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E-mail: biomed@csu.edu.cn
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Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.
| Uniprot primary ID | O75116 |
| PDB ID | 4WOT 4L6Q |
| DrugBank ID | |
| BioGrid ID | 114860 |
| GuidetoPHARMACOLOGY ID | 1504 |
| PharmGKB ID | PA34624 |
| KEGG ID | hsa:9475 |
| DIP ID | |
| STRING ID | 9606.ENSP00000317985 |
| IntAct ID | O75116 |
| DMDM | |
| BRENDA | |
| Reactome | R-HSA-4420097 R-HSA-5627117 R-HSA-416572 R-HSA-416482 R-HSA-3928663 R-HSA-3928662 |
| SignaLink | O75116 |
| BioCyc | |
| Entrez Gene (Gene ID) | 9475 |
| BindingDB | O75116 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.897 | 0.007 | 0.921 | 0.007 | 0.909 | 0.003 | 0.909 | 0.003 | 0.947 | 0.005 | 0.817 | 0.009 | Download |
| Estate fingerprints | 0.839 | 0.006 | 0.855 | 0.009 | 0.847 | 0.005 | 0.847 | 0.005 | 0.916 | 0.005 | 0.696 | 0.013 | Download |
| MACCS fingerprints | 0.821 | 0.003 | 0.821 | 0.011 | 0.821 | 0.007 | 0.823 | 0.007 | 0.910 | 0.000 | 0.647 | 0.009 | Download |
| Daylight fingerprints | 0.889 | 0.003 | 0.811 | 0.003 | 0.850 | 0.000 | 0.858 | 0.004 | 0.860 | 0.000 | 0.704 | 0.007 | Download |
| ECFP2 fingerprints | 0.897 | 0.005 | 0.873 | 0.009 | 0.885 | 0.005 | 0.885 | 0.005 | 0.961 | 0.003 | 0.772 | 0.010 | Download |
| ECFP4 fingerprints | 0.940 | 0.000 | 0.960 | 0.005 | 0.950 | 0.000 | 0.950 | 0.000 | 0.978 | 0.004 | 0.904 | 0.005 | Download |
| ECFP6 fingerprints | 0.935 | 0.005 | 0.981 | 0.004 | 0.958 | 0.004 | 0.958 | 0.004 | 0.978 | 0.004 | 0.919 | 0.006 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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