Target name

O00519: Fatty-acid amide hydrolase 1


  Protein function

Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

  Database links

Uniprot primary ID O00519
PDB ID
DrugBank ID DB00818 DB00599
BioGrid ID 108464
GuidetoPHARMACOLOGY ID 1400
PharmGKB ID PA27955
KEGG ID hsa:2166
DIP ID
STRING ID 9606.ENSP00000243167
IntAct ID O00519
DMDM
BRENDA 3.5.1.99 3.5.1.4
Reactome
SignaLink
BioCyc MetaCyc:HS04139-MONOMER
Entrez Gene (Gene ID) 2166
BindingDB O00519

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.780 0.000 0.958 0.003 0.869 0.003 0.853 0.005 0.940 0.000 0.746 0.005 Download
Estate fingerprints 0.881 0.003 0.839 0.003 0.860 0.000 0.864 0.005 0.920 0.000 0.721 0.006 Download
MACCS fingerprints 0.832 0.004 0.906 0.005 0.869 0.003 0.862 0.004 0.940 0.000 0.736 0.007 Download
Daylight fingerprints 0.753 0.005 0.847 0.004 0.800 0.000 0.790 0.000 0.846 0.005 0.601 0.003 Download
ECFP2 fingerprints 0.957 0.005 0.943 0.003 0.950 0.000 0.950 0.000 0.984 0.005 0.896 0.005 Download
ECFP4 fingerprints 0.946 0.005 0.974 0.004 0.960 0.000 0.960 0.000 0.990 0.000 0.921 0.003 Download
ECFP6 fingerprints 0.924 0.005 0.990 0.000 0.957 0.005 0.956 0.005 0.990 0.000 0.916 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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