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E-mail: biomed@csu.edu.cn
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Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.
| Uniprot primary ID | O14672 |
| PDB ID | 1M1I |
| DrugBank ID | |
| BioGrid ID | 106616 |
| GuidetoPHARMACOLOGY ID | 1658 |
| PharmGKB ID | PA24505 |
| KEGG ID | hsa:102 |
| DIP ID | DIP-39889N |
| STRING ID | 9606.ENSP00000260408 |
| IntAct ID | O14672 |
| DMDM | |
| BRENDA | 3.4.24.81 |
| Reactome | R-HSA-2691232 R-HSA-2122948 R-HSA-1980150 R-HSA-1980148 R-HSA-1474228 R-HSA-1442490 R-HSA-3928665 R-HSA-2660826 R-HSA-2644606 R-HSA-2894862 R-HSA-177929 R-HSA-2979096 |
| SignaLink | O14672 |
| BioCyc | MetaCyc:ENSG00000137845-MONOMER |
| Entrez Gene (Gene ID) | 102 |
| BindingDB | O14672 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.896 | 0.007 | 0.972 | 0.005 | 0.934 | 0.005 | 0.934 | 0.005 | 0.974 | 0.005 | 0.872 | 0.008 | Download |
| Estate fingerprints | 0.925 | 0.005 | 0.935 | 0.008 | 0.930 | 0.005 | 0.930 | 0.005 | 0.990 | 0.000 | 0.865 | 0.008 | Download |
| MACCS fingerprints | 0.896 | 0.008 | 0.988 | 0.003 | 0.942 | 0.004 | 0.935 | 0.005 | 0.990 | 0.000 | 0.887 | 0.008 | Download |
| Daylight fingerprints | 0.800 | 0.000 | 1.000 | 0.004 | 0.900 | 0.000 | 0.890 | 0.000 | 0.971 | 0.003 | 0.818 | 0.004 | Download |
| ECFP2 fingerprints | 0.879 | 0.006 | 0.997 | 0.007 | 0.938 | 0.006 | 0.933 | 0.005 | 0.990 | 0.000 | 0.881 | 0.010 | Download |
| ECFP4 fingerprints | 0.902 | 0.017 | 1.000 | 0.000 | 0.952 | 0.009 | 0.950 | 0.008 | 0.988 | 0.004 | 0.907 | 0.013 | Download |
| ECFP6 fingerprints | 0.883 | 0.009 | 1.000 | 0.000 | 0.944 | 0.007 | 0.938 | 0.006 | 0.988 | 0.004 | 0.893 | 0.009 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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