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E-mail: biomed@csu.edu.cn
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Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.
| Uniprot primary ID | O00748 |
| PDB ID | |
| DrugBank ID | DB06695 DB06209 DB00688 DB00762 |
| BioGrid ID | 114351 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA377 |
| KEGG ID | hsa:8824 |
| DIP ID | |
| STRING ID | 9606.ENSP00000317842 |
| IntAct ID | O00748 |
| DMDM | |
| BRENDA | 3.1.1.1 3.1.1.84 |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 8824 |
| BindingDB | O00748 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.979 | 0.003 | 0.967 | 0.005 | 0.973 | 0.005 | 0.973 | 0.005 | 0.998 | 0.004 | 0.950 | 0.000 | Download |
| Estate fingerprints | 0.920 | 0.000 | 0.958 | 0.010 | 0.939 | 0.006 | 0.938 | 0.004 | 0.990 | 0.000 | 0.879 | 0.011 | Download |
| MACCS fingerprints | 0.885 | 0.008 | 0.969 | 0.004 | 0.927 | 0.007 | 0.925 | 0.008 | 0.990 | 0.000 | 0.859 | 0.014 | Download |
| Daylight fingerprints | 0.874 | 0.008 | 0.862 | 0.000 | 0.868 | 0.004 | 0.868 | 0.004 | 0.900 | 0.000 | 0.737 | 0.012 | Download |
| ECFP2 fingerprints | 0.990 | 0.000 | 0.950 | 0.004 | 0.970 | 0.000 | 0.970 | 0.000 | 0.996 | 0.005 | 0.939 | 0.006 | Download |
| ECFP4 fingerprints | 0.990 | 0.000 | 0.930 | 0.005 | 0.960 | 0.000 | 0.960 | 0.000 | 1.000 | 0.000 | 0.920 | 0.000 | Download |
| ECFP6 fingerprints | 0.988 | 0.004 | 0.922 | 0.005 | 0.955 | 0.005 | 0.958 | 0.004 | 1.000 | 0.000 | 0.913 | 0.008 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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