Target name

O77636: Disintegrin and metalloproteinase domain-containing protein 17


  Protein function

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2 (By similarity).

  Database links

Uniprot primary ID O77636
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
DIP ID
STRING ID 9823.ENSSSCP00000009208
IntAct ID
DMDM
BRENDA 3.4.24.86
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID)
BindingDB O77636

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.920 0.000 0.982 0.000 0.951 0.003 0.950 0.000 0.990 0.000 0.906 0.005 Download
Estate fingerprints 0.940 0.007 0.900 0.006 0.920 0.000 0.921 0.003 0.978 0.004 0.841 0.006 Download
MACCS fingerprints 0.990 0.000 0.950 0.003 0.970 0.000 0.970 0.000 0.990 0.000 0.944 0.005 Download
Daylight fingerprints 0.845 0.007 0.997 0.000 0.921 0.003 0.914 0.005 0.980 0.000 0.849 0.006 Download
ECFP2 fingerprints 0.982 0.004 0.982 0.000 0.982 0.004 0.982 0.004 1.000 0.000 0.968 0.004 Download
ECFP4 fingerprints 0.974 0.005 1.000 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.971 0.003 Download
ECFP6 fingerprints 0.950 0.007 0.994 0.000 0.972 0.004 0.972 0.004 1.000 0.000 0.948 0.004 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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