Details-Calcnet-TargetNet

Target name

O60240: Perilipin-1

Protein function

Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.

Database links

Uniprot primary ID	O60240
PDB ID
DrugBank ID
BioGrid ID	111361
GuidetoPHARMACOLOGY ID
PharmGKB ID	PA33409
KEGG ID	hsa:5346
DIP ID
STRING ID	9606.ENSP00000300055
IntAct ID
DMDM
BRENDA
Reactome	R-HSA-381340 R-HSA-163560
SignaLink
BioCyc
Entrez Gene (Gene ID)	5346
BindingDB	O60240

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.602	0.009	0.930	0.007	0.766	0.005	0.721	0.007	0.854	0.005	0.562	0.012	Download
Estate fingerprints	0.794	0.011	0.706	0.007	0.750	0.007	0.761	0.007	0.809	0.003	0.501	0.016	Download
MACCS fingerprints	0.723	0.013	0.773	0.009	0.748	0.004	0.743	0.007	0.803	0.005	0.498	0.012	Download
Daylight fingerprints	0.416	0.010	0.876	0.007	0.646	0.007	0.542	0.008	0.672	0.008	0.328	0.012	Download
ECFP2 fingerprints	0.763	0.007	0.853	0.009	0.808	0.006	0.799	0.006	0.891	0.003	0.620	0.013	Download
ECFP4 fingerprints	0.706	0.010	0.906	0.005	0.806	0.007	0.784	0.007	0.885	0.005	0.620	0.012	Download
ECFP6 fingerprints	0.643	0.013	0.951	0.008	0.797	0.009	0.760	0.012	0.882	0.004	0.623	0.015	Download

Download datasets

Positive dataset

Negative dataset