Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.
| Uniprot primary ID | O00311 |
| PDB ID | 4F99 4F9A 4F9C 4F9B |
| DrugBank ID | |
| BioGrid ID | 113914 |
| GuidetoPHARMACOLOGY ID | 1960 |
| PharmGKB ID | PA26272 |
| KEGG ID | hsa:8317 |
| DIP ID | DIP-31728N |
| STRING ID | 9606.ENSP00000234626 |
| IntAct ID | O00311 |
| DMDM | |
| BRENDA | 2.7.11.1 |
| Reactome | R-HSA-68962 R-HSA-176187 |
| SignaLink | O00311 |
| BioCyc | |
| Entrez Gene (Gene ID) | 8317 |
| BindingDB | O00311 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.942 | 0.008 | 0.956 | 0.004 | 0.949 | 0.007 | 0.947 | 0.005 | 0.990 | 0.000 | 0.898 | 0.008 | Download |
| Estate fingerprints | 0.937 | 0.005 | 0.859 | 0.005 | 0.898 | 0.004 | 0.899 | 0.003 | 0.960 | 0.000 | 0.794 | 0.007 | Download |
| MACCS fingerprints | 0.942 | 0.004 | 0.898 | 0.005 | 0.920 | 0.000 | 0.921 | 0.003 | 0.970 | 0.000 | 0.839 | 0.006 | Download |
| Daylight fingerprints | 0.848 | 0.006 | 0.974 | 0.005 | 0.911 | 0.003 | 0.907 | 0.005 | 0.970 | 0.000 | 0.828 | 0.006 | Download |
| ECFP2 fingerprints | 0.980 | 0.000 | 0.900 | 0.005 | 0.940 | 0.000 | 0.943 | 0.005 | 0.990 | 0.000 | 0.884 | 0.005 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 0.956 | 0.005 | 0.968 | 0.004 | 0.968 | 0.004 | 0.990 | 0.000 | 0.930 | 0.005 | Download |
| ECFP6 fingerprints | 0.980 | 0.000 | 0.978 | 0.004 | 0.979 | 0.003 | 0.979 | 0.003 | 0.990 | 0.000 | 0.956 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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