Target name

O75116: Rho-associated protein kinase 2


  Protein function

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.

  Database links

Uniprot primary ID O75116
PDB ID 4WOT 4L6Q
DrugBank ID
BioGrid ID 114860
GuidetoPHARMACOLOGY ID 1504
PharmGKB ID PA34624
KEGG ID hsa:9475
DIP ID
STRING ID 9606.ENSP00000317985
IntAct ID O75116
DMDM
BRENDA
Reactome R-HSA-4420097 R-HSA-5627117 R-HSA-416572 R-HSA-416482 R-HSA-3928663 R-HSA-3928662
SignaLink O75116
BioCyc
Entrez Gene (Gene ID) 9475
BindingDB O75116

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.897 0.007 0.921 0.007 0.909 0.003 0.909 0.003 0.947 0.005 0.817 0.009 Download
Estate fingerprints 0.839 0.006 0.855 0.009 0.847 0.005 0.847 0.005 0.916 0.005 0.696 0.013 Download
MACCS fingerprints 0.821 0.003 0.821 0.011 0.821 0.007 0.823 0.007 0.910 0.000 0.647 0.009 Download
Daylight fingerprints 0.889 0.003 0.811 0.003 0.850 0.000 0.858 0.004 0.860 0.000 0.704 0.007 Download
ECFP2 fingerprints 0.897 0.005 0.873 0.009 0.885 0.005 0.885 0.005 0.961 0.003 0.772 0.010 Download
ECFP4 fingerprints 0.940 0.000 0.960 0.005 0.950 0.000 0.950 0.000 0.978 0.004 0.904 0.005 Download
ECFP6 fingerprints 0.935 0.005 0.981 0.004 0.958 0.004 0.958 0.004 0.978 0.004 0.919 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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