Target name

O95822: Malonyl-CoA decarboxylase, mitochondrial


  Protein function

Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation.

  Database links

Uniprot primary ID O95822
PDB ID 2YGW 4F0X
DrugBank ID
BioGrid ID 116989
GuidetoPHARMACOLOGY ID
PharmGKB ID PA30861
KEGG ID hsa:23417
DIP ID DIP-60405N
STRING ID 9606.ENSP00000262430
IntAct ID O95822
DMDM
BRENDA 4.1.1.9
Reactome R-HSA-390918
SignaLink
BioCyc
Entrez Gene (Gene ID) 23417
BindingDB O95822

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.975 0.005 0.983 0.003 0.979 0.003 0.979 0.003 1.000 0.000 0.955 0.005 Download
Estate fingerprints 1.000 0.000 0.940 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.939 0.003 Download
MACCS fingerprints 0.982 0.004 0.978 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.952 0.004 Download
Daylight fingerprints 0.954 0.005 0.894 0.006 0.924 0.005 0.927 0.005 0.954 0.005 0.850 0.009 Download
ECFP2 fingerprints 1.000 0.000 0.980 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.980 0.000 Download
ECFP4 fingerprints 1.000 0.000 0.986 0.003 0.993 0.005 0.993 0.005 1.000 0.000 0.989 0.003 Download
ECFP6 fingerprints 1.000 0.000 0.988 0.005 0.994 0.005 0.994 0.005 1.000 0.000 0.990 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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