Target name

O43570: Carbonic anhydrase 12


  Protein function

Reversible hydration of carbon dioxide.

  Database links

Uniprot primary ID O43570
PDB ID 4KP8 1JCZ 4QJO 4Q0L 4KP5 4QJ0 4QJW 4HT2 1JD0 4WW8
DrugBank ID DB00774 DB00562 DB00909 DB00999
BioGrid ID 107225
GuidetoPHARMACOLOGY ID 2747
PharmGKB ID PA25987
KEGG ID hsa:771
DIP ID
STRING ID 9606.ENSP00000178638
IntAct ID O43570
DMDM
BRENDA 4.2.1.1
Reactome R-HSA-1475029
SignaLink
BioCyc
Entrez Gene (Gene ID) 771
BindingDB O43570

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.923 0.005 0.899 0.000 0.911 0.003 0.913 0.005 0.963 0.005 0.827 0.005 Download
Estate fingerprints 0.910 0.000 0.890 0.003 0.900 0.000 0.900 0.000 0.960 0.000 0.803 0.005 Download
MACCS fingerprints 0.870 0.000 0.870 0.000 0.870 0.000 0.870 0.000 0.950 0.000 0.740 0.000 Download
Daylight fingerprints 0.710 0.000 0.850 0.000 0.780 0.000 0.765 0.005 0.820 0.000 0.570 0.000 Download
ECFP2 fingerprints 0.980 0.000 0.940 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.920 0.000 Download
ECFP4 fingerprints 0.966 0.005 0.954 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.924 0.005 Download
ECFP6 fingerprints 0.950 0.000 0.962 0.004 0.956 0.005 0.953 0.005 0.990 0.000 0.910 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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