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E-mail: biomed@csu.edu.cn
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Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.
| Uniprot primary ID | P00375 |
| PDB ID | 2FZJ 3K47 3K45 3D80 1U70 3D84 |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | mmu:13361 |
| DIP ID | |
| STRING ID | 10090.ENSMUSP00000022218 |
| IntAct ID | P00375 |
| DMDM | |
| BRENDA | 1.5.1.3 |
| Reactome | R-MMU-196757 R-MMU-113510 R-MMU-69205 R-MMU-1474151 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 13361 |
| BindingDB | P00375 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.950 | 0.000 | 0.990 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 1.000 | 0.000 | 0.950 | 0.000 | Download |
| Estate fingerprints | 0.940 | 0.005 | 0.980 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.921 | 0.003 | Download |
| MACCS fingerprints | 0.948 | 0.004 | 0.990 | 0.003 | 0.969 | 0.003 | 0.969 | 0.003 | 1.000 | 0.000 | 0.947 | 0.007 | Download |
| Daylight fingerprints | 0.888 | 0.008 | 1.000 | 0.000 | 0.946 | 0.005 | 0.942 | 0.004 | 0.990 | 0.000 | 0.896 | 0.005 | Download |
| ECFP2 fingerprints | 0.950 | 0.000 | 0.990 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 1.000 | 0.000 | 0.950 | 0.000 | Download |
| ECFP4 fingerprints | 0.950 | 0.000 | 0.990 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 1.000 | 0.000 | 0.950 | 0.000 | Download |
| ECFP6 fingerprints | 0.950 | 0.000 | 0.990 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 1.000 | 0.000 | 0.950 | 0.000 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
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