Target name

O42275: Acetylcholinesterase


  Protein function

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.

  Database links

Uniprot primary ID O42275
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
DIP ID
STRING ID
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID)
BindingDB O42275

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.673 0.005 0.909 0.000 0.791 0.003 0.767 0.005 0.880 0.000 0.605 0.005 Download
Estate fingerprints 0.746 0.005 0.750 0.005 0.748 0.004 0.741 0.003 0.820 0.000 0.496 0.005 Download
MACCS fingerprints 0.853 0.005 0.725 0.003 0.789 0.003 0.794 0.005 0.870 0.000 0.584 0.005 Download
Daylight fingerprints 0.652 0.004 0.830 0.000 0.741 0.003 0.710 0.000 0.750 0.000 0.487 0.005 Download
ECFP2 fingerprints 0.840 0.000 0.922 0.005 0.881 0.003 0.872 0.004 0.960 0.000 0.768 0.004 Download
ECFP4 fingerprints 0.799 0.003 0.985 0.003 0.892 0.004 0.878 0.004 0.970 0.000 0.794 0.005 Download
ECFP6 fingerprints 0.767 0.005 0.993 0.000 0.880 0.000 0.860 0.000 0.960 0.000 0.781 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn