Target name

O43497: Voltage-dependent T-type calcium channel subunit alpha-1G


  Protein function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the

  Database links

Uniprot primary ID O43497
PDB ID
DrugBank ID DB00661 DB05246 DB00593 DB00568 DB04841 DB00909 DB00347
BioGrid ID 114427
GuidetoPHARMACOLOGY ID 535
PharmGKB ID PA381
KEGG ID hsa:8913
DIP ID
STRING ID 9606.ENSP00000352011
IntAct ID O43497
DMDM
BRENDA
Reactome R-HSA-419037
SignaLink
BioCyc
Entrez Gene (Gene ID) 8913
BindingDB O43497

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.929 0.003 0.863 0.005 0.896 0.005 0.900 0.000 0.960 0.000 0.796 0.005 Download
Estate fingerprints 0.856 0.008 0.744 0.007 0.800 0.007 0.810 0.007 0.885 0.005 0.604 0.012 Download
MACCS fingerprints 0.881 0.003 0.755 0.003 0.818 0.004 0.828 0.004 0.911 0.003 0.641 0.007 Download
Daylight fingerprints 0.774 0.011 0.814 0.007 0.794 0.005 0.791 0.007 0.870 0.000 0.590 0.011 Download
ECFP2 fingerprints 0.988 0.004 0.900 0.000 0.944 0.005 0.946 0.005 0.990 0.000 0.891 0.003 Download
ECFP4 fingerprints 0.980 0.000 0.940 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.916 0.005 Download
ECFP6 fingerprints 0.969 0.003 0.969 0.003 0.969 0.003 0.969 0.003 0.990 0.000 0.940 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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