Target name

O00311: Cell division cycle 7-related protein kinase


  Protein function

Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.

  Database links

Uniprot primary ID O00311
PDB ID 4F99 4F9A 4F9C 4F9B
DrugBank ID
BioGrid ID 113914
GuidetoPHARMACOLOGY ID 1960
PharmGKB ID PA26272
KEGG ID hsa:8317
DIP ID DIP-31728N
STRING ID 9606.ENSP00000234626
IntAct ID O00311
DMDM
BRENDA 2.7.11.1
Reactome R-HSA-68962 R-HSA-176187
SignaLink O00311
BioCyc
Entrez Gene (Gene ID) 8317
BindingDB O00311

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.942 0.008 0.956 0.004 0.949 0.007 0.947 0.005 0.990 0.000 0.898 0.008 Download
Estate fingerprints 0.937 0.005 0.859 0.005 0.898 0.004 0.899 0.003 0.960 0.000 0.794 0.007 Download
MACCS fingerprints 0.942 0.004 0.898 0.005 0.920 0.000 0.921 0.003 0.970 0.000 0.839 0.006 Download
Daylight fingerprints 0.848 0.006 0.974 0.005 0.911 0.003 0.907 0.005 0.970 0.000 0.828 0.006 Download
ECFP2 fingerprints 0.980 0.000 0.900 0.005 0.940 0.000 0.943 0.005 0.990 0.000 0.884 0.005 Download
ECFP4 fingerprints 0.980 0.000 0.956 0.005 0.968 0.004 0.968 0.004 0.990 0.000 0.930 0.005 Download
ECFP6 fingerprints 0.980 0.000 0.978 0.004 0.979 0.003 0.979 0.003 0.990 0.000 0.956 0.005 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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