The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
 |
 |
 |
 |
 |
 |
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.
| Uniprot primary ID | O75907 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 114241 |
| GuidetoPHARMACOLOGY ID | 2821 |
| PharmGKB ID | PA27303 |
| KEGG ID | hsa:8694 |
| DIP ID | |
| STRING ID | 9606.ENSP00000332258 |
| IntAct ID | O75907 |
| DMDM | |
| BRENDA | 2.3.1.20 |
| Reactome | R-HSA-1482883 R-HSA-75109 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 8694 |
| BindingDB | O75907 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.871 | 0.007 | 0.961 | 0.000 | 0.916 | 0.005 | 0.909 | 0.006 | 0.980 | 0.000 | 0.831 | 0.007 | Download |
| Estate fingerprints | 0.886 | 0.007 | 0.798 | 0.004 | 0.842 | 0.004 | 0.848 | 0.004 | 0.910 | 0.000 | 0.686 | 0.010 | Download |
| MACCS fingerprints | 0.958 | 0.004 | 0.894 | 0.007 | 0.926 | 0.005 | 0.928 | 0.004 | 0.980 | 0.000 | 0.852 | 0.008 | Download |
| Daylight fingerprints | 0.887 | 0.005 | 0.937 | 0.004 | 0.912 | 0.004 | 0.910 | 0.005 | 0.969 | 0.003 | 0.828 | 0.008 | Download |
| ECFP2 fingerprints | 0.973 | 0.005 | 0.947 | 0.005 | 0.960 | 0.000 | 0.960 | 0.000 | 0.994 | 0.005 | 0.920 | 0.005 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.958 | 0.004 | Download |
| ECFP6 fingerprints | 0.971 | 0.003 | 0.989 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.962 | 0.004 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
| |
|
|
| |
|
|