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[H]N([H])C([H])([H])C(=O)N([H])[C@@]([H])(C1=NN=C(N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12
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[H]N(C(=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12
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[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(N([H])[H])=C(C2=C([H])C([H])=C(N([H])C([H])([H])C3=C([H])C([H])=NC(Cl)=C3[H])C([H])=C2[H])C(=N1)C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC(N([H])[H])=C(C2=C([H])C([H])=C(N([H])C([H])([H])C3=C([H])SC(Cl)=C3[H])C([H])=C2[H])C(=N1)C([H])([H])C([H])([H])[H]
[H]N([H])C([H])([H])C(=O)N([H])[C@@]([H])(C1=NN=C(N1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])SC(Cl)=C2[H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@]1([H])N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12
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[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])[H]
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[H]N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12
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[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
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[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H]
[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
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[H]N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H]
[H]N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])N=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])N=C([H])S2)C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C(ON=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1N=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C3C([H])=C([H])N([H])C3=C2[H])[C@@]([H])(C([H])([H])[H])C1([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C(F)=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(N=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(N=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=N2)C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])SC(=N2)C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C(F)=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C(F)=C2[H])C2=C(F)C([H])=NC([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C(F)C([H])=NC([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C(OC(F)(F)F)=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2F)C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C(=C1[H])C1=NC2=C(C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C(=O)N1C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C(OC2=C([H])C3=C(N=C(N(C3=O)C([H])([H])[C@]3([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])=C([H])C([H])=C1F
[H]C1=NC2=C(C([H])=C1OC1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N(C(=N2)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=NC2=C(C([H])=C1OC1=C([H])C([H])=C(Br)C([H])=C1F)C(=O)N(C(=N2)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C3=C(N=C2[H])N=C(N(C3=O)C([H])([H])[C@]2([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(OC2=NC3=C(N=C(N(C3=O)C([H])([H])[C@]3([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])=C([H])C([H])=C1F
[H]C1=C([H])C2=C(N=C1OC1=C([H])C([H])=C(Cl)C([H])=C1F)C(=O)N(C(=N2)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C2OC([H])([H])OC2=C([H])C(OC2=NC3=C(N=C(N(C3=O)C([H])([H])[C@]3([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])=C1[H]
[H]C1=NC2=C([H])C([H])=C(OC3=NC4=C(N=C(N(C4=O)C([H])([H])[C@]4([H])C([H])([H])N(C([H])([H])C([H])([H])C4([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C3[H])C([H])=C2S1
[H]C1=C([H])C2=C(N=C1OC1=C([H])C([H])=C(Br)C([H])=C1F)C(=O)N(C(=N2)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])N=C2C(OC2=NC3=C(N=C(N(C3=O)C([H])([H])[C@]3([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])=C1[H]
[H]C1=C([H])C([H])=C2C(F)=C([H])C([H])=C(OC3=NC4=C(N=C(N(C4=O)C([H])([H])[C@]4([H])C([H])([H])N(C([H])([H])C([H])([H])C4([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C3[H])C2=N1
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC2=NC3=C(N=C(N(C3=O)C([H])([H])[C@]3([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]C1=NC(OC2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C2=C1N=C(N(C2=O)C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(OC2=C([H])C([H])=C(Cl)C([H])=C2F)=C([H])C2=C1N=C(N(C2=O)C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C2OC([H])([H])OC2=C([H])C(OC2=C([H])C3=C(N=C(N(C3=O)C([H])([H])[C@]3([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=N2)=C1[H]
[H]C1=NC2=C([H])C([H])=C(OC3=C([H])C4=C(N=C(N(C4=O)C([H])([H])[C@]4([H])C([H])([H])N(C([H])([H])C([H])([H])C4([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=N3)C([H])=C2S1
[H]C1=C([H])C([H])=C2C(F)=C([H])C([H])=C(OC3=C([H])C4=C(N=C(N(C4=O)C([H])([H])[C@]4([H])C([H])([H])N(C([H])([H])C([H])([H])C4([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=N3)C2=N1
[H]C1=NC2=C([H])C(OC3=C([H])C4=C(N=C(N(C4=O)C([H])([H])[C@]4([H])C([H])([H])N(C([H])([H])C([H])([H])C4([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=N3)=C([H])C([H])=C2N1C([H])([H])[H]
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[H]C1=C2OC([H])([H])OC2=C([H])C(OC2=NC3=C(N=C2[H])N=C(N(C3=O)C([H])([H])[C@]2([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]C1=NC2=C([H])C([H])=C(OC3=NC4=C(N=C3[H])N=C(N(C4=O)C([H])([H])[C@]3([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2S1
[H]C1=C([H])C([H])=C2C(F)=C([H])C([H])=C(OC3=NC4=C(N=C3[H])N=C(N(C4=O)C([H])([H])[C@]3([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2=N1
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC2=NC3=C(N=C2[H])N=C(N(C3=O)C([H])([H])[C@]2([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
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[H]N(C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C(N([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(N([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C(N([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C(N([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(N([H])C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H]
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[H]N([H])C(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(N([H])C([H])=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H]
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[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])[H]
[H]N(C([H])=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)C([H])([H])[H])[C@]([H])(N(C(=O)[C@]([H])(N([H])C(=O)C(N([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
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[H]N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]N(C(=O)C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C(N(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC1=C(OC([H])([H])[C@@]([H])(N2N=NN=C2[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C#N)C([H])=C([H])C([H])=C1[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1[C@]([H])(C([H])([H])OC1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C#N)C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#N)C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1[C@]([H])(C([H])([H])OC1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C#N)C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN(N=N1)C([H])([H])C([H])([H])[C@]([H])(C#N)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C([H])([H])[C@]([H])(C#N)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN(N=N1)C([H])([H])[C@]([H])(C#N)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])[C@]([H])(C#N)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN(N=N1)[C@@]([H])(C([H])([H])C#N)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1[C@@]([H])(C([H])([H])C#N)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN(N=N1)[C@]([H])(C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#N)C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1[C@]([H])(C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#N)C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
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[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C(F)(F)F)C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N1C(=O)N([H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])S(=O)(=O)N([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C(OC([H])([H])C([H])([H])N2N=NN=C2[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N2N=NN=C2[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])SC([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N(C(=O)[C@@]([H])(N([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N(C(=O)[C@@]([H])(N([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N(C(=O)[C@@]([H])(N([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2\C([H])=C([H])\C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C1=C([H])C([H])=C(C([H])=N1)C1=C2C(OC([H])([H])[C@@]([H])(N([H])C(=O)C3=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C3[H])C2([H])[H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)N(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)N(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)N(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]1([H])N2C3=C(C([H])=C([H])C([H])=C3C1([H])[H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C2=O)C([H])([H])C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]C1=C([H])C(OC([H])([H])C(=O)N2C([H])([H])C([H])([H])C3(C([H])([H])N(C([H])([H])C4=C([H])C([H])=C5OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C5=C4[H])C3([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1OC([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C2(C1([H])[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C2(C1([H])[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C(OC([H])([H])C(=O)N2C([H])([H])C([H])([H])C3(C([H])([H])N(C([H])([H])C4=C(Cl)C([H])=C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C4[H])C3([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1OC([H])([H])[H]
[H]C1=C([H])C(OC([H])([H])C(=O)N2C([H])([H])C([H])([H])C3(C([H])([H])N(C([H])([H])C4=C([H])C([H])=C(C([H])=C4[H])C4=NN=C(O4)C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1OC([H])([H])[H]
[H]C1=NN(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C2(C1([H])[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C2(C1([H])[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C2(C1([H])[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]C1=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])[H])=N1)C([H])([H])N1C([H])([H])C2(C1([H])[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C2=C(N=C(S2)C([H])([H])C(=O)N2C([H])([H])C([H])([H])C3(C([H])([H])N(C([H])([H])C4=C([H])C([H])=C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C4[H])C3([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N1N=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])N(C([H])([H])C3=C(Cl)C([H])=C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C2(C1([H])[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1=C([H])N3C([H])=C(SC3=N1)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C2(C1([H])[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1=C([H])N3C([H])=C(SC3=N1)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]C1=NN(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C2(C1([H])[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1=C([H])N3C([H])=C(SC3=N1)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]C1=C(SC2=NC(=C([H])N12)C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C3=NC([H])=C([H])C([H])=N3)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C2(C1([H])[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1=C([H])N3C([H])=C(Cl)C([H])=C([H])C3=N1)C([H])([H])C2([H])[H]
[H]C1=C(N=C2C([H])=C([H])C(Cl)=C([H])N12)C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C3=NC([H])=C([H])C([H])=N3)C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C(Cl)C([H])=C12)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C12)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C([H])=C12)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C(Cl)C(Cl)=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C(Cl)C([H])=C(Cl)C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@@]1(C(=O)N([H])C2=C([H])C(Cl)=C(Cl)C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C(C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C12)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]C([H])=C([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)N([H])[C@]2(C(=O)N([H])C3=C([H])C(Cl)=C([H])C(Cl)=C23)C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C(C([H])=C12)C([H])([H])[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C(Cl)C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C12)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C12)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C12)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C12)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C12)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C(C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
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