Target name

O43353: Receptor-interacting serine/threonine-protein kinase 2


  Protein function

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

  Database links

Uniprot primary ID O43353
PDB ID 4C8B
DrugBank ID
BioGrid ID 114300
GuidetoPHARMACOLOGY ID 2190
PharmGKB ID PA34395
KEGG ID hsa:8767
DIP ID DIP-27518N
STRING ID 9606.ENSP00000220751
IntAct ID O43353
DMDM
BRENDA 2.7.10.2
Reactome R-HSA-450302 R-HSA-202424 R-HSA-168638 R-HSA-445989 R-HSA-209543 R-HSA-446652 R-HSA-450321
SignaLink O43353
BioCyc
Entrez Gene (Gene ID) 8767
BindingDB O43353

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.707 0.014 0.767 0.008 0.737 0.009 0.728 0.010 0.814 0.005 0.472 0.018 Download
Estate fingerprints 0.720 0.009 0.748 0.011 0.734 0.011 0.730 0.009 0.810 0.005 0.468 0.020 Download
MACCS fingerprints 0.738 0.011 0.746 0.010 0.742 0.010 0.741 0.012 0.810 0.000 0.483 0.020 Download
Daylight fingerprints 0.741 0.009 0.725 0.018 0.733 0.011 0.734 0.008 0.810 0.013 0.464 0.016 Download
ECFP2 fingerprints 0.819 0.007 0.735 0.005 0.777 0.005 0.787 0.005 0.878 0.004 0.557 0.013 Download
ECFP4 fingerprints 0.804 0.011 0.726 0.012 0.765 0.007 0.776 0.007 0.873 0.005 0.537 0.014 Download
ECFP6 fingerprints 0.796 0.007 0.752 0.007 0.774 0.007 0.778 0.006 0.864 0.005 0.547 0.015 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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