Copper-containing oxidase that catalyzes both the o-hydroxylation of monophenols and the subsequent oxidation of the resulting o-diphenols into reactive o-quinones, which evolve spontaneously to produce intermediates, which associate in dark brown pigments. Involved in the initial step of melanin synthesis. Melanins constitute a mechanism of defense and resistance to stress such as UV radiations, free radicals, gamma rays, dehydratation and extreme temperatures, and contribute to the fungal cell-wall resistance against hydrolytic enzymes in avoiding cellular lysis. Fungal pigments are also involved in the formation and stability of spores (By similarity).
| Uniprot primary ID | O42713 |
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| BRENDA | 1.14.18.1 |
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| BindingDB | O42713 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
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| FP2 fingerprints | 0.940 | 0.000 | 0.932 | 0.007 | 0.936 | 0.005 | 0.936 | 0.005 | 0.980 | 0.000 | 0.874 | 0.007 | Download |
| Estate fingerprints | 0.895 | 0.008 | 0.897 | 0.008 | 0.896 | 0.005 | 0.896 | 0.005 | 0.961 | 0.003 | 0.789 | 0.011 | Download |
| MACCS fingerprints | 0.900 | 0.000 | 0.910 | 0.005 | 0.905 | 0.005 | 0.905 | 0.005 | 0.960 | 0.000 | 0.809 | 0.003 | Download |
| Daylight fingerprints | 0.840 | 0.000 | 0.820 | 0.000 | 0.830 | 0.000 | 0.830 | 0.000 | 0.890 | 0.000 | 0.670 | 0.000 | Download |
| ECFP2 fingerprints | 0.961 | 0.003 | 0.923 | 0.013 | 0.942 | 0.006 | 0.945 | 0.005 | 0.983 | 0.005 | 0.887 | 0.011 | Download |
| ECFP4 fingerprints | 0.970 | 0.000 | 0.878 | 0.008 | 0.924 | 0.007 | 0.928 | 0.004 | 0.986 | 0.005 | 0.852 | 0.010 | Download |
| ECFP6 fingerprints | 0.970 | 0.000 | 0.886 | 0.011 | 0.928 | 0.008 | 0.930 | 0.005 | 0.990 | 0.000 | 0.858 | 0.012 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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