Target name

O60240: Perilipin-1


  Protein function

Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels.

  Database links

Uniprot primary ID O60240
PDB ID
DrugBank ID
BioGrid ID 111361
GuidetoPHARMACOLOGY ID
PharmGKB ID PA33409
KEGG ID hsa:5346
DIP ID
STRING ID 9606.ENSP00000300055
IntAct ID
DMDM
BRENDA
Reactome R-HSA-381340 R-HSA-163560
SignaLink
BioCyc
Entrez Gene (Gene ID) 5346
BindingDB O60240

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.602 0.009 0.930 0.007 0.766 0.005 0.721 0.007 0.854 0.005 0.562 0.012 Download
Estate fingerprints 0.794 0.011 0.706 0.007 0.750 0.007 0.761 0.007 0.809 0.003 0.501 0.016 Download
MACCS fingerprints 0.723 0.013 0.773 0.009 0.748 0.004 0.743 0.007 0.803 0.005 0.498 0.012 Download
Daylight fingerprints 0.416 0.010 0.876 0.007 0.646 0.007 0.542 0.008 0.672 0.008 0.328 0.012 Download
ECFP2 fingerprints 0.763 0.007 0.853 0.009 0.808 0.006 0.799 0.006 0.891 0.003 0.620 0.013 Download
ECFP4 fingerprints 0.706 0.010 0.906 0.005 0.806 0.007 0.784 0.007 0.885 0.005 0.620 0.012 Download
ECFP6 fingerprints 0.643 0.013 0.951 0.008 0.797 0.009 0.760 0.012 0.882 0.004 0.623 0.015 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn