Target name

O95180: Voltage-dependent T-type calcium channel subunit alpha-1H


  Protein function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the

  Database links

Uniprot primary ID O95180
PDB ID
DrugBank ID DB01118 DB01054 DB01023 DB01115 DB00568 DB04841 DB00909
BioGrid ID 114426
GuidetoPHARMACOLOGY ID 536
PharmGKB ID PA380
KEGG ID hsa:8912
DIP ID
STRING ID 9606.ENSP00000334198
IntAct ID O95180
DMDM
BRENDA
Reactome R-HSA-419037
SignaLink
BioCyc
Entrez Gene (Gene ID) 8912
BindingDB O95180

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.696 0.005 0.808 0.000 0.752 0.004 0.737 0.005 0.850 0.000 0.508 0.006 Download
Estate fingerprints 0.798 0.004 0.696 0.005 0.747 0.005 0.760 0.000 0.820 0.000 0.496 0.005 Download
MACCS fingerprints 0.740 0.005 0.732 0.000 0.736 0.005 0.738 0.004 0.820 0.000 0.472 0.004 Download
Daylight fingerprints 0.700 0.005 0.698 0.003 0.699 0.003 0.700 0.005 0.746 0.005 0.400 0.005 Download
ECFP2 fingerprints 0.867 0.005 0.843 0.003 0.855 0.005 0.858 0.004 0.930 0.000 0.709 0.006 Download
ECFP4 fingerprints 0.860 0.000 0.902 0.003 0.881 0.003 0.878 0.004 0.950 0.000 0.760 0.005 Download
ECFP6 fingerprints 0.840 0.007 0.900 0.005 0.870 0.000 0.866 0.005 0.940 0.000 0.739 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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