Target name

O00767: Acyl-CoA desaturase


  Protein function

Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).

  Database links

Uniprot primary ID O00767
PDB ID 4ZYO
DrugBank ID
BioGrid ID 112225
GuidetoPHARMACOLOGY ID
PharmGKB ID PA34984
KEGG ID hsa:6319
DIP ID
STRING ID 9606.ENSP00000359380
IntAct ID O00767
DMDM
BRENDA 1.14.19.1
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 6319
BindingDB

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.864 0.007 0.954 0.005 0.909 0.003 0.904 0.007 0.960 0.000 0.820 0.008 Download
Estate fingerprints 0.856 0.005 0.836 0.007 0.846 0.005 0.848 0.004 0.916 0.005 0.693 0.007 Download
MACCS fingerprints 0.907 0.005 0.827 0.005 0.867 0.005 0.870 0.000 0.939 0.003 0.737 0.005 Download
Daylight fingerprints 0.847 0.005 0.985 0.005 0.916 0.005 0.910 0.000 0.969 0.003 0.842 0.008 Download
ECFP2 fingerprints 0.942 0.004 0.938 0.004 0.940 0.000 0.940 0.000 0.990 0.000 0.876 0.005 Download
ECFP4 fingerprints 0.980 0.000 0.986 0.005 0.983 0.005 0.983 0.005 1.000 0.000 0.970 0.005 Download
ECFP6 fingerprints 0.968 0.004 0.992 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.965 0.005 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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