Target name

P00374: Dihydrofolate reductase


  Protein function

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.

  Database links

Uniprot primary ID P00374
PDB ID 4M6J 3NXV 1DRF 1S3U 4G95 1S3W 3OAF 1HFQ 1HFP 4KAK 2W3M 1KMS 1U72 1OHJ 1OHK 3NXO 1U71 4KBN 1PDB 3NXX 4KFJ 3NXT 3L3R 3NZD 2C2S 4DDR 4M6L 2C2T 3GYF 3NXY 3N0H 1S3V 3NU0 4KEB 1YHO 1DLS 1DLR 3GI2 3EIG 2W3A 2W3B 3FS6 3F91 1PD9 1PD8 4QHV 3GHW 1KMV 3GHC 1HFR 3NXR
DrugBank ID DB01157 DB00563 DB00205 DB00440 DB01131 DB06813 DB00798
BioGrid ID 108065
GuidetoPHARMACOLOGY ID 2603
PharmGKB ID PA143
KEGG ID hsa:1719
DIP ID
STRING ID 9606.ENSP00000396308
IntAct ID P00374
DMDM 118992
BRENDA 1.5.1.3
Reactome R-HSA-1474151 R-HSA-113510 R-HSA-69205 R-HSA-196757
SignaLink
BioCyc
Entrez Gene (Gene ID) 1719
BindingDB P00374

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.909 0.003 0.953 0.003 0.931 0.003 0.930 0.000 0.972 0.004 0.867 0.005 Download
Estate fingerprints 0.906 0.005 0.910 0.004 0.908 0.004 0.907 0.005 0.960 0.000 0.813 0.007 Download
MACCS fingerprints 0.939 0.003 0.941 0.000 0.940 0.000 0.940 0.000 0.980 0.000 0.887 0.005 Download
Daylight fingerprints 0.796 0.005 0.964 0.000 0.880 0.000 0.870 0.000 0.960 0.000 0.780 0.000 Download
ECFP2 fingerprints 0.959 0.003 0.975 0.000 0.967 0.005 0.966 0.005 0.990 0.000 0.930 0.000 Download
ECFP4 fingerprints 0.954 0.005 0.986 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.942 0.004 Download
ECFP6 fingerprints 0.938 0.004 0.990 0.000 0.964 0.005 0.962 0.004 0.990 0.000 0.930 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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