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E-mail: biomed@csu.edu.cn
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Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
| Uniprot primary ID | O00519 |
| PDB ID | |
| DrugBank ID | DB00818 DB00599 |
| BioGrid ID | 108464 |
| GuidetoPHARMACOLOGY ID | 1400 |
| PharmGKB ID | PA27955 |
| KEGG ID | hsa:2166 |
| DIP ID | |
| STRING ID | 9606.ENSP00000243167 |
| IntAct ID | O00519 |
| DMDM | |
| BRENDA | 3.5.1.99 3.5.1.4 |
| Reactome | |
| SignaLink | |
| BioCyc | MetaCyc:HS04139-MONOMER |
| Entrez Gene (Gene ID) | 2166 |
| BindingDB | O00519 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.780 | 0.000 | 0.958 | 0.003 | 0.869 | 0.003 | 0.853 | 0.005 | 0.940 | 0.000 | 0.746 | 0.005 | Download |
| Estate fingerprints | 0.881 | 0.003 | 0.839 | 0.003 | 0.860 | 0.000 | 0.864 | 0.005 | 0.920 | 0.000 | 0.721 | 0.006 | Download |
| MACCS fingerprints | 0.832 | 0.004 | 0.906 | 0.005 | 0.869 | 0.003 | 0.862 | 0.004 | 0.940 | 0.000 | 0.736 | 0.007 | Download |
| Daylight fingerprints | 0.753 | 0.005 | 0.847 | 0.004 | 0.800 | 0.000 | 0.790 | 0.000 | 0.846 | 0.005 | 0.601 | 0.003 | Download |
| ECFP2 fingerprints | 0.957 | 0.005 | 0.943 | 0.003 | 0.950 | 0.000 | 0.950 | 0.000 | 0.984 | 0.005 | 0.896 | 0.005 | Download |
| ECFP4 fingerprints | 0.946 | 0.005 | 0.974 | 0.004 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.921 | 0.003 | Download |
| ECFP6 fingerprints | 0.924 | 0.005 | 0.990 | 0.000 | 0.957 | 0.005 | 0.956 | 0.005 | 0.990 | 0.000 | 0.916 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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