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E-mail: biomed@csu.edu.cn
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Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
| Uniprot primary ID | O00408 |
| PDB ID | 4HTX 3ITM 4HTZ 4JIB 4C1I 4D08 4D09 1Z1L 3IBJ 3ITU |
| DrugBank ID | DB08811 DB00201 |
| BioGrid ID | 111164 |
| GuidetoPHARMACOLOGY ID | 1297 |
| PharmGKB ID | PA33125 |
| KEGG ID | hsa:5138 |
| DIP ID | DIP-40269N |
| STRING ID | 9606.ENSP00000334910 |
| IntAct ID | O00408 |
| DMDM | |
| BRENDA | 3.1.4.17 |
| Reactome | R-HSA-418457 R-HSA-418555 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 5138 |
| BindingDB | O00408 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.818 | 0.004 | 0.960 | 0.005 | 0.889 | 0.003 | 0.880 | 0.000 | 0.960 | 0.000 | 0.783 | 0.007 | Download |
| Estate fingerprints | 0.862 | 0.004 | 0.824 | 0.009 | 0.843 | 0.005 | 0.846 | 0.005 | 0.940 | 0.000 | 0.684 | 0.007 | Download |
| MACCS fingerprints | 0.824 | 0.008 | 0.892 | 0.012 | 0.858 | 0.006 | 0.850 | 0.008 | 0.940 | 0.000 | 0.714 | 0.014 | Download |
| Daylight fingerprints | 0.800 | 0.000 | 0.980 | 0.000 | 0.890 | 0.000 | 0.880 | 0.000 | 0.950 | 0.000 | 0.800 | 0.000 | Download |
| ECFP2 fingerprints | 0.860 | 0.005 | 0.926 | 0.007 | 0.893 | 0.007 | 0.889 | 0.006 | 0.969 | 0.003 | 0.789 | 0.010 | Download |
| ECFP4 fingerprints | 0.890 | 0.015 | 0.986 | 0.003 | 0.938 | 0.008 | 0.934 | 0.010 | 0.977 | 0.005 | 0.880 | 0.012 | Download |
| ECFP6 fingerprints | 0.866 | 0.005 | 1.000 | 0.000 | 0.935 | 0.005 | 0.930 | 0.000 | 0.975 | 0.005 | 0.875 | 0.005 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
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