Target name

P00375: Dihydrofolate reductase


  Protein function

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.

  Database links

Uniprot primary ID P00375
PDB ID 2FZJ 3K47 3K45 3D80 1U70 3D84
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID mmu:13361
DIP ID
STRING ID 10090.ENSMUSP00000022218
IntAct ID P00375
DMDM
BRENDA 1.5.1.3
Reactome R-MMU-196757 R-MMU-113510 R-MMU-69205 R-MMU-1474151
SignaLink
BioCyc
Entrez Gene (Gene ID) 13361
BindingDB P00375

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.950 0.000 0.990 0.000 0.970 0.000 0.970 0.000 1.000 0.000 0.950 0.000 Download
Estate fingerprints 0.940 0.005 0.980 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.921 0.003 Download
MACCS fingerprints 0.948 0.004 0.990 0.003 0.969 0.003 0.969 0.003 1.000 0.000 0.947 0.007 Download
Daylight fingerprints 0.888 0.008 1.000 0.000 0.946 0.005 0.942 0.004 0.990 0.000 0.896 0.005 Download
ECFP2 fingerprints 0.950 0.000 0.990 0.000 0.970 0.000 0.970 0.000 1.000 0.000 0.950 0.000 Download
ECFP4 fingerprints 0.950 0.000 0.990 0.000 0.970 0.000 0.970 0.000 1.000 0.000 0.950 0.000 Download
ECFP6 fingerprints 0.950 0.000 0.990 0.000 0.970 0.000 0.970 0.000 1.000 0.000 0.950 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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