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[H]C1=NC2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C(=N1)N1C([H])([H])C([H])([H])[C@@]([H])(OC2=C([H])C([H])=C3N=C(C([H])=C([H])C3=C2[H])C([H])([H])[H])C1([H])[H]
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[H]C1=NC2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C(=N1)N1C([H])([H])C([H])([H])[C@@]([H])(OC2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=N2)C1([H])[H]
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[H]N(C1=C(C([H])=C(C([H])=N1)C1=C([H])N=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[3H]C([3H])([3H])OC1=CC2=NN=CC(C3=CN=C(NC(C)C)C(C)=C3)=C2C=C1OC
[H]C1=NC([H])=C([H])C(=C1[H])C1=C([H])C([H])=NN2C1=NC(=C2C1=C([H])C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])N=C1[H])C([H])([H])[H]
[H]C1=NN2C(=NC(=C2C2=C([H])C([H])=C(N=C2[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N2C(=NC(=C2C2=C([H])C([H])=C(N=C2[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C(C([H])=C(C([H])=N2)C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(=N2)C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C(F)(F)F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(Br)=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(=N2)C(F)(F)F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C(F)(F)F)C1=C([H])C([H])=C(OC([H])([H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C(F)C([H])=C([H])C([H])=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(Br)C([H])=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(C#N)C([H])=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(C([H])=N2)C2([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(=N2)C#N)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C(Br)C([H])=C([H])C(OC([H])([H])[H])=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])[18F])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(=N2)C2([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(=N2)C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(C([H])=N2)C(F)(F)F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C(C(=C(C([H])=N2)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]OC1([H])C([H])([H])C([H])([H])N(C2=C(OC3([H])C([H])([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C([H])([H])C3([H])[H])N=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])N(C2=C(OC3([H])C([H])([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C([H])([H])C3([H])[H])N=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]OC1([H])C([H])([H])N(C2=C(OC3([H])C([H])([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C([H])([H])C3([H])[H])N=C([H])C([H])=N2)C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C(OC3([H])C([H])([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C([H])([H])C3([H])[H])N=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])=C(N=C1[H])N1C([H])([H])C2(C([H])([H])OC2([H])[H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(C([H])([H])OC2([H])[H])C([H])([H])C1([H])[H]
[H]OC1([H])C([H])([H])C([H])([H])N(C2=C(OC3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])N=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])C(F)(F)F
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C2([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])=C([H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@]1([H])N(C2=C(OC3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])N=C([H])C([H])=N2)C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])N(C2=C(OC3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])N=C([H])C([H])=N2)C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])C([H])([H])N(C2=C(OC3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])N=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C([H])N=C2OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C([H])N=C2OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])N=C(N2C([H])([H])C([H])([H])C([H])(C#N)C([H])([H])C2([H])[H])C(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=N1
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C(OC3([H])C([H])([H])N(C4=C([H])N=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])N=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C(OC3([H])C([H])([H])N(C4=NC([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])N=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C(O[C@@]3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C([H])([H])C3([H])[H])N=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C(OC3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])N=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C1([H])[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C(N=C([H])C([H])=N2)C([H])([H])C2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2([H])[H])=C(N=C1[H])C1=C([H])C2=C(N=C1[H])C([H])=C([H])C([H])=C2[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2([H])[H])=C(N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2([H])[H])=C(N=C1[H])C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(F)=C1[H]
[H]C1=NC([H])=C(C([H])=N1)C1=C(OC2([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2([H])[H])N=C([H])C([H])=N1
[H]C1=NC(OC2([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2([H])[H])=C(N=C1[H])C1=C([H])C(=NC([H])=C1[H])C([H])([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2([H])[H])=C(N=C1[H])C1=C([H])N=C(OC([H])([H])[H])N=C1[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2([H])[H])=C(N=C1[H])C1=C([H])N=C(OC([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2([H])[H])=C(N=C1[H])C1=C([H])N=C(C([H])=C1[H])C([H])([H])[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=NC(OC3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])=C(C([H])=N2)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=NC(OC3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])=C(C([H])=N2)C2=C([H])C(=NC([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=NC(OC3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])=C(C([H])=N2)C2=C(OC([H])([H])[H])N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=NC(OC3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])=C(C([H])=N2)C2=C([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
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[H]C1=NC(OC2([H])C([H])([H])N(C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])=C(C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1OC([H])([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=C(N=C([H])C([H])=N2)C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(N=C([H])C([H])=N2)C2=C([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(N=C([H])C([H])=N2)C2=C([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(N=C([H])C([H])=N2)C2=C([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(OC3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])=C(N=C2C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C(OC([H])([H])[H])=N1)C1=C(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])N=C2C([H])=C([H])C([H])=C([H])C2=N1
[H]C1=NC(=C([H])C([H])=C1[H])C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C([H])C([H])=N1
[H]OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C([H])C([H])=N1
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])C(F)(F)C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C(F)(F)C1([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C([H])=C1[H])N1C([H])([H])C([H])(OC2=C(C([H])=C(F)C([H])=N2)N2C([H])([H])C([H])([H])C(F)(F)C([H])([H])C2([H])[H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C([H])=C1[H])N1C([H])([H])C([H])(OC2=C(C([H])=C(C([H])=N2)C([H])([H])[H])C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C([H])=C1[H])N1C([H])([H])C([H])(OC2=C(C([H])=C(F)C([H])=N2)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC(OC3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])=C(N=C2C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])=C(N=C1[H])C1=C([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=NC([H])=C([H])N=C2C2=C([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(N=C([H])C([H])=N2)C2=C([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C(=O)C3=NC([H])=C([H])C([H])=C3[H])C2([H])[H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(C([H])=C([H])C([H])=N2)[C@@]2([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(C([H])=C([H])C([H])=N2)[C@@]2([H])C([H])([H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N1C([H])=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])(OC2=C(N=C([H])C([H])=N2)C2=C([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(N=C([H])C([H])=N2)C2=C([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C2([H])[H])C1([H])[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=NC(OC3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])=C(C([H])=N2)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])C#CC([H])([H])OC([H])([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
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[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(C([H])=C([H])C([H])=N2)C2=C([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(N=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])C(=O)C([H])([H])C2([H])[H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])N=C2OC2([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])N=C2OC2([H])C([H])([H])N(C(=O)C3=NC4=C(N3[H])C([H])=C([H])C([H])=C4[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C([H])=C1C(=O)N1C([H])([H])C([H])(OC2=C(C([H])=C([H])C([H])=N2)[C@@]2([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H]
[H]N1C([H])=C(C([H])=C1C(=O)N1C([H])([H])C([H])(OC2=C(N=C([H])C([H])=N2)C2=C([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H]
[H]N1C(=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(C([H])=C([H])C([H])=N2)[C@@]2([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]O[C@]([H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=C(OC3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])N=NC([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=NC(OC3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])[C@@]([H])(OC2=C(N=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=NC([H])=C([H])N=C2C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])C([H])=N1)C(=O)N1C([H])([H])C([H])(OC2=NC([H])=C([H])C([H])=C2C2=C([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H]
[H]N1C([H])=C([H])N=C1C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=NC([H])=C([H])C([H])=C2C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=NC([H])=C([H])C([H])=C2C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=NC([H])=C([H])C([H])=C2C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C([H])C(=N3)C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C(C([H])=N3)C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=NC(=C([H])C(=C1[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=NC([H])=C([H])C([H])=C2C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(C(=O)N2C([H])([H])C([H])([H])C([H])(OC3=NC([H])=C([H])C([H])=C3C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C(=O)C3=NC4=C(S3)C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C(=O)C3=NC([H])=C4C([H])=C([H])C([H])=C([H])C4=C3[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C(=O)C3=C([H])C(Cl)=C([H])C([H])=N3)C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C([H])C([H])=N2)C2=C([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])[C@]([H])(OC2=C(N=C([H])C([H])=N2)C2=C([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(N=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=C(C([H])=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(C([H])=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=NC([H])=C([H])N=C2C2=C([H])C([H])=C([H])N=C2[H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C(=O)C3=NC([H])=C(C([H])=C3[H])C([H])([H])[H])C2([H])[H])=C(N=C1[H])C1=C([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C(=O)C3=C([H])N=C(C([H])=C3[H])C([H])([H])[H])C2([H])[H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(N=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N1C([H])=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])(OC2=C(N=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(N=C3C([H])=C([H])C([H])=C([H])C3=N2)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C(=O)C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C(OC2([H])C([H])([H])C([H])([H])N(C(=O)C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C(OC2([H])C([H])([H])C([H])([H])N(C(=O)C3=NC([H])=C([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=NC(=C([H])C(=C1[H])C1=NC([H])=C([H])N=C1OC1([H])C([H])([H])C([H])([H])N(C(=O)C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])C(=C1[H])C1=NC([H])=C([H])N=C1OC1([H])C([H])([H])C([H])([H])N(C(=O)C2=NC([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])C(=C1[H])C1=C([H])C([H])=C([H])N=C1OC1([H])C([H])([H])C([H])([H])N(C(=O)C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])C(=C1[H])C1=C([H])C([H])=C([H])N=C1OC1([H])C([H])([H])C([H])([H])N(C(=O)C2=NC([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])N=C(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(OC2([H])C([H])([H])C([H])([H])N(C(=O)C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C2([H])[H])=N1
[H]C1=C([H])N=C(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(OC2([H])C([H])([H])C([H])([H])N(C(=O)C3=NC([H])=C([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])=N1
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])[C@@]([H])(OC2=C(C([H])=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C(OC2([H])C([H])([H])N(C3=NC([H])=C4C([H])=C([H])C([H])=C([H])C4=C3[H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C(OC2([H])C([H])([H])N(C3=NC([H])=C([H])C4=C([H])C([H])=C([H])C([H])=C34)C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C(OC2([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C3([H])[H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C([H])C(=N1)N1C([H])([H])C([H])([H])C([H])(OC2=NC([H])=C([H])C([H])=C2C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC(=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC(=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C4=C(C([H])=N3)C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])(OC2=C(N=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C4=C(C([H])=N3)C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])(OC2=C(C([H])=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(O[C@]2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(O[C@]2([H])C([H])([H])N(C3=NC([H])=C4C([H])=C([H])C([H])=C([H])C4=C3[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(O[C@]2([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H]
[H]C1=C([H])N=C(C(O[C@]2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C(O[C@]2([H])C([H])([H])N(C3=NC([H])=C4C([H])=C([H])C([H])=C([H])C4=C3[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C(O[C@]2([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])[C@@]([H])(OC2=C(N=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=NC4=C(S3)C([H])=C([H])C([H])=C4[H])C2([H])[H])=C(C([H])=C1[H])C1=C([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2([H])[H])=C(C([H])=C1[H])C1=C([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])(OC2=C(N=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])C1=C([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=NC4=C(S3)C([H])=C([H])C([H])=C4[H])C2([H])[H])=C(N=C1[H])C1=C([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C(C([H])=C3[H])[N+]([O-])=O)C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(OC2=NC([H])=C([H])C([H])=C2C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C(Br)C([H])=C3[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC([H])([H])C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(OC2=NC([H])=C([H])C([H])=C2C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C(=O)C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(OC2=NC([H])=C([H])C([H])=C2C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC1=C([H])N=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(OC2=NC([H])=C([H])C([H])=C2C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C(C#N)C([H])=C3[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C(C([H])=C3[H])C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC4=C([H])C(=C([H])C([H])=C4C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC([H])=C(C([H])=C3[H])C(=O)OC([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC4=C([H])C(=C([H])C([H])=C4C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4C(=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=NC4=C(C([H])=C3[H])C([H])=C(C([H])=C4[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C(C([H])=C4C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4C(=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C([H])N=N3)C2([H])[H])=C(Br)C([H])=C1[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=N3)C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(=N3)C([H])([H])[H])C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=N3)C([H])([H])[H])C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C(=C([H])C([H])=N3)C([H])([H])[H])C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C(C([H])=C([H])C([H])=N3)C([H])([H])[H])C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(Cl)=N3)C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=N3)C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C(Cl)=C([H])C([H])=N3)C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C(Cl)C([H])=C([H])C([H])=N3)C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(OC2=C(C([H])=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(=N3)C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=N3)C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C(=C([H])C([H])=N3)C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C(C([H])=C([H])C([H])=N3)C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(Cl)=N3)C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=N3)C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C(Cl)C([H])=C([H])C([H])=N3)C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)N1C([H])([H])C([H])([H])C([H])(C2=NC3=C(N=C2OC2([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C2([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C([H])=C1[H])N1C([H])([H])C([H])(OC2=NC3=C(N=C2C2([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C([H])C([H])=C3[H])C1([H])[H]
CCOC(=O)C1=CC=C2N3C(=NN=C3C3=CC=CC=C3)C(C)=NC2=C1
CC1=NC2=CC=C(CN3CCCC(CO)C3)C=C2N2C1=NN=C2C1=CC=CC=C1Cl
CC1=NC2=CC=C(CN3CCCC(O)C3)C=C2N2C1=NN=C2C1=CC=CC=C1Cl
COC1CCN(CC2=CC=C3N=C(C)C4=NN=C(N4C3=C2)C2=CC=CC=C2Cl)CC1
CC1=NC2=CC=C(CN3CCC(O)CC3)C=C2N2C1=NN=C2C1=CC=CC=C1Cl
CC1=NC2=CC=C(CN3CCC(O)C3)C=C2N2C1=NN=C2C1=CC=CC=C1Cl
CC1=NC2=CC=C(N[C@H]3CC[C@H](O)CC3)C=C2N2C1=NN=C2C1=CC=CC=C1Cl
CC1=NC2=CC=C(NC3CCOCC3)C=C2N2C1=NN=C2C1=CC=CC=C1Cl
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CC1=NC2=CC=C(CNCC3=CC=CC=C3)C=C2N2C1=NN=C2C1=CC=CC=C1Cl
CC1=NC2=CC=C(CN3CCOCC3)C=C2N2C1=NN=C2C1=CC=CC=C1Cl
CN(C)CC1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CC=CC=C1Cl
CCNCC1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CC=CC=C1Cl
CC1=NC2=CC=C(C=C2N2C1=NN=C2C1=CC=CC=C1Cl)C(=O)NCC1=CC=CC=N1
CC1=NC2=CC=C(C=C2N2C1=NN=C2C1=CC=CC=C1Cl)C(=O)NCCN1CCOCC1
CC1=NC2=CC=C(C=C2N2C1=NN=C2C1=CC=CC=C1Cl)C(=O)NCCN1CCCC1
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CC1=NC2=CC=C(C=C2N2C1=NN=C2C1=CC=CC=C1Cl)C(=O)NCCC1=CC=CC=C1
CN(CC1=CC=CC=C1)C(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CC=CC=C1Cl
CCNC(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CN=CC(OC)=C1
CCNC(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CC=CN=C1OC
CCNC(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CN=CC=C1C
CCNC(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CC=NC=C1
CCNC(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CN=CC=C1
CCNC(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=NC=CC=C1
CCNC(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=C(Cl)C=CC=C1Cl
CCNC(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CC=CC=C1F
CCNC(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CC=CC=C1OC
CCNC(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CC=CC=C1Cl
CCNC(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CC=CC=C1
CCOC(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CC=CC=C1Cl
CCOC(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CC=CC=C1