Target name

O60725: Protein-S-isoprenylcysteine O-methyltransferase


  Protein function

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

  Database links

Uniprot primary ID O60725
PDB ID
DrugBank ID
BioGrid ID 117026
GuidetoPHARMACOLOGY ID
PharmGKB ID PA29598
KEGG ID hsa:23463
DIP ID
STRING ID 9606.ENSP00000343552
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 23463
BindingDB O60725

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.940 0.000 0.922 0.006 0.931 0.003 0.931 0.003 0.967 0.005 0.869 0.006 Download
Estate fingerprints 0.906 0.013 0.874 0.005 0.890 0.007 0.891 0.007 0.949 0.003 0.778 0.013 Download
MACCS fingerprints 0.900 0.005 0.942 0.000 0.921 0.003 0.920 0.005 0.970 0.000 0.843 0.007 Download
Daylight fingerprints 0.901 0.003 0.921 0.008 0.911 0.006 0.911 0.006 0.959 0.003 0.824 0.007 Download
ECFP2 fingerprints 0.967 0.009 0.971 0.000 0.969 0.006 0.969 0.006 0.990 0.000 0.937 0.009 Download
ECFP4 fingerprints 0.970 0.005 0.984 0.000 0.977 0.005 0.977 0.005 0.990 0.000 0.948 0.006 Download
ECFP6 fingerprints 0.963 0.005 0.985 0.004 0.974 0.005 0.974 0.005 0.990 0.000 0.948 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn