Target name

O70536: Sterol O-acyltransferase 1


  Protein function

Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption.

  Database links

Uniprot primary ID O70536
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID rno:81782
DIP ID
STRING ID 10116.ENSRNOP00000005677
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 81782
BindingDB O70536

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.899 0.006 0.965 0.005 0.932 0.004 0.929 0.003 0.980 0.000 0.865 0.007 Download
Estate fingerprints 0.807 0.005 0.729 0.004 0.768 0.004 0.776 0.005 0.870 0.000 0.536 0.005 Download
MACCS fingerprints 0.815 0.005 0.909 0.005 0.862 0.004 0.856 0.005 0.950 0.000 0.728 0.006 Download
Daylight fingerprints 0.826 0.005 0.964 0.005 0.895 0.005 0.886 0.005 0.940 0.000 0.795 0.007 Download
ECFP2 fingerprints 0.941 0.006 0.979 0.000 0.960 0.000 0.959 0.003 1.000 0.000 0.918 0.006 Download
ECFP4 fingerprints 0.979 0.003 0.987 0.000 0.983 0.005 0.983 0.005 1.000 0.000 0.970 0.000 Download
ECFP6 fingerprints 0.973 0.005 0.993 0.000 0.983 0.005 0.983 0.005 1.000 0.000 0.968 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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