Target name

O75907: Diacylglycerol O-acyltransferase 1


  Protein function

Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.

  Database links

Uniprot primary ID O75907
PDB ID
DrugBank ID
BioGrid ID 114241
GuidetoPHARMACOLOGY ID 2821
PharmGKB ID PA27303
KEGG ID hsa:8694
DIP ID
STRING ID 9606.ENSP00000332258
IntAct ID O75907
DMDM
BRENDA 2.3.1.20
Reactome R-HSA-1482883 R-HSA-75109
SignaLink
BioCyc
Entrez Gene (Gene ID) 8694
BindingDB O75907

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.871 0.007 0.961 0.000 0.916 0.005 0.909 0.006 0.980 0.000 0.831 0.007 Download
Estate fingerprints 0.886 0.007 0.798 0.004 0.842 0.004 0.848 0.004 0.910 0.000 0.686 0.010 Download
MACCS fingerprints 0.958 0.004 0.894 0.007 0.926 0.005 0.928 0.004 0.980 0.000 0.852 0.008 Download
Daylight fingerprints 0.887 0.005 0.937 0.004 0.912 0.004 0.910 0.005 0.969 0.003 0.828 0.008 Download
ECFP2 fingerprints 0.973 0.005 0.947 0.005 0.960 0.000 0.960 0.000 0.994 0.005 0.920 0.005 Download
ECFP4 fingerprints 0.980 0.000 0.980 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.958 0.004 Download
ECFP6 fingerprints 0.971 0.003 0.989 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.962 0.004 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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