Target name

O42713: Polyphenol oxidase 2


  Protein function

Copper-containing oxidase that catalyzes both the o-hydroxylation of monophenols and the subsequent oxidation of the resulting o-diphenols into reactive o-quinones, which evolve spontaneously to produce intermediates, which associate in dark brown pigments. Involved in the initial step of melanin synthesis. Melanins constitute a mechanism of defense and resistance to stress such as UV radiations, free radicals, gamma rays, dehydratation and extreme temperatures, and contribute to the fungal cell-wall resistance against hydrolytic enzymes in avoiding cellular lysis. Fungal pigments are also involved in the formation and stability of spores (By similarity).

  Database links

Uniprot primary ID O42713
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
DIP ID
STRING ID
IntAct ID
DMDM
BRENDA 1.14.18.1
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID)
BindingDB O42713

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.940 0.000 0.932 0.007 0.936 0.005 0.936 0.005 0.980 0.000 0.874 0.007 Download
Estate fingerprints 0.895 0.008 0.897 0.008 0.896 0.005 0.896 0.005 0.961 0.003 0.789 0.011 Download
MACCS fingerprints 0.900 0.000 0.910 0.005 0.905 0.005 0.905 0.005 0.960 0.000 0.809 0.003 Download
Daylight fingerprints 0.840 0.000 0.820 0.000 0.830 0.000 0.830 0.000 0.890 0.000 0.670 0.000 Download
ECFP2 fingerprints 0.961 0.003 0.923 0.013 0.942 0.006 0.945 0.005 0.983 0.005 0.887 0.011 Download
ECFP4 fingerprints 0.970 0.000 0.878 0.008 0.924 0.007 0.928 0.004 0.986 0.005 0.852 0.010 Download
ECFP6 fingerprints 0.970 0.000 0.886 0.011 0.928 0.008 0.930 0.005 0.990 0.000 0.858 0.012 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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