Target name

O00408: cGMP-dependent 3',5'-cyclic phosphodiesterase


  Protein function

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.

  Database links

Uniprot primary ID O00408
PDB ID 4HTX 3ITM 4HTZ 4JIB 4C1I 4D08 4D09 1Z1L 3IBJ 3ITU
DrugBank ID DB08811 DB00201
BioGrid ID 111164
GuidetoPHARMACOLOGY ID 1297
PharmGKB ID PA33125
KEGG ID hsa:5138
DIP ID DIP-40269N
STRING ID 9606.ENSP00000334910
IntAct ID O00408
DMDM
BRENDA 3.1.4.17
Reactome R-HSA-418457 R-HSA-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 5138
BindingDB O00408

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.818 0.004 0.960 0.005 0.889 0.003 0.880 0.000 0.960 0.000 0.783 0.007 Download
Estate fingerprints 0.862 0.004 0.824 0.009 0.843 0.005 0.846 0.005 0.940 0.000 0.684 0.007 Download
MACCS fingerprints 0.824 0.008 0.892 0.012 0.858 0.006 0.850 0.008 0.940 0.000 0.714 0.014 Download
Daylight fingerprints 0.800 0.000 0.980 0.000 0.890 0.000 0.880 0.000 0.950 0.000 0.800 0.000 Download
ECFP2 fingerprints 0.860 0.005 0.926 0.007 0.893 0.007 0.889 0.006 0.969 0.003 0.789 0.010 Download
ECFP4 fingerprints 0.890 0.015 0.986 0.003 0.938 0.008 0.934 0.010 0.977 0.005 0.880 0.012 Download
ECFP6 fingerprints 0.866 0.005 1.000 0.000 0.935 0.005 0.930 0.000 0.975 0.005 0.875 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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