Target name

O95136: Sphingosine 1-phosphate receptor 2


  Protein function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

  Database links

Uniprot primary ID O95136
PDB ID 1ZTI
DrugBank ID
BioGrid ID 114708
GuidetoPHARMACOLOGY ID 276
PharmGKB ID PA162402353
KEGG ID hsa:9294
DIP ID DIP-60682N
STRING ID 9606.ENSP00000466933
IntAct ID O95136
DMDM
BRENDA
Reactome R-HSA-419408 R-HSA-418594
SignaLink
BioCyc
Entrez Gene (Gene ID) 9294
BindingDB O95136

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.632 0.010 0.818 0.006 0.725 0.007 0.696 0.008 0.822 0.006 0.459 0.014 Download
Estate fingerprints 0.583 0.005 0.789 0.018 0.686 0.010 0.651 0.009 0.732 0.006 0.380 0.019 Download
MACCS fingerprints 0.487 0.009 0.843 0.008 0.665 0.005 0.594 0.012 0.709 0.006 0.351 0.015 Download
Daylight fingerprints 0.569 0.010 0.799 0.007 0.684 0.005 0.644 0.005 0.706 0.005 0.378 0.011 Download
ECFP2 fingerprints 0.743 0.014 0.843 0.009 0.793 0.009 0.785 0.010 0.859 0.003 0.592 0.021 Download
ECFP4 fingerprints 0.745 0.017 0.835 0.011 0.790 0.008 0.780 0.012 0.877 0.009 0.582 0.015 Download
ECFP6 fingerprints 0.730 0.016 0.870 0.010 0.800 0.013 0.786 0.014 0.878 0.008 0.609 0.023 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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