Target name

O14672: Disintegrin and metalloproteinase domain-containing protein 10


  Protein function

Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

  Database links

Uniprot primary ID O14672
PDB ID 1M1I
DrugBank ID
BioGrid ID 106616
GuidetoPHARMACOLOGY ID 1658
PharmGKB ID PA24505
KEGG ID hsa:102
DIP ID DIP-39889N
STRING ID 9606.ENSP00000260408
IntAct ID O14672
DMDM
BRENDA 3.4.24.81
Reactome R-HSA-2691232 R-HSA-2122948 R-HSA-1980150 R-HSA-1980148 R-HSA-1474228 R-HSA-1442490 R-HSA-3928665 R-HSA-2660826 R-HSA-2644606 R-HSA-2894862 R-HSA-177929 R-HSA-2979096
SignaLink O14672
BioCyc MetaCyc:ENSG00000137845-MONOMER
Entrez Gene (Gene ID) 102
BindingDB O14672

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.896 0.007 0.972 0.005 0.934 0.005 0.934 0.005 0.974 0.005 0.872 0.008 Download
Estate fingerprints 0.925 0.005 0.935 0.008 0.930 0.005 0.930 0.005 0.990 0.000 0.865 0.008 Download
MACCS fingerprints 0.896 0.008 0.988 0.003 0.942 0.004 0.935 0.005 0.990 0.000 0.887 0.008 Download
Daylight fingerprints 0.800 0.000 1.000 0.004 0.900 0.000 0.890 0.000 0.971 0.003 0.818 0.004 Download
ECFP2 fingerprints 0.879 0.006 0.997 0.007 0.938 0.006 0.933 0.005 0.990 0.000 0.881 0.010 Download
ECFP4 fingerprints 0.902 0.017 1.000 0.000 0.952 0.009 0.950 0.008 0.988 0.004 0.907 0.013 Download
ECFP6 fingerprints 0.883 0.009 1.000 0.000 0.944 0.007 0.938 0.006 0.988 0.004 0.893 0.009 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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