NC=C(S1)C1=CC(=NC(=N1)C1=CC=CC=N1)C1=C(Cl)C=CC=C1 CCNC1=NC=C(S1)C1=CC(=NC(=N1)C1=CC=CC=N1)C1=C(Cl)C=CC=C1 ClC1=C(C=CC=C1)C1=NC(=NC(=C1)C1=CN=C(NC2CCC2)S1)C1=CC=CC=N1 CC(C)NC1=NC=C(S1)C1=CC(=NC(=N1)C1=CC=CC=N1)C1=C(Cl)C=CC=C1 CC[C@H](C)NC1=NC=C(S1)C1=CC(=NC(=N1)C1=CC=CC=N1)C1=C(Cl)C=CC=C1 CC(C)NC1=NC=C(S1)C1=CC(=NC=N1)C1=C(Cl)C=CC=C1 CC(C)NC1=NC=C(S1)C1=CC(=NC(N)=N1)C1=C(Cl)C=CC=C1 CC(C)NC1=NC=C(S1)C1=CC(=NC(=N1)N(C)C)C1=C(Cl)C=CC=C1 CC(C)NC1=NC=C(S1)C1=CC(=NC(NCCN(C)C)=N1)C1=C(Cl)C=CC=C1 CC(C)NC1=NC=C(S1)C1=CC(=NC(NCCO)=N1)C1=C(Cl)C=CC=C1 CC(C)NC1=NC=C(S1)C1=CC(=NC(NCC(O)CO)=N1)C1=C(Cl)C=CC=C1 CNC(=O)NCC1=C(C=CC=C1)C1=NC(NCCN(C)C)=NC(=C1)C1=CN=C(NC(C)C)S1 [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NC(=N1)N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])N=C(S1)N([H])C([H])(C([H])([H])[H])C([H])([H])[H] CC(C)NC1=NC=C(S1)C1=CC(=NC(NCCN(C)C)=N1)C1=C(CNC(=O)NC2CC2)C=CC=C1 CC(C)(C)C1=NN(C(NC(=O)NC2=C(Cl)C(Cl)=CC=C2)=C1)C1=CC=CC(CC(N)=O)=C1 NC(=O)CC1=CC(=CC=C1)N1N=C(C=C1NC(=O)NC1=C(Cl)C(Cl)=CC=C1)C1=CC=CC=C1 NC(=O)CC1=CC(=CC=C1)N1N=C(C=C1NC(=O)NC1=C(Cl)C(Cl)=CC=C1)C1=C(F)C=CC=C1 NC(=O)CC1=CC(=CC=C1)N1N=C(C=C1NC(=O)NC1=C(Cl)C(Cl)=CC=C1)C1=CC=CS1 NC(=O)CC1=CC(=CC=C1)N1N=C(C=C1NC(=O)NC1=C(Cl)C(Cl)=CC=C1)C1=CSC=C1 NC(=O)CC1=CC(=CC=C1)N1N=C(C=C1NC(=O)NC1=C(Cl)C(Cl)=CC=C1)C1CCCC1 CN1NC(=O)N(CC2=CC(=CC=C2)N2N=C(C=C2NC(=O)NC2=C3C=CC=CC3=CC=C2)C(C)(C)C)C1=O CC(C)(C)C1=NN(C(NC(=O)NC2=C3C=CC=CC3=CC=C2)=C1)C1=CC=CC(CN2NC(=O)C(C)(C)C2=O)=C1 CC(C)(C)C1=NN(C(NC(=O)NC2=CC=C(Cl)C=C2)=C1)C1=CC=CC(CNS(=O)(=O)NC(=O)N2CCCC2)=C1 CC(C)(C)C1=NN(C(NC(=O)NC2=CC=C(Cl)C=C2)=C1)C1=CC=CC(CCN)=C1 CNC(=O)CNC(=O)CNC(=O)C1=CC(=CC=C1)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C CC(C)(C)C1=NN(C(NC(=O)NC2=C3C=CC=CC3=CC=C2)=C1)C1=CC=CC(CC(=O)N2CCOCC2)=C1 CC(C)(C)C1=NN(C(NC(=O)NC2=CC=C(Cl)C=C2)=C1)C1=CC=CC(CC(N)=O)=C1 CC(C)(C)C1=NN(C(NC(=O)NC2=C3C=CC=CC3=CC=C2)=C1)C1=CC=C(CN2CCS(=O)(=O)CC2)C=C1 CC(C)(C)C1=NN(C(NC(=O)NC2=CC=C(Cl)C=C2)=C1)C1=CC=C(CN)C=C1 CC(C)(C)C1=NN(C(NC(=O)NC2=C3C=CC=CC3=CC=C2)=C1)C1=CC=C(CO)C=C1 CC(C)(C)C1=NN(C(NC(=O)NC2=C3C=CC=CC3=CC=C2)=C1)C1=CC=C(CCC(O)=O)C=C1 CC(C)(C)C1=NN(C(NC(=O)NC2=C(Cl)C(Cl)=CC=C2)=C1)C1=CC=C(CC(=O)N2CCS(=O)(=O)CC2)C=C1 CC(C)(C)C1=NN(C(NC(=O)NC2=C3C=CC=CC3=CC=C2)=C1)C1=CC=CC(CC(N)=O)=C1 [H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])(N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])O[H] [H]OC([H])([H])C([H])([H])C([H])(N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])O[H] [H]OC(=O)C([H])([H])C([H])([H])N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C(SC([H])([H])[H])=NC(=C2C2=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])Cl)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])Cl)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])Cl)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])Br)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])I)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C([H])=C([H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])C(F)(F)F)C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])S1)C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C(\F)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])OC1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C(O1)C([H])=C([H])C([H])=C2[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C(OC1([H])[H])C([H])=C([H])C([H])=C2[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])O1)C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=NN([H])C(=O)N1C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C(O[H])=C2C(O[C@]([H])(C3=C([H])C(O[H])=C(O[H])C(O[H])=C3[H])[C@]([H])(OC(=O)C3=C([H])C(O[H])=C(O[H])C(O[H])=C3[H])C2([H])[H])=C1[H] [H]OC1=C([H])C(O[H])=C2C(O[C@]([H])(C3=C([H])C(O[H])=C(O[H])C([H])=C3[H])[C@]([H])(OC(=O)C3=C([H])C(O[H])=C(O[H])C(O[H])=C3[H])C2([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)[C@@]1([H])C([H])([H])C2=C([H])C(OC3=C([H])C([H])=NC4=C3C([H])([H])C([H])([H])C(=O)N4[H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N([H])C(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(=O)N([H])[C@@]1([H])C([H])([H])C2=C([H])C(OC3=C([H])C([H])=NC4=C3C([H])([H])C([H])([H])C(=O)N4[H])=C([H])C([H])=C2C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C(C2=NC(=NN2[H])C([H])([H])[H])C(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(C2=NC(=NN2[H])C([H])([H])[H])C(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C2N=C([H])C([H])=NC2=C([H])C([H])=C1[H])C1=C(C2=NC(=NN2[H])C([H])([H])[H])C(=C([H])S1)C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C(=O)N([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(N([H])C2=NC([H])=NC(=C2[H])C2=C(N=C([H])C([H])=C2[H])N([H])C2=C([H])C(N([H])C(=O)C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)=C([H])C([H])=C2C([H])([H])[H])C([H])=C1[H] CC1=CC(C)=C2C=C3C=CC(CCC(=O)NCCCCC(=O)NCCOC4=CC=C(NC5=NC=NC(=N5)C5=C(NC6=CC(NC(=O)C7=CC=CC(=C7)C(F)(F)F)=CC=C6C)N=CC=C5)C=C4)=[N+]3[B](F)(F)N12 [H]N([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C(=O)N([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(N([H])C2=NC([H])=NC(=N2)C2=C(N=C([H])C([H])=C2[H])N([H])C2=C([H])C(N([H])C(=O)C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)=C([H])C([H])=C2C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC([H])([H])C([H])(N([H])C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C([H])([H])[H])C([H])([H])O[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C([H])([H])[H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C(F)C([H])=C(F)C([H])=C1[H])C(=O)N2C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N2C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N2C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C([H])C(F)=C1[H])C(=O)N2C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC3=C(C([H])=N2)C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2F)C(=O)N3C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C([H])C([H])=C1F)C(=O)N2C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C([H])([H])[H])C1([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(SC1=C([H])C([H])=C([H])C([H])=C1F)C(=O)N2C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=C2C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3F)C(=O)N(C2=N1)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=NC([H])=N1 [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1F)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C1([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N1C(=O)C(OC2=C([H])C([H])=C(F)C([H])=C2F)=C([H])C2=C1N=C(N=C2[H])N([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C([H])([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C1([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1C(=O)C(OC2=C([H])C([H])=C(F)C([H])=C2F)=C([H])C2=C1N=C(N=C2[H])N([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])N1C(=O)C(OC2=C([H])C([H])=C(F)C([H])=C2F)=C([H])C2=C1N=C(N=C2[H])N([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C([H])([H])C#N)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C([H])([H])[H])[C@]1([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C([H])([H])[H] [H]OC([H])([H])C(N([H])C1=NC2=C(C([H])=N1)C([H])=C(OC1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N2C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C2C(=N1)N(C(=O)N(C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C2([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC([H])=C3C(=N2)N([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2Cl)C3([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N1N=C(C(=C1[H])C1=C([H])C2=C([H])C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1N=C(C(=C1[H])C1=C([H])C2=C([H])C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1N=C(C(=C1[H])C1=C([H])C2=C(OC([H])([H])[H])C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1N=C(C(=C1[H])C1=C([H])C2=C(OC([H])([H])[H])C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])N2N=C(C(=C2[H])C2=C([H])C3=C([H])C([H])=C([H])N=C3C([H])=C2[H])C2=C([H])C([H])=C([H])C(=N2)C([H])([H])[H])=C1[H] [H]N(C(=O)C([H])([H])N1N=C([H])C(=C1C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C2=C([H])C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1N=C([H])C(=C1C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C2=C([H])C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1N=C([H])C(=C1C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])[H])C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1N=C([H])C(=C1C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])[H])C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])N2N=C([H])C(=C2C2=C([H])C([H])=C([H])C(=N2)C([H])([H])[H])C2=C([H])C3=C([H])C([H])=C([H])N=C3C([H])=C2[H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N1N=C(C(=C1[H])C1=C([H])C2=C([H])C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N1N=C(C(=C1[H])C1=C([H])C2=C([H])C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N1N=C(C(=C1[H])C1=C([H])C2=C(OC([H])([H])[H])C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N(C(=S)C([H])([H])N1N=C(C(=C1[H])C1=C([H])C2=C([H])C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)C([H])([H])N1N=C(C(=C1[H])C1=C([H])C2=C([H])C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N(C(=S)C([H])([H])C([H])([H])N1N=C(C(=C1[H])C1=C([H])C2=C([H])C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)C([H])([H])C([H])([H])N1N=C(C(=C1[H])C1=C([H])C2=C([H])C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N1C(=NC(=C1C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=C([H])N([H])C1=O)C1=NC(N([H])C([H])([H])[H])=C([H])N=C1[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@@]3([H])OC(OC3([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1C2=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C(=O)C1=C([H])C([H])=C(N([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C1C([H])([H])C2([H])[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C1C2=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C1C2=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(OC2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C3=O)=C(F)C([H])=C1F [H]OC([H])([H])[C@]([H])(O[H])C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C(=O)C1=C([H])C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3F)C([H])=C1C([H])([H])C2([H])[H] [H]C1=C(F)C([H])=C(F)C(OC2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])=C2C3=O)=C1[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1C2=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C(N([H])C3=C(F)C([H])=C(F)C([H])=C3[H])=C([H])C([H])=C1C2=O [H]OC([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C(N([H])C3=C(F)C([H])=C(F)C([H])=C3[H])=C([H])C([H])=C1C2=O [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C(N([H])C3=C(F)C([H])=C(F)C([H])=C3[H])=C([H])C([H])=C1C2=O [H]N([H])C1=C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C3=O)C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C(N([H])C3=C(N([H])[H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C1C2=O [H]N([H])C1=C([H])C(F)=C([H])C([H])=C1N([H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C2=O [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C2=O [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C2=O)C1=C([H])C([H])=C(F)C([H])=C1F [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C2=O)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C2=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C2=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C2=O [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C2=O)C1=C(Cl)C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C2=O)C1=C(C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C(F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C2=O [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C2=O)C1=C(F)C(F)=C([H])C(F)=C1[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C(=O)C1=C([H])C([H])=C(N([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C1C([H])([H])C2([H])[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C(=O)C1=C([H])C([H])=C(N([H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])C([H])=C1C([H])([H])C2([H])[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C(=O)C1=C([H])C([H])=C(N([H])C3=C(Cl)C([H])=C(F)C([H])=C3[H])C([H])=C1C([H])([H])C2([H])[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C(=O)C1=C([H])C([H])=C(N([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C1C([H])([H])C2([H])[H] [H]N([H])C1=C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[C@]4([H])OC(OC4([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2C3=O)C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C(=O)C1=C([H])C([H])=C(N([H])C3=C(N([H])[H])C([H])=C([H])C([H])=C3[H])C([H])=C1C([H])([H])C2([H])[H] [H]N([H])C1=C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])=C([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])=C2C3=O)C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C(=O)C1=C([H])C([H])=C(N([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])=C1C([H])([H])C2([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C(=O)C1=C([H])C([H])=C(N([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])=C1C([H])([H])C2([H])[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C1C2=O)C1=C([H])C([H])=C(F)C([H])=C1F [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[C@]3([H])OC(OC3([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1C2=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C(=O)C1=C([H])C([H])=C(N([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C1C([H])([H])C2([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C(=O)C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] CC(=O)C1=CC(=CC=C1C)C(=O)N[C](=O)(NCC1=CC=C(C=C1)N1N=C(C=C1NC(=O)NC1=CC=CC2=CC=CC=C12)C(C)(C)C)C1CCCC1 [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] CC1=C(C=C(C=C1)C(=O)N[C](=O)(NCC1=CC=C(C=C1)N1N=C(C=C1NC(=O)NC1=CC=CC2=CC=CC=C12)C(C)(C)C)C1CCCC1)C(O)=O CC1=CC=C(C=C1C(O)=O)C(=O)N[C](C)(=O)NCC1=CC=C(C=C1)N1N=C(C=C1NC(=O)NC1=CC=CC=C1)C(C)(C)C CC1=CC=C(C=C1C(O)=O)C(=O)N[C](=O)(N[C](C)(=O)NCC1=CC=C(C=C1)N1N=C(C=C1NC(=O)NC1=CC=CC=C1)C(C)(C)C)C1CCCC1 CC1=CC(=CC=C1C(O)=O)C(=O)N[C](C)(=O)NCC1=CC=C(C=C1)N1N=C(C=C1NC(=O)NC1=CC=CC=C1)C(C)(C)C [H]OC(=O)C1=C(C([H])=C([H])C(=C1[H])C(=O)[N+]1=C([H])C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C(=O)[N+]1=C([H])C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] ClC1=CC=C(C=C1)C1=C[N-]C(=N1)[C@@H]1CC2=CC=CC=[C]2=CN1 BrC1=CC=C(C=C1)C1=CNC(=N1)[C@@H]1CC2=CC=CC=[C]2=CN1 [H]C1=C([H])C2=C3OS(=O)(=O)N=C4C([H])=C([H])C5=NS(=O)(=O)OC(=C2C([H])=C1[H])C5=C34 ClC1=CC(=CC=C1)C1=CNC(=N1)[C@@H]1CC2=CC=CC=[C]2=CN1 [H]N(C(=O)C1=C([H])C(=NN(C2=C([H])C([H])=C(F)C([H])=C2[H])C1=O)C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F [H]N([H])C([H])([H])C([H])([H])C(=O)C1=C([H])C(OC2=C([H])C(=C([H])C([H])=C2[H])C(=O)C([H])([H])C([H])([H])N([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(N=C([H])N=C2C([H])=C1O[C@]1([H])C([H])([H])OC([H])([H])C1([H])[H])N([H])C1=C([H])C([H])=C(F)C(Cl)=C1[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C(OC([H])([H])[C@]3([H])OC(OC3([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1C2=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(C([H])=C3[H])C(=O)OC([H])([H])C([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(F)C(F)=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(OC(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C1=NN([H])C2=NC(OC3=C([H])C([H])=C(F)C([H])=C3F)=NC([H])=C12)[C@]([H])(C([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])[H] [H]N(C1=NN([H])C2=C1C([H])=NC(OC1=C(F)C([H])=C(F)C([H])=C1[H])=N2)[C@]1([H])C([H])([H])C([H])([H])S(=O)(=O)C1([H])[H] [H]N(C1=NN([H])C2=C1C([H])=NC(OC1=C(F)C([H])=C(F)C([H])=C1[H])=N2)C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NN([H])C2=C1C([H])=NC(OC1=C(F)C([H])=C(F)C([H])=C1[H])=N2)C1([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H] [H]N(C1=NN([H])C2=C1C([H])=NC(OC1=C(F)C([H])=C(F)C([H])=C1[H])=N2)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=NN([H])C2=NC(OC3=C([H])C([H])=C(F)C([H])=C3F)=NC([H])=C12)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NN([H])C2=C1C([H])=NC(OC1=C(F)C([H])=C(F)C([H])=C1[H])=N2)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NN([H])C2=C1C([H])=NC(OC1=C(F)C([H])=C(F)C([H])=C1[H])=N2)S(=O)(=O)C([H])([H])C([H])([H])[H] [H]N(C1=NN([H])C2=C1C([H])=NC(OC1=C(F)C([H])=C(F)C([H])=C1[H])=N2)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])C1=NN([H])C2=C1C([H])=NC(OC1=C(F)C([H])=C(F)C([H])=C1[H])=N2 [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NN([H])C2=C1C([H])=NC(OC1=C(F)C([H])=C(F)C([H])=C1[H])=N2 [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NN([H])C2=C1C([H])=NC(OC1=C(F)C([H])=C(F)C([H])=C1[H])=N2 [H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=NN([H])C2=C1C([H])=NC(OC1=C(F)C([H])=C(F)C([H])=C1[H])=N2 [H]N([H])C1=NN([H])C2=C1C([H])=NC(OC1=C(F)C([H])=C(F)C([H])=C1[H])=N2 [H]OC1=C([H])C(O[H])=C2C(=O)C(O[H])=C(OC2=C1[H])C1=C([H])C(O[H])=C(O[H])C([H])=C1[H] [H]OC1=C([H])C(O[H])=C2C(=O)C(O[H])=C(OC2=C1[H])C1=C([H])C(O[H])=C(O[H])C(O[H])=C1[H] [H]OC1=C([H])C([H])=C2C(=O)C(O[H])=C(OC2=C1[H])C1=C([H])C(O[H])=C(O[H])C([H])=C1[H] [H]OC1=C([H])C(OC([H])([H])[H])=C([H])C2=C1C(=O)C(O[H])=C(O2)C1=C([H])C(O[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C(O[H])=C2C(O[C@]([H])(C3=C([H])C(O[H])=C(O[H])C(O[H])=C3[H])[C@]([H])(OC(=O)C3=C(O[H])C(O[H])=C(O[H])C([H])=C3[H])C2([H])[H])=C1[H] [H]OC1=C([H])C(O[H])=C2C(O[C@]([H])(C3=C([H])C(O[H])=C(O[H])C(O[H])=C3[H])[C@@]([H])(O[H])C2([H])[H])=C1[H] [H]N(C(=O)C([H])([H])N1N=C(C(=C1[H])C1=C([H])C([H])=C2N=C([H])C([H])=NC2=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1N=C(C(=C1[H])C1=C([H])C([H])=C2N=C(C(=NC2=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1N=C(C(=C1[H])C1=C([H])C([H])=C2N=C([H])C([H])=NC2=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1N=C(C(=C1[H])C1=C([H])C([H])=C2N=C(C(=NC2=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1N=C([H])C(=C1C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C2N=C([H])C([H])=NC2=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])SC([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C1=NOC([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]2(C(=O)N([H])C3=C2C([H])=C([H])C(=C3[H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])[H])C(=O)N([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(F)=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H])C([H])([H])[H])C1=NOC([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=N1)C1(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=NC2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N=C1[H])C(C(=O)N2[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=NC2=C(C([H])=N1)C1(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])C1(C(=O)N([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O[H] [H]N([H])C1=C2C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=C(N([H])C2=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1N=C([H])C(=C1C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C2N=C(C(=NC2=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1N=C([H])C(=C1C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C2N=C([H])C([H])=NC2=C1[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]N(C(=O)C([H])([H])N1N=C([H])C(=C1C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C2N=C(C(=NC2=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N1N=C(C(=C1[H])C1=C([H])C([H])=C2N=C([H])C([H])=NC2=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N1N=C(C(=C1[H])C1=C([H])C([H])=C2N=C(C(=NC2=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N(C(=S)C([H])([H])N1N=C(C(=C1[H])C1=C([H])C([H])=C2N=C([H])C([H])=NC2=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)C([H])([H])N1N=C(C(=C1[H])C1=C([H])C([H])=C2N=C(C(=NC2=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=S)C([H])([H])N1N=C(C(=C1[H])C1=C([H])C([H])=C2N=C([H])C([H])=NC2=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N(C(=S)C([H])([H])N1N=C(C(=C1[H])C1=C([H])C([H])=C2N=C(C(=NC2=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])N2N=C(C(=C2[H])C2=C([H])C([H])=C3N=C([H])C([H])=NC3=C2[H])C2=C([H])C([H])=C([H])C(=N2)C([H])([H])[H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])N2N=C(C(=C2[H])C2=C([H])C([H])=C3N=C(C(=NC3=C2[H])C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C(=N2)C([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C(C2=C([H])C3=C(C([H])=C2[H])C2(C(=O)N3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C(F)C([H])=C1F)C([H])([H])OC1=C(Br)C(=O)N(C2=C([H])C(=C([H])C([H])=C2C([H])([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(N2C(=O)C(Br)=C(OC([H])([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C2C([H])([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(C(=C([H])C([H])=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C(=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])C([H])=C(C([H])=C1N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H])C(=O)N([H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])=C(Br)C(=O)N1C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C(=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]OC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C(N2C([H])=NC(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3F)=C(Cl)C2=O)=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)=C(Cl)C1=O)C([H])([H])[H] [H]OC([H])([H])[C@]([H])(O[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)=C(Cl)C1=O)C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)=C(Cl)C1=O)C([H])([H])[H] [H]N([H])C(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)=C(Cl)C1=O)C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)=C(Br)C1=O)C([H])([H])[H] [H]OC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)=C(C1=O)C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)=C(C1=O)C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)=C(Cl)C1=O)C([H])([H])[H] [H]OC(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])N2N=C([H])N=C(N([H])C3=C(C([H])=C([H])C(=C3[H])C(=O)N([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])[H])C2=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=NOC([H])=C1[H] [H]N(C(=O)OC([H])([H])[H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C(=N4)C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])N4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])N([H])C5=C4C([H])=C([H])C([H])=C5[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C#CC([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C(C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C(OC([H])([H])[H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=NC5=C([H])C([H])=C([H])C([H])=C5N=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])N(C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])N=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C(F)=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C([H])=N4)C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])N4C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C(=N4)C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C5=C(C([H])=C([H])C([H])=C5[H])N4C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C([H])=O)C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])N(C5=C4C([H])=C([H])C([H])=C5[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C(OC([H])([H])[H])C([H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C(F)C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])N([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])O4)C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C5=C(OC([H])([H])O5)C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(F)=C(N2C(=O)C(Br)=C(OC([H])([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C2C([H])([H])[H])C(F)=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C(Br)C(=O)N(C(=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=C([H])C(Cl)=C(N2C(=O)C(Br)=C(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2C([H])([H])[H])C(Cl)=C1[H] [H]C1=C([H])C(Cl)=C(N2C(=O)C(Br)=C(OC([H])([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C2C([H])([H])[H])C(Cl)=C1[H] [H]C1=C([H])C(=C(N2C(=O)C(Br)=C(OC([H])([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C2C([H])([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C(F)C([H])=C1F)C([H])([H])OC1=C(Br)C(=O)N(C(=C1[H])C([H])([H])[H])C1=C(F)C([H])=C(C([H])=C1F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C(F)C([H])=C1F)C([H])([H])OC1=C(Cl)C(=O)N(C(=C1[H])C([H])([H])[H])C1=C(F)C([H])=C(C([H])=C1F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C(F)C([H])=C1F)C([H])([H])OC1=C(Br)C(=O)N(C(=C1[H])C([H])([H])[H])C1=C(F)C([H])=C(C([H])=C1F)N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(F)=C(N2C(=O)C(Br)=C(OC([H])([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C2C([H])([H])[H])C(F)=C1[H] [H]OC([H])([H])C([H])([H])OC1=C([H])C(F)=C(N2C(=O)C(Br)=C(OC([H])([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C2C([H])([H])[H])C(F)=C1[H] [H]N([H])C(=O)C([H])([H])OC1=C([H])C(F)=C(N2C(=O)C(Br)=C(OC([H])([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C2C([H])([H])[H])C(F)=C1[H] [H]OC([H])([H])C1=C([H])C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])=C(Br)C(=O)N1C1=C(F)C([H])=C([H])C([H])=C1F [H]OC([H])([H])C1=C([H])C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])=C(Cl)C(=O)N1C1=C(F)C([H])=C([H])C([H])=C1F [H]C1=C([H])C(F)=C(N2C(=O)C(Br)=C(OC([H])([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(F)=C1[H] [H]C1=C([H])C(F)=C(N2C(=O)C(Cl)=C(OC([H])([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(F)=C1[H] [H]C1=C([H])C(F)=C(N2C(=O)C(Br)=C(OC([H])([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C2C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(F)=C1[H] [H]N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]N([H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]N([H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]N([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]N([H])C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C(F)C([H])=C1F)C([H])([H])OC1=C(Br)C(=O)N(C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(F)=C(N2C(=O)C(Cl)=C(OC([H])([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C2C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C([H])C(C2=C([H])C3=C(C([H])=C2[H])C2(C(=O)N3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=NN([H])C([H])=N1 [H]N(C(=O)C1=C([H])C(C2=C([H])C3=C(C([H])=C2[H])C2(C(=O)N3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=NOC([H])=C1[H] [H]N(C(=O)C1=C([H])C(C2=C([H])C3=C(C([H])=C2[H])C2(C(=O)N3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(C2=C([H])C3=C(C([H])=C2[H])C2(C(=O)N3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(C2=C([H])C3=C(C([H])=C2[H])C2(C(=O)N3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(C2=C([H])C3=C(C([H])=C2[H])C2(C(=O)N3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(C2=C([H])C3=C(C([H])=C2[H])C2(C(=O)N3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C(C2=C([H])C3=C(C([H])=C2[H])C2(C(=O)N3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(C2=C([H])C3=C(C([H])=C2[H])C2(C(=O)N3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C(F)=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1Cl)C1(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C(Cl)C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(C2=C([H])C3=C(C([H])=C2[H])C2(C(=O)N3[H])C([H])([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(C2=C([H])C3=C(C([H])=C2[H])C(C(=O)N3[H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(F)=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(F)=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(F)=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(F)=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(F)=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(F)=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])[H])C1=C([H])C(F)=C([H])C([H])=C1Cl)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=NN=C(N2C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(SC(=N1)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=C(N=C2[H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=C(N=C2[H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N(C1=NC2=C(N=C(N=C2[H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N(C1=NC2=C(N=C(N=C2[H])N([H])C([H])([H])C([H])([H])[H])N1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=C(N=C2[H])N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC3=C(N=C(N([H])C4=C(F)C([H])=C([H])C([H])=C4[H])N3C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=N2)C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC3=C(N=C(N([H])C4=C(F)C([H])=C([H])C([H])=C4[H])N3C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=N2)C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=C(N=C2[H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N1C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=C(N=C2[H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N1C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(N=C(N=C2[H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C(=NC3=C2N=C(N=C3[H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N2C(=NC3=C2N=C(N=C3[H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=C(N=C2[H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N1C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C(=NC3=C2N=C(N=C3[H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC3=C(N=C(N([H])C4=C(F)C([H])=C([H])C([H])=C4F)N3C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=N2)C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC3=C(N=C(N([H])C4=C(F)C([H])=C(F)C([H])=C4F)N3C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=N2)C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC3=C(N=C(N([H])C4=C(F)C([H])=C(F)C([H])=C4[H])N3C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=N2)C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=C(N=C2[H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C([H])N=C(N=C2N1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F [H]OC(C([H])([H])[H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC([H])=C3N=C(N([H])C4=C([H])C([H])=C(F)C([H])=C4F)N(C3=N2)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC([H])=C3N=C(N([H])C4=C([H])C([H])=C(F)C([H])=C4F)N(C3=N2)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C([H])N=C(N=C2N1C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F [H]N(C1=NC2=C([H])N=C(N=C2N1C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F [H]O[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC([H])=C3N=C(N([H])C4=C([H])C([H])=C(F)C([H])=C4F)N(C3=N2)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C2=NC([H])=C3N=C(N([H])C4=C([H])C([H])=C(F)C([H])=C4F)N(C3=N2)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC([H])=C3N=C(N([H])C4=C(F)C([H])=C(F)C([H])=C4F)N(C3=N2)[C@@]2([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC([H])=C3N=C(N([H])C4=C(F)C([H])=C(F)C([H])=C4F)N(C3=N2)[C@]2([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N2C(=NC3=C([H])N=C(N=C23)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C2=C(F)C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]N([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C(=NC3=C([H])N=C(N=C23)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C2=C(F)C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]N(C1=NC2=C([H])N=C(N=C2N1[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1F [H]N(C1=NC2=C([H])N=C(N=C2N1[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1F [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC([H])=C3N=C(N([H])C4=C([H])C([H])=C(F)C([H])=C4F)N(C3=N2)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC([H])=C3N=C(N([H])C4=C([H])C([H])=C(F)C([H])=C4F)N(C3=N2)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1(C(=O)N([H])C2=C([H])C([H])([H])[C@]([H])(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])C([H])=C([H])N=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H])C(F)(F)F [H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(SC([H])([H])[H])=C([H])C([H])=C1[H] [H]N1C2=C(C([H])=C([H])C(=C2[H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])[H])C2=NN=C(O2)C([H])([H])[H])C2(C1=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N1C2=C(C([H])=C([H])C(=C2[H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])[H])C2=NOC(=N2)C([H])([H])[H])C2(C1=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N1C2=C(C([H])=C([H])C(=C2[H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])[H])C2=NC(=NO2)C([H])([H])[H])C2(C1=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N1C(=NN=C1C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=NN=C1C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=NC([H])=C1C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=O)C2(C3=C1C([H])=C(C([H])=C3[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C1=C([H])N=C(N1[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H] [H]N1C([H])=NN=C1C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=NN=C1C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=NN=C1C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=NN=C1C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(C(=O)N2[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1C(=NN=C1C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=NN=C1C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C3(C(=O)N4[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NOC2=C(C([H])=C([H])C([H])=C12)C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NOC2=C(C([H])=C([H])C([H])=C12)C1=C([H])C2=C(C([H])=C1Cl)C1(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C(C(=O)N4[H])(C([H])([H])[H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C3(C(=O)N4[H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C3(C(=O)N4[H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C3([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N([H])C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C(C(=O)N4[H])(C([H])([H])[H])C([H])([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H] [H]N([H])C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C3(C(=O)N4[H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H] [H]N([H])C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C3(C(=O)N4[H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C3([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H] [H]N([H])C1=NN=C2N1C([H])=C([H])C(=C2C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C([H])S1 [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=NC([H])=C([H])S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C([H])S1 [H]N(C(=O)N([H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC(=C([H])S1)C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC(=C([H])S1)C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC(=C([H])S1)C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC(=C([H])S1)C([H])([H])C([H])([H])OC([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C([H])([H])C(=O)N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C(=O)N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])SC([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C(=O)N([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C(=O)N([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C#N)C2=C([H])C([H])=C([H])C([H])=C12)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C#N)C([H])=C1Cl)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(F)C(Cl)=C1Cl)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N([H])C(=O)C([H])([H])N1C(=O)C([H])([H])C([H])([H])N(C(=O)C2=C(SC(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1([H])[H])C([H])([H])[C@@]1([H])OC(OC1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])N(C(=O)C2=C(SC(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1([H])[H])C([H])([H])C1=NN([H])N=N1 [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(F)C(Cl)=C1Cl)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C(C3=C([H])C([H])=C(F)C([H])=C3F)=C3C(=C2[H])N(C(=O)C([H])([H])C3([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]C1=NC(=C2N=C([H])C([H])=C(C2=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=NC2=C(C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]C1=NC2=C(C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]C1=NC2=C(C3=C(Cl)C([H])=C([H])C([H])=C3[H])[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]C1=NC2=C(C3=C(F)C([H])=C([H])C([H])=C3[H])[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]C1=NC2=C(C3=C(C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])[H])[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]C1=NC2=C(C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3OC([H])([H])[H])[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]C1=NC2=C(C3=C(Cl)C([H])=C([H])C([H])=C3Cl)[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]C1=NC2=C(C3=C(F)C([H])=C([H])C([H])=C3F)[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C(=C(C([H])=C1[H])C1=C2N=C([H])C([H])=C(C2=C([H])C([H])=[N+]1[O-])C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]C1=NC2=C(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])=C3C([H])([H])[H])[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C1=C2N=C([H])C([H])=C(C2=C([H])C([H])=[N+]1[O-])C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=C([H])C([H])=C(C2=C3N=C([H])C([H])=C(C3=C([H])C([H])=[N+]2[O-])C2=C(F)C([H])=C(F)C([H])=C2[H])C(=C1[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]C1=NC2=C(C3=C(F)C([H])=C([H])C([H])=C3F)[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]C1=NC2=C(C3=C(Cl)C([H])=C([H])C([H])=C3Cl)[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]C1=NC2=C(C3=C(Cl)C([H])=C([H])C([H])=C3Cl)[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1Cl [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C(C3=C([H])C([H])=C(F)C([H])=C3F)=C3C([H])=C([H])[N+]([O-])=C(C3=N2)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=NC3=C(C4=C(Cl)C([H])=C([H])C([H])=C4Cl)[N+]([O-])=C([H])C([H])=C3C(=C2[H])C2=C([H])C([H])=C(F)C([H])=C2Cl)C([H])([H])C1([H])[H] [H]C1=C([H])C(Cl)=C(C(Cl)=C1[H])C1=C2N=C(C([H])=C(C3=C([H])C([H])=C(F)C([H])=C3Cl)C2=C([H])C([H])=[N+]1[O-])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=NC2=C(C3=C(Cl)C([H])=C([H])C([H])=C3Cl)[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1Cl [H]C1=C([H])C([H])=C(C([H])=N1)C1=NC2=C(C3=C(Cl)C([H])=C([H])C([H])=C3Cl)[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1Cl [H]N1C([H])([H])C([H])([H])C([H])(C2=NC3=C(C4=C(F)C([H])=C([H])C([H])=C4F)[N+]([O-])=C([H])C([H])=C3C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C1=C([H])C(=NC2=C(C3=C(F)C([H])=C([H])C([H])=C3F)[N+]([O-])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C3=C(F)C([H])=C([H])C([H])=C3F)[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C1=C([H])C(=NC2=C(C3=C(F)C([H])=C([H])C([H])=C3F)[N+]([O-])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C4=C(Cl)C([H])=C([H])C([H])=C4Cl)[N+]([O-])=C([H])C([H])=C3C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C3=C(Cl)C([H])=C([H])C([H])=C3Cl)[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C3=C(Cl)C([H])=C([H])C([H])=C3Cl)[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1([H])C([H])([H])C(N(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(OC2=NC3=C(C4=C(Cl)C([H])=C([H])C([H])=C4Cl)[N+]([O-])=C([H])C([H])=C3C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C1=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])=NC2=C(C3=C(Cl)C([H])=C([H])C([H])=C3Cl)[N+]([O-])=C([H])C([H])=C12 [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1SC1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1SC1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1Cl)N1N=C(C([H])=C1N([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1SC1=C([H])N2C(=NN=C2C2=C([H])C([H])=C([H])C([H])=C2SC([H])([H])C([H])([H])O[H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])N=C(N=C2N([H])C([H])([H])[H])N([H])C([H])([H])[H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])N=C(N=C2OC([H])([H])[H])N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])N=C(N=C2OC([H])([H])[H])N([H])C([H])([H])[H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])N=C(N=C2OC([H])([H])[H])N([H])C([H])([H])[H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N(C(=O)C2=C([H])C([H])=C(Br)C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H] [H]OC([H])([H])C1=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Br)=C([H])C([H])=C2C(=O)N1C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N(C(=O)C2=C([H])C([H])=C(Br)C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N(C(=O)C2=C([H])C([H])=C(Br)C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N(C(=O)C2=C([H])C([H])=C(Br)C([H])=C12)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)OC([H])([H])[H] [H]OC(=O)C1=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Br)=C([H])C([H])=C2C(=O)N1C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(Cl)=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(N([H])C2=C([H])C([H])=C(C(=C([H])[H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C(Cl)=C2[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(N([H])C2=C([H])C([H])=C(C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C(Cl)=C2[H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(Cl)=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C(N([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])[H])C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(N([H])C2=C([H])C([H])=C(C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C(Cl)=C2[H])C([H])=C([H])C(Br)=C1[H] [H]N([H])C1=C(C([H])=C([H])C([H])=C1[H])N(C1=C([H])C([H])=C(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(Cl)=C1[H])C([H])([H])[H] [H]N([H])C1=C(N([H])C2=C([H])C([H])=C(C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C(Cl)=C2[H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(N([H])C2=C([H])C([H])=C(C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C(Cl)=C2[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(N([H])C2=C([H])C([H])=C(C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C(=C2[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(Cl)=C1[H])C1=C(C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C(N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)C2=C(Br)C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C(N([H])C2=C([H])C([H])=C(C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C(Cl)=C2[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(N([H])C2=C([H])C([H])=C(C(=O)C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C(Cl)=C2[H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)OC([H])([H])C([H])([H])[H])C1=C(N([H])C2=C([H])C([H])=C(C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C(Cl)=C2[H])C([H])=C([H])C([H])=C1[H] [H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1Cl [H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C([H])([H])[H])C2=C(F)C([H])=C(F)C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C2=C([H])C([H])=C(F)C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(Cl)C([H])=C([H])C([H])=C2C(F)(F)F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(Cl)C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(N=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(F)C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])C1=NC2=C(N=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(F)C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(N=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(F)C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(F)C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(F)C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC(=C1C1=C([H])C2=C(N=C(N2C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(F)C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC(=C1C1=C([H])C2=C(N=C([H])N2C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N(C1=NC2=C(N1[H])C([H])=C(C([H])=C2[H])C1=C(N=C(N1[H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]O\N=C(/C(=O)N([H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(N1[H])C([H])=C(C([H])=C2[H])C1=C(N=C(N1[H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=NC2=C1C([H])=C(C([H])=C2[H])C1=C(N=C(N1[H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=NC(=C1C1=C([H])C2=C(N=C(N(C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])N2S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N(C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(F)C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C([H])C(=O)N2C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C([H])C(=O)N2C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N([H])C(C(=O)N([H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C([H])C(=O)N2C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)(C([H])([H])[H])C([H])([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]OC1=C([H])C2=C(C([H])=C([H])C(=O)N2C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]O[C@@]1([H])C(=O)N(C2=C(C(=C([H])C(OC([H])([H])[H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C([H])C(=O)N2C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C([H])C(=O)N2C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C([H])C(=O)N2C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N([H])C1(C(=O)N([H])C([H])([H])C([H])([H])OC2=C([H])C3=C(C([H])=C([H])C(=O)N3C3=C(Cl)C([H])=C([H])C([H])=C3Cl)C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]OC1=C([H])C2=C(C([H])=C(O[H])C(=O)N2C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]OC1=C([H])C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2Cl)N(C1=O)C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]OC1=C([H])C2=C(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])[C@@]([H])(O[H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C2=C1C([H])=C([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]O[C@@]1([H])C(=O)N(C2=C(C(=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1N=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)OC([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C([H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])N2N=C([H])N=C(N([H])C3=C([H])C(N([H])C(=O)C4=C([H])C(F)=C([H])C(=C4[H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C([H])C([H])=C3C([H])([H])[H])C2=C1C([H])([H])[H] [H]OC(=O)C1=C([H])N2N=C([H])N=C(N([H])C3=C([H])C(N([H])C(=O)C4=C([H])C(F)=C([H])C(=C4[H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C([H])C([H])=C3C([H])([H])[H])C2=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C1=NC([H])=C2C(=O)N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])N3C2=N1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C2C(=O)N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])N3C2=N1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C1=NC([H])=NC(=N1)N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C1=NC([H])=NC(=N1)N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)ON1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1OC(=O)C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1OC(=O)C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)N1OC(=O)C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H] [H]N(C(=S)N1OC(=O)C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N1OC(=O)C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N1OC(=O)C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)ON1C(=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)ON1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)ON1C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])N1OC(=O)C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])N1OC(=O)C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)ON1C([H])([H])C([H])([H])SC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)ON1C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)ON1C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)ON1C([H])([H])[C@@]1([H])OC1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)ON1C([H])([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(O[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)[C@]([H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1 [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(O1)C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=NC(=C1C1=C([H])C([H])=NC(F)=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N1C(SC([H])([H])C([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(F)=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(F)=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N1C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=NC(=C1C1=C([H])C([H])=NC(Cl)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])C([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(Cl)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=NC(=C1C1=C([H])C([H])=NC(F)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])C([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(F)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(Cl)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(F)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NN([H])C2=NN=C(C([H])=C12)C1=C2C([H])=C([H])C([H])=C([H])N2N=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C1=NOC([H])=C1[H] [H]N([H])C1=NC(N([H])C2=C(C([H])=C([H])C(=C2[H])C(=O)N([H])C([H])([H])[H])C([H])([H])[H])=C2C([H])=NN(C2=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C1=NN(C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C1=NN([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2F)=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C([H])C([H])=C([H])C([H])=N2)=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC(=N2)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC(=N2)N([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC(=N2)C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC(OC([H])([H])[H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC(=N2)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC(=N2)N(C([H])([H])[H])C([H])([H])C([H])([H])C#N)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC(=N2)N([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C([H])N=C(N=C2N1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C1=C([H])N([H])C([H])=N1 [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C1=NC([H])=C(N1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C1=NC([H])=C([H])N1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C1=C2N([H])C([H])=NC2=NC([H])=N1 [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=NC(Cl)=NC([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C(F)=C([H])C(=C1OC1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N([H])C(=O)N([H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1OC1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(F)(F)F)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1OC1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C(F)=C([H])C(Cl)=C1OC1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(=C(S1)C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H] [H]N(C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]N(C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H] [H]N(C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1F [H]N(C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]N(C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1[H] [H]N(C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N(C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(C#N)=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(C#N)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C(OC([H])([H])[H])C(C#N)=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C(OC([H])([H])[H])C(Cl)=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C(OC([H])([H])[H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C(OC([H])([H])[H])C(=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]O\N=C(\C(=O)N([H])C1=C(OC([H])([H])[H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]O[C@@]([H])(C(=O)N([H])C1=C(OC([H])([H])[H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C(OC([H])([H])[H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=C(OC([H])([H])[H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(N([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])=C1[H])C1=C(OC([H])([H])[H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(N([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])=C1[H])C1=C(OC([H])([H])[H])C(C#N)=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC2=C([H])C([H])=NC(=N2)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C(OC([H])([H])[H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H])C1=C(OC([H])([H])[H])C(C#N)=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C(OC([H])([H])[H])C(C#N)=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C1=C([H])C([H])=C(F)N=C1[H])C1=C(OC([H])([H])[H])C(C#N)=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C1=C([H])C([H])=NC(=C1[H])C([H])([H])[H])C1=C(OC([H])([H])[H])C(C#N)=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(N([H])C2=C([H])C([H])=NC(=N2)N([H])C([H])([H])[H])C([H])=C1[H])C1=C(OC([H])([H])[H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C(S1)C1=NC(=NC(=C1[H])C1=C(Cl)C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C(S1)C1=NC(=NC(=C1[H])C1=C(Cl)C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C(S1)C1=NC(=NC(=C1[H])C1=C(Cl)C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C1=NC([H])=C([H])N=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H])C1=C([H])C([H])=NO1 [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=NO1)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])N1C(=O)C2=C(N=C1C([H])([H])[H])C([H])=C([H])C(=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])N1C(=O)C2=C(N=C1C([H])([H])[H])C([H])=C([H])C(=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])N1C(=O)C2=C(N=C1C([H])([H])[H])C([H])=C([H])C(=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=NC([H])=C([H])S1)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])OC([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])OC([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])N1C(=O)C2=C(N=C1C([H])([H])[H])C([H])=C([H])C(=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H])C1=NC([H])=C([H])S1 [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H])C1=NC([H])=C(S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H])C1=NOC([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])SC([H])=N1)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C([H])S1)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H])C1=NN=C([H])S1 [H]N(C1=NC2=C(N=C([H])N2C2=NN([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=N1)C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)C2=C([H])C([H])=C([H])C([H])=C2O1)C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)C2=C([H])C([H])=C([H])C([H])=C2O1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(=C([H])C(Cl)=N1)C1=C(C(=O)C2=C([H])C([H])=C([H])C([H])=C2O1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)C2=C([H])C([H])=C([H])C([H])=C2O1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)C2=C([H])C([H])=C([H])C([H])=C2O1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)C2=C([H])C([H])=C([H])C([H])=C2O1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)C2=C([H])C([H])=C([H])C([H])=C2O1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)C2=C([H])C([H])=C([H])C([H])=C2O1)C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)C2=C([H])C([H])=C([H])C([H])=C2O1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C3=C(C([H])=C([H])C2=C1[H])N1C(S3)=NN=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C2OC([H])([H])OC2=C([H])C(=C1[H])C1=NN(C2=NC(=O)N(C(=O)C2=N1)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(F)=C([H])C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(Cl)=C([H])C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=C([H])C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(F)=C([H])C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(F)=C([H])C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])SC(=N1)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(F)=C([H])C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(F)=C([H])C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C1=C(C(F)=C([H])C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C1=C(C(F)=C([H])C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C1=C(C(F)=C([H])C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=N1)C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C(F)C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)N(C1=NC(=NC([H])=C1[H])N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N([H])N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=NC(=NC([H])=C1[H])N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H] [H]N(C(=O)N(C1=NC(=NC([H])=C1[H])N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)N(C1=C([H])C([H])=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])[C@@]([H])(N([H])C1=NC([H])=C([H])C(=N1)N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N(C1=NC(=NC([H])=C1[H])N([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C(=O)N(C1=NC(=NC([H])=C1[H])N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N(C1=NC(=NC([H])=C1[H])N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)N(C1=NC(=NC([H])=C1[H])N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)N(C1=NC(=NC([H])=C1[H])N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F [H]N(C(=O)N(C1=NC(=NC([H])=C1[H])N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]OC(C([H])([H])[H])(C([H])([H])[H])[C@@]([H])(N([H])C1=NC([H])=C([H])C(=N1)N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])[C@@]([H])(N([H])C1=NC([H])=C([H])C(=N1)N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N(C1=NC(=NC([H])=C1[H])N([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])[C@@]([H])(N([H])C1=NC([H])=C([H])C(=N1)N(C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N(C1=NC(=NC([H])=C1[H])N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N(C1=NC(=NC([H])=C1[H])N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])[C@@]([H])(N([H])C1=NC([H])=C([H])C(=N1)N(C(=O)N([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N(C1=C([H])C([H])=NC(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N(C1=NC(=NC([H])=C1[H])N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C(=O)N(C1=NC(=NC([H])=C1[H])N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1=NC([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C12 [H]C1=C([H])C(Cl)=C([H])C(=C1[H])C1=NC([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C12 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C(N1[H])C1=C2C([H])=C(N([H])C2=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C2=NC([H])=C([H])C(C3=C(N=C(N3[H])C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C2C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=NC([H])=C([H])C(C3=C(N=C(N3[H])C3=C([H])C([H])=C(C([H])=C3[H])[S@+]([O-])C([H])([H])[H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C2C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=NC([H])=C([H])C(C3=C(N=C(N3[H])C3=C([H])C([H])=C(SC([H])([H])[H])C([H])=C3[H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C2C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=NC([H])=C([H])C(C3=C(N=C(N3[H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C2C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=NC([H])=C([H])C(C3=C(N=C(N3[H])C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C2C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])N=C12)C1=C(N=C(N1C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])=NC2=C(N=C([H])N=C12)C1=C(N=C(N1C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(=NC(=C1C1=C2C([H])=C(N([H])C2=NC([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=NC([H])=C([H])C(C3=C(N=C(N3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C2C([H])=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=NC([H])=C([H])C(C3=C(N=C(N3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C2C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=NC([H])=C([H])C(C3=C(N=C(N3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C2C2=C1C([H])=C([H])C([H])=C2[H] [H]N1C(=NC(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])N=C12)C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])=C([H])C2=C(N=C([H])N=C12)C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C([H])=NC2=C(N=C([H])N=C12)C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=O [H]N(C(=O)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C2=O [H]N(C(=O)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C([H])C([H])=C1F [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)C1=C([H])OC([H])=C1[H])C1=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C([H])C([H])=C1F [H]N(C(=O)C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])SC([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)C1=C([H])OC([H])=C1[H])C1=C(F)C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)C1=C([H])OC([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C([H])C([H])=C1F [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(S1)C([H])([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C1[H] [H]N(C(=O)C1=C([H])SC([H])=C1[H])C1=C([H])C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C(C([H])=C1F)C([H])([H])[H] [H]N(C(=O)C1=C([H])SC([H])=C1[H])C1=C([H])C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C([H])C([H])=C1F [H]N(C(=O)C1=C([H])SC([H])=C1[H])C1=C([H])C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])SC([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C1[H] [H]N(C(=O)C1=C([H])OC([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C1[H] [H]N(C(=O)C1=C([H])SC([H])=C1[H])C1=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C(C([H])=C1F)C([H])([H])[H] [H]N(C(=O)C1=C([H])SC([H])=C1[H])C1=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C([H])C([H])=C1F [H]N(C(=O)C1=C([H])SC([H])=C1[H])C1=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])SC([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]C1=C([H])C(Cl)=C(C(Cl)=C1[H])C1=C2C([H])=C([H])C(SC3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])=NN2C([H])=NC1=O [H]C1=C([H])C([H])=C(C(SC2=NN3C([H])=NC(=O)C(=C3C([H])=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])C(F)=C([H])C([H])=C1SC1=NN2C([H])=NC(=O)C(=C2C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=NC(=O)C(=C2C([H])=C([H])C(SC3=C([H])C([H])=C([H])C([H])=C3[H])=NN12)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C([H])=C(SC2=NN3C([H])=NC(=O)C(=C3C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C(SC2=NN3C([H])=NC(=O)C(=C3C([H])=C2[H])C2=C(F)C([H])=C([H])C([H])=C2C(F)(F)F)C([H])=C1[H] [H]C1=C([H])C([H])=C(SC2=NN3C([H])=NC(=O)C(=C3C([H])=C2[H])C2=C(F)C([H])=C([H])C([H])=C2F)C([H])=C1[H] [H]C1=C([H])C([H])=C(SC2=NN3C([H])=NC(=O)C(=C3C([H])=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]C1=NC(=O)C(=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3[H])=NN12)C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=NC(=O)C(=C2C([H])=C([H])C(SC3=C([H])C([H])=C([H])C(F)=C3[H])=NN12)C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=C([H])C(Cl)=C([H])C(SC2=NN3C([H])=NC(=O)C(=C3C([H])=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C1[H] [H]C1=C([H])C(=C([H])C(SC2=NN3C([H])=NC(=O)C(=C3C([H])=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C1[H])C([H])([H])[H] [H]C1=C([H])C(SC2=NN3C([H])=NC(=O)C(=C3C([H])=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C(C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C([H])=C1SC1=NN2C([H])=NC(=O)C(=C2C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=C([H])C(Cl)=C(C(Cl)=C1[H])C1=C2C([H])=C([H])C(SC3=C([H])C([H])=C(Cl)C(Cl)=C3[H])=NN2C([H])=NC1=O [H]C1=C([H])C(Cl)=C(C(Cl)=C1[H])C1=C2C([H])=C([H])C(SC3=C([H])C([H])=C(C(=C3[H])C([H])([H])[H])C([H])([H])[H])=NN2C([H])=NC1=O [H]C1=NC(=O)C(=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C(Cl)=C3[H])=NN12)C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=NC(=O)C(=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3Cl)=NN12)C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=C([H])C(Cl)=C(C(Cl)=C1[H])C1=C2C([H])=C([H])C(SC3=C([H])C([H])=C(Cl)C([H])=C3C([H])([H])[H])=NN2C([H])=NC1=O [H]C1=C([H])C(Cl)=C(C(Cl)=C1[H])C1=C2C([H])=C([H])C(SC3=C([H])C([H])=C(C([H])=C3C([H])([H])[H])C([H])([H])[H])=NN2C([H])=NC1=O [H]N=C1N([H])C(=C([H])C(=C1C#N)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N=C1N([H])C(=C([H])C(C2=C([H])C([H])=C(O2)C([H])([H])[H])=C1C#N)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N=C1N([H])C(=C([H])C(=C1C#N)C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N=C1N([H])C(=C([H])C(=C1C#N)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N=C1N([H])C(=C([H])C(C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])=C1C#N)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N=C1N([H])C(=C([H])C(=C1C#N)C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N1C(=O)C(C#N)=C(C([H])=C1C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N1C(=O)C(C#N)=C(C([H])=C1C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N1C(=O)C(C#N)=C(C([H])=C1C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] OCCNC(=O)C1=CC2=C(NCC1)N=CN=C2NC1=CC(Cl)=C(OC2=CC=CC3=C2C=CS3)C=C1 [O-][N+](=O)C1=C(C=CC=C1)C1=NNC=C1\C=C1/C(=O)NC2=CC=CC=C12 CN(C)C1=NC(=NC2=CC=C(C=C12)C1=CNN=C1)[C@@H]1CNC[C@H]1C1=CC=CC=C1 COC1=CC=C(C=C1)[C@@H]1CN(C)C[C@H]1C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 NCC1=CC=C(C=C1)C(=O)NC(C1=CC=C(Cl)C=C1)C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 CN(C)CC(=O)NC(C1=CC=C(Cl)C=C1)C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 ClC1=CC=C(C=C1)[C@@H]1CNC[C@H]1C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 COC1=C2N=C(NC(=O)C2=CC(=C1)C1=CNN=C1)C(N)C1=CC=CC(Cl)=C1 NC(C1=CC=CC(Cl)=C1)C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 COC1=CC=C(C[C@H](N)C2=NC3=CC=C(C=C3C(=O)N2)C2=CNN=C2)C=C1 COC1=C2N=C(NC(=O)C2=CC(=C1)C1=CNN=C1)[C@H](N)CC1=CC=CC(F)=C1 N[C@H](CC1=CC=C(F)C=C1)C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 N[C@@H](CC1=CC=C(Cl)C=C1)C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 O=C1NC(=NC2=CC=C(C=C12)C1=CNN=C1)[C@@H]1CNC[C@H]1C1=CC=CC=C1 COC1=CC=C(C=C1)C(N)C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 CN1N=C(NC(=O)NC2=CC(=C(CN3CCN(C)CC3)C=C2)C(F)(F)F)C=C1C#CC1=CN=C2C=CC=NN12 CN1N=C(NC(=O)NC2=CC(=C(CN3CCN(C)CC3)C=C2)C(F)(F)F)C=C1C#CC1=CN=C2C=NC=CN12 CN1CCN(CC2=C(C=C(NC(=O)C3=CC=C(C)C(=C3)C#CC3=CN=CC4=NC=CN34)C=C2)C(F)(F)F)CC1 CN1N=C(NC(=O)NC2=CC(=C(CN3CCN(C)CC3)C=C2)C(F)(F)F)C=C1C#CC1=CN=CC2=NC=CN12 CCOC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 CN(C)CCNC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 FC1=CC(F)=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(=C2)C(=O)NCCN2CCOCC2)C=C1 CS(=O)(=O)CCNC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 FC1=CC(F)=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(=C2)C(=O)NCCCl)C=C1 CNC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 OCCOC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 COC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 OCC(O)CNC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 CSCCNC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 FCCNC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 CC1(C)OC[C@H](COC2=CC3=C(CCC4=C(C=CC(NC5=CC=C(F)C(NC(=O)C6=CC=CS6)=C5)=C4)C3=O)C=C2)O1 OCCOC1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=CC(NC(=O)C5=CC=CC=C5)=C4)=C3)C2=O)C=C1 OCCOC1=CC2=C(CCC3=C(C=CC(NC4=CC=C(F)C(NC(=O)C5=CC=CC=C5)=C4)=C3)C2=O)C=C1 OC[C@H](O)COC1=CC2=C(CCC3=C(C=CC(NC4=CC=C(F)C(NC(=O)C5=CC=CC=C5)=C4)=C3)C2=O)C=C1 FC1=CC(F)=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(=C2)C(=O)OCCN2CCOCC2)C=C1 FC1=CC(F)=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(OCCN3CCOCC3)=C2)C=C1NC(=O)C1=CC=CC=C1 CC1=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(OCCN3CCOCC3)=C2)C=C(NC(=O)C2=COC=C2)C(F)=C1 FC1=CC=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(OCCN3CCOCC3)=C2)C=C1NC(=O)C1=COC=C1 FC1=CC=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(OCCN3CCOCC3)=C2)C=C1NC(=O)C1=CC=CC=C1 FC1=CC=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(OCCN3CCOCC3)=C2)C=C1NC(=O)C1=CC=CS1 FC1=CC=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(OCCN3CCOCC3)=C2)C=C1NC(=O)C1=CSC=C1 FC1=CC=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(=C2)C(=O)NCCN2CCOCC2)C=C1NC(=O)C1=CC=CC=C1 C[C@@H](NC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1)C1CCCCC1 COC1=CC2=C(CCC3=C(C=CC(NC4=CC=C(F)C(NC(=O)C5=CC=CC=C5)=C4)=C3)C2=O)C=C1 CC(=O)OC1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 OCCOC1=CC2=C(CCC3=C(C=CC(NC4=CC=C(F)C(NC(=O)C5CCOC5)=C4)=C3)C2=O)C=C1 CC1=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(OCCN3CCOCC3)=C2)C=C(NC(=O)C2CCOC2)C(F)=C1 OC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 COC(=O)[C@H](CC(C)C)NC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 CC1(C)OC[C@@H](COC2=CC3=C(CCC4=C(C=CC(NC5=CC=C(F)C(NC(=O)C6=CC=CC=C6)=C5)=C4)C3=O)C=C2)O1 FC1=CC(F)=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC=C2)C=C1NC(=O)C1=CC=CC=C1 CCCOC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 FC1=CC(F)=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(OCCN3CCOCC3)=C2)C=C1NC(=O)C1CCOC1 CCOC(=O)CNC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 CC(C)C[C@H](NC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1)C(O)=O CNC(=O)CC[C@H](NC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1)C(=O)NC COCCNC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 FC1=CC(F)=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(=C2)C(=O)N2CCOCC2)C=C1 OC[C@@H](O)COC1=CC2=C(CCC3=C(C=CC(NC4=CC=C(F)C(NC(=O)C5=CC=CS5)=C4)=C3)C2=O)C=C1 CN1CCN(CCNC(=O)C2=CC3=C(CCC4=C(C=CC(NC5=C(F)C=C(F)C=C5)=C4)C3=O)C=C2)CC1 OCCNC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 CN1CCN(CCCNC(=O)C2=CC3=C(CCC4=C(C=CC(NC5=C(F)C=C(F)C=C5)=C4)C3=O)C=C2)CC1 NC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 COC(=O)CC[C@H](NC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1)C(=O)OC OCC(CO)NC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 FC1=CC(F)=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(OCCN3CCOCC3)=C2)C=C1NC(=O)C1=CSC=C1